213 周玲, 沈桂平, 许晶晶, 邓伶莉, 董继扬, 黄秀敏 GDM GDM metabolomics GDM GDM GDM GDM GDM The Application of Metabolomics for Gestational Diabetes Mellitus ZHOU Ling,SHEN Gui-ping,XU Jing-jing,DENG Lingli,DONG Ji -yang,huang Xiu -min. Department of Electronic Science,Xiamen University,Xiamen 361005,Fujian Province, China (ZHOU Ling,SHEN Gui-ping,XU Jing-jing,DENG Ling-li,DONG Ji-yang);Department of Obstetrics and Gynecology, Zhongshan Hospital Xiamen University,Xiamen 361001,Fujian Province,China(HUANG Xiu-min) Corresponding authors:dong Ji-yang,E-mail:jydong@xmu.edu.cn;HUANG Xiu-min,E-mail:huangxmxm@163.com Abstract Gestational diabetes mellitus (GDM) easily lead to some complications,such as preeclampsia, polyhydramnios,macrosomia,and so on. The traditional diagnostic protocols for GDM mainly rely on detecting elevated glucose levels in blood,often late in the second trimester. Therefore the treatment time for the patients is not enough and the serious risk to maternal and child health raise. Metabolomics is an approach that investigates the metabolic responses of living systems to internal or external stimuli or genetic modification. The application of metabolomics to GDM research will help to interpret the pathogenesis of GDM. In addition,it can also provide the theoretical and experimental support for prevention and treatment of GDM as well as the prognosis of mothers and their infants. The characteristics of the common detection methods and the metabolomics studies of GDM were analyzed and compared in detail in this paper,and the metabolomic studies in GDM was further reviewed. Keywords Diabetes,gestational;Amniotic fluid;plasma;urine;metabolomics (J Int Obstet Gynecol, 2014, 41:213-217) gestational diabetes mellitus GDM [7-8] 1%~2% [1-3] GDM GDM GDM [4-6] GDM 3 [9] GDM metabolomics GDM 81201143 81371639 [10-12] 2013121007 361005 GDM E-mail jydong@xmu.edu.cn E-mail huangxmxm@163.com 1 GDM
214 liquid chromatography LC GDM GDM GDM Gra 觭 a [16] 1 GDM 1 GDM GDM GDM ++ +++ + + + + +++ a b + GDM ++ +++ + b ++ a b GDM + ++ +++ GDM Hedderson [13] 2.1 GDM [17-19] GDM GDM GDM Savvidou [19] GDM [14] Georgiou [17] 11 GDM GDM Diaz [10] NMR GDM TMAO GDM TMAO 2 GDM GDM Diaz [10] GDM 3-20 60 2- [15] BMI Diaz [9] 21 GDM Diaz [20] N- - NMND PAG GDM GDM 2 nuclear Scioscia [21] magnetic resonance NMR mass spectrum P P-IPG MS gas chromatography GC P-IPG
215 GDM Dunn [30] Sachse [22] 8 16 GDM GDM NMR [23-24] [31] [32] T 2 -edited spectrum Wharton s jelly [33] diffusion -edited GDM spectrum 2.4 standard spectrum Diaz [9] NMR 2.2 GFR NMR [25-26] Gra 觭 a [12] GDM GDM Gra 觭 a [16] GDM 2.5 [34] 14~25 GDM GDM 14~25 Cohn [27] KEGG http://www.genome.jp/ NMR kegg/ Bicyc http://biocyc.org/ http://www.hmdb.ca/ GDM GDM GDM 2.3 Cetin [28] GDM [7, 18] GDM KEGG Bitsanis [29] GDM 3 GDM 2
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