214 liquid chromatography LC GDM GDM GDM Gra 觭 a [16] 1 GDM 1 GDM GDM GDM a b + GDM b ++ a b GDM GDM Hedderson [1

Size: px

Start display at page:

Download "214 liquid chromatography LC GDM GDM GDM Gra 觭 a [16] 1 GDM 1 GDM GDM GDM a b + GDM b ++ a b GDM GDM Hedderson [1"

翠丁
9 years ago
Views:

1 213 周玲, 沈桂平, 许晶晶, 邓伶莉, 董继扬, 黄秀敏 GDM GDM metabolomics GDM GDM GDM GDM GDM The Application of Metabolomics for Gestational Diabetes Mellitus ZHOU Ling,SHEN Gui-ping,XU Jing-jing,DENG Lingli,DONG Ji -yang,huang Xiu -min. Department of Electronic Science,Xiamen University,Xiamen ,Fujian Province, China (ZHOU Ling,SHEN Gui-ping,XU Jing-jing,DENG Ling-li,DONG Ji-yang);Department of Obstetrics and Gynecology, Zhongshan Hospital Xiamen University,Xiamen ,Fujian Province,China(HUANG Xiu-min) Corresponding authors:dong Abstract Gestational diabetes mellitus (GDM) easily lead to some complications,such as preeclampsia, polyhydramnios,macrosomia,and so on. The traditional diagnostic protocols for GDM mainly rely on detecting elevated glucose levels in blood,often late in the second trimester. Therefore the treatment time for the patients is not enough and the serious risk to maternal and child health raise. Metabolomics is an approach that investigates the metabolic responses of living systems to internal or external stimuli or genetic modification. The application of metabolomics to GDM research will help to interpret the pathogenesis of GDM. In addition,it can also provide the theoretical and experimental support for prevention and treatment of GDM as well as the prognosis of mothers and their infants. The characteristics of the common detection methods and the metabolomics studies of GDM were analyzed and compared in detail in this paper,and the metabolomic studies in GDM was further reviewed. Keywords Diabetes,gestational;Amniotic fluid;plasma;urine;metabolomics (J Int Obstet Gynecol, 2014, 41: ) gestational diabetes mellitus GDM [7-8] 1%~2% [1-3] GDM GDM GDM [4-6] GDM 3 [9] GDM metabolomics GDM [10-12] GDM [email protected] [email protected] 1 GDM

2 214 liquid chromatography LC GDM GDM GDM Gra 觭 a [16] 1 GDM 1 GDM GDM GDM a b + GDM b ++ a b GDM GDM Hedderson [13] 2.1 GDM [17-19] GDM GDM GDM Savvidou [19] GDM [14] Georgiou [17] 11 GDM GDM Diaz [10] NMR GDM TMAO GDM TMAO 2 GDM GDM Diaz [10] GDM [15] BMI Diaz [9] 21 GDM Diaz [20] N- - NMND PAG GDM GDM 2 nuclear Scioscia [21] magnetic resonance NMR mass spectrum P P-IPG MS gas chromatography GC P-IPG

3 215 GDM Dunn [30] Sachse [22] 8 16 GDM GDM NMR [23-24] [31] [32] T 2 -edited spectrum Wharton s jelly [33] diffusion -edited GDM spectrum 2.4 standard spectrum Diaz [9] NMR 2.2 GFR NMR [25-26] Gra 觭 a [12] GDM GDM Gra 觭 a [16] GDM 2.5 [34] 14~25 GDM GDM 14~25 Cohn [27] KEGG NMR kegg/ Bicyc GDM GDM GDM 2.3 Cetin [28] GDM [7, 18] GDM KEGG Bitsanis [29] GDM 3 GDM 2

4 216 2 GDM GDM hyperglycemia in pregnancy Panel[J]. Diabetes Care e97. 24~28 [2] Sacks DA Hadden DR Maresh M Consensus Panel -recommended criteria GDM [4] Kim C Newton KM incidence of type 2 diabetes GDM pregnancy[j]. Curr Diab Rep [6] Nanda S Savvidou M Syngelaki A weeks[j]. Prenat Diagn [7] Zhao X Fritsche J Wang J 4 GDM [1] Weinert LS. International Association of Diabetes and Pregnancy Study Groups recommendations on the diagnosis and classification of comment to the International Association of Diabetes and Pregnancy Study Groups Consensus et al. Frequency of gestational diabetes mellitus at collaborating centers based on IADPSG the Hyperglycemia and Adverse Pregnancy Outcome HAPO Study [J]. Diabetes Care [3]. [J]. Knopp RH. Gestational diabetes and the a systematic review[j]. Diabetes Care [5] Homko CJ. New recommendations for the diagnosis of diabetes in et al. Prediction of gestational diabetes mellitus by maternal factors and biomarkers at 11 to 13 et al. Metabonomic fingerprints of fasting plasma and spot urine reveal human pre-diabetic metabolic traits[j]. Metabolomics [8] Cantor GH,Beckonert O,Bollard ME,et al. Integrated histopathological and urinary metabonomic investigation of the pathogenesis of microcystin-lr toxicosis[j]. Vet Pathol,2013,50(1): [9] Diaz SO Barros AS Goodfellow BJ et al. Following healthy pregnancy by nuclear magnetic resonance NMR metabolic profiling of human urine[j]. J Proteome Res [10] Diaz SO Pinto J Gra 觭 a G [35-37] NMR MS [11] Odibo AO Goetzinger KR Odibo L GDM study[j]. Prenat Diagn GDM [12] Gra 觭 a G Duarte IF Barros AS the metabolic profile of second trimester amniotic fluid magnetic resonance metabonomic study [J]. J Proteome Res GDM [13] Hedderson MM Darbinian J Havel PJ GDM GDM Care et al. Metabolic biomarkers of prenatal disorders:an exploratory NMR metabonomics study of second trimester maternal urine and blood plasma [J]. J Proteome Res et al. First-trimester prediction of preeclampsia using metabolomic biomarkers:a discovery phase et al. Impact of prenatal disorders on a nuclear et al. Low prepregnancy adiponectin concentrations are associated with a marked increase in risk for development of gestational diabetes mellitus [J]. Diabetes

5 217 [14] Hacker NF Moore JG Gambone JC. Essentials of ovstetrics and gynecology[m]. 4th ed. New York Elsevier [15] Fanos V Atzori L Makarenko K et al. Metabolomics application in maternal-fetal medicine[j]. Biomed Res Int [16] Gra 觭 a G Diaz SO Pinto J et al. Can biofluids metabolic profiling help to improve healthcare during pregnancy? [J]. J Spectrosc / [17] Georgiou HM Lappas M Georgiou GM et al. Screening for biomarkers predictive of gestational diabetes mellitus[j]. Acta Diabetol [18] Sánchez-Vera I Bonet B Viana M et al. Changes in plasma lipids and increased low-density lipoprotein susceptibility to oxidation in pregnancies complicated by gestational diabetes consequences of obesity[j]. Metabolism [19] Savvidou M Nelson SM Makgoba M et al. First-trimester prediction of gestational diabetes mellitus examining the potential of combining maternal characteristics and laboratory measures [J]. Diabetes [20] Diaz SO Barros AS Goodfellow BJ et al. Second trimester maternal urine for the diagnosis of trisomy 21 and prediction of poor pregnancy outcomes[j]. J Proteome Res [21] Scioscia M Kunjara S Gumaa K et al. Urinary excretion of inositol phosphoglycan P -type in gestational diabetes mellitus [J]. Diabet Med [22] Sachse D Sletner L M 覬 rkrid K et al. Metabolic changes in urine during and after pregnancy in a large multiethnic population-based cohort study of gestational diabetes [J]. PLoS One e [27] Cohn BR Fukuchi EY Joe BN et al. Calculation of gestational age in late second and third trimesters by ex vivo magnetic resonance spectroscopy of amniotic fluid [J]. Am J Obstet Gynecol e1-76.e10. [28] Cetin I de Santis MS Taricco E et al. Maternal and fetal amino acid concentrations in normal pregnancies and in pregnancies with gestational diabetes mellitus [J]. Am J Obstet Gynecol [29] Bitsanis D Ghebremeskel K Moodley T et al. Gestational diabetes mellitus enhances arachidonic and docosahexaenoic acids in placental phospholipids[j]. Lipids [30] Dunn WB Brown M Worton SA et al. The metabolome of human placental tissue investigation of first trimester tissue and changes related to preeclampsia in late pregnancy [J]. Metabolomics [31]. [D] [32] Nagy ZP Jones -Colon S Roos P et al. Metabolomic assessment of oocyte viability[j]. Reprod Biomed Online [33] Romanowicz L Bankowski E. Altered sphingolipid composition in Wharton s jelly of pre -eclamptic newborns [J]. Pathobiology [34]. [M] [35] Gra 觭 a G Goodfellow BJ Barros AS et al. UPLC -MS metabolic profiling of second trimester amniotic fluid and maternal urine and comparison with NMR spectral profiling for the identification of pregnancy disorder biomarkers[j]. Mol Biosyst [23]. NMR [J]. [36] Scioscia M Gumaa K Selvaggi LE et al. Increased inositol B phosphoglycan P -type in the second trimester in pregnant women [24]. with type 2 and gestational diabetes mellitus[j]. J Perinat Med 2009 NMR [J] [25] Gra 觭 a G Duarte IF Barros AS et al. 1 H NMR based metabonomics of human amniotic fluid for the metabolic characterization of fetus malformations[j]. J Proteome Res [26] Ottolenghi C Abermil N Lescoat A et al. Gestational age -related reference values for amniotic fluid organic acids[j]. Prenat Diagn [37] Heazell AE Bernatavicius G Warrander L et al. A metabolomic approach identifies differences in maternal serum in third trimester pregnancies that end in poor perinatal outcome [J]. Reprod Sci [ ]!!!!!!!!!!!!"!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!"!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!"!!!!!!!!!!!!"

综合报道

综合报道 55 doi:10.3969j.issn.1000-3606.2014.01.01 论著不同围生因素对妊娠的影响赵玉祥岳虹霓杨占华江苏省淮安市保健院新生儿科 ( 江苏淮安 223002) 摘要 : 目的探讨妊娠期高血压疾病胎膜早破等围生因素对妊娠的影响方法回顾性