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1 An Update on the Most Costly Pig Disease PRRS 最昂贵猪病 - 蓝耳病的最新情况 S Professor Morrison DVM, MBA, PhD 莫教授 College of Veterinary Medicine University of Minnesota

2 Outline 提纲 We re not decreasing incidence. 我们没有降低蓝耳病发生率 We need more insight on source of virus. 我们需要更深地洞察病毒的来源 PRRS control: 蓝耳控制 Eliminating PRRSv from sow herds makes sense, 从母猪群中清除 PRRSv 是可行的 It takes too long for many herds to eliminate virus (stable). 很多母猪场清除病毒 ( 稳定 ) 花费的时间太久

3 Weekly incidence from 765 sow farms shows a predictable pattern (7 years) 765 个母猪场每周发病率表示的预测模式指数加权移动平均传播临界值实际

4 Incidence has not decreased in last 3 years (23% 26% 26%) 最近 3 年发病率没有降低图 1 蓝耳累积发病率 / 周, 开始于 7 月, 年

5 Contrast this with the dramatic decrease in PED incidence 与显著下降的 PED 发病率比较图 1 PED 积发病率 / 周, 开始于 7 月, 年

6 PED - Model Conclusions 模型结论 Local spatial spread and movements account for >75% of trans. >75% 的传播由局部空间扩散和移动引起 Contaminated feed may also be important 污染饲料可能也很重要 Other modes may be important for introductions to new geographic areas 其它模式对病毒引入到新的地理区域可能是重要的 Feed trucks 料车 Market trucks 货车污染饲料料车污染物货车区域移动 Period 1: May Sept 2013 VanderWaal et al 2016

7 PRRS - Need better understanding of potential sources of virus 蓝耳需要更好地理解潜在病毒的来源 Airborne 空气 Transport 运输 People, fomites 人 / 污染物 Manure removal 粪便转移 Feed? 饲料

8 Trees around a farm and top of hill are protective (Arruda et al, 2016) 猪场周边有树或高处有山可以赶到保护作用

9 Outline 提纲 We re not decreasing incidence. 我们没有降低蓝耳病发生率 We don t know source of virus, 我们不知道病毒来源 PRRS control: Eliminating PRRSv from sow herds makes sense, 从母猪群中清除 PRRSv 是可行的 It takes too long for many herds to eliminate virus (stable). 很多母猪场清除病毒 ( 稳定 ) 花费的时间太久

10 We can effectively eliminate virus from sow herds 我们能更有效地把病毒从母猪群中清除出去 Sow herd and growing pigs will perform better 母猪群和生长猪交有更好的生产成绩 Lower mortality, better ADG 更低死亡率, 更佳平均日增重阳性稳定分类方法阳性稳定, 用田间毒感染阳性稳定暂定阴性 ELISA 阴性阳性稳定, 用活疫苗感染

11 Time To Stable (SHMP) is variable 稳定时间 ( 猪健康监测项目 ) 是变化的

12 Time To Stable study 稳定时间的研究 Eligibility criteria 入选标准 Acutely infected breeding herds 母猪群急性感染 Load-close-expose with resident virus or MLV vaccine 用本场毒株或 MLV 疫苗感染并闭群 Intention to achieve stability 目的获得稳定 Notes: 备注 ~ 50% infected with % 感染株 ~ 50% with prior history of PRRS detection (past 3 years)( 过去 3 年 )50% 场有检测到 PRRS 61 Farms, 16 systems 61 个农场,16 个系统 Linhares et al, 2014

13 Summary of findings 研究发现小结 TTS was 38 weeks, TTBP was 16.5 weeks with 2.2 pigs / sow 38 周达到 TTS( 断奶仔猪检测不到病毒 ), 16.5 周达到达到 TTBP( 达到原来生产基准线 ),2.2 仔猪 / 母 Shorter TTS 更短的 TTS - LVI; Also System, prior infection history 活病毒接种, 系统, 先前有过感染 Shorter TTBP / Total Loss: 更短的 TTBP/ 总损失 - MLV; Also System, prior infection history 活疫苗 ; 系统, 先前有过感染 Linhares et al, 2014

14 Early TTS is possible 早期 TTS 是可能的稳定时间

15 study: Eligibility criteria 研究 : 准入标准 SHMP breeding herds infected with PRRSv SHMP 项目中母猪群感染过毒株 Agreement to test at least 30 litters (6 x 5 sera) at least 4 consecutive times 同意至少连续 4 次监测, 每次最少 30 窝 (6 x 5 血清 ) No requirement to implement herd closure or exposure 不需要执行封群或感染 107 farms, 5 Systems 107 个场,5 个系统 Betlach et al, 2014

16 Summary: 2016 study (TTS wks) 小结 :2016 年研究 (TTS 周 ) Early TTS is possible 提早达到稳定是可能的

17 2016 study TTS by System 2016 研究系统的 TTS TTS Probability Median TTS (95 th CI): 平均 TTS Best: 最好 37 (32 42) weeks 周 Longer 长的 : 44 (39 51) weeks 周

18 Comparing 2013 and 2016 studies 2013 年与 2016 年研究的比较 90% 80% 70% 60% 50% 40% 30% 20% 10% 0% 80% % Reached stability 达到稳定 Time To Stability 断奶检测不到病毒时间 Time to Baseline 生产达到以前标准时间

19 Goal is to have shorter time to achieve stability with high success rate. 目标是用更短时间获得高成功率的稳定 - Internal biosecurity 内部生物安全

20 Farrowing 分娩达到稳定时间 Median time: 中值 21.2 weeks Range: 范围 8 to 32 weeks

21 Prevalence over time 随时间发病率变化 Prevalence decreases over time, reflecting decreasing spread, presumably due to sow herd immunity and internal biosecurity practices. 随时间发病降低, 反映传播降低, 可能由于母猪群免疫和生物安全措施 Can we speed up this process? 我们可以加快这个进程吗 Smooth = 4 months moving average

22 Benefit / Cost of Wean-down 提前断 Benefits: 好处 Shorter TTS - Lower mortality & increased ADG 更短 TTS- 更低死亡率增加 ADG Earlier introduction of gilts 更早引入后备猪 Earlier commingling 更早混群奶的好处和成本 Costs: 成本 Increased feed cost in wean-down pigs 增加早期断奶饲料费用 Altrenogest 烯丙孕素 Increased mortality in wean-down pigs 增加断奶猪的死亡率 Break-even of 3.4 weeks 3.4 周的盈亏平衡

23 Wean-down project 提前断奶项目 Breeding herds are invited to enroll 欢迎母猪场加入 Goal is to enroll 30 wean down herds and compare their TTS to 30 matched non wean down herds. 目标是有 30 个母猪场做提前断奶和相对应的 30 个场比较它们的 TTS.

24 Summary 总结 We need to understand source of virus to decrease incidence. 我们需要理解病毒来源以降低疾病发生率 We can improve our ability to eliminate PRRS virus from sow farms. 我们可以提高母猪场清除 PRRSV 的能力

25 Thank you Collaborators 合作人员 Andrea Arruda, Carlos Vilalta, Carl Betlach, Hunter Baldrey, Kim VanderWaal, Daniel Linhares, Andres Perez Acknowledgements 致谢 SHMP participants for sharing data SHIC (swinehealth.org) for funding Boehringer Ingelheim for funding

PRRS Epidemiology 蓝耳病流行病学 Professor Mo 莫教授 Bob Morrison DVM, MBA, PhD College of Veterinary Medicine University of Minnesota 鲍勃莫里森, 兽医博士, 工商管理硕士美国明尼苏

PRRS Epidemiology 蓝耳病流行病学 Professor Mo 莫教授 Bob Morrison DVM, MBA, PhD College of Veterinary Medicine University of Minnesota 鲍勃莫里森, 兽医博士, 工商管理硕士美国明尼苏达大学兽医学院 PRRS Control 蓝耳病防控 Most important pathogen