disease-free survival DFS 5 overall survival OS g /L 28. 3% 17 /60 Pearson χ 2 sc- χ SPSS Pearson χ 2 χ 2 Kaplan-Mei

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48 1 2 1 1 1. 325200 2. 325200 vasodilator stimulated phosphoprotein 60 3 χ 2 Kaplan-Meier P < 0. 05 5 cm TNM Ⅲ ~ Ⅳ P < 0. 05 3 P < 0. 05 Cox P < 0. 05 / / R735. 3 + 5 R730.

1 vasodilator stimulated phosphoprotein 60 3 χ 2 Kaplan-Meier P < cm TNM Ⅲ ~ Ⅳ P < P < Cox P < / / R R A DOI: /j.cnki.syzlzz Expression of in colonic carcinoma and its relation to prognosis Song Shengjiang 1 Sun Limin 2 Xu Dingyin 1 et al 1. Department of General Surgery Rui'an People's Hospital Rui'an China 2. Department of Pathology Rui'an People's Hospital Rui'an China Abstract Objective To investigate the expression of vasodilator stimulated phosphoprotein in colonic carcinoma and its relation to prognosis. Methods The expression of in colonic carcinoma and pericancerous tissues was detected by immunohistochemistry in 60 colonic carcinoma patients. The relationship between expression and clinicopathological features was analyzed by χ 2 test. Kaplan-Meier survival curve was used to measure prognosis. Results The expression of was significantly higher in colonic carcinoma tissues than in pericancerous tissues P < High expression was positively correlated with large tumor size 5 cm lymphatic metastasis and advanced TNM stage Ⅲ ~ Ⅳ all P < The 3-year overall survival rate and the disease-free survival rate were lower in patients with positive expression than in those with negative expression both P < Conclusion expression is up-regulated in colonic carcinoma and the elevated level is associated with malignant clinicopathological features and poor prognosis which indicates that may be used as a prognostic marker for patients with colonic carcinoma. Key words colonic neoplasms /pathology phosphoproteins /metabolism lymphatic metastasis gene expression prognosis immunohistochemistry Y vasodilator stimulated phosphoprotein Enabled Ena /

2 disease-free survival DFS 5 overall survival OS g /L 28. 3% 17 /60 Pearson χ 2 sc- χ SPSS Pearson χ 2 χ 2 Kaplan-Meier Logrank Cox 1 cm ~ / > Santa Cruz SP μm ph % H 2 O 2 10% DAB SP % 0 6% ~ 25% 1 26% TNM ~ 50% 2 51% ~ 75% 3 > 75% 4 = 10 5 cm 1 TNM Ⅲ ~ Ⅳ P P < % = P < <

3 n = % Kaplan-Meier n = 11 n = 49 χ2 P 3 OS 13. 0% < cm < * G1 ~ G G * 3 33 TNM Ⅰ ~ Ⅱ * Ⅲ ~ Ⅳ 4 38 * P < DFS 8. 8% 3 OS 29. 2% DFS 28. 6% Log-rank OS DFS P < Cox TNM 3 CRC Kaplan-Meier 2 3 Cox n = 60 HR 95% CI P HR 95% CI P ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ * ~ * TNM ~ * ~ * ~ * ~ * * P < 0. 05

4 zyxin vinculin profilin trial J. Med Oncol Han K Jin J Maia M et al. Lower exposure and faster clearance of bevacizumab in gastric cancer and the impact 9 of patient variables analysis of individual data from AV- AGAST phase Ⅲ trial J. AAPS J Hu S Cao B Zhang M et al. Epigenetic silencing BCL6B induced colorectal cancer proliferation and metastasis by inhibiting P53 signaling J. Am J Cancer Res EGF sirna EGF 4 Peng Y Murray EL Sarkar M et al. The cytoskeletonassociated Ena / proteins are unanticipated partners Rac1 of the PMR1 mrna endonuclease J. RNA Gharehbaghian A Salimian M Taherian AA et al. Variations in intraplatelet phospho- expression due to TNM pre-analytical sample preparations illustration of a quality control issue in platelet pharmacology J. Iran J 60 Pharm Res Kim SD Lee YJ Baik JS et al. Baicalein inhibits ago- nist- and tumor cell-induced platelet aggregation while suppressing pulmonary tumor metastasis via camp-mediated phosphorylation along with impaired MAPKs TNM AJCC 14 Ⅲ Ⅳ and PI3K-Akt activation J. Biochem Pharmacol PCAF J Kaplan-Meier < 20% 3 8 Zeng H Zheng R Guo Y et al. Cancer survival in China a population-based study J. Int J < 10% Cox TNM Cancer Schmit MA Mirakaj V Stangassinger M et al. Vasodilator phosphostimulated protein protects endo- Tu 15 thelial barrier function during hypoxia J. Inflammation Dertsiz L Ozbilim G Kayisli Y et al. Differential expression of in normal lung tissue and lung adeno- carcinomas J. Thorax Su K Tian Y Wang J et al. HIF-1alpha acts downstream of TNF-alpha to inhibit vasodilator-stimulated phosphoprotein expression and modulates the adhesion and proliferation of breast cancer cells J. DNA Cell 1 Zhang X Xu J Liu H et al. Predictive biomarkers for the efficacy of cetuximab combined with cisplatin and capecitabine in advanced gastric or esophagogastric junction adenocarcinoma a prospective multicenter phase 2 Biol Tanaka N Yoshida H Suzuki Y et al. Relative expression of hmena11a and hmenainv splice isoforms is a useful biomarker in development and progression of human breast carcinoma J. Int J Oncol

5 52 mirna Meta RNA microrna mirna PubMed The Cochrane Library ISI Web of Science CNKI mirna Meta-DiSc 1. 4 Meta 9 mirna Meta mirna % CI ~ % CI ~ % CI ~ % CI ~ % CI ~ Q * mirna / RNAs / Meta R R A DOI: /j.cnki.syzlzz Diagnostic value of mirnas in peripheral blood circulation for ovarian cancer A meta-analysis Zeng Yu Xu Pengfei Chen Chen et al Department of Clinical Laboratory Nanjing Obstetric and Gynecology Hospital Nanjing China Abstract Objective To evaluate the detection of micrornas mirnas in peripheral blood circulation for diagnosis of ovarian cancer. Methods PubMed the Cochrane Library ISI Web of Science CNKI WanFang and VIP databases were searched. Literatures regarding to the diagnostic values of peripheral blood circulating mirnas for ovarian cancer published before May 2015 were collected according to the inclusion and exclusion criteria. Meta-analysis was performed by Meta-DiSc Results A total of 9 studies involving cases were enrolled. The results of meta-analysis indicated that the pooled sensitivity and specificity of peripheral circulation mrnas for diagnosis of ovarian cancer were % CI and % CI respectively. The positive likelihood ratio was % CI and the negative likelihood ratio was % CI The diagnostic odds ratio was % CI The SROC AUC was under the curve and the Q * value was Conclusion Peripheral blood circulation mirnas are potential markers for diagnosis of ovarian cancer. Key words ovarian neoplasms /diagnosis micrornas /blood meta-analysis as topic 檯檯檯檯檯檯檯檯檯檯檯檯檯檯檯檯檯檯檯檯檯檯檯檯檯檯檯檯檯檯檯檯檯檯檯檯檯檯檯檯檯檯檯檯檯檯 13 Zhang JW Su K Shi WT et al. Matrine inhibits the adhesion and migration of BCG823 gastric cancer cells by affecting the structure and function of the vasodilatorstimulated phosphoprotein J. Acta Pharmacol Sin Thirunavukarasu P Talati C Munjal S et al. Effect of incorporation of pretreatment serum carcinoembryonic antigen levels into AJCC staging for colon cancer on 5-70% ~ 80% year survival J. JAMA Surg Tu K Li J Verma VK et al. Vasodilator-stimulated phosphoprotein promotes activation of hepatic stellate cells by regulating Rab11-dependent plasma membrane targeting of transforming growth factor beta receptors J. Hepatology

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% ~ 30% % 1 mirna true positive 125 carbohydrate antigen 125 CA125 CA199 carcinoembryonic antigen CEA 4 human epididymis prot 52 Journal of Practical Oncology Vol. 31 No. 1 2016 mirna Meta 210003 RNA microrna mirna PubMed The Cochrane Library ISI Web of Science CNKI 2015 5 mirna Meta-DiSc 1. 4 Meta 9 mirna 1 068 Meta mirna 0.