PRODUCTION AND HEALTH RESEARCH UPDATES 生产和健康研究最新进展卡美农业咨询您的国际外援 CARTHAGE & MHJ AGRITECH CONSULTING YOUR INTERNATIONAL BACKUP 1

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1 PRODUCTION AND HEALTH RESEARCH UPDATES 生产和健康研究最新进展卡美农业咨询您的国际外援 CARTHAGE & MHJ AGRITECH CONSULTING YOUR INTERNATIONAL BACKUP 1

2 Joseph F. Connor, D.V.M., M.S. Carthage Veterinary Service, Ltd. PO Box 220 Carthage, IL 康纳博士迦太基兽医服务公司 2

3 母猪研究 Sow Research 3

4 卡氏创新养猪解决方案公司 - 断奶到育肥 CISS Wean-to-Finish 4

5 CISS-VMRF 5

6 6

Accelerated Swine Enteric Coronavirus Stabilization Procedures 加快猪肠道冠状病毒稳定的操作方案 PEDv1, PEDv2, PDCoV Day 0 第 0 天 Wean down to 7 days of age and remove from farm 7 日龄断奶, 并送出场外饲养 Planned

7 Accelerated Swine Enteric Coronavirus Stabilization Procedures 加快猪肠道冠状病毒稳定的操作方案 PEDv1, PEDv2, PDCoV Day 0 第 0 天 Wean down to 7 days of age and remove from farm 7 日龄断奶, 并送出场外饲养 Planned Natural Exposure(PNE) to all sows 对所有母猪进行有计划的自然攻毒 Planned Natural Exposure(PNE) to replacement gilts 对所有对替换后备母猪进行有计划的自然攻毒 Close herd to new introductions for weeks 闭群周, 期间不引猪 7

8 Accelerated Swine Enteric Coronavirus Stabilization Procedures 加快猪肠道冠状病毒稳定的操作方案 PEDv 1 Day 0-10 Sows and Day 0-14 Gilts 0-10 天母猪和 0-14 天后备母猪 Remove all piglets for 10 days from initial natural planned exposure by induction for sow and 14 days for gilts 对预产期 10 日内的母猪和 14 日内的后备母猪进行诱导分娩 Day 17 天 Allow piglet survivability in sows McREBEL for at least one turn 对至少一轮生产实施 McREBEL 管理法 8

9 Accelerated Swine Enteric Coronavirus Stabilization Procedures 加快猪肠道冠状病毒稳定的操作方案 PEDv1, PEDv2, PDCoV Sanitation 卫生 Begin intensive sanitation on last day of natural planned exposure(npe) 从有计划的自然攻毒的最后一天开始加强卫生 Fully wash gestation barns by Day 14 post-break. 爆发后 14 天内彻底清洁妊娠舍 Farrowing- 分娩舍 Wear boots assigned to specific room 每个单元都要有专门的靴子 Soak 浸泡 Degreaser 去油污 Hot water wash 热水清洗 Bleach or Virkon disinfect 漂白剂或卫可消毒 Dry overnight 隔夜干燥 9

10 PEDv 转阴时间 PEDv Time to Negative ORIGINAL PROGRAM 原有程序 ACCELERATE D PROGRAM 加速程序 10

11 PEDv 造成每 1000 头母猪的损失 PEDv Losses per 1000 Sows PEDv Original Program vs Accelerated Program 原有程序 vs 加速程序 Weeks to Negative 转阴周数 Average Losses per 1000 Sows ± Baseline 每 1000 头母猪相比基准生产水平的损失 Original 原有程序 ,147.3 Accelerated 加速程序 , vs 1.0 PSY 11

12 不同胎次的保护力度 Protection based on Parity 胎次平均断奶后死亡率各胎次断奶后死亡率胎次周 12

13 Killed Vaccine versus Modified Live 灭活苗 vs 弱毒活苗 PED 病毒疫苗 PEDv Vaccines Once a natural exposure has occurred, a killed vaccine will trigger an amnestic response in an animal 一旦实施自然攻毒, 灭活苗就会激发动物体内的免疫记忆反应 This will trigger an increase in antibody production for a period of time 这会在一定时间内加强抗体的产生 The antibody production of an injected vaccine will be predominately IgG 注射疫苗产生的抗体主要是 IgG 抗体 Duration of this protective response without an additional live exposure is unknown 无额外活病原体攻毒时产生的保护反应的持续时间尚未可知 13

14 疫苗对 IgG 血清抗体的效应 Effect of Vaccine on IgG Serum Antibodies 控制组 Control 疫苗组 Vaccine SEM SEM 衣壳 N Capsid S S 疫苗对 IgA 血清抗体的效应 Effect of Vaccine on IgA Serum Antibodies 控制组 Control 灭活苗在曾受感染的猪群中的效应 Killed Vaccine Effect on a Previously Exposed Herd 疫苗组 Vaccine SEM SEM 衣壳 N Capsid S S P < P < Greiner et al, AASV 2015 Carthage Research Consortium 14

15 灭活苗在曾受感染的猪群中的效应 Killed Vaccine Effect on a Previously Exposed Herd 项目 Item PEDv 疫苗对仔猪死淘率断奶前死亡率和掉队率的影响 ( 后备母猪和 2 胎以上母猪 ) Effect of PEDv vaccine on litter removals, PWM and falloff% (gilts and P2+'S) 死淘率 % Removals % 断奶后死亡率 % PWM % 掉队率 % Falloffs % 控制组 Control 疫苗组 Vaccine SEM SEM P < Greiner et al, AASV 2015 Carthage Research Consortium 15

16 加仑保育猪饮水量 Nursery Pig Water Intake 猪舍受影响 Greiner et al, Annual AASV Meeting 16

17 生长育肥猪 Grow Finish Pigs 3 号猪舍加仑不进食 Greiner et al, Annual AASV Meeting 17

18 220 磅 ( 约 100 公斤 ) 的猪受感染期间 During Infection of 220 lb Pigs Water intake dropped and feed intake dropped 饮水量和采食量都下降 Feed 采食量 Was 7 lbs a day prior to clinical signs 临床症状出现前是每天 7 磅 ( 约 3.2 公斤 ) Lowest point for 3 days was 2 lbs a day 最低的 3 天是每天 2 磅 (0.9 公斤 ) Greiner et al, Annual AASV Meeting 18

19 220 磅 ( 约 100 公斤 ) 的猪受感染期间 During Infection of 220 lb Pigs Overall 整体 ADG was reduced 31% during the 9 days since clinical signs 临床症状出现后 9 天内日均增重降低 31% Feed intake returned to a normal level 1 week post-initial feed drop and roughly 9 days post-first clinical signs 采食量降低约一周后又恢复正常, 此时约为最初的临床症状出现后 9 天 Greiner et al, Annual AASV Meeting 19

20 Stall Acclimation Timing Has no Effects on Reproductive Measurements 定位栏驯化时间对繁殖参数无影响 Number of gilts 后备母猪数量 No. of matings 配种次数 No. of follicles 卵泡数量 4 wk conception rate, % b 4 周受胎率,% Farrowing rate, % c 分娩率,% RELwk1 转移 1 周 Greiner et al, Annual AASV Meeting RELwk2 转移 2 周 RELwk3 转移 3 周 P-value P 值 1.9 ± ± ± ± ± ± ± ± ± ± ± ±

21 Stall Acclimation Has no Effects on Litter Performance 定位栏驯化时间对窝产性能无影响 RELwk1 转移 1 周 RELwk2 转移 2 周 RELwk3 转移 3 周 P-value P 值 Total born/litter 每窝总产数 13.4 ± ± ± Pigs born alive/litter 每窝活产数 12.5 ± ± ± Stillborn/litter 每窝死产数 0.5 ± ± ± Mummified fetuses/litter 每窝木乃伊胎数 0.3 ± ± ± Total birth weight/litter, kg d 每窝总产出生重, 公斤 Pigs born alive weight/litter, kg 每窝活产出生重, 公斤 Litter BW variation (SD) 窝出生重差异 ( 正态分布 ) Born alive pigs < 0.68 kg, % 活产 <0.68 公斤仔猪的百分比,% 16.2 ± ± ± ± ± ± ± ± ± ± ± ± Gilts rebred within 7 d, % 7 天内重配后备母猪百分比,% Greiner et al, Annual AASV Meeting 95.4 ± ± ±

22 Treatment affects proportion of Gilts in different Estrus Interval Categories (p < 0.05) 治疗对不同发情间隔类群的后备母猪比例的影响 ( p < 0.05 ) 正常,18-24 天 Treatments 治疗 Greiner et al, Annual AASV Meeting 22

23 发情间隔影响后备母猪繁殖力 Estrus Interval Affects Gilt Fertility Conception rate, % 受胎率,% Farrowing rate, % 分娩率,% Total born/litter 每窝总产数 Shorter 较短 Normal 正常 Longer 较长 P-value P 值 ± ± ± ± 7.4 a 87.4 ± 1.9 a 74.7 ± 4.5 b ± 0.7 a 13.5 ± 0.2 b 14.0 ± 0.5 b 0.05 Gilts that expressed abnormal estrus intervals were more likely to fail to farrow by 11.15% compared to those that expressed normal estrus intervals 相比发情间隔正常的后备母猪, 发情间隔不正常的后备母猪分娩失败的几率要高出 11.15% Gilts expressed a short inter-estrus interval were likely to have reduced total born piglets compared to those with normal or longer estrus intervals 相比发情间隔较长或正常的后备母猪, 发情间隔较短的后备母猪窝产总数要少 Greiner et al, Annual AASV Meeting 23

24 泌乳期饲喂频率的影响 - 研究 1 Influence of Frequency in Lactation Feeding Study 1 Item T1-4X T2-2X P-Value 项目 T1-4 次 T2-2 次 P 值 ADFI (Kg) 1 日均采食量 PW Morbidity (%) 断奶前发病率 % PW Mortality (%) 断奶前死亡率 % Wean Pigs per sow 每头母猪断奶仔猪数 Wean to Estrus Interval (Days) 断奶到发情间隔 ( 天 ) 5.76 a 6.96 b a a a 7.10 a a a a 5.15 a.66 Litter Size after cross foster 交叉寄养后窝仔数 :12.74 piglets (T1=12.63, T2=12.81) 1 Covariate used in model Days on Test 实验期间使用的协变量 Different letters following values indicates differences with statistical significance 小写字母表明统计显著性差异 (P 0.05) 24

25 泌乳期饲喂频率的影响 - 研究 2 Influence of Frequency in Lactation Feeding Study 2 Item 项目 7 lbs fed 4x daily 每天 4 次, 7 磅 14 lbs fed 2x daily 每天 2 次, 14 磅 SEM Probability, P < P 值 < WEI 断奶到发情间隔 ADFI 日均采食量 (kg) BF Change 背膘变化 WEIGHTDIFF 体重差异 _% PIGIN_n NONVALUE_n 无价值猪数量 REMOVED 死淘率 _% ADG 日均增重 _KG LITTERGAIN 窝增重 _KG

26 泌乳期饲喂频率的影响 - 研究 3 Influence of Frequency in Lactation Feeding Study 3 7 lbs fed 4x daily 每天 4 次, 7 磅 14 lbs fed 2x daily 每天 2 次, 14 磅 Probability, P < P 值 < Item 项目 SEM WEI 断奶到发情间隔 ADFI 日均采食量 (kg) SUBSQU BA SUBSQU. SB SUBSQU. MM * TOTAL BORN * sample size 52 sows with some missing subs perf data 实验对象 52 头母猪, 某些亚性能数据缺失 26

27 泌乳天数对总产数的影响 Influence of Days of Lactation on Total Born Lactation length 泌乳期长 L/S/Y 每头母猪年产窝数 Born Alive 活产数 Extra pigs 多余仔猪数 Value pig,$ 猪价值,$ ROF 饲料收益 Pig Value 猪价值 = $35 Unpublished data 未公开数据 Increase in TB more than loss of L/S/Y 总产数的增加大于每头母猪年产窝数的损失 27

28 卡美农业技术咨询 ( 苏州 ) 有限公司 CARTHAGE & MHJ AGRITECH CONSULTING (SUZHOU) CO., LTD. 感谢关注! THANK YOU FOR YOUR ATTENTION! 28

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前言种猪是猪场生产的命脉! 种猪是猪群健康的源头! 后备母猪是 : 猪场提高生产水平关键的限制因素! 提高母猪繁殖力的措施 --- --- 第一胎母猪的培育广西柯新源 ( 集团 ) 技术总监麦月仪 TEL:13929060281 2013.03 前言种猪是猪场生产的命脉! 种猪是猪群健康的源头! 后备母猪是 : 猪场提高生产水平关键的限制因素! 母猪繁殖障碍

PRODUCTION AND HEALTH RESEARCH UPDATES 生产和健康研究最新进展 卡美农业咨询您的国际外援 CARTHAGE & MHJ AGRITECH CONSULTING YOUR INTERNATIONAL BACKUP 1

PRODUCTION AND HEALTH RESEARCH UPDATES 生产和健康研究最新进展卡美农业咨询您的国际外援 CARTHAGE & MHJ AGRITECH CONSULTING YOUR INTERNATIONAL BACKUP 1