Microsoft Word - Roche_Internet_newsletter_

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1 October, 2011

2 01.. < > 02 (Chronic kidney disease CKD) Creatinine GFR.. < > 03.. < > 04.. < > - 2 -

3 2011 PD User Club / Continuous Education in Diagnostics F 2011 PD Continuous Education in Diagnostics :,, Reorganization of the lab: Consolidation, Optimization, Automation Point of Care Testing (POCT) POCT management and future trend in the hospital HE4 - HE4 -a new tool in ovarian cancer diagnostics Anti -CCP All you want to know about Anti-CCP and were afraid to ask :? Infectious disease positive or negative: what really matters! Procalcitonin- Clinical Utility of Procalcitonin, a marker protein for infection and sepsis Bone Markers Renaissance of Serum Markers in Bone Metabolisme Roche rita.wu@roche.com - 3 -

4 Roche Tina-quant Cystatin C (Chronic kidney disease CKD) Creatinine GFR (Glomerular filtration rate ) creatinine GFR Cystatin C CKD Creatinine CKD 3 50 Cystatin C 1 2 (Figure 1) Figure 1: Stages of chronic kidney disease according to NKF KDOQI 1 Cystatin C creatinine (Figure 2) Figure 2: ROC analysis of cystatin C and creatinine 2-4 -

5 Roche Tina-quant Cystatin C Figure 3: CV comparison of different manufacturers based on data of package insert Roche sandy.wang@roche.com 1. National kidney Foundation Kidney Disease Outcomes Quality Intiative, 2. Artunc, F., Fischer, I.U., Risler, T., Erley, C.M. (2005). Improved estimation of FGR by serum cystatin C in patients undergoing cardiac catherization. Int J Cardiol 102,

6 Elecsys S100 A valuable addition to the diagnosis of traumatic brain injury (Minor Traumatic Brain Injury) Glasgow Coma Score guideline Glasgow Coma Score 13 Computed Tomography; CT Glasgow Coma Score Glasgow Coma Score : 3-20% S100 S100 Elecsys S100 heterodimer S100 A1b homodimer S100BB S100 BBB 3 cut off μg/l S100 Rule Out (GCS 13-15) Dr. Biberthaler 2006 S100 (Negative Predictive Value) 99.7% 1 S100 secondary - 6 -

7 Elecsys 2010/ cobas e411/e601 Modular E170 Total Turnaround Time Roche 1. Biberthaler, P. et al. (2006). Shock 25(5),

8 Elecsys TORCH TORCH Rubella IgG TORCH Toxoplasma gondii (Toxoplasma gondii) ( ) (tissue cysts) 1 ( ) 2,3 4,5,6 IgG IgM IgM IgG (IgG / IgM) 3,5 Rubella congenital Rubella syndrome CRS CRS CRS IgG - 8 -

9 IgM IgG 7,8,9,10,11,12,13 Cytomegalovirus % CMV CMV CMV % 10% CMV 1% 40% CMV HIV CMV CMV IgG CMV IgG IgM CMV IgM CMV IgG CMV IgM IgG CMV 14,15,16,17,18,19 TORCH? Roche TORCH : Rubella IgG Rubella IgM Toxo IgG Toxo IgM CMV IgG CMV IgM HSV cobas 4000 cobas 6000 cobas 8000 Roche TORCH rita.wu@roche.com - 9 -

10 1. Montoya JG, Liesenfeld O. Toxoplasmosis. Lancet 2004;363: Luft BJ, Remington JS. Toxoplasmic encephalitis in AIDS. Clin Infect Dis 1992;15: Khalifa KES, Roth A, Roth B, Arasteh KN, Janitschke K. Value of PCR for Evaluationg Occurrence of Parasitemia in Immunocompromised Patients with Cerebral and Extracerebral Toxoplasmosis. J Clin Microbiol 1994;32: Remington JS, Mc Leod R & Desmonts G 2001, Toxoplasmosis, , in J.S. Remington & J.O. Klein (ed.), Infectious Diseases of the Fetus and Newborn Infant, 5th ed. W.B. Saunders, Philadelphia, Pa. 5. Thulliez P. Maternal and foetal infection: in Toxoplasmosis (eds D.H.M. Joynson, T.G. Wreghitt) Cambridge University Press, 2001: ISBN Wong SY, Remington JS. Toxoplasmosis in pregnancy. Clin Infect Dis 1994;18: Pustowoit B, Liebert UG. Predictive Value of Serological Tests in Rubella Virus Infection during Pregnancy. Intervirology 1998;41: Cooper LZ, Alford CA. Rubella, in Infectious Diseases of the Fetus & Newborn Infant,: 5th Ed 2001, pp , ed Remington JS & Klein JO, Philadelphia: W.B. Saunders. 9. Banatvala JE, Brown DWG. Rubella. Lancet 2004;363: Best JM, Banatvala JE. Rubella Principles and Practice of Clinical Virology, 4th edition, ed by Zuckerman AJ, Banatvala JE and Pattison JR 2000: , John Wiley & Sons, Ltd. 11. Pustowoit B, Grangeot-Keros L, Hobman TC, Hofmann J. Evaluation of recombinant rubella-like particles in a ommercial immunoassay for the detection of anti-rubella IgG. Clin Diagn Virol 1996;5: Detection and Quantitation of Rubella IgG Antibody: Evaluation and Performance Criteria for Multiple Component Test Products, Specimen Handling, and Use of Test Products in the Clinical Laboratory; Approved Guideline. NCCLS document I/LA6-A (ISBN) NCCLS, 940 West Valley Road, Suite 1400, Wayne, Pennsylvania USA, Skendzel L. Rubella Immunity. Defining the Level of Protective Antibody. Am J Clin Pathol 1996;106: Revello MG, Gerna G. Diagnosis and Management of Human Cytomegalovirus Infection in the Mother, Fetus, and Newborn Infant. Clin Microbiol Rev 2002;15(4):

11 15. Munro SC, Hall B, Whybin LR, et al. Diagnosis of and Screening for Cytomegalovirus Infection in Pregnant Women. J Clin Microbiol 2005;43(9): Lazzarotto T, Gabrielli L, Lanari M, et al. Congenital Cytomegalovirus Infection: Recent Advances in the Diagnosis of Maternal Infection. Hum Immunol 2004;65: Guerra B, Simonazzi G, Banfi A, et al. Impact of diagnostic and confirmatory tests and prenatal counseling on the rate of pregnancy termination among women with positive cytomegalovirus immunoglobulin M antibody titers. Am J Obstet Gynecol 2007;196: Duff P. A thoughtful algorithm for the accurate diagnosis of primary CMV infection in pregnancy. Am J Obstet Gynecol 2007;196: Ljungman P. Risk of cytomegalovirus transmission by blood products to immunocompromised patients and means for reduction. Brit J Haematol 2004;125: (

样本样本类型生物液体样品应该使用实验室检测常规方式收集 3 建议选择新抽取的血清作为样本, 而不要使用全血作为样品样本储存及稳定性 1. 装有血液的试管必须始终竖

样本样本类型生物液体样品应该使用实验室检测常规方式收集 3 建议选择新抽取的血清作为样本, 而不要使用全血作为样品样本储存及稳定性 1. 装有血液的试管必须始终竖 SYNCHRON CX 生化分析系统 TBA 生化信息表总胆汁酸 Copyright 2013 Beckman Coulter, Inc. REF A76837 用于体外诊断本文件仅适用于 CX ( ) PRO 系统仅在中华人民共和国境内供应年度审核审核人 : 日期审核人 : 日期原理用途