% ~ 30% % 1 mirna true positive 125 carbohydrate antigen 125 CA125 CA199 carcinoembryonic antigen CEA 4 human epididymis prot

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1 52 Journal of Practical Oncology Vol. 31 No mirna Meta RNA microrna mirna PubMed The Cochrane Library ISI Web of Science CNKI mirna Meta-DiSc 1. 4 Meta 9 mirna Meta mirna % CI ~ % CI ~ % CI ~ % CI ~ % CI ~ Q * mirna / RNAs / Meta R R A DOI: /j.cnki.syzlzz Diagnostic value of mirnas in peripheral blood circulation for ovarian cancer A meta-analysis Zeng Yu Xu Pengfei Chen Chen et al Department of Clinical Laboratory Nanjing Obstetric and Gynecology Hospital Nanjing China Abstract Objective To evaluate the detection of micrornas mirnas in peripheral blood circulation for diagnosis of ovarian cancer. Methods PubMed the Cochrane Library ISI Web of Science CNKI WanFang and VIP databases were searched. Literatures regarding to the diagnostic values of peripheral blood circulating mirnas for ovarian cancer published before May 2015 were collected according to the inclusion and exclusion criteria. Meta-analysis was performed by Meta-DiSc Results A total of 9 studies involving cases were enrolled. The results of meta-analysis indicated that the pooled sensitivity and specificity of peripheral circulation mrnas for diagnosis of ovarian cancer were % CI and % CI respectively. The positive likelihood ratio was % CI and the negative likelihood ratio was % CI The diagnostic odds ratio was % CI The SROC AUC was under the curve and the Q * value was Conclusion Peripheral blood circulation mirnas are potential markers for diagnosis of ovarian cancer. Key words ovarian neoplasms /diagnosis micrornas /blood meta-analysis as topic 檯檯檯檯檯檯檯檯檯檯檯檯檯檯檯檯檯檯檯檯檯檯檯檯檯檯檯檯檯檯檯檯檯檯檯檯檯檯檯檯檯檯檯檯檯檯 13 Zhang JW Su K Shi WT et al. Matrine inhibits the adhesion and migration of BCG823 gastric cancer cells by affecting the structure and function of the vasodilatorstimulated phosphoprotein VASP J. Acta Pharmacol Sin Thirunavukarasu P Talati C Munjal S et al. Effect of incorporation of pretreatment serum carcinoembryonic antigen levels into AJCC staging for colon cancer on 5-70% ~ 80% year survival J. JAMA Surg Tu K Li J Verma VK et al. Vasodilator-stimulated phosphoprotein promotes activation of hepatic stellate cells by regulating Rab11-dependent plasma membrane targeting of transforming growth factor beta receptors J. Hepatology

2 % ~ 30% % 1 mirna true positive 125 carbohydrate antigen 125 CA125 CA199 carcinoembryonic antigen CEA 4 human epididymis protein 4 HE4 CA % ~ 80% quality assessment of diagnostic accuracy studies QUADAS 14 4 RNA microrna mirna / / 1-1 mirna 0 QUADAS 14 mirna 14 7 / mirna mirna 3 / mirna TP FP FN TN area under the curve AUC QUADAS 1. 4 Meta-DiSc 1. 4 Meta mirna Meta summary receiver operating characteristic SROC mirna AUC Q PubMed The Cochrane Library ISI TP false positive FP false negative FN true negative TN 1 2 Meta 5 Meta sensitivity SEN specificity SPE positive likelihood ratio + LR negative likelihood ratio - Web of Science CNKI LR diagnostic odds ratio DOR 2015 SROC AUC SROC 5 mirna Q * microrna or mirna ovarian cancer or ovarian carcinoma or ovarian 2 tumor sensitivity or specificity or diagnosis 2. 1 mi-rna microrna QUADAS 9. 2 mirna

3 54 Journal of Practical Oncology Vol. 31 No / / TP FP FN TN AUC QUADS Kan et al / / Suryawanshi et al / / Zheng et al / / Chung et al / / NA 10 Hong et al / / NA 8 Guo et al / / Kuhlmann et al / / Gao et al / / Liang et al / / TP true positive FP false positive FN false negative TN true negative AUC area under the curve QUADAS quality assessment of diagnostic accuracy studies TP true positive FP false positive FN false negative TN true negative AUC area under the curve 1 Spearman P P > SEN SPE + LR - LR DOR SEN SPE + LR - LR DOR I % 71. 6% 69. 9% 66. 5% 45. 2% 2 ~ mirna Meta Meta mirna SEN % CI ~ SPE % CI ~ LR % CI ~ LR % CI ~ ROC DOR % CI ~ ~ 1- Spearman 6 SROC AUC SE = ROC Q SE = mirna

4 mirna 4 mirna 5 mirna

5 56 Journal of Practical Oncology Vol. 31 No mirna SROC mirna Meta P /Q Meta P /Q SEN ~ ~ SPE ~ ~ LR ~ ~ LR ~ ~ DOR ~ ~ AUC SEN sensitivity SPE specificity + LR positive likelihood ratio -LR negative likelihood ratio DOR diagnostic odds ratio AUC area under the curve SEN ~ ~ SPE ~ ~ LR ~ ~ LR ~ ~ DOR ~ ~ AUC SEN sensitivity SPE specificity + LR positive likelihood ratio -LR negative likelihood ratio DOR diagnostic odds ratio AUC area under the curve

6 < Meta P /Q 4 < SEN ~ ~ SPE ~ ~ LR ~ ~ LR ~ ~ DOR ~ ~ AUC SEN sensitivity SPE specificity + LR positive likelihood ratio -LR negative likelihood ratio DOR diagnostic odds ratio AUC area under the curve 2. 4 Begg s z = P = Egger s t = P = % CI ~ mirna 21 ~ 24 RNA 2008 Mitchell ~ 24 RNA 125 RNA % mirna % mirna Mitchell 16 mirna mirna mir-15b mir-16 mir-24 mirna / / mirna RNase / mirna mirna / mirna 17 / mirna mirna mirna CA125 Zhen 15 Meta CA125 Meta DOR QUADAS ROC CA125 mirna 20% ~ % CI ~ % % CI ~ 0. 80

7 58 Journal of Practical Oncology Vol. 31 No RNA + LR % CI ~ LR % CI ~ RNA mirna AUC Q * AUC Q * 1 mirna mirna > mirna mirna mi LR > 5 - LR < Jayson GC Kohn EC Kitchener HC et al. Ovarian cancer 18 mi- J. Lancet Ortiz-Munoz B Aznar-Oroval E Garcia Garcia A et al. HE4 Ca125 and ROMA algorithm for differential diagnosis between benign gynaecological diseases and ovarian cancer J. Tumour Biol Wang J Zhang KY Liu SM et al. Tumor-associated circulating micrornas as biomarkers of cancer J. Mole- cules Whiting P Rutjes AW Reitsma JB et al. The development of QUADAS a tool for the quality assessment of studies of diagnostic accuracy included in systematic reviews J. BMC Med Res Methodol SROC Spearman P > Deeks JJ Macaskill P Irwig L. The performance of tests of publication bias and other sample size effects in sys- mirna tematic reviews of diagnostic test accuracy was assessed SEN SPE DOR J. J Clin Epidemiol Kan CW Hahn MA Gard GB et al. Elevated levels of circulating microrna-200 family members correlate with se- 3 rous epithelial ovarian cancer J. BMC Cancer SEN SPE 7 Chung YW Bae HS Song JY et al. Detection of micror- NA as novel biomarkers of epithelial ovarian cancer from the serum of ovarian cancer patients J. Int J Gynecol Cancer Guo F Tian J Lin Y et al. Serum microrna-92 expression in patients with ovarian epithelial carcinoma J. J mirna Int Med Res mirna 9 Hong F Li Y Xu Y et al. Prognostic significance of serum microrna-221 expression in human epithelial ovarian mirna cancer J. J Int Med Res Suryawanshi S Vlad AM Lin HM et al. Plasma micror- mirna NAs as novel biomarkers for endometriosis and endometriosis-associated ovarian cancer J. Clin Cancer Res mirna Zheng H Zhang L Zhao Y et al. Plasma mirnas as diagnostic and prognostic biomarkers for ovarian cancer CA125 CA125 J. PLoS One e Kuhlmann JD Baraniskin A Hahn SA et al. Circulating U2 small nuclear RNA fragments as a novel diagnostic tool for patients with epithelial ovarian cancer J. Clin Chem Meta 13 Gao YC Wu J. MicroRNA-200c and microrna-141 as potential diagnostic and prognostic biomarkers for ovarian cancer J. Tumour Biol mirna 4850.

8 * paraneoplastic neurological syndrome PNS 22 PNS % % / R73 R DOI: /j.cnki.syzlzz A Clinical analysis of 22 cases of paraneoplastic neurological syndrome Wang Xiaohang 1 2 Chen Mei 1 2 Hou Qun 2 1. The First Clinical Medical College Zhejiang Chinese Medical University Hangzhou China 2. Department of Neurology Zhejiang Provincial Hospital of TCM Hangzhou China Abstract Objective To review the clinical features diagnosis and prognosis of paraneoplastic neurological syndrome. Methods The clinical data lab results and pathological types of 22 patients with paraneoplastic neurological syndrome were retrospectively reviewed. Relevant literatures were reviewed. Results Among 22 patients 14 cases had paraneoplastic neurological symptoms before the diagnosis of tumor 63. 6% and 8 after tumor diagnosis 36. 4%. Clinical neurological symptoms included peripheral neuropathy in 8 cases peripheral neuropathy with myelitis in 2 cases peripheral neuropathy with cranial neuritis in 2 cases peripheral neuropathy with multiple myositis in 2 cases optic neutitis with epilepsy in 2 cases limbic encephalitis in 2 cases cerebellar degeneration in 2 cases and brainstem encephalitis in 2 cases. The primary tumors included lung cancer in 4 cases prostatic cancer in 4 cases lymphoma in 4 cases leukemia in 2 cases ovarian cancer in 2 cases thyroid cancer in 2 cases nasopharyngeal carcinoma in 2 cases and hypopharyngeal car * cmm3210@ aliyun. com 檱檱檱檱檱檱檱檱檱檱檱檱檱檱檱檱檱檱檱檱檱檱檱檱檱檱檱檱檱檱檱檱檱檱檱檱檱檱檱檱檱檱檱檱檱檱 14 Liang H Jiang Z Xie G et al. Serum microrna-145 as a novel biomarker in human ovarian cancer J. Tumour Biol Zhen S Bian LH Chang LL et al. Comparison of serum human epididymis protein 4 and carbohydrate antigen 125 as markers in ovarian cancer A meta-analysis J. Mol Clin Oncol Mitchell PS Parkin RK Kroh EM et al. Circulating micrornas as stable blood-based markers for cancer detection J. Proc Natl Acad Sci U S A Gulino R Forte S Parenti R et al. MicroRNA and pediatric tumors Future perspectives J. Acta Histochem / Jaeschke R Guyatt GH Sackett DL. Users' guides to the medical literature Ⅲ. How to use an article about a diagnostic test. B. What are the results and will they help me in caring for my patients The Evidence-Based Medicine Working Group J. JAMA