94年版「全民健康保險藥品給付規定」

Transcription

1 BUREAU OF NATIONAL HEALTH INSURANCE

2

3 (evidence-based) ( ) (professional autonomy) ()

4 Drugs acting on the nervous system Drugs used for pain relief Psychotherapeutic drugs Neurologic drugs Drugs used in anesthesia Miscellaneous Parasympathomimetic (Cholinergic) Agents Cardiovascular-renal drugs Antiplatelet agents Vasodilators Vasoconstrictors Agents used to treat urological disorders Thrombolytic drugs Drugs used for dyslipidemia Miscellaneous Beta blocking agents Metabolic & nutrient agents Parenteral nutritions Vitamins Miscellaneous Hematological drugs Hematopoietic agents Blood components and blood substituents i

5 5 Hormones & drugs affecting hormonal mechanism Oral hypoglycemic drugs Androgens and anabolic steroids and antagonists Estrogens,progestins & drugs used for infertility Drugs related to anterior pituitary & hypothalamic function Miscellaneous Rispiratory tract drugs Inhalants Miscellaneous Gastrointestinal drugs Antiemetic drugs Miscellaneous Immunologic agents Vaccines and Immunoglobulins Immunomodulators Antineoplastic drugs Antimicrobial drugs Penicillins Cephalosporins Macrolides Carbapenem Carbapenems Antifungal drugs ii

6 10.7. Antiviral drugs Miscellaneous Antidotes in poisoning General antidotes Specific antidotes ENT and dental preparations Dermatological preparations Ophthalmic preparations Gynecological preparations A r-tpa(actilyse)tenecteplase (Metalyse) ( ( ) ) B r-tpa(actilyse) C Human albumin Novo SevenFeiba () () () isotretinoin acitretin tirofiban (Aggrastat) iii

7 28 Disease Activity Score, DAS (DMARDs) etanerceptadalimumab etanercept ( ) tacrolimus pilocarpine hydrochloride Index iv

8 () (86/1/1) () 1. Insulin 2. CAPD 3. CAPD ( ) 4. desferrioxamine Desferal 5. 20,000U EprexRecormon 100mcg Aranesp 6. -interferon 7. G-CSF (Filgrastimlenograstim( 8. (human growth hormone) 9. ~ ( ) 86/9/1(92/5/1) 10. (TPN) 85/10/193/12/1 11. octreotidelanreotide (Sandostatin Somatuline ) octreotide(sandostatin ) (93/12/1)lanreotide inj 30 mg Somatuline (88/6/1)octreotide LAR(Sandostatin LAR Microspheres for Inj.) (89/7/1) 12. streptomycinkanamycin enviomycin 86/9/1 ~ 1 ~

9 13. ( ) 87/4/ /11/1 15. apomorphine hydrochloride 10mg/ml Britaject Pen on-and-off 15 91/2/1 16. perniciousanemia B12 B12 (91/4/1) 17. aldesleukin(proleukin Inj) ( ) (91/12/1) 18. (92/10/1) 19. etanerceptadalimumab (93/8/1) () () morphine 85/10/1 ( ) -A -B 85/1/1 86/1/194/6/1 (87/4/1) () ( () ( ) ~ 2 ~

10 () () () () () (primary data) (Computer Clinical Information System) ~ 3 ~

11 1 Drugs acting on the nervous system 1.1. Drugs used for pain relief : (88/09/0192/2/1) 1. ( 40gm) 2.flurbiprofen 40mg patch(flur Di Fen Patch) (92/2/1) (1) (2) (3) (4) (NSAIDs) (88/12/1) tramadol (87/4/1) (1) NSAIDS (2) VAS VRS (Visual Analogue Scale Verbal Rating Scale) tramadol HClacetaminophen Ultracet Tablets(93/7/1) NSAIDscelecoxibnabumetone meloxicametodolacnimesulide (90/7/1) 1. (1) (2) (3) (4) ~ 4 ~

12 (5) (6) (7) 2. misoprostol 1.2. Psychotherapeutic drugs (SSRI) (SNRI) fluvoxamine maleate fluoxetineparoxetinesertralinevenlafaxine HClmilnacipran mirtazapinecitalopramescitalopram (88/12/189/10/191/5/192/6/193/5/194/2/1) bupropion HCL(Wellbutrin S-R Tab. 150mg)(92/1/1) Antipsychotics clozapine Clozaril Serotonin-dopamine antagonists ( clozapineolanzapinerisperidonequetiapineamisulpride ziprasidonearipiprazole ) (91/9/192/1/1 92/7/194/1/1) 1. (Clinical Global Impression CGI clozapine 400 mg/day risperidone 6 mg/day olanzapine 20 mg/day quetiapine 600 mg/day amisulpride 800mg/day(92/1/1) ~ 5 ~

13 ziprasidone120mg/day(92/7/1) aripiprazole 15mg/day 94/1/ Neurologic drugs Skeletal muscle relaxants tizanidine HCl(Sirdalud tab)(90/10/1) Antiepileptic drugs sodium valproate (Depakine Lyophilized Injection)(89/7/1 93/2/193/6/1) phenytoin phenytoin valproic acid (Seizure clusters) (Status epilepticus) gabapentin (Neurontin cap) lamotrigine (Lamictal) vigabatrin (Sabril)tiagabine (Gabitril)(89/9/189/2/193/6/1) add on therapy topiramate (Topamax)(90/9/192/11/193/6/194/3/1) 1. (add on therapy) 2. (94/3/1) (1) 2 (2) topiramate 100mg levetiracetam(keppra) (93/6/1) (add on therapy) donepezil (Aricept)rivastigmine ~ 6 ~

14 Exelon capsules (90/10/1)galantamine hydrobromide (Reminyl) 92/1/1 1. NINDS-ADRDA DSM ICD MMSE CDR MMSE 10~26 CPR MMSE CDR MMSE ( ) CDR 3. heart block 4. (93/4/1) (1) CTMRI Hachinskki lschemic Scale (2) CBS,VDRL,BUN,Creatinine,GOT,GPT,T4,TSH (3) (4) (5) MMSE CDR 5. (93/4/1) (91/11/193/2/1) 1. Monoamine oxidase B inhibitorsselegiline 2. levodopa Dopamine agonistropinirolepramipexolepergolide lisurideamantadine levodopa COMT entacapone Comtan film-coated tab. 3. "on"state methylphenidate HCl(Concerta Extended Release Tablets)(93/9/1) 1. DSM ICD Drugs used in anesthesia propofol(91/2/1) ~ 7 ~

15 cis-atracuriumatracurium(91/2/1) vecuroniumrocuronium(91/2/1) 1. (1) (2) local anesthetics xylocaine 2 % jelly 1.5. Miscellaneous riluzole (Rilutek) (87/4/1)(92/11/1) 1. (ALS/MND) (92/11/1) 2 (spinal muscular atrophy ) (segmental or focal motor neuron disease ) (polio ) botulinum toxin type A Botox (90/1/193/1/194/6/1) 1. (1) (2) Spasm Intensity Scale ~ 8 ~

16 (94/6/1) (3) (4) 2. focal dystonia (1) (2) Tsuis rating scale for cervical dystonia (3) (4) (5) 3. (1) (2) Modified Ashworth Scale (3) (4) ~ ~ (94/6/1) (5) ~ ~ (94/6/1) (6) (7) 4. 93/1/194/6/1 (1) Modified Ashworth Scale R1/R2 ~ 9 ~

17 (94/6/1) (2) (94/6/1) (3) (4) Botox 360u (94/6/1) (5) (6) Botox Dysport (91/2/193/1/194/6/1) 1. (1) (2) Spasm Intensity Scale (94/6/1) (3) (4) 2. focal dystonia (1) (2) Tsuis rating scale for cervical dystonia (3) (4) (5) 3. (1) (2) Modified Ashworth Scale ~ 10 ~

18 (3) (4) ~ ~ 93/1/1 (5) ~ ~ (94/6/1) (6) (7) 4 93/1/194/6/1 (1) Modified Ashworth Scale R1/R2 (94/6/1) (2) (94/6/1) (3) (4) Dysport 1000u (5) (6) Dysport Spasm Intensity Scale Modified Ashworth Scale ~ 11 ~

19 tolterodine L-tartrate (Detrusitol F.C TabletsDetrusitol SR Prolonged-release cap): (90/7/193/10/1) 1. (1) 24 (2) (3) (1) (2) (3) detrusor areflexia 1.6 Parasympathomimetic (Cholinergic) Agents93/8/194/2/ pilocarpine hydrochloride 1. (Sjogren's syndrome) (1) (2) (3) pilocarpine hydrochloride ( ) pilocarpine hydrochloride (4) (5mg/tab.) 2. (1) 26GY (2) (3) pilocarpine hydrochloride ( ) 10 () (4) (5mg/tab.) 3. ~ 12 ~

20 : (Sjogren's syndrome) (1) (2) (3) 2. (1) (2) (3) 3. (1) Shirmer' s 5 5 (2) Rose Bengal score 4 ( van Bijsterveld's ) 4. 4mm 2 1 focus (1 Focus 50 ) 5. (1) (15 1.5cc) (2) X ( ) (3) / 6. (1) SSA SSB 1. (1)(2) (1) ( ) 6 ( ) (2) 4 ( 3456 )3 ( ) ~ 13 ~

21 2 Cardiovascular-renal drugs 2.1. Antiplatelet agents acetylsalicylic acid(aspirin)89/2/ ticlopidine (ticlopidine acetylsalicylic acid )(87/4/188/9/190/1/1) 1. acetylsalicylic acid (Aspirin) acetylsalicylic acid (Aspirin) (88/9/1) 2. acetylsalicylic acid(aspirin) (stent) (87/4/1)90/1/ tirofiban hydrochloride (Aggrastat) 91/2/1 1. (1) ST 1mm0.1mv hemodynamics 9999 (2) PTCA tirofiban mg 3. ( ) abciximab ReoPro (90/7/1) 1. heparin Q 2. Q PTCA abciximab tinzaparin sodium Innohep Injection (90/7/191/9/1) cilostazol(pletaal tablets)(90/6/1) clopidogrel Plavix (90/1/193/4/194/8/1) 1. (90/1/194/8/1) ~ 14 ~

22 (1)acetylsalicylic acid (Aspirin) (2) 2. 3 acetylsalicylic acid (Aspirin) (90/1/194/8/1) 3. ST ( Q ) acetylsalicylic acid ( Aspirin) 9 93/4/1 94/8/ Vasodilators buflomedil FlodilLoftyl nimodipine inj Nimotop (87/4/193/2/1) CT Scan papaverine inj 2.3. Vasoconstrictors 2.3.1sumatriptan succinate Imigran (88/9/193/8/1) 1. (International Headache Society) (1) (2)(4) (2) (3) ( ) (4) ~ 15 ~

23 2. ( ) mg(93/8/1) 5. ergotamine Prinzmetal 2.4. Agents used to treat urological disorders alprostadil(86/9/1) potassium citrate Urocit-K tab pentosan Polysulfate Sodium(Elmiron Cap)(92/12/1) (1) (2) (3) glomerulation Hunner's 500 (4) 300 (5) Thrombolytic drugs r-tpa Actilyse Inj tenecteplase(metalyse Inj.) (91/12/1) (93/1/1) ~ 16 ~

24 r-tpa (Actilyse) tenecteplase(metalyse Inj.) ( -A) (93/1/1) 8. r-tpa tenecteplase) ( ICU CCU ) r-tpa Actilyse Inj (93/1/1) (NIHSS) X 酶 ( -C) 4. r TPA (Actilyse) ( -B) ( )NIHSS recombinant human activated protein C Xigris Powder For Solution For Infusion(93/11/1) 1. (1) (2) suspected (3) (4) 38 C 36 C 90 / 20 / PaCO2 32 mm Hg 12,000/mm34,000/mm3 >10% ~ 17 ~

25 (5) 90mm Hg 70mm Hg <0.5ml/kg/hr PaO2/FiO2 250 PaO2/FiO2200 <80,000/mm3 >2mg/dl 2 ph base deficit 5mEq/L (6)Apache II score 2. (1) (2) (3) Heparin 15 IU/kg/hr (4) (5) ( INR( )>2.0 ) (6) <30,000/mm3 (7) ( ) (8) C ~ 18 ~

26 C S antithrombin III anticardiolipin( )antiphospholipid CD4 50/mm Drugs used for dyslipidemia ( )86/1/187/4/187/7/191/9/ ezetimibe (Ezetrol Tablets)(94/6/1) ( ) 1. Statins Severe myalgiamyositis 2. Statins 3 Statins 2.7. Miscellaneous (87/4/1) 2.8. Beta blocking agentsmetoprolol succinate 23.75mg Betaloc ZOK 25mg(93/5/1) ~ 19 ~

27 LDL-C 160mg/dl <160mg/dl LDL-C 130mg/dl 100mg/dl(87/7/1) TC/HDL-C>5 2 ( ) HDL-C<40mg/dl 200mg/dl <200mg/dl TC 240mg/dl <240 mg/dl ( 130mg/dl <130mg/dl ) TG 200mg/dl <200mg/dl(87/4/1) ( TC/HDL-C>5 HDL-C<40mg/dl) TC 200mg/dl < 160mg/dl(87/7/1) TG 200mg/dl ( < 150mg/dl(87/7/1) TC/HDL-C>5 HDL-C<40mg/dl) 500mg/dl () () ( ) ( ) ( ) ( ) ( ) () ( ) (TIA) 70% () ( ) ( 93/9/1 ) ~ 20 ~

28 3 Metabolic & nutrient agents 3.1. Parenteral nutritions Intrafat (500cc) 3.2. Vitamins mecobalamin (85/4/1) ( ) (NCV) D3 (alfacalcidolcalcitriol) 86/1/191/7/1 1.Vit.D ( ) 2. ( ) 3. (BUN 80 mg/dl creatinine 4.0 mg/dl PTH-i ) 10.5 mg/dl 4. bisphosphonatescalcitoninraloxifene 3.3. Miscellaneous /1/1 3. (hypermmonemia) 88/3/ ( ) ketosteril tab ~ 21 ~

29 1. 6 mg % 2. 5 mg % Amiyu... (93/12/1) glucosamine sulfate 88/9/193/8/1 1. (1) (Ahlbäck ) stage III(III) (stage I, II, III ) (2) Lequesne s severity index for knee OA 7 points mg Lequesne s severity index (93/8/1) 3. glucosamine :Ahlbäck Classification of severity of osteoarthritis of the knee (Ahlbäck 1968) Stage I II III IV V Radiographic change At most a slight reduction of the cartilage height Obliteration of the joint space Bone loss of 7mm measured along the medial or lateral margins of the joint from a line perpendicular to the axis of the tibia and tangential to the unaffected articular surface Bone loss >7mm measured as above Bone loss >7mm with subluxation, defined as lateral displacement of the tibia by at least 10 mm in relation to the femur THE JOURNAL OF BONE AND JOINT S URGERY, Vol. 72-B, No.2, March ~ 22 ~

30 oral calcium salt 89/2/1 1. osteoporosis osteomalacia 2. hyperphosphatemia hypocalcemia 3. glucocorticoid Nutrineal PD4 with 1.1% Amino Acid(91/2/1) (92/10/1) 1. CAPD 2. 3.serum albumin <=3.5gm/dl npna <0.9 CAPD : npna (normalized protein equivalent of total nitrogen appearance) (gm/kg/day) =[10.76 (0.69 UNA+1.46)] body weight (kg) 4.Kt/Vurea>=2.0/week weekly creatinine clearance >=60 L/week/1.73m 2 ( (PET)high and high-average transporters )weekly creatinine clearance >=50 L/week/1.73m 2 ( (PET)low and low-average transporters )(92/10/1) 5. amino acid agalsidase alfa(replagal inj.) 93/9/ agalsidase beta Fabrazyme inj. 93/10/ "Baxter" Extraneal Peritoneal Dialysis Solution With 7.5% Icodextrin (93/12 /1) 1. (1) 4.25% 4 400cc. (2) high transporters high average transporters (3) 2. ~ 23 ~

31 4 Hematological drugs 4.1. Hematopoietic agents (hu-erythropoietin EPO (EprexRecormon) darbepoetin alfa Aranesp)(93/5/1) 1.Hb 8 gm/dl ferritin 100 mg/dl 2.transferrin saturation % 20 % (1) hematocrit (Hct)28 % (2) creatinine6 mg % hematocrit 28 % (3) Hct 26 % 30 % 30 % 30 % (4)Hct ( ) (5) u EprexRecormon 100mcg Aranesp ( Hct... ) (93/5/1) (6) Hct CAPD Hct ( ) (7) Hct G-CSF (filgrastin inj Filgrastimlenograstim inj Granocyte) 85/10/1 93/4/1 1. (1) (2) (3) ( 1000/cumm (ANC) 500/cumm) (4) 1000/cumm (ANC) 500/cumm ~ 24 ~

32 (5) (86/9/1) (6) 100/cumm (7) MDS ANC<500/cumm G-CSF (8) 4~5 G-CSF 10g /KG/day /cumm 2000/cumm 4.2. blood substituents and blood components Human Albumin 1. Human Albumin (1) ml (hematocrit)30 % (hemoglobin)10 gm/dl dextran hydroxyethylstarch polyvinylpyrolidone 50 gm86/1/ gm (2) 2.5 gm/dl i. ( ) 25 gm ii. ( ) 25 gm iii iv 3.0 gm/dl ~ 25 ~

33 i ii iii 40 % 37.5 gm 2. (1) (2) Human Albumin ( ) (rviia,novoseven) 和活化的凝血酶原複合物濃 (Activated PCC, APCC,Feiba) (88/6/193/7/1 94/2/1) 1. rviia 10~20g/kg IVq 2~3 hr1~3 2. A (1) (low responder) ( ) 5 BU/ml () (2) (2) (high responder) ( ) >5 BU/ml <5 BU/ml ( ) I. 5 BU/ml i. rviia 70~90g/kg IVq 2 hr1~3 APCC 50~100 U/kg IVq6-12h1 ~ 4 ii ii. 100 U/kg IV bolus 5~10 U/kg/hr IV inf. 100 U/kg IV q8-12 hr,5 II II. >5 BU/ml i. rviia 70~90g/kg IVq 2 hr3 APCC 50~100 U/kg IV q6-12h34 ii ii. (protein A)Plasmaphoresis ~ 26 ~

34 (3) rviia 70~90g/kg IVq2 ~3 hr,rviia 70~90g/kg IVq 3 ~ 6 hr III. APCC 50~100 U/kg IV q6-12hr 3. (1) I. (5BU/ml) II., 5BU/ml 200U/kg IV q12-24hr,2-3 I. II. III. III. >5BU/ml rviia 70-90g/kg IV q2h, 3 APCC U/kg IV q6-12hr,4 (2) I. APCC II. rviia 70-90g/kg IV q2h, 3 4. rviiaapcc ( ) APCC,Feiba,, 100U/kg 200U/kg(94/2/1) ~ 27 ~

35 5 Hormones & drugs affecting hormonal mechanism 5.1. Oral hypoglycemic drugs acarbose (Glucobay) 86/1/187/4/189/6/191/7/ guar gum (Guarina grguarem ) 5.2. Androgens and anabolic steroids and antagonists danazol 86/1/ finasteride Proscar tab; dutasteride(avodart Soft Capsules) (86/1/187/4/193/10/1) 1. (TRUS of prostate) 20 (Qmax) 15 ml/sec (PSA) 2. (uroflow-metry) flutamide (Fugerel)buserelin (Supremon injnasal sol'n) 90/8/1 1. T3 2. PSA 3. T2T3 irradiation tumor volume reduction neoadjuvant bicalutamide (Casodex tab) 89/10/1 LHRH ~ 28 ~

36 5.3. Estrogens,progestins & drugs used for infertility Estradiol Estraderm TTSOestro V.T(93/5/1) estradiol 3.8mg/12.5cm/patch Climara 50 Transdermal Patch 90/4/ FSH (pure FSH) hypothalamus failure( ) (85/1/1) HMG hypothalamus failure( ) (85/1/1) Utrogestan Cap progesterone 5.4. Drugs related to anterior pituitary & hypothalamic function (Somatropin) (94/6/1) 3. ( ) (1) insulin, clonidine, L-Dopa (with or without propranolol), glucagon, arginine 10 ng/ml 20 mu/l (2) (3) ) (4) 23 (5) 0.18 mg/kg/wk (0.48 IU/kg/wk) 0.3 mg/kg/wk (0.8 IU/kg/wk)20 IU/m2/wk (6) ~ 29 ~

37 (94/6/1) 4. (1) (2) (3) 14 (4) 1 IU/kg/wk mg/kg/wk (5) 14 2 / Genotropin Prader-Willi Syndrome 93/5/1 1. <=16 <= IU/kg 0.035mg/kg 4. (1) (Lipid profile) Sleeping Study Body Composition (DXA) X (2) bromocriptine ~ 30 ~

38 octreotide inj (Sandostatin inj) 87/11/1 1. dopamine octreotide (Sandostatin LAR Microspheres for Injection) 89/7/1 1. dopamine 2. octreotide 3. 20mg somatostatin 87/11/189/5/ lanreotide inj 30mg/vial Somatuline 88/6/189/5/1 93/12/1 1. dopamine 2. (93/12/1) cabergoline(dostinex Tab.)(91/6/1) Miscellaneous Gn-RH analogue BuserelinGoserelinLeuprorelinTriptorelin Nafarelin(acetate) (92/1/1)(93/4/1) 1. ( ) 85/1/1 2. (1) ~ 31 ~

39 central precocious puberty, CPPLHRH LH 10 miu/ml (Idiopathic CPP, ICPP) (Pathologic CPP, PCPP i. ii. iii. a. b. target heightth target heightth= c. 2.0 (PAH) vi. PCPP iiiii GnRH analogue 3.75 mg ( i. ii. (2) (86/9/1) (tamoxifenmegestrol ) 3. 87/10/1 (1) () (AFS rafs ) GnRH analogue ALT AST creatinine > 2 mg % ~ 32 ~

40 (2) (Salmon calcitonin nasal sprayinjection) ( Paget's disease) 85/10/193/8/ bisphosphonate alendronate Fosamax (87/11/191/7/191/10/193/8/1) 1. (1) (93/8/1) (2) (serum creatinine) 1.6mg/dl 2 calcitonin raloxifene D clodronatepamidronate 85/1/187/4/193/2/ mmol/l (11.0mg %) 5.6 mg % zoledronic acid(zometa)(93/6/193/12/1) 1. (HCM) 2.75 mmol/l (11.0mg/dl) 5.6 (93/6/1) 2.Multiple Myeloma, Breast Cancer, Prostate Cancer (93/12/1) etidronate Etibon (87/10/1) Paget s disease risedronate sodium Actonel 94/4 /1 1. (1) (2) (serum creatinine) 1.6mg/dl 2. calcitonin raloxifene D raloxifene hydrochloride Evista 60mg Tablets 90/4/191/10/ mg 3. bisphosphonatescalcitonin D3 ~ 33 ~

41 5.5.5 teriparatide (Forteo ) (94/5/1) X DXA 4. bisphosphonatescalcitoninraloxifene D rasburicase Fasturtec (93/5/1) 1. high grade (1). 10mg/dl 8mg/dl (2). (3).allopurinol 2. ~ 34 ~

42 6 Respiratory tract drugs 6.1. Inhalants 1. 2-agonists anticholinergics steroid inhalants (91/8/1) ( ) 2.formoterol fumarate dihydrate(oxis Turbuhaler) 6.2. Miscellaneous surfactant (ExosurfSurvanta) (85/1/1) 1. hyaline membrane disease (respiratory distress syndrome) 2. hyaline membrane disease FI2 40 % blood gas Pa2 80 mmhg 2 artery/2 alveoli loratadine syrup Clarityne (88/6/1) ( ) zafirlukast (Accolate tabs (88/8/190/1/1 ) PFR cromoglycate ketotifen montelukast sodium (Singulair Coated Tab, Singulair Chewable Tabs) (90/7/1) PER cromoglycate ketotifen (mild persistent asthma) (1) ~ 35 ~

43 (2) (3) (4) (PFR) 80 % % montelukast sodium (Singulair Chewable Tab.4mg) (92/1/1) 1. ~ cromoglycate ketotifen ~ 36 ~

44 (nebulizer) (MDI)(91/8/1) (DPI) 20 ( 2 -agonists) 180 (puff) (MDI) (BID) 60 (vial) (anticholinergic s) 180 (puff) 20 (spacer) () 120 (vial) (steroid mcg inhalants) (MDI) mcg (MDI) 7 ml 1.5/kg (inspiratory flow) 30 4 (DPI) ~ 37 ~

45 (MDI) (nebulizer) (DPI) ( 2 -agonists) (puffs) (MDI) (BID) (anticholinergic s) spacer (steroid PEFR inhalants) (MDI) mcg 0.05mg/kg 2mg/ MDI MDI spacer aerochamber ~ 38 ~

46 7 Gastrointestinal drugs (1) (2) (3) (4) gefarnatecetraxatecarbenoxolone (5) dibismuth trioxide, sucralfate, pirenzepine HCl, Gaspin, Caved-S, misoprostol, proglumide 2. (1) active healing (92/10/1) (2) scar stage (3) The Los Angeles Classification of Esophagitis Grade A Grade B (92/10/1) (4) The Los Angeles Classification of Esophagitis Grade C Grade D (92/10/1) Zollinger-Ellision (5) NSAIDs NSAIDs (92/10/1) (6) ~ 39 ~

47 24 ph (92/10/1) (7) (92/10/1) (8) (9) (92/10/1) (10) (11) NSAID ( misoprostol) 1.The Los Angeles Classification of Esophagitis Grade A:One or more mucosal break,each <=5mm long,confined to the mucosal folds Grade B:One or more mucosal break > 5mm long,confined to the mucosal folds but not continuous between the tops of two mucosal folds Grade C:One or more mucosal break continuous between the tops of two or more mucosal folds but which involve less than 75% of the esophageal circumference Grade D:Mucosal breaks which involve less than 75% of the esophageal circumference 2. () (92/10/1) 7.2. Antiemetic drugs serotonin antagonists ondansetrongranisetrontropisetron (93/2/193/9/1) ~ 40 ~

48 1. 2. / (1) ondansetron 8~32mggranisetron 1~3mgtropisetron 5mg (2) ondansetron 8~32mggranisetron 1~3mgtropisetron 5mg dexamethasone metoclopramide dexamethasone metoclopramide 3. ondansetron granisetron (93/9/1) (1) total body or half body irradiation (2) pelvis or upper abdominal region of single irradiation dose> 6 Gy (3) dexamethasone metoclopramide rochlorperazine 1. cisplatin(>50mg/m2/day)carmustine(250mg /m2 /day),cyclophosphamide (>1500mg/m2/day)methotrexate ( 1.2gm/m2 /day) 2. cisplatin(30mg/m2/day 50mg/m2/day) carmustine( 250mg/m2/day),cyclophosphamide(1500 mg/m2/day) doxorubicin(45mg /m2 /day)epirubicin (70mg/ m2 /day) CPT-11idarubicin(10mg/ m2 /day)daunorubicin(60mg/ m2 /day )dactinomycin(actinomycin-d)arsenic trioxidemelphalan (50 mg/m2/day)cytarabinecarboplatinoxaliplatin ifosfamide mitoxantronedacarbazine 3. (93/9/1) 7.3. Miscellaneous mesalazine Asacol balsalazide (Basazyde)(94/5/1) ~ 41 ~

49 8 Immunologic agents 8.1. Vaccines and Immunoglobulin Hepatitis B immune globulin HBsAg (-)Anti-HBc(-) HBsAg (+) TAT injtetanus Antitoxin ( ) T. toxoid cc (Gamimune-N; Venoglobulin ) 1. ) 2. (ITP) (< 20,000/cumm) 3. (ITP) ( 20,000/cumm () Intravenous Immune Globulin (IVIG) ( ) 6. 93/2/1 1. (1) (2) (3) (4) (5) Thymoglobuline injlymphoglobuline inj 1. ~ 42 ~

50 ...) (1) (2) (3) graft versus host disease (4) Immunoglobulin ATG-FreseniusThymoglobuline (90/11/1) 1. HLA 2. 45mg/kg/day Immunomodulators cyclosporin Sandimmun oral sol n, cap, inj86/1/186/9/1 89/7/ ( ) ( ) 5. ( ) 6. biopsy cytostatics 50% 7. cyclosporin 40% cyclosporin cyclosporin tacrolimus Prograf(88/8/193/12/1) 1. cyclosporin interferon beta-la(rebif Micrograms)(91/4/1) ~ 43 ~

51 interferon beta-1b(betaferon 8MIU)(92/3/1)(92/12/1) (93/3/1) 1 (1) (2) etanercept(enbrel) ; adalimumab Humira Solution for Injection, vial Humira Solution for Injection, Pre-Filled Syringe(92/3/1 93/8/193/9/194/3/1) etanercept(enbrel) (94/3/1) (1) methrotexate corticosteroids X (2) etanercept 3. (1).(2).(3). (1) ( systemic) (polyarticular) ( ) (extended oligoarticular) (2) ( ) methotrexate 10 / / methotrexate 3 ( ) prednisolone 0.25 (3) 3 : 5 3 ~ 44 ~

52 ( X ) 4. etanercept (1) (2) (3) (4) ( sepsis) (5) (pre-malignancy) (6) (Immunodeficiency) 5. etanercept (1) ( ) ( intercurrent infection)( ) (2) core set data 6 (ESR)CRP 30% i ii iii 30% etanercept ( ) etanercept(enbrel) ; adalimumab Humira Solution for Injection, vial Humira Solution for Injection, Pre-Filled Syringe (92/3/193/8/193/9/1) DAS28 DMARD X 4. 93/8/193/9/1 5 (1)(2)(3) (4) ~ 45 ~

53 (5) (1) 1987 (2) 28 ( Disease Activity Score, DAS 28) 5.1 X 128 ( ) : DAS28 = 0.56 TJC SJC lnesr GH 2TJC: SJC: ESR : ( mm/h)gh :100 mm ( general health status) (3) (Disease-Modifying Anti- Rheumatic Drugs, DMARD) DMARDs (methotrexate hydroxychloroquine sulfasalazined-penicillamineazathioprineleflunomide cyclosporine ) (93/8/1) i DMARD 6 ( ) (standard target dose) ii DMARDs DMARDs ( ) ( therapeutic doses) 2 (93/8/1) DAS DAS (4) (93/9/1)... i ii ~ 46 ~

54 ( TB / ) iii 12 iv v vi 10 (multiple sclerosis) (5) (93/8/193/9/1) i ii iii ( ) iv ( ) 28 ( Disease Activity Score, DAS 28) (DMARDs) etanerceptadalimumab leflunomide(aravaarheuma ) (92/9/193/5/1) 1 2. methotrexate methotrexate Interferon-: interferon alpha-2a(roferon-a)interferon alpha-2b(intron A)(92/10/1) 1. B C C ribavirin (1)HBsAg(+) HBeAg(+) ALT ( ) (ALT5X) (2)HBsAg(+) HBeAg(+) ALT ~ 47 ~

55 (2XALT<5X) HBcAg 93/2/1 (3) HBsAg(+) 93/2/1 (4) HBsAg(+) HBeAg(-) ALT ( ) (ALT2X) HBcAg 93/8/1 (5)Anti-HCV ALT ( ) (ALT2X) METAVIR system F1 93/2/193/8/ /4/1 (1).Chronic myelogenous leukemia (2).Multiple myeloma (3).Hairy cell leukemia (4). (a-2a2b type) (87/4/1) (5). Kaposi s sarcoma 87/4/1 (6). (low grade non-hodgkin s lymphoma) (high tumor burden) (89/1/1) ( LDH > 350 IU/L ) (7). ( a-2atype)89/1/1 (8).Kasabach-Merritt 93/4/1 (9). Lymphangioma 93/4/ interferon alfacon-1 Infergen 93/7/193/8/1. C ribavirin Anti-HCV ALT ( ) (ALT2X) METAVIR system F1 ~ 48 ~

56 peginterferon alpha-2b Peg-Intron 92/10/1 C ribavirin Anti-HCV ALT ( ) (ALT2X) METAVIR system F1 93/2/193/8/ peginterferon alfa-2a Pegasys 92/11/1 C ribavirin Anti-HCV ALT ( ) (ALT2X) METAVIR system F1 93/2/193/8/1 ~ 49 ~

57 9 Antineoplastics 9.1. Aromatase Inhibitor exemestane (Aromasin Sugar Coated Tablets) 88/11/1(90/10/1) (estrogen receptor) tamoxifene anastrozole (Arimidex)88/6/192/3/193/6/1 1. (92/3/1) 2. tamoxifen (92/3/1) 3. tamoxifen (93/6/1) (1) (2) (3) letrozole (Femara Film-coated tab)88/11/1(90/10/1)(92/3/1) 9.2. carboplatin ParaplatinCarboplatin inj (CCr < 60) 9.3. docetaxel Taxotere87/7/192/11/193/8/1 (92/11/1) 9.4. gemcitabine (Gemzar)(92/12/193/8/1) /12/1 ~ 50 ~

58 9.5. paclitaxel 88/8/188/11/189/6/189/10/191/4/191/8/1 93/8/194/1/1 1. cisplatin (94/1/1) 2. cisplatin (94/1/1) 3. ( anthracycline) 91/4/1(94/1/1) 4. taxol doxorubicin 91/4/1(94/1/1) 5. 88/11/ streptococcus pyrogene (Picibanil) 9.7. protein bound polysaccharide (PSK Krestin) 87/7/194/1/ (94/1/1) 3. (94/1/1) 9.8. toremifene tab Fareston 88/6/1 (estrogen receptor) 9.9. vinorelbine (Navelbine) 91/1/ oxaliplatin (Eloxatin Freeze Dried Power for Infusion 50mg) 89/7/1 91/10/193/8/1 5FU folinic acid irinotecan Campto (91/10/1) tegafur 1. 89/10/1 2. Cisplatin ~ 51 ~

59 Ufur 93/4/ irinotecan(campto injection)(90/10/193/8/1) : (1)5-Fu folinic acid (2) 5-Fu aldesleukin(proleukin for Injection)(90/10/193/8/1) doxorubicin Hydrochloride Liposome injection(lipo-dox, Caelyx)(91/3/1 93/8/193/11/1) : 1. PLATINUM PACLITAXEL (91/3/1) 2. CD4 <200CD4 Lymphocyte/MM3 AIDS related Kaposis Sarcoma (91/3/1) 3. (93/11/1) tretinoin Vesanoid Soft Gelatin88/10/ topotecan Hycamtin inj.88/10/193/8/ capecitabine Xeloda 88/10/191/4/192/6/193/8/1 1. capecitabine docetaxel anthracycline 2. taxanes anthracycline anthracycline 3. (92/6/1) trastuzumab (Herceptin)(91/4/193/8/1) 1. HER2 (91/4/1) 2.paclitaxel IHC Test3 FISH(+) (93/8/1) 3. ~ 52 ~

60 9.19. estramustine sod. phosphate monohydrate(estracyt)(91/4/1) rituximab (Mabthera) 1. B (91/4/1) 1. CHOP CD20 B 60 (93/1/1) fludarabine phosphate (Fludara Oral, Film -Coated Tablet Fludara Lyophilized IV Injection )(92/12/1) 1. Fludara Oral,Film -Coated Tablet B- CLL alkylating agent 92/12/1 2. Fludara Lyophilized IV Injection alkylating agent 93/3/ imatinib(glivec)(91/5/193/7/1) 1. (blast crisis) ALPHA- (CML) 2. CML ~ 53 ~

61 9.23. arsenic trioxide(asadin Inj.)(91/8/1) (92/9/1) gefitinib (Iressa):(93/11/1) 1. platinum docetaxel paclitaxel 2. (1) platinumcisplatin carboplatin taxanespaclitaxel docetaxel X measurable evaluable (2) X X temozolomide (Temodal) (94/3/1) 1. AA(anaplastic astrocytoma) GBM (Glioblastoma multiforme) 2. ~ 54 ~

62 10 Antimicrobial agents (87/7/1) 3. common cold 90/2/1 4. () 87/4/ (91/4/1) (1). (sepsis) (septic shock) (2). 1000/cumm 500/cumm (3) ( )86/10/1(92/9/1) (4) (5) (6) ~ 55 ~

63 (7) (8) (9) (10) ( ) 7. (1) 72 (2)72 7 (3) (1) 90/2/1 90/2/1 (2) Cephamycin cefoxitin,cefmetazole ampicillin -lactamase inhibitor ampicillin/sulbactam,amoxicillin/clavulanic acid 90/2/ /2/1 10. ~ 56 ~

64 11 TPR chart Penicillins amoxicillin + clauvulanic acid Augmentin tab(85/1/1) ampicillin + sulbactam Unasyn Ansullina (91/7/1) Cephalosporins Cefaclor85/1/189/7/ Cefuroxime tab 87/4/ Macrolides erythromycinazithromycinclarithromycinroxithromycin (90/11/193/9/1) 1. (mycoplasma) (chlamydia) (legionella) macrolides 2.azithromycin(Zithromax) 500mgclarithromycin(Klaricid TabKlaricid Paediatric Suspension) roxithromycin(rulid) 500mg(93/9/1) 3.clarithromycin(Klaricid Tab) 250mg 4. ~ 57 ~

65 10.5. Carbapenem imipenem+cilastatinmeropenem TienamMepem (87/11/1)93/2/1 (93/5/1) 1. carbapenem (sensitivity) 2. carbapenem ( )(93/5/1) ertapenem Invanz inj.(93/5/1) Antifungal drugs fluconazole oral Diflucan oral 85/10/187/4/ fluconazole Inj Diflucan inj 85/10/1 1. ( ) itraconazol (Sporanox cap)85/1/191/4/191/8/ (91/4/1) 2. ~ 58 ~

66 (91/8/ terbinafine (Lamisil tab )(85/1/191/4/1) mg amphotericin B Injection colloidal dispersion liposomal complex Amphocil InjectionAmBisome for Injection(91/8/1) (93/2/1) invasive fungal infection caspofungin Injection (Cancidas Injection 50mg) (92/8/1) (94/1/1) Antiviral drugs acyclovir Zovirax tromantadine Virumerzfamciclovir Famvir valaciclovir Valtrex 1. (1) 疱 (2) 疱 疱 VI (3) 疱 疱 S2 (4) 疱 疱 (5) (6) ( 38 ) ( ) 85/1/1 (7) 疱 疱 (8) (acute retina necrosis) (9) 疱 ~ 59 ~

67 (86/1/187/4/1) (10) acyclovir 87/11/1 A. B. (TBI) ribavirin ribavirin Virazole 87/4/1 ( ) (rispiratory syncytial virus) 1. (1) (2) (3) (4) 2. (PaO 2 ) 65mmHg (SaO 2 ) 90% 3. RSV ribavirin Robatrol Rebetol C interferon-alfa 2a interferon-alfa 2b interferon alfacon-1 peginterferon -alfa 2b peginterferon alfa-2a (92/10/192/11/193/7/1) Anti-HCV ALT ( ) (ALT2X) METAVIR system F1 93/2/193/8/ lamivudinezeffix 100mg 92/10/1 B ~ 60 ~

68 1.HBsAg(+) HBeAg(+) ALT ( ) (ALT5X) (Prothrombin time3 Bilirubin3.0mg/ml)(93/2/1) 2. HBsAg(+) 3. HBsAg(+) 93/2/1 4.HBsAg(+) HBeAg(+) ALT (2X ALT<5X) HBcAg 93/8/1 5.HBsAg(+) HBeAg(-) ALT ( ) (ALT2X) HBcAg 93/8/ (91/7/1) Miscellaneous teicoplanin vancomycin 88/3/ (antibiotics-associated colitis) metronidazole vancomycin 4. vancomycin 10 gm( ) moxifloxacin (Avelox film-coated tablet)(91/2/1 92/11/194/3/1) 1. ( ) 2. (400mg) linezolid(zyvox Injection Tablets)(91/4/1) 1. MRSA(methicillin-resistant staphylococcus aureus) vancomycin vancomycinteicoplanin vancomycinteicoplanin ~ 61 ~

69 2. VER(vancomycin-resistant enterococci) 3 (osteomyelitis) (endocarditis) 4 ( ) telithromycin (Ketek) (93/10/1) ( ) ~ 62 ~

70 11 Antidotes in poisoning 11.1 General antidotes Carbomix Specific antidotes flumazenil (Anexate inj ) benzodiazepine edrophonium chloride Enlon mesna Uromitexan inj EndoxanIfosphamide ~ 63 ~

71 12 ENT preparations beclomethasone cap. for spray (Salcoat)87/10/ sod. monofluorophosphate, sod. fluoride gel (Fluocaril gel) ofloxacin (Tarivid Otic Solution)(88/8/1) 1. ( ) 2. ~ 64 ~

72 13 Dermatological preparations mupirocin Bactroban oint 85/4/ MRSA (methicillin resistant staphylococcus aureus ) cadexomer iodine Iodosorb powder 87/4/ calcipotriol 87/4/189/2/194/3/194/5/ calcipotriol 87/4/189/2/194/3/1 psoriasis (30gm) (30mL) (30gm) (30mL) calcipotriol Daivobet 94/5/1 1. psoriasis (30gm) (30gm) isotretinoin (Roaccutane)86/9/187/4/194/3/ ( ) mg 120 mg/kg ) acitretin Neotigason (87/11/1) ( ) methoxsalen (87/11/1) PUVA ( ) ~ 65 ~

73 13.7. doxepin HCl cream (Ichderm)(88/6/1) tazarotene(tazorac Topical Gel)(91/4/1) tacrolimus(protopic Ointment ) (91/12/193/8/1) 1 >30% 2 (1) 30%~50%1tube/30g/wk >50% 2tube/30g/wk (2) 30%~50%1tube/30g/2wk >50% 1tube/30g/wk (3) rule of nines( 1) ( 2Barkin ) (4) (5) 30 93/8 /1 (6) 93/8 /1 1rule of nines 9% 18% 18% 18% 36% 1% 2 (From Roger M. Barkin) calcitriol(silkis ointment)(92/11/193/9/1) 35% (30gm) (30gm) : rule of nines pimecrolimus (Elidel 1% ) (92/11/193/8/194/3/1) 1. (94/3/1) >30% 2. (1) 30%~50%1tube/30g/wk >50% 2tube/30g/wk(94/3/1) ~ 66 ~

74 (2) 30%~50%1tube/30g/2wk >50% 1tube/30g/wk (3) rule of nines(13.9 1) (13.9 2Barkin ) (94/3/1) (4) (5) 30 93/8/1 (6) 93/8/1 ~ 67 ~

75 14 Ophthalmic preparations betaxololcarteolollevobunolol timolol Fotil (91/12/1) pilocarpine -receptor blocker (Cosopt)(92/2/1) Acyclovir 1. 疱 疱 V1 2. 疱 疱 3. (acute retina necrosis) maxitrol oph ointpimafucin oint Quinolone 87/4/1 93/2/ ofloxacin,norfloxacin,ciprofloxacin 87/4/1 93/2/ lomefloxacin (Okacin)(90/12/01)93/2/1 1.lomefloxacin hydrochloride /7/193/2/1 1. (basal Schirmer test) 5 mm 2. ~ 68 ~

76 14.6. Carbonic Anhydrase Inhibitor(TrusoptAzopt 1% Sterile Ophthalmic Suspension)(90/10/1) -blocker latanoprostxalatan isopropyl unoprostone(rescula)travoprost (Travatan)bimatoprost(Lumigan) Xalacom (93/2/1) 1.-blockers ketorolac tromethamine Acular Ophthalmic Solution (89/11/1) Miscellaneous botulinum toxin type A Botox(90/1/1) 1. 2 (1) (2) Spasm Intensity Scale (3) (4) Botox botulinum toxin type A(Dysport)(91/2/1) 1. (1) (2) Spasm Intensity Scale (3) (4) ~ 69 ~

77 Dysport Spasm Intensity Scale ~ 70 ~

78 15 Gynecological preparations prostaglandin E (Prostin E VT ) ~ 71 ~

79 amoxicillin amphotericin B ampicillin ampicillin bacampicillin benzathine penicillin cefadroxil cefazolin cephalexin cephalexin87/07/01 cephradine cephaloridine clindamycin cephalothin cloxacillin cephapirin colistin cephradine dicloxacillin clindamycin doxycyclin cloxacillin ethambutol(emb) doxycycline griseofulvin gentamicin hetacillin hetacillin isoniazid(inh) kanamycin ketoconazole lincomycin( 10ml ) methacycline metronidazole metronidazole oxacillin minocycline oxytetracycline mycostatin penicillin nalidixicacid rifamycin SV Inj( ) neomycin rolitetracycline nitrofurantoin streptomycin nitroxoline flucloxacillin(94/3/1) oxytetracycline penicillin pyrazinamide(pza) rifampicin ( ) tetracycline trimethoprime/ sulfa methoxazole ~ 72 ~

80 -A r-tpa(actilyse) tenecteplase(metalyse) SGOT CPK (100mg) 1 (50mg) ~ 73 ~

81 -B r-tpa(actilyse) ( NIHSS) mg ~ 74 ~

82 -C NIHSS<6 NIHSS>25 / 1/ heparin (aptt) <100,000/mm 3 >185mmHg >110mmHg <50mg/dl >400mg/dl 6 warfarin sodiuminr> ~ 75 ~

83 3 / ~ 76 ~

84 thiamine malabsorption syndrome total parenteral nutrition,tpn alcohol withdrawal syndrome 2 6 B12 phenytoin 1 89/2/1 - ~ 77 ~

85 Human Albumin 2.5gm/dl 3.0gm/dl A B C D E F G H I J K A/G(gm/dl) Albumin 3 3 Albumin Albumin gm/dl ~ 78 ~

86 Novo SevenFeiba ( 10 B.u.) ( ) PT: PTT: :C VIII:C IXC VIII Ab (1) B.u. (2) B.u. IX Ab (1) B.u. (2) B.u. (1) (2) (3) ~ 79 ~

87 Intravenous Immune Globulin(IVIG) (Kawasaki Disease) A. (bulbar conjunctiva) B. (ESR) C- ( ) C. Streptococcal Inf. (scarlet fever) Viral & rickettsial exanthems Drug reaction (eg. Stevens-Johnson syndrome) Juvenile rheumatoid arthritis Staphylococcal scalded skin syndrome Toxic shock syndrome IVIG IVIG () IVIG ~ 80 ~

88 : trastuzumab (Herceptin) rituximab (Mabthera) HER2 paclitaxel IHC Test3 FISH+. B ( ) CHOP CD20 B 60 ( ) ~ 81 ~

89 fludarabine phosphate Fludara Oral,Film -Coated Tablet fludarabine phosphate Fludara Lyophilized IV Injection imatinib (Glivec) B- CLL alkylating agent B LG-NHL ( alkylating agent ) ( ) (blast crisis) ALPHA- (CML) CML ( ) ~ 82 ~

90 : A. platinum docetaxel paclitaxel platinumcisplatin carboplatin taxanespaclitaxel docetaxel. ( X ) ( B. X ) temozolomide (Temodal) AA(anaplastic astrocytoma) GBM (Glioblastoma multiforme) ( ) Iressa 8. ~ 83 ~

91 isotretinoin : : isotretinoin isotretinoin isotretinoin : 1. isotretinoin 2. isotretinoin 4 3. isotretinoin : : : 20 ~ 84 ~

92 acitretin : : acitretin acitretin acitretin : 1. acitretin 2. acitretin acitretin : : : 20 ~ 85 ~

93 tirofiban (Aggrastat) ST 1mm0.1mv hemodynamics Troponin CK-MB ( ) (48 ) 1 (12.5mg) 2 (25mg) 3 (37.5mg) ~ 86 ~

94 28 Disease Activity Score, DAS 28 TENDERNESS SWELLING TENDERNESS MCP I MCP II MCP III MCP IV MCP V PIP II PIP III PIP IV PIP V ( + ) ( + ) SWELLING / MCP (MCP : Metacarpophalangeal ) PIP (PIP: Proximal Interphalangeal) 100 mm ~ 87 ~

95 (DMARDs) DMARDs Standard Target Dose Therapeutic Dose methotrexate hydroxychloroquine sulphasalazine intramuscular Gold D-penicillamine azathioprine / 7.5 / 6.5 / / / 40 / / 2 / 50 / 50 / / / 2 / / 100 / cyclosporines / 2.5 / ( General Health Status) ~ 88 ~

96 etanerceptadalimumab ( Disease Activity Score, DAS 28 DAS ( X ) DAS28 DAS28 MCP I MCP II MCP III MCP IV MCP V PIP II PIP III PIP IV PIP V ( + ) ( + ) (general health assessment)100 mm ~ 89 ~

97 DMARDs ( ) ( etanerceptadalimumab DMARDs methotrexate mg/week hydroxychloroquine mg/day sulphasalazine g/day IM Gold mg/week D-penicillamine mg/day azathioprine mg/day leflunomide mg/day cyclosporine mg/day DAS 28 DMARDs ( standard target dose) etanerceptadalimumab etanerceptadalimumab / etanerceptadalimumab (multiple sclerosis) etanerceptadalimumab 6 DAS etanerceptadalimumab ( ) ~ 90 ~

98 etanercep 性别 ~ 91 ~

99 etanercept methotrexate etanercept etanercept (sepsis) etanercept etanercept ~ 92 ~

100 ZIAGEN ORAL SOLUTION abacavir Sulfate 20mg ZIAGEN TABLETS abacavir Sulfate 300mg VIDEX CHEWABLE BUFFERED TABLETS didanosine 100mg VIDEX EC DELAYED-RELEASE CAPSULES didanosine 250mg & 400mg STOCRIT CAPSULES efavirenz 200mg & 600mg CRIXIVAN CAPSULES indinavir Sulfate 200mg & 400mg 3TC FILM COATED TABLETS lamivudine 150mg 3TC ORAL SOLUTION lamivudine 10mg/ml OKAVIR TABLETS lamivudine 150mg KALETRA SOFT GELATIN CAPSULES lopinavir ritonavir 133.3mg 33.3mg VIRACEPT TABLETS nelfinavir 250mg VIRAMUNE ORAL SUSPENSION nevirapine Anhydrous 10mg/ml VIRAMUNE TABLETS nevirapine Anhydrous 200mg NORVIR (RITONAVIR ORAL SOLUTION) ritonavir 80mg/ml NORVIR SOFT GELATIN CAPSULES ritonavir 100mg FORTOVASE SOFT GELATIN CAPSULES saquinavir (amorphous) 200mg ZERIT (STAVUDINE) CAPSULES stavudine 30mg ZERIT (STAVUDINE) CAPSULES stavudine 40mg HIVID TABLETS zalcitabine 0.750mg RETROVIR CAPSULES zidovudine 100mg RETROVIR SYRUP zidovudine 10mg/ml TRIZIVIR TABLETS zidovudine lamivudine abacavir Sulfate 300mg 150mg 300mg ZIVIR-100 CAPSULES zidovudine 100mg COMBIVIR TABLETS zidovudine lamivudine 300mg 150mg ~ 93 ~

101 tacrolimus Barkin ~ 94 ~

102 (/) () (/) ( ) : ~ 95 ~

103 ~ 96 ~

104 pilocarpine hydrochloride 1. pilocarpine hydrochloride pilocarpine hydrochloride pilocarpine hydrochloride pilocarpine hydrochloride pilocarpine hydrochloride pilocarpine hydrochloride pilocarpine hydrochloride pilocarpine hydrochloride pilocarpine hydrochloride pilocarpine hydrochloride pilocarpine hydrochloride pilocarpine hydrochloride pilocarpine hydrochloride 10 ~ 97 ~

105 Abciximab 14 Acarbose 28 Accolate 35 Acetaminophen 5 Tramadol HCl Acetylsalicylic acid 14 Acitretin 65 Actilyse 16 Actonel 33 Acular oph slon 69 Acyclovir 59,68 Adalimumab 2,45 Agalsidase alfa 23 Agalsidase beta 23 Aggrastat 14 Aldesleukin 2,52 Alendronate 33 Alfacalcidol 21 Alprostadil 16 AmBisome 59 Amisulpride 5 Amiyu 22 Amoxicillin+ clauvulanic acid 57 Ampicillin+sulbactam 57 Amphocil 59 Amphotericin B 59 Anastrozole 50 Anexate 63 Ansullina 57 Aricept 6 Aranesp 1,24 Arava 47 Arheuma 47 Arimidex 50 Aripiprazole 5 Aromasin 50 Arsenic Trioxide 54 Asacol 41 Asadin 54 Aspirin 14 ATG-fresenius 43 Atracurium 8 (Index) ~98~ Atrovent 35 Augmentin tab 57 Avelox 61 Avodart 28 Azithromycin 57 Azopt 69 Bactroban oint 65 Balsalazide 41 Basazyde 41 Beclomethasaone cap. For 64 spray Betaferon 44 Betaloc ZOK 19 Betaxolol 68 Bicalutamide 28 Bimatoprost 69 Bisphosphonate 33 Botox 8,69 Botulinum toxin type A 8,69 Bricanyl 35 Britaject Pen(Apo-go Pen) 2 Bromocriptine 30 Budesonide 35 Buflomedil 15 Bupropion 5 Buserelin 28,31 Cabergoline 31 Cadexomer iodine 65 Caelyx 52 Calcipotriol ointment 65 Calcitriol 21 Calcium saltoral 23 Campto 52 Cancidas Inj 59 Capecitabine 52 Carbapenem 58 Carbenoxolone 39 Carbomix 63 Carboplatin 50 Carteolol 68 Casodex tab 28 Caspofungin Injection 59

106 Caved-s 39 Cefaclor 57 Cefuroxime tab 57 Celecoxib 4 Cephalosporins 57 Cetraxate 39 Cilostazol 14 Ciprofloxacin 68 Cis-atracurium 8 Citalopram 5 Clarithromycin 57 Clarityne 35 Climara 29 Clodronate 33 Clopidogrel 14 Clozapine 5 Clozaril 5 Comtan 7 Concerta 7 Cosopt 68 Cyclosporin 43 Cytotec 39 Daivobet 65 Daivonex(oint,scalp soln) 65 Danazol 28 Darbepoetin alfa 1,24 Depakine lyophilized inj 6 Desferal 1 Desferrioxamine 1 Detrusitol 12 Dibismuth trioxide 39 Diflucan 58 Docetaxel 50 Donepezil 6 Dorzolamide(Trusopt) 68 Dostinex Tab 31 Doxepin 66 Doxorubicin 52 Dutasteride 28 Dysport 10,69 Edrophonium chloride 63 Elidel 66 Elmiron 16 (Index) Eloxatin 51 Enbrel 2,44 Enlon 63 Enviomycin 1 Epo 1,24 Eprex 1,24 Entacapone 7 Ertapenem 58 Erythromycin 57 Escitalopram 5 Estracyt 53 Estraderm TTS 29 Estradiol 29 Estramustine 53 Etanercept 2,44 Etibon 33 Etidronate 33 Etodolac 4 Enviomycin 1 Evista 33 Exelon 7 Exemestane 50 Exosurf 35 Extraneal Peritoneal 23 Dialysis Soln Ezetimibe 19 Ezetrol 19 Fabrazyme 23 Famciclovir 59 Famvir 59 Fareston 51 Fasturtec 34 Feiba 26 Femara 50 Filgrastim 1,24 Finasteride 28 Flodil 15 Flucloxacillin 72 Fluconazole 58 Fludara 53 Fludarabine 53 Flumazenil 63 Fluocaril gel 64 ~99~

107 Fluoxetine 5 Flurbiprofen Patch 4 Flur Di Fen Patch 4 Flutamide 28 Fluvoxamine Maleate 5 Forteo 34 Fosamax 33 Fotil 68 FSH 29 Fugerel 28 Gabapentin 6 Gabitril 6 Galantamine HBr 7 Gamimune-N 42 Gaspin 39 G-CSF 1,24 Gefarnate 39 Gefitinib 54 Gemcitabine 50 Gemzar 50 Genotropin 30 Glivec 53 Glucobay 28 Glucosamine Sulfate 22 Gn-RH analogue 31 Goserelin 31 Granisetron 40 Granocyte 1,24 Growth hormone 1,29 Guar gum 28 Guarem 28 Guarina gr. 28 H2 receptor blockers 39 Hepatitis B immune globulin 42 Herceptin 52 HMG 29 Hu-erythropoietin 24 Human albumin 25 Human growth hormone 1,29 Humira 2,45 Hycamtin 52 Ichderm 66 Icodextrin 23 (Index) ~100~ Imatinib 53 Imigran 15 Imipenem+Cilastatin 58 Immunoglobulin 43 Infergen 48 Innohep 14 Insulin 1 Interferon- 2,47 Interferon- 43 Interferon alpha-2a 47 Interferon alpha-2b 47 Interferon alfacon-1 48 Interferon beta-la 43 Interferon beta-1b 44 Intrafat 21 Intravenous 42 Immunoglobulin (IVIG) Intron A 47 Invanz 58 Iodosorb powder 65 Iressa 54 Irinotecan 52 Isopropyl unoprostone 69 Isotretinoin 65 Itraconazol 58 Kanamycin 1 Keppra 6 Ketek 62 Ketorolac tromethamine 69 Ketosteril tab 21 Klaricid 57 Krestin 51 Lamictal 6 Lamisil 59 lamivudine 60 Lamotrigine 6 Lanreotide 1,31 Latanoprost 69 Leflunomide 47 Lenograstim 1,24 Letrozole 50 Leuprorelin 31

108 Levetiracetam 6 Levobunolol 68 Linezolid 61 Lipo-Dox 52 Lisuride 7 Loftyl 15 Lomefloxacin 68 Loratadine syrup 35 Lumigan 69 Lymphoglobuline 42 Mabthera 53 Macrolides 57 Maxitrol 68 Mecobalamin 21 Meloxicam 4 Mepem 58 Meropenem 58 Mesalazine 41 Mesna 63 Metalyse 16 Methoxsalen 65 Methylphenidate HCl 7 Metoprolol Succinate 19 Milnacipran 5 Mirtazapine 5 Misoprostol 5,39 Montelukast sod 35 Morphine 2 Moxifloxacin 61 Mupirocin 65 Nabumetone 4 Nafarelin(acetate) 31 Navelbine 51 Neotigason 65 Neurontin cap 6 Nimesulide 4 Nimodipine inj 15 Nimotop 15 Norfloxacin 68 NovoSeven 26 Nutrineal pd4 with 1.1% 23 amino acid Octreotide 1,31 (Index) Oestro v.t 29 Ofloxacin 64,68 Okacin 68 Olanzapine 5 Ondansetron 40 Oxaliplatin 51 Oxis 35 Paclitaxel 51 Pamidronate 33 Papaverine inj 15 Paraplatin 50 Paroxetine 5 Pegasys 49 peginterferon alfa-2a 49 peginterferon alpha-2b 49 Peg-Intron 49 Penicillins 57 Pentosan Polysulfate 16 Sodium Pergolide 7 Picibanil 51 Pilocarpine Hydrochloride 12 Pimafucin 68 Pimecrolimus 66 Pirenzepine 39 Plavix 14 Pletaal 14 Potassium citrate 16 Pramipexole 7 Proglumide 39 Prograf 43 Proleukin 2,52 Propofol 7 Proscar 28 Prostaglandin E 71 Prostin E 71 Proton pump inhibitors 39 Protopic oint 66 PSK(protein bound 51 polysaccharide) Pulmicort aerosol 35 Quetiapine 5 Raloxifene 33 ~101~

109 Rasburicase 34 Rebetol 60 Rebif 43 Recombinant Human 17 Activated Protein C Recormon 1,24 Reminyl 7 ReoPro 14 Replagal 23 Rescula 69 Ribavirin 60 Rilutek 8 Riluzole 8 Risedronate 33 Risperidone 5 Rituximab 53 Rivastigmine 6 Roaccutane 65 Robatrol 60 Rocuronium 8 Roferon-A 47 Ropinirole 7 Roxithromycin 57 r-tpa 16 Rulid 57 Sabril 6 Salagen 12 Salcoat 64 Salmon calcitonin 33 Sandimmum 43 Sandostatin 1,31 Sandostatin LAR 1,31 Selegiline 7 Serotonin antagonists 5,40 Sertraline 5 Silkis ointment 66 Singulair 35 Sirdalud tab 6 Sod.Fluoride gel 64 Sod.Monofluorophosphate, 64 Sod.valproate inj 6 Somatostatin 31 Somatropin 29 (Index) Somatuline 1,31 Sporanox 58 Streptococcus pyrogene 51 Streptomycin 1 Sucralfate 39 Sumatriptan succinate 15 Supremon 28 Surfactant 35 Survanta 35 Tacrolimus 43,66 Tarivid 64 TAT inj(tetanus Antitoxin) 42 Taxotere 50 Tazarotene 66 Tazorac 66 Tegafur 51 Teicoplanin 61 Telithromycin 62 Temodal 54 Temozolomide 54 Tenecteplase 16 Terbinafine 59 Teriparatide 34 Thymoglobuline 43 Ticlopidine 14 Tienam 58 Tiagabine 6 Timolol 68 Tinzaparin sod 14 Tirofiban HCl inj 14 Tizanidine HCl 6 Tolterodine 12 Topamax 6 Topiramate 6 Topotecan 52 Toremifene 51 TPN 1 Tramadol 4 Trastuzumab 52 Travatan Oph 69 Travoprost 69 Tretinoin 52 Triptorelin 31 ~102~

110 Tromantadine 59 Tropisetron 40 Trusopt 69 Ultracet 4 Ufur 52 Unasyn 57 Urocit-k 16 Uromitexan 63 Utrogestan 29 Valaciclovir 59 Valtrex 59 Vancomycin 61 Vasodilators 19 Vecuronium 8 Venlafaxine 5 Venoglobulin 42 Ventolin 35 Vesanoid 52 Vigabatrin 6 Vinorelbine 51 Virazole 60 Virumerz 59 Vit.D 21 Vitamins 21 Wellbutrin S-R Tab 5 Xalacom 69 Xalatan 69 Xeloda 52 Xigris 17 Xylocaine 2% jelly 8 Zafirlukast 35 Zeffix 60 Ziprasidone 5 Zithromax 57 Zoledronic Acid 33 Zometa 33 Zovirax 59 Zyvox 61 (NSAID) 4 (NSAID) 4 (Index) ~103~ (NSAID) A 73 r- TPA(Actilyse) tenecteplase(metaly se) ( ) -B 74 r- TPA(Actilyse) ( ) -C 75 -A 77 -B Human albumin 79 Novo SevenFeiba 80 IVIG isotretinoin 84

111 (Index) 85 acitretin 86 tirofiban (Aggrastat) Disease Activity Score, DAS (DMARDs) 89 etanercept adalimumab 91 etanercept ( ) tacrolimus Pilocarpine Hydrochloride ~104~

112 (Index) GPN ISBN

113 (Index) ISBN GPN

114 (Index)