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X
X X X SPA
DPA X DEXA X DEXA DP A C T QCT
I N VD
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cm mm cm Colles BMD DS
Bone Remod eling CT P T H O H DCT C P T H O H D P T H O H D P T H C C T
I IGF I IGF I O H DIGF I P T H Ca P K BMD
D O H D D D VDR BBAA BMD TGF X BMD
I AK P AKP AK P AK P AK P A KP BGP O H D BGP BG P PGP BGP I PICP PICP PICP P ICP H O P
h d H OP H OP H OP H OP H OLG H OP T RA P T RAP TRA P Pyr I N NTXH OP mmol L mg dl D PCa
D D h h X X X SPA
BMC g m BW cm BMD g cm X DEXA X BMC AREA BMD DEXA QC T CT QC T X USA DXA
X X
D
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X X W H O M M SD M SD SD M SD M SD SD M M M M X I II III Singh III
J harnaria III III Ost eoporosis OP A systemic skeletal disease characterized by low bone mass and microarchitectural deterioration of bone tiss ue with a consequent increase in bone fragility and susceptibility to fracture OP SD
SD I II A B C D E F A B a D b c e f g BMD
CV
risedronate
testosterone mg testosterone
D V D V D osteocalcin X DXA X QDR
D V D V D V D V D
Evista emmethal
D
mg D D D
D
D
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Vit D C T Ca Vit D P T H CT Vit D
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VitD mg
VitD
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lendrona tefosamax calcitonin D T R H
H RT Albright Lindsay mg d Gallagher
mg d mg d mg d mg d mg d BMD BAD Speroff Robert mg d mg d D BDM BMD mg d D mg mg D O H D mmol l N ananda Kmarkov
Tibolone mg d BDM BDM BDM
P C P P O P Alendrona te BDM
D
D
Forteo teriparatide FDA
mcg D BMD raloxifene FDA Univer sity of Cat anzaro Stefano Palomba
Fertility and Ste rility osteoporosis I I
H RT H R T DVT H R T NIH women s health initia tive WHI mg MPA mg
HR T WH I WH I mg H RT H R T selective estrogen re ceptormodulator SER M SERM raloxifene SERM
Multiple Outcomes Of Raloxifene Evaluation MORE mg MORE H R T LDL C TG C SERM SERM SERM bis phos phonates
O H R etidr onate R alendronltte Fosamax International T rial
F OSIT F racture Interevention Trial FIT mg mg Hosking mg P mg risedronate
mg mg mg mg mg Calcitonin
B PRO OF IU P T H P TH P T H P T H
teriparatide g u g g g FDA D D D D T ilyard
g g D D BB D D
FDA OP
FDA Evista Osten D
D D D l D DD D
D AA
CC D A D E
D X
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P T H D P T H P T H P T H P T H P TH P T H P T H P TH P T H P T H P T H P T H P TH D CT C
P T H CT C T CT C T P T H D C T CT CT CT H OP C T CT P TH CT CT CT CT CT CT D D O H D O H D
O H D D D P T H D D P T H TH T H D O H D T H T H C T P T H CAM P O H D P T H H OP
D D D G H TH T H G H G H G H TH
G H TH IL IL TNF LIF IL M CSF GM CSF IL r IF N r IL GM CSF IL IL TN F O H D P T H IL IL IL IL TN F LI F GM CSF M CSF IL IL IL TNF P TH IL T GM CFU IL
DI F IL IL TN F IL GM CSF TNF TNF IL l IL IL TN F IL LIF IL TN F GM CSF TN F PGE IL IL TGF IL IL TGF IG F O H D
IL IL TN F IL IL T NF fibroblast growth factor FGF DN A i S lin ke grow th factor IGF IGI IG FI IG FII IG FI IGF I P T H IGF II IG FII IGF I IG FII IGF I IGF chondro modulin ehm Hiraki Tanaka DNA ChM ChM ChM
transforming grow th factor TGF TGF TGF TGF
C C
A D D A A
A C D D D D D D Calcitriol Calcijex Rocaltrol D D hexafluoro Vitamin D isoflavones isofla
vones isoflavones Ipriflavone isoflavones OCS
X N telopeptide
D D K D
A C D
C D mg mg
C D C D
X X D g g g g g g g
g g g g g g g g g g g g g g g g g g g g g g g
D A D E
D A D D
D D D A A A mg mg A A A mg A D E K A
mm
cm cm cm cm
cm cm
cm cm cm
cm cm
osteoporosis syndrome
P T H CT D C
Singh Singh Nosland Cameson I
CT ct CT Ca Ca Ca mg d d m x x
X x cm
D X D X D D mg mg
min mg kg IU D
g g g g g
Osteoporosis I
Bone Remod eling CT P T H O H DCT C P T H O H D P T H O H D P T H C C T
I IGF I IGF I O H DIGF I P T H Ca P K BMD D O H D
D D VDR BBAA BMD TGF I P TH T T
D D O H D O H D P T H mg P T H D K Ca O H D
BB BMD bb
cm mm cm Colles BMD DS X
BMD I AK P AKP AK P AK P AK P A KP BGP O H D BGP BG P PGP
BGP I PICP PICP PICP P ICP H O P h d H OP H OP H OP H OP H OLG H OP T RA P T RAP TRA P PYr I N NTXH OP
mmol L mg dl D P Ca D D h h X X
X SPA BMC g m BW cm BMD g cm X DEXA X BMC AREA BMD DEXA QC T CT QC T X
USA DXA I II D K P T H C T O H D TGFB mg d
mg mg d mg mg Livial mg C T P T H Vit D O H D Ca mg d CTCa P T H Vit D Ca CTCT U U Elcatonin C T
U U U Ca U d CT Miacalcic U U U ml C T C T C T CT Vir D Ca P T H Vit D O H D Vit D Ca Vit D VD O H D g D Alfacalcidol O H D O H D g d
Ca mg g Ca g g g g g D mgvit D U P T H EH T P
Bonefos mg mg Disoduum Etidronatemg mg d mg ml Ipriflavone C T Osten CT mg C T Oxandrolone mg d mg mg Vit K mg d
mg Vit D Ca Vit D Ca P Vit D
Ca P ml Ca mg Vit D C T Ca Vit D
P T H CT Vit D
Colles
X X X X
a c b X l
X
X X l
X
X
l X X
P T H P T H X
P T H C T MRI B D Cushing
X W H O I
X X X CT CT X
l W H O WH O WH O BMD BMD BMD
WH O BMD X C T X X WH O BMD BMD W H O W H O BMD l BMD BMD
BMD BMD BMD WH O WH O
X
T T TT SH B CT MRI M
AL P BLAp ALP BLAP
ALP BLAP BGP K I
Ca Cr H O P H OP H OP
H OP CR Ca Cr H OP CR Ca Cr
mmol L l mg L D F T HD O H D CT P T H
D l
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X X X X X X X X X X X X X X x X X
X X X X X X X X X X
X X X X X CT X l
W H O
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X X X CT OCT CT X SP A DPA
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l BMC g cm BW cm BMD BMC BW g cm X X DEXA X X CT
C T QCT CT C T C T C T X X CT C T CT peripheral quantit ative computer tomograph PQCT CT CT P OCT X CT MCT CT PQCT POCT
PQCT FDA
Hologio
l X X
X
OH D E
ADFR ADFR
ADFR ADFR FDA