(TSGH Pharmacy Newsletter) 101-102 Actos 30mg tab Pioglitazone Diabetes-related HCl agent Aggrastat 025mg inj Tirofiban HCl Antiplatelet agent Alphagan 02% oph Brimonidine Glaucoma soln tartrate Asadin 10mg inj Arsenic trioxide Oncology (APL)
Avelox 400mg tab Moxifloxacin Fluoroquinolone ( ) Bipiden 5mg inj Biperiden Antiparkinsonian, Lactate agent Britaject Pen Apomorphine Antiparkinsonian 10mg/ml 3ml inj HCl agent Broen C SC tab Bromelain, Anti-inflammatory L-Cysteine agent Caltagon 50 IU FC tab Kallidinogenase Vasodilating agent Combivent Metered Ipratropium Anticholinergic agent Aerosol 200puff bromide+salbut amol sulphate Comtan 200mg tab Entacapone Neurology Dilatrend 625mg tab Carvedilol Beta-blocker Ebastel 5mg tab Ebastine Long acting, 2 nd H1-receptor antagonist Evista 60 mg tab Raloxifene selective estrogen receptor modulator Exelon 3mg cap Rivastigmine Parasympathomimeti c agent Femara 25mg FC tab Letrozole Aromatase inhibitor Geniquin 200mg F Hydroxychloro- Antirheumatic agent Ctab quine
Glivec 100mg cap Imatinib Oncology (Blasis Crisis), mesylate Alpha- (CML) Herbesser 10mg inj Diltiazem Calcium channel Blocker, Imdur 60mg CR tab Isosorbide 5-mononitrate Nitrates Keto 10mg FC tab Ketorolac tromethamine NSAID Kinzolam 2mg tab Estazolam Hypnotics Kytril 1mg tab Granisetron HCl Antiemetics Kytril 1mg/ml inj Granisetron HCl Antiemetics Maxtam 500mg inj Sulbactam -lactamase inhibitor Ampicillin Meptin Liquid 5ug/ml 60ml procaterol Bronchodilator Micardis 40mg tab Telmisartan Angiotensin II receptor antagonist Nexium 40mg tab Esomeprazole Antiulcer agent,, Norditropin 5mg/15ml inj Somatropin Endocrine& Metabolic Nutrineal 2L Amino acids Nutritionals ONSD 001% Neostigmine Mydriatics
oph soln methylsulfate Oxalip 50mg inj Oxaliplatin Oncology Picibanil 5KE/vial Streptococcus Oncology,,, (OK-432) pyogenes PegIntron 100 mcg Peginterferon α Antivirals C inj 2b Peysan 75mg FC tab Phyxol 6mg/ml 15ml inj Dipyridamole Vasodilating agent, paclitaxol Antineoplastic agent Plavix 75mg tab Clopidogrel Antiplatelet agent Pletaal 50mg tab Cilostazol Platelet aggregation inhibitor Premelle Cycle 5 Conjugated Hormone Estrogens / Medroxy-proge sterone Prograf 1mg cap Tacrolimus Immunosuppression Rebetol 200mg tab Ribavirin Antivirals C Remeron 30mg tab Mirtazapine Antidepressant Sabril 500mg tab Vigabatrin Anticonvulsant Seretide 250 Salmeterol 50 Long-acting β 2 Accuhaler 60doses mcg / agonist & steroid Fluticasone 250 mcg
Seroquel 200mg tab Quetiapine Antipsychotic agent Seroquel 50mg tab Quetiapine Antipsychotic agent Sintrix 1gm inj Ceftriaxone 3 nd Cephalosporin,, Symbicort Turbuhaler 120dose Budesonide/ Formoterol Long-acting β 2 agonist & steroid B2 Xidanef 100 ml syrup Ketotifen Myotonic mediators (leukotrienes) inhibition, Zyprexa 5mg tab Olanzapine Antipsychotic agent Low-molecular weight heparin--- Dalteparin(Fragmin ) : ( ) 1 aspirin, ticlopidine,, thromboxane A 2, ADP, glycoprotein IIb / IIIa inhibitor, fibrinogen glycoprotein IIb / IIIa receptor, 2, streptokinase, urokinase, anistrelase, plasminogen activator,,, 3Warfarin, heparin, Heparin Warfarin
Heparin Warfarin IV 60 36 1 2 1 2 1 2 3 4 Cytochrome P450,, (unknown) B (safe) X
, Heparin, : Heparin Heparin ( ) --- 1 Xa,,,,, 2,,, 3
,, (LDL) Heparin Heparin Dalteparin(Fragmin ) 12000-15000 5000 Xa, Xa aptt, IV: 2 hrs 1-15 hrs SC: 3-4 hrs ( ) 1 2,,,,,, Anti-Xa, Platelet count and stool occult blood tests PT, aptt PT, aptt Protamine( ) Protamine
Fragmin 14 : 1 ( ) 75 /,, antithrombin, Heparin aptt( ) Bolus ( / ) Hold( ) % Rate change Repeat aptt < 50 50 0 + 10% 4 hrs 50-59 0 0 + 10% 4 hrs 60-85 0 0 0 86-95 0 0-10% 4 hrs 96-120 0 300-10% 4 hrs > 120 0 60-15% 4 hrs 1 Loading dose 75 U/Kg, 10 2 Maintainance dose: 20U/Kg/hr, 28U/Kg/hr 3 APTT 60-85 4 4 hrs, APTT 5APTT, APTT
2 12 100 /,,, APTT, Anti-factor Xa level, : Anti-factor Xa level Repeat Anti-factor Xa level ( / ) <035 25% 035-049 25% 4 4 05-10 11-15 0 20% 16-20 3 30% >20 Anti-F Xa 05 40% 4 3 INR(international normalized ratio), ( )
: 1 :, INR 1-13, 02 INR 11-13 14-19 20-30 31-35 >35 50% 50% 25%, INR < 35, 50% 2 : INR 11-14 15-19 20-30 31-35 >35 20% 20% 10%, INR < 35, 20% : 1 Huang JM: Low-molecular weight heparins 1998; 12:1251-1281 2 Streif W: Venous thromboembolic events in pediatric patient1998;12:1283-1312 3Verheugt FWA: Acute coronary care and beyond: the expanding role of low-molecular weight heparin 2001;24SI:1-24 17304