MMP ψδw m C Caspase-9 PI3K-Akt /PKB 2. 2 抗 炎 作 用 Oh 14 Lee 7 LPS RAW BUN Cr ALT PKCa AST NO inos COX-2-1 MDA AP-1

Transcription

1 36 3 Chinese Traditional Patent Medicine 1 * R doi /j. issn A Rhus verniciflua Stokes Toxicodendron vernicifluum Stokes F. A. Barkley B RVS Samoszuk 4 UACC urushiol 60% ~ 70% 15 BNL SV A. 8 MnSOD ~ 17 GSH Huang 6 Anacardiaceae Rhus succe- danea L. Toxicodendron succedaneum L. Kuntze fustin fisetin 3 alkyl hydroquinone sulfuretin butein 1 1 2% ~ 5% ' E -heptadecatrienylhydroquinone HQ ~ % ~ 7% Topo Ⅱ Choi 3 Son 5 RCMF RCMF hydroquinone 10' Z 13' E leukemia HL-6 2 TopoⅡ-DNA HL 抗 肿 瘤 作 用 Kotake 2 DNA TopoⅡα S Tel panyu1226@ 126. com * 1964 Tel lishunxiang@ hotmail. com 593

2 MMP ψδw m C Caspase-9 PI3K-Akt /PKB 2. 2 抗 炎 作 用 Oh 14 Lee 7 LPS RAW BUN Cr ALT PKCa AST NO inos COX-2-1 MDA AP-1 NF-κB Jung 15 PRF Kim 8 phospho-jnk1 /2-9 Caspase-9 PI3K-Akt / PKB NF-κB NO E2 PGE2 -α TNF-α inos adriamycin COX-2 LPS Cheon 9 Lee 10 MARKs p38 LPS RAW Li 11 Ko 12 Lee 16 fisetin ERK Kim 13 JNK 1L-1Β- Caspase Bax Bcl-2 p38mark C Kim 13 Bcl-2 Lee Bax 17 sulfuretin 594

3 HO-1 LPS C57BL /6 RAW NOPGE2TNF-α IL-1β SH-SY5YRA BDNF GDNF 2. 3 抗 菌 作 用 Choi 18 Cho 27 Escherichia coli Saccharomyces cerevisiae Kim 19 HT22 GR GSH-Px BV2 LPS NO Suk 20 ~ Helicobacter pylori IL / 神 经 调 节 作 用 Sapkota 26 RNA ROS SOD Kim 其 他 方 面 作 用 降 血 糖 降 血 脂 作 用 Jung 21 streptozocin P < Lee 1 Epalrestat Aminoguanidine Jeong 22 NO inos NF-κB β- I Oh 23 NFκB TC TG LDL HDL NO A HMG- CoA TBARS CAT SOD GPx 1 Lee E H Song D G Lee J Y et al. Inhibitory effect of the compounds isolated from Rhus verniciflua on aldose reductase 2. 5 抗 凝 血 作 用 Lee 24 and advanced glycation endproducts J. Biol Pharm Bull Kotake T Dina S Konishi T et al. Molecular cloning of a β- C-6 > C-2 > C-4 galactosidase from radish that specifically hydrolyzes β- 1 C-2 3 -and β galactosyl residues of arabinogalactan protein J. J Plant Physiol O- SO 3 Liu 25 3 Choi H S Seo H S Kim S R et al. Antiinflammatory and antiproliferative effects of Rhus verniciflua Stokes in RAW cells J. Mol Med Rep

4 4 Samoszuk M Tan J Chorn G. The chalcone butein from Rhus verniciflua Stokes inhibits clonogenic growth of human breast cancer cells co-cultured with fibroblasts J. BMC Complem Altern MBMC Complem Altern Med Son Y O Lee K Y Lee J C et al. Selective antiproliferative and apoptotic effects of flavonoids purified from Rhus verniciflua Stokes on normal versus transformed hepatic cell lines J. Toxicol Lett Huang C P Fang W H Lin L I et al. Anticancer activity of botanical alkyl hydroquinones attributed to topoisomerase II poisoning J. Toxicol Appl Pharmacol Lee J H Lee H J Lee H J et al. Rhus verniciflua Stokes prevents cisplatin-induced cytotoxicity and reactive oxygen species production in MDCK-I renal cells and intact mice J. Phytomedicine / Kim K S Jung H S Choi W C et al. A case of recurred hepatocellular carcinoma refractory to doxorubicin after liver transplantation showing response to herbal medicine product Rhus verniciflua Stokes extract J. Integr Cancer Ther Cheon S H Kim K S Kim S et al. Efficacy and safety of Rhus verniciflua Stokes extracts in patients with previously treated advanced non-small cell lung cancer J. Forsch Komplementmed Lee S Kim K Jung H et al. Efficacy and safety of standardized allergen-removed Rhus verniciflua Stokes extract in patients with advanced or metastatic pancreatic cancer A Korean Single- Center Experience J. Oncology Li Y Ma C Qian M et al. Butein induces cell apoptosis and inhibition of cyclooxygenase2 expression in A549 lung cancer cells J. Mol Med Rep Ko J H Lee S J Lim K T. 36kDa Glycoprotein isolated from Rhus verniciflua Stokes fruit has a protective activity to glucose / glucose oxidase-induced apoptosis in NIH /3T3 cells J. Toxicol in Vitro Kim J H Go H Y Jin D H et al. Inhibition of the PI3K- Akt / PKB survival pathway enhanced an ethanol extract of Rhus verniciflua Stokes-induced apoptosis via a mitochondrial pathway in AGS gastric cancer cell lines J. Cancer Lett Oh P S Lee S J Lim K T. Glycoprotein isolated from Rhus verniciflua Stokes inhibits inflammation-related protein and nitric oixide production in LPS-stimulated RAW cells J. Biol Pharm Bull Jung C H Kim J H Myung H H et al. Phenolic-rich fraction from Rhus verniciflua Stokes RVS suppress inflammatory response via NF-κB and JNK pathway in lipopolysaccharide-induced RAW macrophages J. J Ethnopharmacol Lee J D Huh J E Jeon G J et al. Flavonol-rich RVHxR 596 from Rhus verniciflua Stokes and its major compoundfisetin inhibits inflammation-related cytokines and angiogenic factor in rheumatoid arthriticfibroblast-like synovial cells and in vivo models J. Int Immunopharmacol Lee D S Jeong G S Li B et al. Anti-inflammatory effects of sulfuretin from Rhus verniciflua Stokes via the induction of heme oxygenase-1 expression in murine macrophages J. Int Immunopharmacol Choi Y H Kim J C Ahn J C et al. Anti-biofouling behavior of natural unsaturated hydrocarbon phenols impregnated in PDMS matrix J. Ind Eng Chem Kim J S Kwon Y S Chun W J et al. Rhus verniciflua Stokes flavonoid extracts have anti-oxidant anti-microbial and α-glucosidase inhibitory effect J. Food Chem Suk K T Baik S K Kim H S et al. Antibacterial effects of the urushiol component in the sap of the lacquer tree Rhus verniciflua Stokes on Helicobacter pylori. J. Helicobacter Jung C H Zhou S Ding G X et al. Antihyperglycemic activity of herb extracts on streptozotocin-induced diabetic rats J. Biosci Biotechnol Biochem Jeong G S Lee D S Song M Y et al. Butein from Rhus verniciflua protects pancreatic β-cells against cytokine-induced toxicity mediated by inhibition of nitric oxide formation J. Biol Pharm Bull Oh P S Lee S J Lim K T. Hypolipidemic and antioxidative effects of the plant glycoprotein 36 kda from Rhus verniciflua Stokes fruit in Triton WR-1339-induced hyperlipidemic mice J. Biosci Biotechnol Biochem Lee J Lim K T. Plant-originated glycoprotein 36 kda suppresses interleukin-4 and -10 in bisphenol A-stimulated primary cultured mouse lymphocytes J. Drug Chem Toxicol Liu C S Nam T G Han M W et al. Protective effect of detoxified Rhus verniciflua Stokes on human keratinocytes and dermal fibroblasts against oxidative stress and identification of the bioactive phenolics J. Biosci Biotechnol Biochem Sapkota K Kim S Kim M K et al. A detoxified extract of Rhus verniciflua Stokes upregulated the expression of BDNF and GDNF in the rat brain and the human dopaminergic cell line SH-SY5Y J. Biosci Biotechnol Biochem Cho N Choi J H Yang H et al. Neuroprotective and antiinflammatory effects of flavonoids isolated from Rhus verniciflua in neuronal HT22 and microglial BV2 cell lines J. Food Chem Toxicol Kim S Park S E Sapkota K et al. Leaf extract of Rhus verniciflua Stokes protects dopaminergic neuronal cells in a rotenone model of Parkinson' s disease J. J Pharm Pharmacol

5 36 3 Chinese Traditional Patent Medicine 29 Lee D S Li B Kim K S et al. Butein protects human dental pulp cells from hydrogen peroxide-induced oxidative toxicity via Nrf2 pathway-dependent heme oxygenase-1 expressions J. Toxicol In Vitro Kang S Y Kang J Y Oh M J. Antiviral activities of flavonoids isolated from the bark of Rhus verniciflua Stokes against fish pathogenic viruses in vitro J. J Microbiol Song N J Yoon H J Kim K H et al. Butein is a novel antiadipogenic compound J. J Lipid Res Choi S J Lee M Y Jo H et al. Preparative isolation and purification of neuroprotective compounds from Rhus verniciflua by high speed counter-current chromatography J. Biol Pharm Bull Park D K Lee Y G Park H J. Extract of Rhus verniciflua bark suppresses 2 4-dinitrofluorobenzene-induced allergic contact dermatitis J. Evid Based Complement Alternat Med R R287 doi /j. issn A CyclinD ph 4 d ph 抗 炎 作 用 P > NO 促 胃 动 力 作 用 10 c-fos 对 食 管 黏 膜 的 改 善 作 用 SMC IP 3 IP 3 RCa SMC Tel zbg@ henu. edu. cn 597