本院現有抗癌藥品一覽表

本院現有抗癌藥品作用及ㄧ覽表 No I Alkylating Agents 20B021 1 Myleran (Busulfan) 2 mg/tab 20C052 Leukeran 2 (Chlorambucil) 2 mg/tab 20A016 3 Alkeran (melphalan) 2 mg/tab 4 5 6 7 8 10M079 Alkeran (melphalan) 50 mg/vial 20E014 Endoxan (Cyclophosphamide) 50 mg/tab 10C164 Endoxan (Cyclophosphamide) 200 mg/vial 10D018 DTIC (Dacarbazine) 200 mg/vial 10I013 Holoxan (Ifosfamide) 2 gm/vial II Antimetabolites 20T051 UFUR 9 (tegafur 100mg + uracil 224mg)/cap 5FU (5Fluorouracil) 10F012 10 250 mg/5 ml/amp 10F149 500 mg/10 ml/amp GSK Glaxo WELLCOM GSK Orion Asta Maintenance not exceed 01 mg/kg/d 瑞帝 百特 16 g/m 2 /cycly 48 mg/day or 60 ug/kg /day 24 mg/day for 36 weeks Induction remission: 0102 mg/kg/d for 36 weeks; Intermittently: 04 mg/kg every 24 weeks 6 mg/day for 23 weeks 和 discontinued for up to 4 weeks,afetr which a maintenance dose of 2 mg/day may be instituted 晚期神經母細胞瘤使用異體骨髓移植 100 240 mg/m2 ( 分三天 ) 單用或合併 RT / cytotoxic drugs Oral: 501000 mg/ m 2 /day over 4 5 days IV: 4001000 mg/ m 2 every 2128 days (or 10001500 mg/ m 2 ) 245 mg/kg/day for a period of 10 days,repeated every 46 weeks Or 15250 mg/ m 2 on day 1 through 5,every 34 wks 12 gm/ m 2 /day for 5 consecutive days every 3 weeks 慢性骨髓性白血病 東洋 Tegafur: 300 mg/m 2 /day 分成三次胃癌, 大腸直腸癌 SOLCO/ HAUPT PHARMA WOLFRAT 12 mg/kg/day IV for 4 days If no toxicity occurs,6 mg/kg IV is given on days 6,8,10 和 12 多發性骨髓瘤, 淋巴瘤, 慢性淋巴性白血病 多發性骨髓瘤緩解療法, 無法切除的卵巢癌 多發性骨髓瘤, 卵巢癌, 小兒神經母細胞瘤 ( 骨髓移植 high dose) 修正日期 : 1010101 奇美醫療財團法人奇美醫院藥劑部製 骨髓抑制, 痙攣, 靜脈栓塞, 間質肺炎, 出血性膀胱炎, 永久性禿頭 使用高劑量時 骨髓抑制, 肝毒性, 肺纖維化, 肺支氣管再生不良, 不孕, 周邊神經病變, 皮膚反應, 胃腸不適 白血球缺乏症, 血小板缺乏症, 肺纖維化和肺部浸潤, 無月經, 禿頭, 不孕, 抗利尿激素不正常分泌, 噁心, 嘔吐, 口腔潰爛 常見 : 禿頭, 口腔炎嚴重的 : 血管炎, 溶血性貧血, 骨髓抑制 ( 常見 ), 肝炎, 黃疸, 肝指數異常, 過敏反應 ( 罕見的 ), 不孕症, 肺纖維化, 肺浸潤 大腸直腸癌, 子宮頸癌, Wilm s tumors, 肺癌, 乳白血病, 心肌病變, 心肌壞死, 頭暈, 抗利尿激素不正常分癌, 卵巢癌, 各種白血病,nonHodgkin s lymphoma, 泌, 噁心, 嘔吐, 胰臟炎, 膀胱炎, 出血性膀胱炎, 性功能神經母細胞瘤,retinoblastoma, 膀胱癌,Hodgkin s 障礙, 肝毒性, 視力模糊, 間質肺炎, 肺纖維化, 禿頭, 外 disease, 多發性骨髓瘤, 軟組織肉瘤滲造成蜂窩性組織炎, 過敏 轉移性黑色素瘤, 腎臟癌, 軟組織或骨組織或骨肉瘤, 固態瘤, 淋巴瘤 噁心和嘔吐, 白血球缺乏症和血小板缺乏症, 致死性肝靜脈栓塞, 腦出血, 姿勢性低血壓, 虛弱, 神經病變, 視力模糊, 頭痛, 類感冒症狀, 痙攣, 厭食, 肝毒性, 禿頭, 過敏 Germ cell testicular, 頭頸癌, 乳癌, 子宮頸癌, 卵巢癌, 軟組織肉瘤,ewing s sarcoma,osteosarcoma, 骨髓抑制, 出血性膀胱炎, 中樞神經毒性, 噁心和嘔吐 Hodgkin s 和 nonhodgkin s 淋巴瘤, 非小細胞肺癌, 急性淋巴性白血病, 和神經母細胞瘤 大腸, 直腸癌, 乳癌, 胃癌, 胰臟癌 噁心, 嘔吐, 口炎, 腹瀉, 皮膚紅疹, 和神經毒性 ( 頭暈, 運動失調 ) 血液惡質症, 心臟毒性, 噁心, 嘔吐, 厭食, 腹瀉, 丘狀紅疹

11 12 13 14 15 16 20M060 6MP (6Mercaptopurine) 50 mg/tab 20C044 Xeloda (Capecitabine) 500 mg/tab AraC (Cytarabine) 10C095 (100 mg/vial) 10C087 (500 mg/vial) 20M010 MTX (Methotrexate) 25 mg/tab MTX (Methotrexate) 10M037 (1gm/10 ml/vial) 10M029 (50 mg/2 ml/vial) 10F054 Fludara (Fludarabine) 50 mg/vial ORION Roche PFIZER/ Pharmacia ORION PHARMACHE MIE BV BAXTER Induction therapy of ALL: 255 mg/kg/day for adults 和 children Maintenance therapy: 1525 mg/kg/day 2500 mg/ m 2 /day in two divided dose for two weeks with a 1week rest period 100200 mg m 2 /day for 57 days 1530 mg/day or 1215 mg/ m 2 /dose as a 4h infusion; oral dose are 1530 mg/day as a single dose; intrathecal dose are 612 mg/week 急性淋巴性白血病 使用 paclitaxel 和 anthracycline 無效之轉移性乳癌, 大腸直腸癌 劑量相關的骨髓抑制 ; 肝毒性 ( 劑量大於 25 mg/kg/day); 免疫抑制 ; 出血, 手口足症, 腹瀉, 噁心, 嘔吐, 水腫, 口炎 慢性骨髓性白血病, 淋巴性白血病, 急性淋巴性白骨髓抑制, 神經病變, 胃腸不適, 肝毒性, 過敏 血病, 急性非淋巴性白血病, 和 meningeal 白血病 乳癌, 急性淋巴性白血病, 頭頸癌, 卵巢癌, nonhodgkin s lymphoma, 骨肉瘤, 大腸直腸癌, Hodgkin s lymphoma IV,25 mg/m2/day x 5 days,repeat every 28 days 使用一種以上含 alkylatingagent 的化療治療無效之 Bcell 慢性淋巴性白血病 白血球缺乏症, 血小板缺乏症, 貧血, 泛血球缺乏症, 血管炎, 神經毒性, 頭痛, 發燒, 痙攣, 運動失調, 嗜睡, 厭食, 噁心和嘔吐, 腹瀉, 口炎, 偽膜性腸炎, 腎毒性, 膀胱炎, 月經失調, 不孕, 肝毒性, 肝毒性, 視力模糊, 間質肺炎, 禿頭, 紅疹, 光毒性,SLE, 過敏 常見 : 顫抖, 食慾變差, 噁心, 嘔吐, 無力, 疲倦嚴重的 : 水腫 ( 常見 ), 皮膚發育不全 ( 罕見的 ), 自體免疫之溶血性貧血,GVHD 使用未經放射線照射之血液造成 ( 罕見的 ), 骨髓抑制 ( 常見 ), 神經毒性, 肺炎 ( 常見 ), 發燒 ( 常見 ), 感染 10G019 Gemzar 17 (Gemcitabine) 200 mg/vial 10P070 Alimta (Pemetrexed) 500 mg/vial 18 10P123 Alimta (Pemetrexed) 100 mg/vial III Antitumor antibiotics 10B064 BLEO 19 (Bleomycin) 15 mg/vial 10M087 20 Mitomycin C 10 mg/vial 21 10D103 COSMEGEN (Dactinomycin) 05 mg/vial Lilly 1000 mg/m 2 once a week for up to 7 weeks 胰臟癌和非小細胞肺癌, 晚期乳癌和卵巢癌 Lilly 日本化藥 Kyowa MSD Max 600 mg/m 2 >400 U cumulative total may cause 肺部毒性 1 Malignant mesothelioma of pleura: 500 mg/m2 IV over 10 minutes on day 1, followed 30 minutes later by cisplatin 75 mg/m2 infused IV over 2 hours; repeat cycle every 21days 2 非小細胞肺癌 : 500 mg/m2 IV over 10 minutes on day 1 of each 21day cycle 1020 unit/ m 2 /week or twice weekly 1 Single dose: 20 mg/m 2 IV 每 6 to 8 weeks 2 2 mg/m 2 /day IV for 5 days 睪丸癌 : 1000 mcg/m(2) IV day 1 in combination with chemotherapy Nephroblastoma: 15 mcg/kg IV every day for 5 days (in combination with other chemotherapy) 骨髓抑制 (doselimiting), 類感冒症狀 (occasionally doselimiting), 疲倦, 發燒, 週邊水腫, 蛋白尿, 皮膚的反應, 胃腸道 常見 : 食慾變差, 噁心, 嘔吐, 疲倦嚴重的 : 皮膚脫屑 ( 常見 ), 皮膚紅疹 ( 常見 ), 顫抖, 腹瀉 ( 常見 ), 口腔炎 ( 常見 ), 貧血, 白血球減少, 嗜中性球減少血小板減少症 ( 常見 ), 咽喉炎 ( 常見 ), 發燒, 感染 ( 常見 ) 睪丸癌,Hodgkin s lymphoma,nonhodgkin s lymphoma, 麟狀上皮細胞癌如 : 頭頸癌, 陰莖, 子宮肺部毒性 ( 劑量限制毒性 ), 嚴重特異體質反應 (1%) 頸, 和陰道癌 ; 腹膜積水之硬化劑 胃癌或胰臟癌, 乳癌, 頭頸癌, 子宮頸, 肺, 大腸直腸和膽管癌, 膀胱癌 小兒癌 睪丸癌 Kaposi's sarcoma Nephroblastoma 骨髓抑制, 噁心, 嘔吐, 腎毒性, 間質性肺炎, 禿頭 骨髓抑制, 口炎, 噁心, 嘔吐, 厭食, 紅疹, 禿頭, 痤瘡, 肝炎

No 22 1 550 mg/m 2 ; 10D084 2 若病人曾接受過 Adriblastina PFIZER 胸部放療或併用 (Doxorubicin) 10 mg/vial cyclophosphamide: 450 mg/m 2 6075 mg/m 2 每三週ㄧ次 10D092 AIDSrelated Kaposi's sarcoma: 20 mg/m 2 IV 每 Lipodox liposome 23 臺灣東洋 三週ㄧ次 (Doxorubicin liposome) 20 mg/10 ml/vial Refractory 卵巢癌 : 50 mg/m 2 每 4 週ㄧ次 10E065 24 Pharmorubicin (Epirubicin) 法瑪西亞普強 10 mg/vial 10I063 25 Zavedos PFIZER 150 mg/m (Idarubicin) 12 mg/ m 2 /day in combination with cytarabine for 3 days 5 mg/vial IV Epitodophyllotoxins Vepesid (VP16) (Etoposide) TEVA 26 10E049 50100 mg/ m 2 /day for 35 ddays,repeated at 34 week intervals 100 mg/5 ml/vial 20E022 50mg/cap V Antimitotic 10V056 Velbe 27 (Vinblastine) 10 mg/10 ml/vial 28 29 30 31 10O023 Oncovin (Vincristin) 1 mg/1 ml/vial 10V022 Navelbine (Vinorelbine) 10 mg/1 ml/vial 20V021 Navelbine (Vinorelbine) 20 mg/cap 10D076 Taxotere (Docetaxel) 20 mg/05 ml/vial Phyxol (Paclitaxel) 10P054 90 mg/15 ml/vial VI Topoisomerase Inhibitors BRISTOL 急性白血病, 膀胱癌, 乳癌, 肝癌,Hodgkin's disease, 心臟毒性, 骨髓抑制, 可逆性的禿頭, 急性噁心嘔吐, 局部神經母細胞瘤,nonHodgkin's lymphoma, 攝護腺癌, 組織蜂窩炎 肉瘤, 甲狀腺癌, 肺癌, 和 Wilms' tumor AIDSrelated Kaposi's sarcoma, 頑固性卵巢癌 Max cumulative dose: 900 mg/ m 2 100120 mg/ m 2 repeated every 34 weeks 淋巴結轉移之乳癌開刀後之輔助治療 HOSPIRA 185 mg/ m 2 /wk 412 mg/ m 2 or 152 mg/ m 2 /day for 5 days Pharmachmie BV PIERRE FABRE SCHERER GMBH AVENTIS PHARMA DAGEN 2 mg/each dose 30 mg/ m 2 weekly Children: 2mg/ m 2 at weekly interval Adult: 14 mg/m 2 with a duration ranging from 48 weeks 120~160 mg/wk 1 st,2 nd,3 th wk: 60mg/m 2 /wk Max 120 mg/wk 4 th ~: 80mg/m 2 /wk,max 160 mg/wk 60100 mg/m 2 every 3 weeks 杏輝 135175 mg/ m 2 every 3 weeks 急性非淋巴性白血病和急性淋巴性白血病 小細胞肺癌, 睪丸癌, 急性非淋巴性白血病, 和淋巴瘤 ; 頑固型兒癌, 肝癌, 卵巢癌, 白血病, 和非小細胞肺癌 骨髓抑制, 口炎, 噁心, 嘔吐, 厭食, 紅疹, 禿頭 骨髓抑制 ( 白血球缺乏症 ); 噁心, 嘔吐, 口炎, 禿頭 ; 缺血性心衰竭 (35% with 累積劑量 1000 to 1600 mg/ m 2 ) 骨髓抑制, 特別是白血球缺乏症, 噁心, 嘔吐, 禿頭, 口炎 ; 缺血性心衰竭, 肝功能異常 白血球缺乏症 (doselimiting factor), 血小板缺乏症 ; 噁心嘔吐 ; 缺血性心衰竭, 心肌梗塞, 低血壓 ( with rapid IV infusion), 周邊神經病變, 厭食, 口炎, 卵巢失去功能, 肝炎, 可逆性的禿頭, 和過敏反應 轉移性睪丸癌 ; 淋巴瘤 ex Hodgkin s disease,kaposis 白血球缺乏症和血小板缺乏症, 噁心嘔吐, 口腔粘膜炎, sarcoma, 乳癌,mycosis fungoids,choriocarcinoma, 抗利尿激素不正常分泌, 缺血性心臟毒性, 掉髮, 皮膚炎, 和 LettererSiwe disease 神經毒性 孩急性淋巴性白血病之誘導治療 ; Hodgkin s disease, Wilm s tumor, 小細胞肺癌,nonHodgkin s 神經毒性, 神經疼痛, 肌肉無力, 白血球缺乏症, 血小板缺 lymphoma,malignant thyoma,kaposi s sarcoma, 乏症 便祕, 噁心和嘔吐, 複視, 禿頭 osteogenic sarcoma,malignant pheochromocytoma, 和其他癌症 白血球缺乏症, 貧血和血小板缺乏症, 神經毒性 ( 比其他晚期乳癌, 非小細胞肺癌,nonHodgkin s lymphoma, 的 vinca alkaloid 少 ), 噁心嘔吐, 腹瀉, 口炎, 禿頭和過 Hodgkin s disease, 和卵巢癌 敏反應 使用其他化療藥無效之晚期或轉移性乳癌 ; 卵巢癌和非小細胞肺癌 白血球缺乏症 (doselimiting), 過敏反應 ( ~60%), 無力, 噁心, 嘔吐, 腹瀉, 禿頭, 感覺神經異常 ; 口腔粘膜炎 卵巢癌, 乳癌, 非小細胞肺癌, 和 AIDSrelated 白血球缺乏症 (doselimiting), 過敏, 口腔粘膜炎, 禿頭, 神 Kaposi s sarcoma; 急性白血病, 黑色素細胞瘤, 和其經病變, 肌痛, 關節痛, 胃腸不適, 心律不整 他癌症

32 33 10T028 Hycamtin (Topotecan) 4 mg/vial 10I097 Campto (Irinotecan) 100 mg/vial VIIHormones 17L078 Leuplin depo 34 (Leuprorelin acetate) 375 mg/vial 17L078 Lupron 35 (Leuproline Acetate) 5 mg/28 ml/vial 17L121 Leuplin Depot 3M Inj 36 (Leuproline Acetate) 1125 mg/syring 27C074 Anrocur 37 (Cyproterone Acetate) 50 mg/tab 20B047 BicalutamideTeva 38 (Bicalutamide) 50 mg/tab 20T019 Nolvadex 39 (Tamoxifen Citrate) 10 mg/tab 20E030 Estracy 40 (Estramustine) 140 mg/cap 20E038 Aromasin 41 (Exemestane) 25 mg/tab 20L021 Femara 42 (Letrozol) 25 mg/tab 20A032 Ansuzole 43 (Anastrozole) 1 mg/tab GLAXO 15 mg/ m 2 /day for 5 days every 3 weeks PFIZER TAKEDA GRUNENTHAL GmbH solid tumor: 120150 mg/ m 2 /wk for 4 wks Advance: 500 mg/ m 2 TAKEDA 125 mg/ m 2 weekly for 4 weeks followed by a rest period of 2 weeks 頑固性小細胞肺癌或轉移性卵巢癌之第二線治療藥白血球缺乏症, 血小板缺乏症, 貧血, 禿頭, 噁心嘔吐, 物 ; 對非小細胞肺癌, 攝護腺癌和大腸直腸癌也有腹瀉, 口腔粘膜炎, 頭痛, 疲倦, 紅疹, 肝酵素異常, 蛋白效 尿 肺癌, 大腸直腸癌, 卵巢癌, 和 nonhodgkin s lymphoma 白血球缺乏症, 腹瀉, 疲倦, 肝功能異常, 禿頭, 皮膚紅疹, 1 mg SC daily,or in the depot formulation 75 IM monthly,1125 mg every 3 months,or 30 mg every 4 months 晚期攝護腺癌熱潮紅 ; 水腫, 骨頭痛, 血栓, 胃腸不適 1125225 mg SC once every 3 months Schering 200300 mg/day 晚期攝護腺癌 陽萎, 頭痛, 月經失調, 男性女乳症, 體正增加, 血脂異常, 胃腸不適, 貧血 ; 肝毒性 TEVA 50 mg QD 晚期攝護腺癌熱潮紅, 乳房腫脹, 男性女乳症, 疼痛, 無力, 便祕 AstraZeneca 1020 mg bid 乳癌 Pharmacy 14 mg/kg/day 分 34 次晚期攝護腺癌 熱潮紅, 噁心和 / 或嘔吐, 陰道出血, 月經失調, 皮膚紅疹, 眼睛 ( 角膜病變, 白內障, 視網膜病變 ), 肝毒性 血小板缺乏症, 白血球缺乏症, 心血管 ( 缺血性心臟病, 靜脈栓塞, 血栓靜脈炎 ), 男性女乳症, 噁心, 嘔吐, 肝毒性, 蕁麻疹 PFIZER 25 mg QD 乳癌頭暈, 頭痛, 疲倦, 失眠, 熱潮紅, 噁心, 嘔吐,HDL 下降 諾華 25 mg QD 晚期乳癌 美時 10 mg QD 停經後雌激素接受器為陽性或不清楚之局部晚期或轉移性乳癌第一線治療 肌肉骨骼 (ie 肌肉疼痛, 骨骼疼痛, 背痛 ), 噁心, 嘔吐, 頭痛, 疲倦 胸部疼痛, 便祕, 腹瀉, 腹痛, 熱潮紅 肌肉骨骼 (ie 肌肉疼痛, 骨骼疼痛, 背痛 ), 無力, 噁心, 嘔吐, 頭痛, 嗜睡, 疲倦, 便祕, 腹瀉, 熱潮紅, 發疹

44 45 10F115 Faslodex (Fulvestrant) 250 mg/5ml/amp 27M074 Farlutal (Medroxyprogesterone) 500 mg/tab AstraZeneca Pfizer VIII Platinum 10C053 Paraplatin 46 (Carboplatin) 450 mg/vial ABIPLATIN (Cisplatin) 海喬 10C172 05 mg/ml,100 ml/vial 47 10P020 ABIPLATIN PHARMACHE (Cisplatin) MIE BV 10mg/20 ml/vial 48 10O031 SANOFI Oxaliplatin (Eloxatin) AVENTIS 50 mg/vial IX Anthracenedione 10M053 49 Novantrone (Mitoxantrone) 景德 20 mg/10 ml X Biological response modifiers 10B022 50 Immucyst (BCG) SANOFI 81 mg/vial 51 10I124 Proleukin (Interleukin2) 18 MIU/vial 250 mg IM once monthly 乳癌 : 1 gm/day Other cancer: 200500 mg/day 雌激素受體陽性的停經後婦女, 已接受過荷爾蒙療法後疾病復發或惡化的之局部晚期或轉移性乳癌 子宮內膜癌, 腎臟癌, 乳癌, 攝護腺癌之緩和療法 背痛, 噁心, 嘔吐, 頭痛, 嗜睡, 疲倦, 便祕, 腹瀉, 腹痛, 貧血, 注射部位疼痛發炎 月經不規則, 腹痛或脹痛 t, 體重減輕, 頭暈, 頭痛, 無力, 和神經緊張 海喬 360 mg/ m 2 once every 4 weeks 卵巢癌, 頭頸癌, 小細胞肺癌 骨髓抑制 ( 血小板缺乏症, 白血球缺乏症 ), 噁心和嘔吐 CHIRON Cumulated dose>800 mg/m2( 6 course) Single agent: 37 mg/ m 2 Combination with taxotere: 14 mg/ m 2 50100 mg/ m 2 once every 34 weeks or 5 days each cycle 85 130 mg/m 2 睪丸癌, 卵巢癌, 膀胱癌, 非小細胞肺癌, 子宮頸癌, 神經毒性, 腎毒性, 耳毒性, 嚴重噁心嘔吐 腎毒性骨癌, 頭頸癌 晚期大腸直腸癌 2 12 mg/ m on day 13 急性白血病, 攝護腺癌 Intravesical: 81mg diluted in 50 ml of 09% sodium chloride are instilled in the bladder via 膀胱尿道原位癌 urinary catheter for treatment of 膀胱癌 carcinoma in situ Metastatic renal cell carcinoma 和黑色素瘤 : 600,000 units/kg Q 8H by a 15minute intravenous infusion for a maximum of 14 doses; followed by 9 腎癌, 轉移性黑色素細胞瘤 days of rest,then repeat schedule for another 14 doses; maximum of 28 doses per course 周邊感覺神經病變 (doselimiting toxicity), 白血球缺乏症, 噁心, 嘔吐, 和腹瀉 白血球缺乏症, 血小板缺乏症, 心臟毒性, 胃腸道毒性, 肝毒性, 皮膚反應 頻尿, 排尿疼痛, 尿急, 血尿, 膀胱炎, 發燒, 泌尿道感染 低血壓, 類感冒症狀, 腎功能變差, 呼吸急促 XI Monoclonal antibodies 52 10B080 Avastin Bevacizumab 100 mg/4 ml/vial Roche 5 mg/kg in 100 ml N/S IV infusion ( 初用 >90min, 若可耐受, 輸注時間可縮短為 60 min 30 min) every 14 days until disease progression is 與 5FU 併用, 治療轉移性大腸直腸癌第一線藥物 detected 常見 : 無力, 腹痛, 頭痛, 深層靜脈栓塞, 血小板減少症, 高血壓, 腹瀉, 噁心, 嘔吐, 食慾不振, 口腔炎, 便秘, 上呼吸道感染, 流鼻血, 呼吸困難, 剝落性皮膚炎, 蛋白尿 嚴重 : 胃腸道穿孔, 傷口癒合困難, 嚴重出血, 嚴重高血壓, 腎症候群, 動脈栓塞, 心衰竭

53 10C225 Erbitux Cetuximab 5 mg/ml,20 ml/vial Merck 400 mg/m2 initial IV loading dose over 120 min, followed by weekly doses of 250 mg/m2 IV over 60 min 頭頸癌 常見 : 低血鎂 (10% to 50%), 便秘, 腹瀉, 噁心嚴重的 : 皮膚紅疹, 青春痘 (1%), 貧血, 白血球減少 ( 常見 ), 輸注相關不良反應 (3%), 腎衰竭 (2%), 間質性肺炎 (05%), 肺栓塞 (1%), 發燒 (5%), 敗血症 (3%) 54 55 56 Mabthera (Rituximab) 10R008 (100 mg/10 ml/vial) 10R024 (500 mg/50 mg/vial) 10T052 Herceptin (Trastuzumab) 440 mg/vial 10A083 Mabcampath (Alemtuzumab) 10 mg/ml,3 ml Roche Roche 先靈 57 20I046 Glivec (Imatinib mesylate) 100 mg/cap Norvatis XII Cytoprotective agents 10M061 58 Uromitexan (mesna) 百特 400 mg/4 ml/amp XIII Miscellaneous antineoplastic agents 59 20H015 Hydrea (Hydroxyurea) 500 mg/cap 375 mg/m 2 IV infusion once weekly for 4 or 8 doses Initial loading dose: 4 mg/kg over 90minutes, followed by weekly infusions of 2 mg/kg IV infused over 30minutes Elapsed or refractory lowgrade or follicular,cd20 positive,b cell nonhodgkin's lymphoma HER2 蛋白質過度表現之乳癌 Initiate therapy at 3 mg as a 2hour IV infusion daily; when the 3mg daily dose is tolerated (eg, infusionrelated toxicities are Grade 2 or less), escalate to 10 mg daily and continue until infusionrelated toxicities are grade 2 or less; when Chronic Lymphocytic Leukemia; CLL the 10mg dose is tolerated,the maintenance dose (30 mg per day,3 times per week on alternate days) may be initiated; total duration of therapy, including dose escalation,is 12 weeks 1 CML: chronic phase 400 mg/day, accelerated/blast crisis phase 600 mg 2 metastatic gastrointestinal stromal tumors (GIST) :400 or 600 mg/day 1 60% ifosfamidedose: 20% of the ifosfamide dose (w/w) at 0,4,8 hr of ifosfamide dose 2 100% ifosfamide dose Bristol 27 g/ m 2 2030 mg/kg/day once daily Philadelphia positive 慢性骨髓性白血病 (CML), 胃腸基底細胞瘤 (GIST) Prophylactic agent to reduce the incidence of ifosfamideinduced 出血性膀胱炎 輸注相關的反應, 腫瘤裂解症狀, 嚴重的皮膚反應, 腹痛, 貧血, 呼吸急促, 低血壓, 白血球缺乏症, 寒顫, 發燒, 頭痛, 噁心, 嘔吐, 血管水腫, 低血壓 疼痛, 無力, 發燒, 寒顫, 噁心 / 腹瀉,, 缺血性心衰竭 發燒, 寒顫, 噁心, 嘔吐, 輸注相關的反應, 血小板缺乏症, 白血球缺乏症 血小板缺乏症, 白血球缺乏症, 肝指數上升, 水腫, 肌痙攣, 噁心, 腹瀉 高血壓, 噁心, 嘔吐, 腹瀉, 腎毒性, 過敏 黑色素瘤, 慢性骨髓性白血病, 無法手術之卵巢癌, 和 as adjunctive therapy to radiation therapy of 表皮樣骨髓抑制, 噁心, 嘔吐, 腹瀉, 便祕, 口腔粘膜炎的頭頸癌, 減少疼痛發作和降低鐮刀型貧血輸血次數 60 20T043 Vesanoid (Tretinoin) 10 mg/cap Roche 45 60 mg/ m 2 /dayin two evenly divided,continue for 3090 days until complete remission has been achieved Induction of remission in patients with 急性前髓性白血病 維他命過高症狀 (CSF 壓力上升, 頭痛, 厭食, 噁心, 嘔吐, 皮膚脫屑, 疲倦, 水腫, 肝臟腫大, 脾臟腫大 ) 61 20G018 Iressa (Gefitinib) 250 mg/tab Astrazeneca 250 mg QD Monotherapy in patients with locally 晚期 / 轉移性非小細胞肺癌 as thirdline therapy,after failure of both platinumbased 和 docetaxel therapies 腹瀉 (48%), 紅疹 (43%), 青春痘 (25%), 皮膚乾燥 (13%), 噁心 (13%), 嘔吐 (12%), 間質性肺疾病 (< 1%)

62 20E048 Tarceva (Erlotinib) 150 mg/tab Roch 150 mg QD Monotherapy in patients with locally 晚期 / 轉移性非小細胞肺癌 as thirdline therapy,after failure of both platinumbased 和 docetaxel therapies 腹瀉 (48%), 紅疹 (43%), 青春痘 (25%), 皮膚乾燥 (13%), 噁心 (33%), 嘔吐 (23%), 間質性肺疾病 (< 1%) 63 20S020 Nexavar Sorafenib 200 mg/tab Bayer 400 mg BID Liver carcinoma 晚期腎癌 (renal cell carcinoma) 高血壓 (17% ), 手足症 (30% ),Pruritus (19% ), 紅疹 (40% ) 噁心 (23% ), 嘔吐 (16% ) 貧血 (44% ),Lymphocytopenia (23% ),Neutropenia (18% ) 64 20S038 Sutent (Sunitinib) 125 mg/cap 輝瑞 50 mg QD with a cycle of 4 weeks on followed by 2 weeks off Gastrointestinal stromal tumor Renal cell carcinoma Dry skin (MRCC,18% ),Rash (GIST,14%; MRCC,27% ), Anemia (GIST,26%; MRCC,71% ),Leukopenia (MRCC, 78% ),Lymphocytopenia (GIST,38%; MRCC,59% ), Neutropenic disorder (GIST,53%; MRCC,72% ), 噁心, 嘔吐 65 20T001 Thado (Thalidomide) 50 mg/cap 東洋 200 mg ~ 800 mg/day 肝癌, 多發性骨髓瘤嗜睡, 便祕, 皮膚紅疹, 周邊神經病變 66 Temodal (Temozolomide) 20T085 (20 mg/cap) 20T069 (100 mg/cap) Schering 1000 mg/m 2 per cycle (5day course) 150 mg/m 2 QD for 5 days every 4 weeks Refractory anaplastic astrocytoma 骨髓抑制, 噁心, 嘔吐, 疲倦, 頭痛, 頭暈, 運動失調, 週邊水腫 67 68 10A075 Asadin (Arsenic trioxide) 10 mg/10 ml 10B109 Velcade (Bortezomib) 35 mg/vial 東洋 嬌生 X VI Imidazoquinazoline derivative agents MAX: 60 doses Refractory to or have relapsed from retinoid and anthracycline chemotherapy: induction,015 mg/kg IV over 12 hours daily until bone marrow remission; consolidation,015 mg/kg IV over 12 hours daily for 25 doses over a period up to 5 weeks; beginning 36 weeks after completing induction Intravenously (bolus) at a dose of 13 milligrams/ square meter twice weekly for two weeks (days 1,4,8,and 11) At least 3 days should elapse between consecutive doses This is followed by a 10day rest period (day 1221); this 3week period is a treatment cycle 急性前骨髓性白血病 Acute promyelocytic leukemia (APL) Multiple myeloma Mantle cell lymphoma 常見 : 噁心 嘔吐 腹瀉及腹痛, 呼吸困難, 白血球增多症, 疲勞 水腫 呼吸困難 咳嗽 皮疹或搔癢 頭痛 嚴重 : Abnormal ECG,QT prolongation,av block, torsadedepointes, 高血糖 常見 : Hypotension (11% to 12% ) Rash (18% to 21% ) Constipation (30% to 43%),Decrease in appetite (34% to 43%),Diarrhea (37%% to 57% ),Nausea (52% to 64% ), Mental disorder (35%),Fever (35% to 36% ) 嚴重 : Congestive heart failure,heart disease (15% ),Toxic epidermal necrolysis,vomiting (35% to 36% ),Neutropenic disorder (19% ),Thrombocytopenia (35% )

69 20A024 Agrylin (Anagrelide) 05 mg/cap Shire US MAX: 05 mg/day increase in any 1 wk X V Dichlorodiphenyl trichloroethane(ddt) derivative agents 70 References: 20M078 Lysodren (Mitotane) 500 mg/tab 1 CCIS,micromedx 2012 HRA Pharma 2 Drug Ffacts and Comparison 2008 MAX:1819 grams ORALLY daily Initial,05 mg ORALLY 4 times daily OR 1 mg ORALLY twice daily for at least 1 wk Initial: 2 to 6 grams ORALLY daily (divided 3 to 4 times/day); maintenance: 2 to 16 grams ORALLY daily (divided 34 times/day); normal dose is 910 grams/day Thrombocytosis,Secondary to myeloproliferative disorders Adrenal carcinoma,inoperable Abdominal pain (164%),Diarrhea (257%),Nausea (171%), Asthenia (231%),Dizziness (154%),Headache (435%), Dyspnea (119%),Fever (89%) 常見 :Rash,Diarrhea,Loss of appetite,nausea,vomiting, Dizziness,Lethargy,Somnolence,Vertigo 嚴重 : Hypertension,Orthostatic hypotension,hemorrhagic cystitis