Chin J Joint Surg Electronic Edition December 2012 Vol. 6 No BBF BBF BBF 1. BBF BBF 2. BBF exopolysaccharide EPS EPS BBF EPS

Size: px

Start display at page:

Download "Chin J Joint Surg Electronic Edition December 2012 Vol. 6 No BBF BBF BBF 1. BBF BBF 2. BBF exopolysaccharide EPS EPS BBF EPS"

配侠侯
7 years ago
Views:

1 Chin J Joint Surg Electronic Edition December 2012 Vol. 6 No. 6 吴岳嵩王志伟徐卫东 100 ~ bacterial biofilms BBF Gibbons 6 BBF 1987 Costerton 7 BBF BBF BBF BBF 8 BBF - BBF BBF 1 2 DOI /cma. j. issn X

2 Chin J Joint Surg Electronic Edition December 2012 Vol. 6 No BBF BBF BBF 1. BBF BBF 2. BBF exopolysaccharide EPS EPS BBF EPS BBF 3. BBF BBF 3 BBF BBF 13 BBF BBF BBF 3 BBF BBF BBF BBF 10 ~ BBF 1 EPS 2 BBF 3 4 BBF β - 2. BBF BBF BBF BBF

3 Chin J Joint Surg Electronic Edition December 2012 Vol. 6 No mm 1 30% 105 5% ~ 10% Al-Maiyah % % 52. 1% Peersman ± 28 min ± 45 min P < 0. 01

4 Chin J Joint Surg Electronic Edition December 2012 Vol. 6 No % % % 1% 2% 2% ~ 6% 19 Kurtz % 0. 92% NIS 1990 ~ Eykyn 21 St. Thomas 1970 ~ % ~ 14 d 3. Maderazo Giulieri % 41% 30% 57% 43% Elek Gallo 28 PE SEM PE PE 5 ~ 8

5 Chin J Joint Surg Electronic Edition December 2012 Vol. 6 No C X CT MRI 99m Simonsen Trampuz quorum-sensing signaling molecules 2. Zimmerli ~

6 Chin J Joint Surg Electronic Edition December 2012 Vol. 6 No ~ % ~ 100% 14% ~ 68% * # 2 g q6 h mg q12 h 450 mg q12 h mg q12 h 750 mg q24 h 500 g q12 h 1 g q12 h mg q12 h 450 mg q12 h mg q12 h mg q24 q12 h 400 mg q24 h 500 mg q8 h - 1 DS tablet q8 h 100 mg q12 h G 500 q6 h 4 2 g q24 h 750 mg q8 h G 500 q6 h 2 g q6 h + 2 ~ mg q8h 750 mg q12 h 2 g q8 h mg q12 h 2 ~ q6 h 300 q6 h 2. 2 g q8 h - 3 g q6 h 2 ~ 4 * po iv im DS 160 mg 800 mg 3 6 # 2g q8h iv 1 g q12h iv floxacillin flucloxacillin oxacillin - FDA G 5 q6h iv 2 g q24h iv 500 mg q8h iv po 3 86% ~ 100%

7 Chin J Joint Surg Electronic Edition December 2012 Vol. 6 No % 2 ~ 4 1 ~ PROSTALAC PROSTALAC Duncan 32 PROSTALAC Prosthesis With Antibiotic-Loaded Acrylic Cement DePuy 11

8 Chin J Joint Surg Electronic Edition December 2012 Vol. 6 No PROSTALAC Villanueva-Martinez % ~ KSS 26 76% 19 56% % 1 Love C Marwin SE Palestro CJ. Nuclear medicine and the infected joint replacement. Semin Nucl Med Nishimura S Tsurumoto T Yonekura A et al. Antimicrobial susceptibility of Staphylococcus aureus and Staphylococcus epidermidis biofilms isolated from infected total hip arthroplasty cases. J Orthop Sci Rohde H Burandt EC Siemssen N et al. Polysaccharide intercellular adhesin or protein factors in biofilm accumulation of Staphylococcus epidermidis and Staphylococcus aureus isolated from prosthetic hip and knee joint infections. Biomaterials

9 Chin J Joint Surg Electronic Edition December 2012 Vol. 6 No Goffart J Gillet P. Endodontic biofilms and secondary infection of total hip arthroplasty. Rev Med Liege Ghanem E Antoci V Jr Pulido L et al. The use of receiver operating characteristics analysis in determining erythrocyte sedimentation rate and C-reactive protein levels in diagnosing periprosthetic infection prior to revision total hip arthroplasty. Int J Infect Dis e Gibbons RJ van Houte J. On the formation of dental plaques. J Periodontol Costerton JW Cheng KJ Geesey GG et al. Bacterial biofilms in nature and disease. Annu Rev Microbiol Costerton JW. Introduction to biofilm. Int J Antimicrob Agents Nishimura S Tsurumoto T Yonekura A et al. Antimicrobial susceptibility of Staphylococcus aureus and Staphylococcus epidermidis biofilms isolated from infected total hip arthroplasty cases. J Orthop Sci Zimmerli W Trampuz A Ochsner PE. Prosthetic-joint infections. N Engl J Med Wadstrom T. Molecular aspects of bacterial adhesion colonization and development of infections associated with biomaterials. J Invest Surg Gilbert P Evans DJ Brown MR. Formation and dispersal of bacterial biofilms in vivo and in situ. J Appl Bacteriol Suppl 67S - 78S. 13 Vuong C Gerke C Somerville GA et al. Quorum-sensing control of biofilm factors in Staphylococcus epidermidis. J Infect Dis Parsek MR Singh PK. Bacterial biofilms an emerging link to disease pathogenesis. Annu Rev Microbiol Ceri H Olson ME Stremick C et al. The calgary biofilm device new technology for rapid determination of antibiotic susceptibilities of bacterial biofilms. J Clin Microbiol Nishimura S Tsurumoto T Yonekura A et al. Antimicrobial susceptibility of Staphylococcus aureus and Staphylococcus epidermidis biofilms isolated from infected total hip arthroplasty cases. J Orthop Sci Al-Maiyah M Hill D Bajwa A et al. Bacterial contaminants and antibiotic prophylaxis in total hip arthroplasty. J Bone Joint Surg Br Peersman G Laskin R Davis J et al. Prolonged operative time correlates with increased infection rate after total knee arthroplasty. HSS J Gallo J Kolar M Novotny R et al. Pathogenesis of prosthesis-related infection. Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub Kurtz SM Lau E Schmier J et al. Infection burden for hip and knee arthroplasty in the United States. J Arthroplasty Eykyn SJ. The mictobiology of postoperative bacteremia. World Journal of Surgery Maderazo EG Judson S Pasternak H. Late infections of total joint prostheses. A review and recommendations for prevention. Clin Orthop Relat Res Giulieri SG Graber P Ochsner PE et al. Management of infection associated with total hip arthroplasty according to a treatment algorithm. Infection Qiu Y Zhang N An YH et al. Biomaterial strategies to reduce implant-associated infections. Int J Artif Organs Schierholz JM Beuth J. Implant infections a haven for opportunistic bacteria. J Hosp Infect Hallab NJ Skipor A Jacobs JJ. Interfacial kinetics of titanium-and cobalt-based implant alloys in human serum metal release and biofilm formation. J Biomed Mater Res A Elek SD Conen PE. The virulence of Staphylococcus pyogenes for man a study of the problems of wound infection. Br J Exp Pathol Gallo J Kolar M Novotny R et al. Pathogenesis of prosthesis-related infection. Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub Simonsen L Buhl A Oersnes T et al. White blood cell scintigraphy for differentiation of infection and aseptic loosening a retrospective study of 76 painful hip prostheses. Acta Orthop Trampuz A Osmon DR Hanssen AD et al. Molecular and antibiofilm approaches to prosthetic joint infection. Clin Orthop

10 Chin J Joint Surg Electronic Edition December 2012 Vol. 6 No Relat Res Zimmerli W Widmer AF Blatter M et al. Role of rifampin for treatment of orthopedic implant-related staphylococcal infections a randomized controlled trial. Foreign-Body Infection FBI Study Group JAMA Duncan CP Beauchamp C. A temporary antibiotic-loaded joint replacement system for management of complex infections involving the hip. Orthop Clin North Am Villanueva-Martinez M Rios-Luna A Pereiro J et al. Hand-made articulating spacers in two-stage revision for infected total knee arthroplasty good outcome in 30 patients. Acta Orthop J /CD 吴岳嵩, 王志伟, 徐卫东. 细菌生物膜与人工关节感染 [J /CD]. 中华关节外科杂志 : 电子版,2012,6( 6) :

政院衛生署疾病管制局九十一年度自行研究計畫

政院衛生署疾病管制局九十一年度自行研究計畫 subih@cdc.gov.tw 1 (1) 3 (2) 4 (3) 6 (4) 7 (5) 7 (6) 11 (7) 11 14 26 35 ( 37 ) 2 10 姙姙姙踪姙姙踪 3 4 5 踪 6 AmpicillinPenicillin, 10 姙姙姙姙踪姙姙姙姙姙 7 姙姙姙姙姙姙姙姙姙姙姙姙姙姙姙姙姙姙 8 姙姙姙姙姙