中国生物化学与分子生物学会工业生化分会理事科技部创新人才评议专家国家自然科学基金教育部博士点基金博士后基金等函审专家天津市药品化妆品评审专家天津医药集团项目评审专家北京药理学会神经与精神药理专业委员会常务理事 Journal of Cancer 期刊编委 E-Journal of Ch

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1 孔德新简历一工作简历 2010/10- 至今, 天津医科大学药学院教授博士生导师, 临床药学系主任天津市基础医学研究中心 PI 2010/ /09, 日本癌研究会分子药理部, 资深研究员 ( 永久职位 ) 2006/ /03, 日本癌研究会分子药理部, 研究员 2005/ /07, 香港中文大学药剂学院, 副研究员 2000/ /03, 大阪大学药学部, 访问学者 1996/ /09, 山东大学生命科学学院, 讲师 1994/ /11, 山东大学生命科学学院, 助教二教育背景 2002/ /03, 大阪大学大学院药学研究科, 博士 1991/ /07, 山东大学药学院, 硕士 1987/ /07, 山东大学药学院, 学士三获奖或荣誉称号 2012/09, 天津市特聘教授 2012/11, 天津市中青年骨干创新人才 2013/05, 日本学术振兴会外籍研究员桥项目入选者 2012/01, 日本学术振兴会外籍聘用研究短期项目入选者 2010/10, 天津医科大学 211 工程特聘教授四近期主持的主要科研项目 STELB 抑制胶质母细胞瘤的作用分子机制及靶点研究国家自然科学基金, 以小分子探针研究靶向抑制 PI3K 亚型抗前列腺癌转移的作用及多重分子机理国家自然科学基金, 天津市高等学校临床药学方向创新团队培养计划天津市高校创新团队项目, 靶向抑制 PI3K 对前列腺癌转移的影响及机理研究, 天津市自然科学基金重点项目, 2012 年 4 月至 2015 年 3 月五主要学术兼职国家卫计委专业技术资格评审专家教育部学位评审专家中国药理学会肿瘤药理专业委员会委员中国抗癌协会抗癌药物专业委员会委员中国药理学会补益药药理专业委员会理事中国药学会生化药物与生物技术专业委员会委员中国生物化学与分子生物学会海洋生化与分子生物学分会理事 1

2 中国生物化学与分子生物学会工业生化分会理事科技部创新人才评议专家国家自然科学基金教育部博士点基金博士后基金等函审专家天津市药品化妆品评审专家天津医药集团项目评审专家北京药理学会神经与精神药理专业委员会常务理事 Journal of Cancer 期刊编委 E-Journal of Chemistry 期刊编委 Biochemistry and Pharmacology 期刊编委 OA Cancer 期刊编委中国医药导报食品与药品期刊编委美国癌症学会 (AACR) 会员日本癌症学会会员, 日本分子靶向癌症治疗学会会员日本药学会会员, 日本生药学会会员六发表论文 1) Wang R, Zhang Q, Peng X, Zhou C, Zhong Y, Chen X, Qiu Y, Jin M, Gong M, Kong D*. Stellettin B induces G1 arrest, apoptosis and autophagy in human Non-small cell lung cancer A549 Cells via blocking PI3K/Akt/mTOR pathway. Sci Rep, 2016,6: ) Wang Y, Liu J, Qiu Y, Jin M, Chen X, Fan G, Wang R, Kong D*. ZSTK474, a specific class I phosphatidylinositol 3-kinase inhibitor, induces G1 arrest and autophagy in human breast cancer MCF-7 cells. Oncotarget, 2016, 7 (15): ) Huang C, Yi X, Kong D, Chen L, Gong M. Controlled release strategy of paclitaxel by conjugating to matrix metalloproteinases-2 sensitive peptide. Oncotarget. 2016, in press. doi: /oncotarget ) Chen Y, Zhou Q, Zhang L, Wang R, Jin M, Qiu Y, Kong D*. Idelalisib induces G1 arrest and apoptosis in chronic myeloid leukemia K562 cells. Oncol Rep. 2016, in press, doi: /or ) Wang P, He Y, Li D, Han R, Liu G, Kong D, Hao J. Class I PI3K inhibitor ZSTK474 mediates a shift in microglial/macrophage phenotype and inhibits inflammatory response in mice with cerebral ischemia/reperfusion injury. J Neuroinflammation. 2016, 13(1):192. 6) Zhao W, Qiu Y, Kong D*. Class I phosphatidylinositol 3-kinase inhibitors for cancer therapy. Acta Pharmaceutica Sinica B, 2016, in press. 7) Zhou Q, Chen Y, Chen X, Zhao W, Zhong Y, Wang R, Jin M, Qiu Y, Kong D*. In Vitro Antileukemia Activity of ZSTK474 on K562 and Multidrug Resistant K562/A02 Cells. Int J Biol Sci. 2016, 12(6):

3 8) Xu J, Gao C, Zhang F, Ma X, Peng X, Zhang R, Kong D, Simard AR, Hao J. Differentially expressed lncrnas and mrnas identified by microarray analysis in GBS patients vs healthy controls. Sci Rep, 2016,6: ) Li Y, Wang Y, Wei Q, Zheng X, Tang L, Kong D, Gong M*. Variant fatty acid-like molecules Conjugation, novel approaches for extending the stability of therapeutic peptides. Sci Rep, 2015; 5: ) Zhang F, Gao C, Ma X, Peng X, Zhang R, Kong D, Simard AR, Hao J*. Expression Profile of Long Noncoding RNAs in Peripheral Blood Mononuclear Cells from Multiple Sclerosis Patients. CNS Neurosci Ther, 2016, in press. doi: /cns ) Chen X, Xu H, Li B, Wang F, Chen X, Kong D, Lin X*. Preparation and Antitumor Activity of CS5931, A Novel Polypeptide from Sea Squirt Ciona Savignyi. Mar Drugs, 2016, 14: pii: E47. 12) Tang SA, Zhou Q, Guo W, Qiu Y, Wang R, Jin M, Zhang W, Li K, Yamori T, Dan S, Kong D*. In vitro Antitumor Activity of Stellettin B, a Triterpene from Marine Sponge Jaspis stellifera, on Human Glioblastoma Cancer SF295 Cells. Mar Drugs. 2014, 12: ) Chen X, Tang SA, Lee E, Qiu Y, Wang R, Duan HQ, Dan S, Jin M, Kong D*. IVSE, isolated from Inula japonica,suppresses LPS-induced NO production via NF-κB and MAPK inactivation in RAW264.7 cells. Life Sci, 2015; 124: ) Wang X, Tang SA, Wang R, Qiu Y, Jin M, Kong D*. Inhibitory effects of JEUD-38, a new sesquiterpene lactone from Inula Japonica Thunb, on LPS-induced inos expression in RAW264.7 cells. Inflammation, 2015; 38(3): ) Kong D*, Yamori T, Yamazaki K, Dan S*. In vitro multifaceted activities of a specific group of novel phosphatidylinositol 3-kinase inhibitors on hotspot mutant PIK3CA. Invest New Drugs, 2014, 32: ) Jin M, Zhou Q, Lee E, Dan S, Duan HQ, Kong D*. AS252424, a PI3K Inhibitor, Downregulates Inflammatory Responsiveness in Mouse Bone Marrow-Derived Mast Cells. Inflammation, 2014, 37 (4): )Zhao W, Guo W, Zhou Q, Ma S, Wang R, Qiu Y, Jin M, Duan HQ, Kong D*. In Vitro Antimetastatic Effect of Phosphatidylinositol 3-Kinase Inhibitor ZSTK474 on Prostate Cancer PC3 Cells. Int. J. Mol. Sci. 2013, 14, ). Kong D, Yamori T*. JFCR39, a panel of 39 human cancer cell lines, and its application in the discovery and development of anticancer drugs. Bioorg. Med. Chem. 2012, 20 (6): ). Kong D, Dan S, Yamazaki K, Yamori T*. Inhibition profiles of phosphatidylinositol 3-kinase inhibitors against PI3K superfamily and human cancer cell line panel JFCR39. Eur. J. Cancer. 2010, 46 (6):

4 20). Kong D, Okamura M, Yoshimi H, Yamori T*. Anti-angiogenic effect of a novel phosphatidylinositol 3-kinase inhibitor, ZSTK474. Eur. J. Cancer. 2009, 45 (3): cover paper. 21). Jin M, Zhao W, Zhang Y, Kobayashi M, Duan H, Kong D*. Antiproliferative Effect of Aaptamine on Human Chronic Myeloid Leukemia K562 cells. Int. J. Mol. Sci. 2011, 12 (11): ). Kong D*, Zhang Y, Yamori T, Duan H, Jin M. Inhibitory Activity of Flavonoids against Class I Phosphatidylinositol 3-Kinase Isoforms. Molecules. 2011, 16 (6): ). Kong D*, Yamori T, Kobayashi M, Duan H. Antiproliferative and antiangiogenic activities of Smenospongine, a marine sponge Sesquiterpene Aminoquinone. Mar. Drugs. 2011, 9 (2): ). Kong D, Yamori T*. Advances in development of Phosphatidylinositol 3-kinase inhibitors. Curr. Med. Chem. 2009, 16 (22): ). Kong D, Aoki S, Sowa Y, Sakai T, Kobayashi M*. Smenospongine, a sesquiterpene aminoquinone from a marine sponge, induces G1 arrest or apoptosis in different leukemia cells. Mar. Drugs 2008, 6 (3): ). Kong D, Yamori T*. Phosphatidylinositol 3-kinase inhibitors: promising drug candidates for cancer therapy. Cancer Sci. 2008, 99 (9): ). Kong D, Yamori T*. ZSTK474 is an ATP-competitive inhibitor of class I PI3 kinase isoforms. Cancer Sci. 2007, 98 (10): ). Kong D*. PI3K inhibitors: novel molecular-targeted drug candidates for cancer therapy. Biochem. Pharmacol. 2012, 1 (6): e ). Kong D, Yamazaki K, Yamori T*. Discovery of phosphatidylinositol 3-kinase inhibitory compounds from the SCADS library. Biol. Pharm. Bull. 2010, 33 (9): ). Kong D, Okamura M, Yoshimi H, Yamori T*. Anti-angiogenic activity of a novel PI3K inhibitor, ZSTK474. EJC Suppl. 2008, 6 (12): ). Kong D, Yamori T*. ZSTK474, a novel phosphatidylinositol 3-kinase inhibitor identified by JFCR39 drug discovery system. Acta Pharmacol. Sin. 2010, 31 (9): ). Kong D, Yaguchi S, Yamori T*. Effect of ZSTK474, a Novel Phosphatidylinositol 3-kinase Inhibitor, on DNA-Dependent Protein Kinase. Biol. Pharm. Bull; 2009, 32 (2): ) Tang SA, Zhu H, Qin N, Zhou JY, Lee E, Kong DX, Jin MH, Duan HQ. Anti-inflammatory terpenes from flowers of Inula japonica. Planta Med. 2014, 80(7):

5 34) Ma Y, Jin YY, Wang YL, Wang RL, Lu XH, Kong DX, Xu WR.The discovery of a novel and selective inhibitor of PTP1B over TCPTP: 3D QSAR pharmacophore modeling, virtual screening, synthesis, and biological evaluation. Chem Biol Drug Des. 2014, 83(6): ) Duan YQ, Ma Y, Wang XJ, Jin YY, Wang RL, Dong WL, Xu WR, Kong DX, Wang SQ. Design potential selective inhibitors for treating cancer by targeting the Src homology 2 (SH2) domain-containing phosphatase 2 (Shp2) with core hopping approach. Protein Pept Lett. 2014, 21(6): )Qiu Y, Lee KS, Choo YM, Kong D, Yoon HJ, Jin BR*. Molecular cloning and antifibrinolytic activity of a serine protease inhibitor from bumblebee (Bombus terrestris) venom. Toxicon, 2013, 63C: ). Zhai, HY, Zhao C, Zhang N, Jin MN, Tang SA, Qin N, Kong DX, Duan HQ*. Alkaloids frompachysandra terminalisinhibit Breast Cancer Invasion and Have Potential for Development As Antimetastasis Therapeutic Agents. J. Nat. Prod. 2012, 75, ). Sugita H, Dan S, Kong D, Tomida A, Yamori T*. A new evaluation method for quantifying PI3K activity. Biochem. Biophys. Res. Commun. 2008, 377 (3): ). Aoki S, Kong D, Suna H, Sowa Y, Sakai T, Setiawan A, Kobayashi M. Aaptamine, a spongean alkaloid, activates p21 promoter in a p53-independent manner. Biochem. Biophys. Res. Commun. 2006, 342 (1): ). Aoki S, Kong D, Matsui K, Kobayashi M. Erythroid differentiation in K562 chronic myelogenous cells induced by crambescidin 800, a pentacyclic guanidine alkaloid. Anticancer Res. 2004, 24(4): ). Aoki S, Kong D, Matsui K, Kobayashi M. Sesquiterpene aminoquinones, from a marine sponge, induce erythroid differentiation in human chronic myelogenous leukemia, K562 cells. Chem. Pharm. Bull. 2004, 52(8): ). Aoki S, Kong D, Matsui K, Kobayashi M. Smenospongine, a spongean sesquiterpene aminoquinone, induces erythroid differentiation in K562 cells. Anti-Cancer Drugs, 2004, 15(4):

填表说明 1. 本表所填数据截至时间为 2011 年 9 月底 2. 本表请用 A4 纸双面打印, 加盖学校公章后上报 3. 表内所填数据请学校认真核实, 确保准确无误 4. 建设完成情况对照

填表说明 1. 本表所填数据截至时间为 2011 年 9 月底 2. 本表请用 A4 纸双面打印, 加盖学校公章后上报 3. 表内所填数据请学校认真核实, 确保准确无误 4. 建设完成情况对照填表说明 1. 本表所填数据截至时间为 2011 年 9 月底 2. 本表请用 A4 纸双面打印, 加盖学校公章后上报 3. 表内所填数据请学校认真核实, 确保准确无误 4. 建设完成情况对照表等相关表格栏高不够请自行增加 5. 表格中填写的相关量