綜論 預防阿茲海默症之健康飲食 1 2 1 2 背景 ( Alois Alzheimer ) (1) 12% 70 1-2% 2025 (2) 病理 senile plaque neurofibrillary tangle 39-42 ( -amyloid protein) A amyloid precursor protein APP APP (3) microglia Miyakawa (4) cross linking free radical hydroxyl radical, OH ( superoxide radical, O 2 - ) hydrogen peroxide, H 2 O 2 acetylcholine, Ach (5) 19 ( apolipoprotein E, apoe ) apoe2 apoe3 apoe-e4 apoe-e4 apoe2 apoe3 apoe-e4 22 06-2211111 3801 chialin164@yahoo.com.tw TJD 2010;2(2):9-14 Taiwan Journal of Dietetics
郭家伶等 一 地中海飲食型態與預防阿茲海默症 (6) Dr. Scarmeas (7) 二 脂肪與阿茲海默症 Amor (8) -3-3 -6 (9) Trkanjec (10) ( low density lipoprotein, LDL ) Luchsinger (11) 980 65 apoe-e4 Morris (12) 815 65-3 -3 Luchsinger (11) 1416 68 三 維生素 B 群與預防阿茲海默症 ( homocysteine, Hcy ) ( methionine ) ( -SH ) B12 B6 B12 B6 (14) Luchsinger (11) 76 108 B12 76 B12 108 B12 Luchsinger (11) 66 B12 22 B12 500 g B12 3 3 Luchsinger (11) 75 370 2 B12 B12 B12. 10.
四 抗氧化劑與阿茲海默症 C E Usoro (15) 14968 70-79 150 mg 231 IU E C E Morris (12) 2889 65-102 C E E Luchsinger (11) 980 65 C E C E 五 酒與預防阿茲海默症 (16) ( resveratrol ) (17) ( polyphenols ) (18) Karuppagounder (19) 45 65 3 ( 140 c.c. ) (17) 4 (19) 六 薑黃素與預防阿茲海默症 ( curcumin ) (20) (21) Ahned 3-30 mg/kg (22) 結語 ATP 5% A E C B6 B12-3 EPA ( eicosapentaenoic acid ) DHA ( docosahexaenoic acid ) - ( -linolenic acid -LA ) : 1. 11.
郭家伶等. 12. 2 3 4 5 B E 6 參考文獻 1. Tabert MH, Liu X, Doty RL, Serby M, Zamora D, Pelton GH, Marder K, Albers MW,Stern Y, Devanand DP. A 10-item smell identification scale related to risk for Alzheimer's disease. Ann Neurol 2005;58 (1):155-160. 2. Brookmeyer R, Johnson E, Ziegler- Graham K, Arrighi HM. Forecasting the global burden of Alzheimer's disease. Alzheimer's Dement 2007;3 (3):186-191. 3. La Ferla FM. Pathways linking Abeta and tau pathologies. Biochem Soc Trans 2010;38(4):993-995. 4. Miyakawa T. Vascular pathology in Alzheimer's disease. Psychogeriatrics 2010;10(1):39-44. 5. Nieoullon A. Acetyl cholinesterase inhibitors in Alzheimer's disease : further comments on their mechanisms of action and therapeutic consequences. Psychol Neuropsychiatr Vieil 2010;8(2)123-131. 6. Panza F,Solfrizzi V,Colacicco AM. Mediterranean diet and cognitive decline. Public Health Nutr 2004;7(7):959-963. 7. Scarmeas N, Louis ED. Mediterranean diet and essential tremor, A case-control Study. Neuroepidemiology 2007;29(3-4):170-177. 8. Amor S, Puentes F, Baker D, van der Valk P. Inflammation in neurodegenative disease, Immunology 2010;129(2)154-169. 9. Su HM. Mechanisms of n-3 fatty acidmediated development and maintenance of learning memory performance. J Nutr Biochem 2010;21(5):364-373. 10. Trkanjec Z, Bene R. Serum HDL,LDL and total cholesterol in patients with latelife onset of Alzheimer's disease versus vascular dementia. Acta Clin Croat 2009;48(3):259-263. 11. Luchsinger JA, Mayeux R. Dietary factor and Alzheimer's disease. Lancet Neurol 2004;3:579-587. 12. Morris MC. The role of nutrition in Alzheimer's disease: epidemiological evidence.eur J Neurol 2009;16 Seppl 1:1-7. 13. Von Arnim CA, Gola U, Biesalski HK. More than the sum of its parts Nutrition in Alzheimer's disease. Nutrition 2010 ;26(7-8):694-700. 14. Nelson C, Wengreen HJ, Munger RG, Corcoran CD. Dietary folate, vitamin B12,vitamin B6 and incident Alzheimer's disease: the cache county memory, health and aging Study. J Nutr Health Aging 2009;13(10):899-905. 15. Usoro OB, Mousa SA. Vitamin E forms in Alzheimer's disease: a review of controversial and clinical experiences. Crit Rev Food Sci Nutr 2010;50(5):414-419. 16. Vingtdeux V, Dreses-Werringloer U. Therapeutic Potential of resveratrol in Alzheimer's disease. BMC Neurosci 2008;9 Suppl 2;S6. 17. S u n AY, Wa n g Q, S i m o n y i A.
Resveratrol as a therapeutic agent for neurodegenerative disease. Mod Neurobiol 2010;41(2-3):375-383. 18. Ho L, Chen LH, Wang J, Zhao W, Talcott ST, Ono K, Teplow D, Humala N, Cheng A, Percival SS,Ferruzzi M, Janle E, Dickstein DL, Pasinetti GM. Heterogeneity in red wine polphenolic contents differentially influences Alzheimer's disease-type neuropayhology and congnitive deterioration. J Alzheimer's Dis 2009:16(1);59-72. 19. Karuppagounder SS, Pinto JT, Xu H, Chen HL. Dietary supplementation with resveratrol reduces plaque pathology in atransgenic model of Alzheimer's disease. Neurochem Int 2009;54(2):111-118. 20. Panza F, Solfrizzi V, Colacicco AM. Mediterranean diet and cognitive decline. Public Health Nutr 2004;7(7):959-963. 21. Begum AN, Jones MR, Lim GP. Curcumin structure-function,bioavailability, and efficacy in models of neuroinflammation and Alzheimer's disease. J Pharmacol Exp Ther 2008;326(1):196-208. 22. Zhang C, Browne A, Child D, Tanzi RE. Curcumin decreases amyloid beta-peptide levels by attenuating the maturation of amyloid-beta precursor protein. J Bio Chem 2010;285(37): 28472-28480. 23. A h n e d T, E n a m S A, Gilani A H. Curcuminoids enhance memory in an amyloid-infused rat model of Alzheimer's disease. Neuroscience 2010;169(3):1296-1306. 24. Morris MC. The role of nutrition in Alzheimer's disease:epidemiological evidence. Eur J Neurol 2009;Seppl 1:1-7.. 13.
郭家伶等. 14.