Commentary 綜合評論Disorders, edition IV-Text Revision (DSM-IV- TR) 4 Tic 18 1 參病理機轉 (Group A β-haemolytic streptococci, GABHS) (Pediatric Autoimmune Neu

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1 摘要台北長庚紀念醫院中醫藥劑部藥師林佩蓉張思平桃園長庚紀念醫院中醫藥劑部藥師童承福 (Tic) (attention-deficit hyperactivity disorder, ADHD) (obsessive compulsive disorder, OCD) tourette syndrome 壹前言 1885 (Gilles de la Tourette) (multiple tics) (echolalia) (coprolalia) (Tourette syndrome, TS) 0.5-3% (ADHD) 60-70% (OCD) 30-50% 1,2 貳臨床表現與評估診斷 (Tic) Tic (motor tics) (phonic or vocal tics) 3 (premonitory urgy) 80% Tic Tic disorder ( ) (Huntington's disease) Manual of Mental 藥學雜誌綜合評論中西醫治療妥瑞症

2 Commentary 綜合評論Disorders, edition IV-Text Revision (DSM-IV- TR) 4 Tic 18 1 參病理機轉 (Group A β-haemolytic streptococci, GABHS) (Pediatric Autoimmune Neuropsychiatric Disorder Associated with Streptococcal Infection, PANDAS) (basal ganglia) - - (cortico-striatal-thalamo-cortical) (dopamine) 5 肆西醫治療 (Tic) ( ) 4 Tic (habit reversal therapy, HRT) (repetitive transcranial magnetic stimulation, rtms) (deep brain stimulation, DBS) 4 表一治療的常用藥物 ( -Adrenergic agonists) - D2 (Dopamine D2 receptor antagonists) - D2 5-HT2 (Dopamine D2 receptor antagonists and 5-HT2 serotonin receptor antagonists) ( ) - D2 5-HT2 (Dopamine D2 receptor and 5-HT2 serotonin receptor partial agonists) (Dopamine-depleting agent) Guanfacine Clonidine Haloperidol Pimozide Fluphenazine Risperidone Ziprasidone Aripiprazole Olanzapine Quetiapine (extrapyramidal syndrome, EPS) QTc interval EPS QTc interval Tetrabenazine 12 THE JOURNAL OF TAIWAN PHARMACY Vol.31 No.1

3 綜合評論伍中醫治療一古代中醫文獻記載與觀點 - () 6,9,10 表二辨證分型與治療藥學雜誌 " " " " 6 二病因病機與辨證論治 ( ) 7,8 ( ) 6,9, 圖一病因病機示意圖

4 綜Commentary 合評論三穴位治療 12 四相關臨床實證研究 % (Haloperidol) 2 92%77.46% 陸結論 14 THE JOURNAL OF TAIWAN PHARMACY Vol.31 No.1

5 1. Du JC, Chiu TF, Lee KM, et al: Tourette Syndrome in Children: An Updated Review, Pediatr Neonatol 2010; 51(5): Wang HS, Kuo MF.: Tourette's syndrome in Taiwan: an epidemiological study oftic disorders in an elementary school at Taipei County, Brain Dev 2003; 25(Suppl 1): S Kenney C, Kuo SH, Joohi JS, et al: Tourette's Syndrome, Am Fam Physician 2008; 77(5): McNaught KStP, Mink JW: Advances in understanding and treatment of Tourette syndrome, Nat Rev Neurol 2011; 7: Leckman JF, Bloch MH, Smith ME, et al: Neurobiological Substrates of Tourette's Disorder, J Child Adolesc Psychopharmacol 2010; 20(4): ; 5(1): 14-5 藥學雜誌綜合評論參考資料 : : ; 7(1): ; 30(4): : ; 3(5): : ; 45(8): ; 27(6): 禪荷

120 02/06/07號小論文

120 02/06/07號小論文投稿類別 : 健康 / 護理類篇名 : 我不是故意作怪 - 妥瑞氏症作者 : 林佩儒台北市立松山高級中學高一 20 班林伊婷台北市立松山高級中學高一 20 班王幼玲台北市立松山高級中學高一 20 班指導老師 : 郭靜靜老師 1 壹前言研究動機與

Commentary 綜合評論Disorders, edition IV-Text Revision (DSM-IV- TR) 4 Tic 18 1 參 病理機轉 (Group A β-haemolytic streptococci, GABHS) (Pediatric Autoimmune Neu

Commentary 綜合評論Disorders, edition IV-Text Revision (DSM-IV- TR) 4 Tic 18 1 參病理機轉 (Group A β-haemolytic streptococci, GABHS) (Pediatric Autoimmune Neu