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1 绎阴元元 / doi: /j.issn [1] [2] [3] 元 CD4+ T ZYSNXD-CC-ZDYJ017 LHZLK-1107 LYTD-04 元元 beearhu@hotmai.com 1858

2 2012 绎 Vol.14 No.4 [4] [5] [6] 151 [7] 263 [8] Dukes C A B B C [9] 10 9 [10] 30 5 [11] 5 6 FOLFOX7 [12] 154 MFA 96 ( ) 58 Mok TS [13] IL-2 [14] [15] FOLFOX 20 g 30 g 30 g 15 g 12 g 6g 9g 30 g 20 g 15 g 15 g [16] [17] 15 g 30 g 15 g 15 g 30 g 30 g 30 g 30 g 15 g 30 g 30 g 2 g 6 g 30 g 12 g 30 g 15 g 15 g 15 g [18] 域芋 [19] 15 g 30 g 12 g 15 g 6 g 10 g 10 g 10 g 1859

3 绎 30 g 30 g 20 g 15 g 10 g [20] [21] 15 g 15 g 15 g 6 g 10 g 6 g 30 g 10 g 15 g Au 原 tophagy [22~24] G2/M Caspase [25,26] HT-29 G2/M DNA Chk1/Chk2 [27] Houttuynia cordata Thunb Hedyotis Diffusa Willd [28,29] [30] II Type II programmed cell death Autophagosome [24,31] Xie [32] HT-29 Caco-2 Bufalin ROS JNK ATG5 Beclin-1 ROS JNK HT-29 G0/G1 p38 MAPK Beclin-1 LC-3 HT-29 [33] Cell senescence [23, 34, 35] LS-174-T SA- 茁 -Gal G0/G1 p21 p16 RB LS-174-T p21 p16 RB [36] DNA He [37] hmlh1 Honokiol Caspase-3 p53 Li [38] 1 Jemal A, Bray F, Center MM, et al. Global cancer statistics. CA Cancer J Clin, 2011, 61(2):69~90. 2,.., 2007:75~90. 3,,.., 2007, 41(5):43~ , 1983: , 2006, 22(9): 1860

4 2012 绎 Vol.14 No ,,,. 151., 2011, 26(4):861~864. 7,,,.., 2011, 27(3):377~379. 8,,,.., 2005, 20(6):344~346. 9,,,.., 2009, 11(6):72~74. 10,.., 2011, 34(2):54~56. 11,,,.., 2009, 32(1):166~ ,. 96., 2000, 16(2):9~ Mok TS, Yeo W, Johnson PJ, et al. A double -blind placebo -con 原 trolled randomized study of Chinese herbal medicine as complemen 原 tary therapy for reduction of chemotherapy -induced toxicity. Ann Oncol, 2007, 18(4):768~ ,,,. IL-2., 2008, 24(2):99~ ,,,.., 2011, 33(4):494~ ,,,. 47., 2009, 15(7):665~ ,,,.., 2005, 39(1):24~25. 18,,,. II I 原 II., 2006, 26(8):677~ ,.., 2010, 18(9):1839~ ,. 105., 2008, 36(8):1201~ ,,,.., 2011, 45(7):43~ Portugal J, Bataller M, Mansilla S. Cell death pathways in response to antitumor therapy. Tumori, 2009, 95(4):409~ Chiantore MV, Vannucchi S, Mangino G, et al. Senescence and cell death pathways and their role in cancer therapeutic outcome. Curr Med Chem, 2009, 16(3):287~ Coates JM, Galante JM, Bold RJ. Cancer therapy beyond apoptosis: autophagy and anoikis as mechanisms of cell death. J Surg Res, 2010, 164(2):301~ Hu B, Shen KP, An HM, et al. Aqueous extract of Curcuma aro 原 matica induces apoptosis and G2/M arrest in human colon carcino 原 ma LS T cells independent of p53. Cancer Biother Radio 原 pharm, 2011, 26(1):97~ Huang WW, Ko SW, Tsai HY, et al. Cantharidin induces G2/M phase arrest and apoptosis in human colorectal cancer colo 205 cells through inhibition of CDK1 activity and caspase -dependent signaling pathways. Int J Oncol, 2011, 38(4):1067~ Wang ZY, Wang DM, Loo TY, et al. Spatholobus suberectus inhibits cancer cell growth by inducing apoptosis and arresting cell cycle at G2/M checkpoint. JEthnopharmacol, 2011, 133(2):751~ Lai KC, Chiu YJ, Tang YJ, et al. Houttuynia cordata Thunb extract inhibits cell growth and induces apoptosis in human primary col 原 orectal cancer cells. Anticancer Res, 2010, 30(9):3549~ Lin J, Chen Y, Wei L, et al. Hedyotis Diffusa Willd extract induces apoptosis via activation of the mitochondrion -dependent pathway in human colon carcinoma cells. Int J Oncol, 2010, 37(5):1331~ Milacic V, Banerjee S, Landis -Piwowar KR, et al. Curcumin in 原 hibits the proteasome activity in human colon cancer cells in vitro and in vivo. Cancer Res, 2008, 68(18):7283~ Maycotte P, Thorburn A. Autophagy and cancer therapy. Cancer Biol Ther, 2011, 11(2):127~ Xie CM, Chan WY, Yu S, et al. Bufalin induces autophagy-medi 原 ated cell death in human colon cancer cells through reactive oxygen species generation and JNK activation. Free Radic Biol Med, 2011, 51(7):1365~ Thyagarajan A, Jedinak A, Nguyen H, et al. Triterpenes from Gan 原 oderma Lucidum induce autophagy in colon cancer through the in 原 hibition of p38 mitogen -activated kinase (p38 MAPK). Nutr Can 原 cer, 2010, 62(5):630~ ,,..,2008, 20(3):447~ Ewald JA, Desotelle JA, Wilding G, et al. Therapy-induced senes 原 cence in cancer. JNatlCancerInst, 2010, 102(20):1536~46. 36,,,. LS-174-T., 2010, 8(11):1048~ He Z, Subramaniam D, Ramalingam S, et al. Honokiol radiosensi 原 tizes colorectal cancer cells: enhanced activity in cells with mis 原 match repair defects. Am J Physiol Gastrointest Liver Physiol. 2011, 301(5):G929~ Li SC, Chen CM, Lin SH, et al. Effects of adlay bran and its ethanolic extract and residue on preneoplastic lesions of the colon in rats. J Sci Food Agric, 2011, 91(3): Pathogenesis and Treatment of Colorectal Cancer in Traditional Chinese Medicine Deng Shan, Hu Bing, Shen KePing (Department of Oncology and Institute of Traditional Chinese Medicine in Oncology, Longhua Hospital affiliated to 1861

5 绎 Shanghai University of Traditional Chinese Medicine, Shanghai , China) Abstract: Colorectal cancer remains the third most common malignancy worldwide. According to traditional Chi 鄄 nese medicine (TCM), colorectal cancer is related to spleen -deficiency, damp -heat and toxicity accumulation. TCM has been confirmed to effectively reduce toxic side effects of chemotherapy, palliate clinical syndrome, im 鄄 prove quality of life, and prevent recurrence and metastasis in colorectal cancer. However, TCM theoretical and syndrome differentiation study has lagged far behind due to progression of therapy model in colorectal cancer. As a type of drug treatment, there are some common biological basis between chemotherapy, targeted therapy and an 鄄 ti-cancer herb therapy in colorectal cancer, such as apoptosis, cellular senescence and autophagy. There are growing needs to explore the effect mechanism and compatibility of anti-cancer herbs, to further enhance the effi 鄄 cacy of TCM treatment in colorectal cancer. Keywords: Colorectal cancer, syndrome differentiation, traditional Chinese medicinal treatment, anti-cancer herbs 1862

<30302DB7E2C3E6CDC6BDE9A3A D34A3A92E6D6469>

<30302DB7E2C3E6CDC6BDE9A3A D34A3A92E6D6469> 212 绎 Vol.14 No.5 ScienceDirect 阴元元元元 / 99978 5 doi: 1.3969/j.issn.1674-3849.212.5.3 2 1 29 72.7% 21 27.1% 24.26% 1 [1] 1 2 21 7.85 [2] 1 29 21% 662 26 9.38 211 3.8 27.2% 1 212-3-26 212-1-19 元 UL16/9-Y4/CMS/WYT1/ICMS