33 243 HAART Meta * 1 1 1 1 1 2 3 3 3 1. 530001 2. 538000 3. 530011 highly active anti-retroviral therapy HAART Pubmed HAART randomized controlled trials RCT Jadad RevMan5. 3 Meta 5 RCT 761 Meta HAART CD + 4 T MD = 31. 61 95% CI = 16. 73 46. 49 OR = 2. 07 95% CI = 1. 51 2. 85 HAART HAART. HAART Meta J. 2018 33 8 1375-1379. HIV Meta DOI 10. 16368 /j. issn. 1674-8999. 2018. 08. 326 R259. 129. 1 A 1674-8999 2018 08-1375 - 05 Meta-analysis of Traditional Chinese Medicine Combined with HAART Intervention for Poor Immune Reconstitution in AIDS Patients TANG Beibei 1 LI Zimu 1 GAO Haibin 1 LUO Longjiang 1 WU Xixi 1 LUO Xiangqun 2 CEN Fengxian 3 JIANG Feng 3 TANG Youming 3 1. Guangxi University of Chinese Medicine Nanning Guangxi China 530001 2. TCM Hospital of Fangchenggang City Fangchenggang Guangxi China 538000 3. Ruikang Hospital Affiliated to Guangxi University of Nanning Guangxi China 530011 Abstract Objective To systematically evaluate the effects of high-level Active Anti-Retroviral Therapy HAART on AIDS patients with poor immune reconstitution. Methods CNKI VIP Wanfang and PubMed databases were searched and the literature on drug preparations combined with HAART were used to treat randomized controlled trials RCT of AIDS patients with immune reconstitution was obtained. According to the improved version of Jadad the quality of the included literature was evaluated. Meta-analysis of the included literature was performed using RevMan 5. 3 software. Results A total of 5 RCTs were included in 761 patients. Meta-analysis showed that the changes of CD + 4 T cells in patients with AIDS treated with traditional Chinese medicine and HAART were significantly better than those in the control group MD = 31. 61 95% CI = 16. 73 46. 49 and that of the treat- * 81460716 81660771 GZLC16-75 S201308-02 2016 133 1375
33 243 ment group was more effective than that of the control group OR = 2. 07 95% CI = 1. 51 2. 85. Conclusion The clinical efficacy of Chinese medicine combined with HAART is significantly better than that of HAART alone in treatment of AIDS patients with poor immune reconstitution. Reference citation TANG Beibei Li Zimu GAO Haibin et al. Meta-analysis of Traditional Chinese Medicine Combined with HAART Intervention for Poor Immune Reconstitution in AIDS Patients J. Acta Chinese Medicine 2018 33 8 1375-1379. Key words AIDS HIV poor immune reconstitution highly effective antiretroviral therapy traditional Chinese medicine therapy Meta-analysis acquired im- HIV /AIDS 3 HAART mune deficiency syndrome AIDS 12 ~ 24 CD + 4 T 100 ~ 200 human immunodeficiency virus HIV 300 ~ 350 μl - 1 < 20% HAART 36 highly active anti-retroviral therapy HAART CD + 4 T 80 ~ 250 μl - 1 4 HAART HIV /AIDS HIV HIV < 50 ml - 1 1 5 1-3 HAART 20% HIV /AIDS HAART HAART 3-5 6 6 CD + 4 T AIDS 7 8 1. 3 HIV /AIDS HIV /AIDS HAART HAART HAART 9 HAART 1. 4 CD + 4 T 1 30% 50 μl - 1 CD + 4 T 1. 1 < 30% 50 μl - 1 Pubmed CD + 4 T 30% 50 μl - 1 2 HIV AIDS 2. 1 2 EndNoteX7 acquired immune deficiency syndrome AIDS HIV immune reconstitution immune response traditional Chinese medicine μl - 1 HAART > 24 CD + 4 T 1. 2 3 randomized controlled trials RCT HIV /AIDS 2. 2 1 18 ~ 75 2 1376
33 243 Excel JADAD 1 3 2 3 4 2. 3 Cochrane 3. 1 RevMan5. 3 Meta 107 89 18 odds ratio OR CD + 4 T means differences MD χ 2 P 0. 10 I 2 50% 1 5 10-14 761 P < 0. 10 I 2 > 50% 3. 2 3 2 2 1 2017 32 HAART 31 + HAART 12 2017 30 HAART 30 + HAART 12 2016 172 + HAART 189 2 + HAART 72 2013 117 + HAART 116 2 + HAART 6 2017 21 + HAART 23 2 + HAART 12 2 / 2017 2 2017 1 2017 6 2013 7 2017 6 3. 3 Meta CD + 4 T 1 3. 3. 1 CD + 4 T 5 3. 3. 2 4 CD + 4 T P = P = 0. 31 I 2 = 16% 0. 81 I 2 = 38% I I 2 50% P 0. 10 50% P 0. 10 MD = 31. 61 95% CI = 16. 73 46. 49 Z = 4. 16 P < 0. 000 1 OR = 2. 07 95% CI = 1. 51 2. 85 Z = 4. 50 P < 0. 000 01 HAART HIV /AIDS HAART HIV /AIDS 2 1 CD 4 + T 1377
33 243 2 3. 4 2 HIV /AIDS HAART 3 4 4 3 4 HIV /AIDS CD 4 + T HIV /AIDS HIV CD T 593. 1378 HIV 2 Meta HAART HIV /AIDS HAART HAART 1 BLANKSON J N PERSAUD D SILICIANO R F. The challenge of viral reservoirs in HIV-1 infection J. Annu Rev Med 2002 53 557 -
33 243 * 1 2 2 2 1. 510000 2. 528000 37 6 T CD + 3 CD + 4 CD + 4 /CD + 8 P < 0. 05 CD + 8 P < 0. 05 IgA IgG IgM P < 0. 05 P > 0. 05 2 5%. J. 2018 33 8 1379-1382. * 20173015 2015AB00342 2 AUTRAN B CARCELAINT G LI T S et al. Restoration of the immune system with anti-retroviral therapy J. Immunol Lett 1999 66 1 /3 207-211. 3 GUIHOT A BOURGARIT A CARCELAIN G et al. Immune reconstitution after a decade of combined antiretroviral therapies for human immunodeficiency virus J. Trends Immunol 2011 32 3 131-137. 4 GAARDBO J C HARTLING H J GERSTOFT J et al. Incomplete immune recovery in HIV infection mechanisms relevance for clinical care and possible solutions J. Clin Dev Immunol 2012 670957. 1 34-37. 5. 13. J. 2016 18 2 113-114 135. IL-2 IL-10 mrna J. 6. HIV /AIDS 2017 23 6 824-825 836. J. 2015 9 4 14. 2 462-467. J. 2013 38 15 2458-2462. 7 GUIGUET M BOUE F CADRANEL J et al. Effect of immunodeficiency HIV viral load and antiretroviral therapy on the risk of individual malignancies FHDH-ANRS CO4 a prospective cohort study J. Lancet Oncol 2009 10 12 1152-1159. 8 ENGSIG F N GERSTOFT J KRONBORG G et al. Long-term mortality in HIV patients virally suppressed for more than three years with incomplete CD4 recovery a cohort study J. BMC Infect Dis 2010 10 318. 9. HIV /AIDS J. 2017 32 8 1351-1354. 10. HAART HIV /AIDS CD + 4 T J. 2017 23 8 688-690. 11. HAART J. 2017 56 19-20. 12. 2 HAART CD + 4 J. 2017 58 2018-04 - 04 1992-1964 - Email 815903749@ qq. com 1379