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3 - A L Aeq CNE L Aeq L Aeq CNE WHO/ISH 1999 [49] 18.6kPa / 12.0kPa EpiInfo6.04 SPSS10.0 Logistic 10 L Aeq.10min db(a) dB(A) 8 L Aeq.8h dB(A) ( ) db(a) 97 L Aeq.8h 85 db(a)

0 Logistic 10 L Aeq.10min 83.5+3.8 db(a) 76.0 96.

4 BMI P<0.05 L Aeq - P>0.05 CNE - P<0.01 L Aeq.8h CNE X 2 = Logistic OR=1.062 BMI OR=1.280 OR=1.945 CNE OR P= dB(A) L Aeq.8h CNE CNE 1dB(A) 4 - Logistic 4

062 BMI OR=1.280 OR=1.945 CNE OR 1.040 P=0.

5 Dose-Response Relationship for Noise Induced Hypertension in Ground Crew at Airport Graduate Student: Zhu Wenjie Supervisor: Department: Prof Zhao Yiming The Third Hospital of Peking University Abstract Objective: 1). To observe the noise exposure level and characteristics of ground crew at airport, 2). To determine the dose-response relationship for noise induced hypertension in ground crew at airport, 3). To evaluate the application value of equivalent continuous A-weighted sound pressure noise level (L Aeq ) and cumulative noise exposure (CNE) as noise exposure assessment indices. Methods: 463 ground crew at airport were selected as investigating population. Some of them were selected to collect personal noise exposure data by dosimeter during a working day. Collected data were translated from dosimeter to computer by cable. The data were saved in computer and calculated for equivalent continuous A-weighted sound pressure noise level (L Aeq ). According to equal-energy rule, L Aeq and noise exposure duration were combined into cumulative noise exposure (CNE). The definition of hypertension followed by WHO/ISH (1999) [49], systolic blood pressure at least 18.6kPa and/or diastolic blood pressure 12.0kPa. The cases, who were diagnosed as suffering from hypertension and taking anti-hypertension drugs routinely, were defined as hypertension. The data were input into computer with EpiInfo 6.04 software and analyzed by SPSS software for data statistics and logistic regression model. Results: Ground crew at airport were exposed to non-steady noise, L Aeq.10min was db(a)( dB(A)), L Aeq.8h was dB(A) ( dB(A)), 97% of ground crew exposure to noise beyond 85dB(A). There were 91 hypertension patients in the population with prevalence of 19.7%. There were significant correlation between 5

To determine the dose-response relationship for noise induced hypertension in ground crew at airport, 3).

6 the hypertension prevalence and noise exposure duration, CNE, age, BMI parents hypertension history (P<0.05). There were no significant correlation between L Aeq and the hypertension prevalence (P>0.05). CNE calculated by L Aeq.8h was better than other noise assessment indices with highest trend chi-square value for dose response relationship (X 2 trend=21.779). From logistic regression model we find age, parents hypertension history, BMI are independent risk factors of hypertension, odds ratio of CNE was without significant (P=0.197). Conclusions: Ground crew at airport was exposed to non-steady noise with feature of dynamic and irregular. The noise exposure level of most crew was beyond 85 db(a). CNE calculated by L Aeq.8h is the best noise assessment index. After adjusting confounding effect, risk of hypertension increased about 4% by 1dB(A) of more noise exposure, but without significant. It needs to explore more cases in future to confirm the real relationship for noise induced hypertension in ground crew at airport. Key Words: non-steady state noise dose-response relationship cumulative noise exposure hypertension dosimeter logistic regression model 6