PEDV management and containment in production systems 养猪生产系统中流行性腹泻的管理和控制 Leman China Swine Conference October 李曼中国大会 2015 年 10 月 12 日 Matt All

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1 PEDV management and containment in production systems 养猪生产系统中流行性腹泻的管理和控制 Leman China Swine Conference October 李曼中国大会 2015 年 10 月 12 日 Matt Allerson, DVM, PhD Holden Farms, Inc. 麦特阿勒森, 美国霍尔顿农场

2 Holden Farms, Inc. (HFI) 美国霍尔顿农场 Holden Farms is a Family Owned and Operated Agriculture Company based in Northfield, Minnesota, USA The Holden Family has been farming since 1876 and the current owners represent the 4th Generation of Holden s farming in Northfield, MN HFI breeds and raises pigs across 19 sow farms (55,000 sows) and over 200 nursery and finish farms HFI will market 1,200,000 pigs annually

3 Holden Farms 美国霍尔顿农场

4 Overview 概要 PEDV in the United States 猪流行性腹泻病毒在美国 Production system impacts 生产系统影响 Management/containment 管理 / 控制 Biosecurity 生物安全

5 PED virus 猪流行性腹泻病毒 Porcine epidemic diarrhea virus (PEDV) 猪流行性腹泻病毒 First observed in the United States in 2013 首次在美国被检测到是 2013 年 Cause of diarrhea that leads to high mortality in young pigs 引起腹泻, 导致仔猪高死亡率

6 PED national incidence project United States 美国猪流行性腹泻发病研究项目 Weekly reporting from 26 systems 26 个系统每周汇报 2.5 million sows 250 万头母猪 1,000 farms 1,000 家农场

7 猪流行性腹泻每周累积发病以及从每年 7 月 1 号起累积统计报告猪群新感染率PED incidence 猪流行性腹泻发病

8 每周新病例数EWMA PED Epidemic Threshold 猪流行性腹泻传染阈值图表 4-PED EWMA 年度分析

9 PED incidence by previous infection 猪流行性腹泻既往感染发病率图表 - 从 2013 年五月 PED 每季腹泻既往感染发病率猪群报告感染率EWMA 以前未感染先前感染过

10 PED production impact 猪流行性腹泻对生产影响 HFI impact HFI 影响 sow farms = 15% of sows PED positive 2 所母猪场 =15% 母猪呈 PED 阳性 Early nursery PED cases 早期保育猪 PED 案例 Few finishing breaks 很少育肥感染 sow farms = 8% of sows PED positive 2 所母猪场 =8% 母猪呈 PED 阳性 Overall, minimal lateral nursery and finishing cases 总体而言, 较少保育后期和育肥案例

11 奶猪数量日期断Farm 1 SPC of pigs weaned 农场 1- 断奶猪的 SPC

12 奶猪数量日期断Farm 2 SPC of pigs weaned 农场 2- 断奶猪的 SPC

13 断奶猪数量Farm 3 SPC of pigs weaned 农场 3- 断奶猪的 SPC 日期

Nursery impact 保育影响 PED 猪流行性腹泻 Count 次数 Mortality 死亡率 ADG FC Neg 阴性 313 2.1% 0.

14 Nursery impact 保育影响 PED 猪流行性腹泻 Count 次数 Mortality 死亡率 ADG FC Neg 阴性 % Pos 阳性 % x mortality 2 倍死亡率 Poorer ADG and FC 糟糕的日增重和饲料转化率

15 4: 阴性猪群比率PED management sow farm 流行性腹泻管理 - 母猪场分类栏 1: 不稳定阳性 2fvi: 稳定阳性, 持续的现场病毒暴露 2: 稳定阳性 3: 暂时阴性从 2013 年五月开始猪群感染状态

16 PED management sow farm 流行性腹泻管理 - 母猪场 What is the overall goal? 总体目标是什么 Take the entire herd back to PED negative status 让整个猪群回到 PED 阴性状态 Stability with ongoing exposure to replacement animals 让正感染的后备保持稳定 Other combinations 其他组合

17 PED management elimination Exposure 流行性腹泻管理 - 感染清除 1. Collect PED infectious material and exposure the entire sow herd 收集腹泻感染材料并感染整个母猪群 2. Load on-site or off-site GDU with gilt supply for a 150 day closure and expose all gilts 将现场或场外 GDU 装够 150 天后备供应, 并感染所有的后备母猪 No further animal entry until elimination is complete 任何动物不得入内直到清除完成

18 PED management elimination Farrowing protocols 流行性腹泻管理 - 清除分娩方案 1. Strict farrowing protocols regarding piglet movement 关于猪仔移动严格的分娩方案 No movement from older to younger rooms 不允许从年长猪移动到年幼猪的圈 2. Minimize exposure of older pigs to younger pigs to break the infection chain 减少年长猪和年幼猪的接触以打破传染链 3. Clean, disinfect, whitewash farrowing rooms 对分娩房清洗, 消毒, 石灰清洗

19 Biosecurity 生物安全 Feed ingredients 饲料成分 Contaminated complete feed as a risk for PED infection (Dee et al., 2014) 被污染的成料为感染流行性腹泻带来风险

20 Early nursery PED cases 早期保育猪流行性腹泻案例 12/21 (57%) of nursery fills over 1 month period PED + 装猪一个月保育,12/21 (57%)PED 阳性

21 Biosecurity 生物安全 Transport vehicles 运输工具 Breeding stock 种猪 Weaned pigs 断奶猪 Feeder pigs 饲养猪 Market 上市 Transport process and vehicles as a source of contamination (Lowe et al., 2014) 运输过程和工具也是污染的来源之一

22 Biosecurity 生物安全 Site sanitation 场地卫生 High success rate of cleanup prior to placing naïve pigs in previously infected sites 将幼猪搬进前, 清洁先前被污染的地点能够有更高的成功率

23 Summary 总结 2014/2015 Fewer new infections 新感染很少 Elimination protocols successful 清除方案有效 Strict focus on biosecurity 严格执行生物安全

24 Thank you! 谢谢 Questions? 欢迎提问

PRRS Epidemiology 蓝耳病流行病学 Professor Mo 莫教授 Bob Morrison DVM, MBA, PhD College of Veterinary Medicine University of Minnesota 鲍勃莫里森, 兽医博士, 工商管理硕士美国明尼苏

PRRS Epidemiology 蓝耳病流行病学 Professor Mo 莫教授 Bob Morrison DVM, MBA, PhD College of Veterinary Medicine University of Minnesota 鲍勃莫里森, 兽医博士, 工商管理硕士美国明尼苏达大学兽医学院 PRRS Control 蓝耳病防控 Most important pathogen