Leo Kanner 1943 8 3 sameness Early Infantile Autism Bleuler 1950-1970 1930 Diagnostic and Statistic Manual of Mental Disorders DSM DSM-I 1952 DSM-II 1968 Childhood Schizophrenia International Classification of Diseases and Injuries, ICD ICD-9 WHO, 1977 1970 Rutter Schopler 1978 Kanner DSM-III 1980 Pervasive Developmental 1

Disorders, PDD DSM-III-R(1987) DSM-IV(1994) Autistic Disorder ICD-10 WHO,1992 Childhood Autism PDD ICD-10 DSM-IV comorbidity PDD ICD-10 WHO, 1993 A.B.C 1. 2. 3. DSM-IV 1.2.3. 6 1. 2 2. 3. 1 1. a. b. c. d. 2 e. f. g. h. 2

3 a. b. c. d. C DSM-IV B 1.2.3 1 3~5 1 3 1 1. Atypical Autism A B A B 6 1. 2 2. 3. 3

B 3. B 1. B 2. ICD-10 DSM-IV PDD PDDNOS 2. Rett s Disorder 5 30 5 48 3. Disintegrative Disorder 4

4. Asperger s Disorder 1944 8 1 1. 5

85% TEACCH theory of mind executivefunction central coherence deficit 2. 10~37% 6

200 450 1% 17~61% 1~14% 15 15 3. 1980 1985 1986 CT (MRI) MRI 7

1995 2 102 112 MRI MRI MRI 4. 8

X X X 80% X X Bregman 532 X 122 (23%) 594 50 (8.4%) X X X X 12 14 20 19 X Y 15 X 7 10 16 17 75~150 60~90% 0~10% 91~93% 2 10 3 7 9

1. dopomine haloperidol pimozide pimozide haloperidol haloperidal serotonin 10

risperidone olanzapine clozaril clozaril clomipramine clomipremine clomipramine fluvoxamine fluoxetine sertraline paroxetine citalopram fenfluramine secretin 30~40% 11

fluramine 1997 Secretin 1998 1998 1999 secretin clomipramine fluvoxamine fluoxetine halopeidal Ritalin methyphenidate imipramine clonidine haloperidol carbamazepine 12

lamotrigene haloperidol propranolol naltrexone haloperidol tics Gilles de la Tourette disorder haloperidol clonidine 70% halopenidal 13

2. 3. 1994 1982 1992 1985 deep pressure 14

4. auditory training Rimland auditory integration training 48 5. 90~1200 2~4 15

B6 X X 3~5% 16

1960 1970 1. 2% 17

( ) 2 6 8 12 ( ) 18 24 36 48 60 ( ) 12 ( ) 18

19 18 24 ; 36 ( ) 48 ( ) ; 60 18-20

1 2 3 4 5 2. 20

( ) 2 6 12 18 24 36 48 60 8 ( ) 3~5 1000 ( ) 21

22

3. 23

1. 1970 Rutter 70% 24

generalization 2. 3. 25

4. 26

10~37% 1. 1/5 1/4 2. 3 % 3. 4. 27

5. 6. 28

29

30

1. 2. 3. 31

1. 32

2. 3. 1. 33

2. 3. 1. prompt-fading technique 2. 34

3. 4. 5. 35

36

20% 30% 50% 37

1. 2. 3. 1. 2. 3. 4. 1. 38

39

40

1. 2. 3. 4. 5. 41

1. 2. 50% 60% 42

TEACCH Lovaas 43