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/ / / / 510640 S 816 A 1002-2813 2016 03-

1 / / / / S 816 A DOI /j. cnki. issn Moore Jukes CARS A B FEED RESEARCH NO

2 Hansen Malloa 2010 Konstantinov 2008 Siggers Hansen Liu 2014 I CFU /ml IgA 5 20 Giang Siggers CFU /kg 40 CFU /kg 20 CFU /kg 2 Yan Yeuny Yu 2008 I5007 IL - 1βmRNA Maynard MUC1 MUC Wang 2009 I T Davis Ohashi 2007 Ross 24 Meng Zhang Yin Toyocerin Kantas Takahashi 2007 Konstantinov Chen 2006 Giang Yoshida 2009 Lq80 19 Sukegawa Wang Kritas FEED RESEARCH NO

3 27 Alexopoulos O157 H7 Lorca 2001 Bach Danicke Mack v HT29 MUC2 230 CFU /g MUC3 mrna 29 Li CFU/d Malago CFU /d CFU ZJ CFU /d Suo Yu 2008 Ohara Walsh CFU /g I CFU /g 22 TLRs I d 4 d I d Lebeer TGF - β mrna IFN - CD4 + T CD4 + Foxp3 + Hou T Treg β 3 TGF - β 4 IL IL Treg TGF - β siga Shah Wadstrom Havenaar FEED RESEARCH NO

4 piglets J. Antonie Van Leeuwenhoek Ross G R Gusils C Oliszewski R et al. Effects of probiotic administration in swine J. J. Biosci. Bioeng Moore P R Evenson A Luckey T D et al. Use of sulfasuxidine streptothricin and streptomycin in nutritional studies with the chick J. The Journal of Biological Chemistry Jukes T H Stokstad E L R Taylor R R et. al. Growth - promoting effect of aureomycin on pigs J. Arch. Biochem Hansen C H Nielsen D S Kverka M et al. Patterns of early gut colonization shape future immune responses of the host J. PLoS One Siggers R H Siggers J Boye M et al. Early administration of probiotics alters bacterial colonization and limits diet - induced gut dysfunction and severity of necrotizing enterocolitis in preterm pigs J. J. Nutr Liu H Zhang J Zhang S H et al. Oral administration of Lactobacillus fermentum I5007 favors intestinal development and alters the intestinal microbiota in formula - fed piglets J. J. Agric. Food Chem Yan F Polk D B. Probiotics as functional food in the treatment of diarrhea J. Curr. Opin. Clin. Nutr. Metab. Care Yeung CY Chiang Chiau JS Chan W T et al. In vitro prevention of Salmonella lipopolysaccharide - induced damages in epithelial barrier function by various lactobacillus strains J. Gastroenterol Res. Pract Maynard C L Elson C O Hatton R D et al. Reciprocal interactions of the intestinal microbiota and immune system J. Nature Wang A Yu H Gao X et al. Influence of Lactobacillus fermentum I5007 on the intestinal and systemic immune responses of healthy and E. coli challenged 11 Zhang L Xu Y Q Liu H Y et al. Evaluation of Lactobacillus rhamnosus GG using an Escherichia coli K88 model of piglet diarrhoea Effects ondiarrhoea incidence faecal microflora and immune responses J. Vet. Microbiol Yin F G Farzan A Wang Q C et al. Reduction of Salmonella enterica Serovar TyphimuriumDT104 Infection in Experimentally Challenged Weaned Pigs Fed a Lactobacillus - Fermented Feed J. Foodborne Pathogens and Disease Kantas D Papatsiros V G Tassis P D et al. A feed additive containing Bacillus toyonensis Toyocerin_ protects against enteric pathogens in postweaning piglets J. Journal of Applied Microbiology Malloa J J Rioperezb J Honrubiaa P. The addition of Enterococcus faecium to diet improves piglet s intestinal microbiota and performance J. Livest. Sci Chen Y J Min B J Cho J H et al. Effects of dietary Enterococcus faecium SF68 on growth performance nutrient digestibility blood characteristics and faecal noxious gas content in finishing pigs J. Asian - Aust. J. Anim. Sci Giang H H Viet T Q Ogle B et al. Growth performance digestibility gut environment and health status in weaned piglets fed a diet supplemented with potentially probiotic complexes of lactic acid bacteria J. Livestock. Sci Takahashi S Egawa Y Simojo N et al. Oral administration of Lactobacillus plantarum strain Lq80 to weaningpiglets stimulates the growth of indigenous lactobacilli to modify the lactobacillal population J. J. Gen. Appl. Microbiol FEED RESEARCH NO

5 Konstantinov S R Smidt H Akkermans A D et al. Feeding of Lactobacillus sobrius reduces Escherichia coli F4 levels in the gut and promotes growth of infected piglets J. FEMS Microbiol Ecol Yoshida Y Tsukahara T Ushida K. Oral administration of Lactobacillus plantarum Lq80and Megasphaera elsdenii inp induces efficient recovery from mucosal atrophy in the small and the large intestines of weaning piglets J. Animal Science Journal Sukegawa S Ihara Y Yuge K et al. Effects of oral administration of heat - killed Enterococcus faecium strain NHRD IHARA in post - weaning piglets J. Animal Science Journal Giang H H Viet T Q Ogle B et al. Effects of different probiotic complexes of lactic acid bacteria on growth performance and gut environment of weaned piglets J. Livest Sci Yu H F Wan N Li X J et al. Effect of viable Lactobacillus fermentum on the growth performance nutrinent digestibility and immunity of weaned pigs J. Journal of Animal and Feed Sciences Davis M E Parrott T Brown D C et al. Effect of a Bacillus - based direct - fed microbial feed supplement on growth performance and pen cleaning characteristics of growing - finishing pigs J. J. Anim. Sci Ohashi Y Tokunaga M Taketomo N et al. Stimulation of indigenous lactobacilli by fermented milk prepared with probiotic bacterium Lactobacillus delbrueckii subsp. Bulgaricus strain 2038 in the pigs J. J. Nutr. Sci. Vitaminol Tokyo Meng Q W Yan L Ao X et al. Influence of probiotics in different energy and nutrient density diets on growth performance nutrient digestibility meat quality and blood characteristics in growing - finishing pigs J. J. Anim. Sci Wang J Ji G F Ho C L et al. Effects of Lactobacillus johnsonii XS4 supplementation on reproductive performance gut environment and blood biochemical and immunological index in lactating sows J. Livest. Sci Kritas S K Marubashi T Filioussis G et al. Reproductive performance of sows was improved by administration of a sporing bacillary probiotic Bacillus subtilis C J. J. Anim. Sci Alexopoulos C Georgoulakis I E Tzivara A et al. Field evaluation of the efficacy of a probiotic containing Bacillus licheniformis and Bacillus subtilis spores on the health status and performance of sows and their litters J. J. Anim. Physiol Anim. Nutr. Berl D nicke S D ll S. A probiotic feed additive containing spores of Bacillus subtilis and B. licheniformis does not prevent absorption and toxic effects of the Fusariumtoxin deoxynivalenol in piglets J. Food and Chemical Toxicology Li X Q Zhu Y H Zhang H F et al. Risks associated with High - Dose Lactobacillus rhamnosus in an Escherichia coli model of piglet diarrhoea Intestinal microbiota and immune imbalances J. PLoS One Suo C Yin Y Wang X et al. Effects of Lactobacillus plantarum ZJ316 on pig growth and pork quality J. BMC Vet. Res Hou C Liu H Zhang J et al. Intestinal microbiota succession and immunomodulatory consequences after introduction of Lactobacillus reuteri I5007 in neonatal piglets J. PLoS One Wadstr m T Andersson K Sydow M et al. Surface properties of lactobacilli isolated from the small intestine of pigs J. J. Appl. Bacteriol Montes A J Pugh D G. The use of probiotics in food - animal practice J. Veterinary medicine FEED RESEARCH NO

35 Lorca G L Valdez G F. A low - ph - inducible stationary - phase acid tolerance response in Lactobacillus acidophilus CRL 639 J. Curr. Microbiol 2001 42 1 21-25.

6 35 Lorca G L Valdez G F. A low - ph - inducible stationary - phase acid tolerance response in Lactobacillus acidophilus CRL 639 J. Curr. Microbiol Bach S J McAllister T A Veria D M et al. Effects of a Saccharomyces cerevisiae feed supplement on Escherichia coli O157 H7 in ruminal fluid in vitro J. Animal Feed Science and Technology Mack D R Michail S Wei S et al. Probiotics inhibit enteropathogenic E. coli adherence in vitro by inducing intestinal mucin gene expression J. Am. J. Physiol Malago J J Koninkx J F J G. Probiotic - pathogen interactions and enteric cytoprotection J. Probiotic Bacteria and Enteric Infections O Hara A M O'Regan P Fanning A et al. Functional modulation of human intestinal epithelial cell responses by Bifidobacterium infantis and Lactobacillus salivarius J. Immunology Walsh M C Gardiner G E Hart O M et al. Predominance of a bacteriocin - producing Lactobacillus salivarius component of a five - strain probiotic in the porcine ileum and effects on host immune phenotype J. FEMS Microbiol. Ecol Lebeer S Vanderleyden J De Keersmaecker S C. Host interactions of probiotic bacterial surface molecules comparison with commensals and pathogens J. Nat. Rev. Microbiol Shah M M 1 Saio M Yamashita H et al. Lactobacillus acidophilus strain L - 92 induces CD4 + CD25 + Foxp3 + regulatory T cells and suppresses allergiccontact dermatitis J. Biol. Pharm. Bull 檪檪檪檪檪檪檪檪檪檪檪檪檪檪檪檪檪檪檪檪檪檪檪檪檪檪檪檪檪檪檪檪檪檪檪檪檪檪檪檪檪檪檪檪檪檪檪 7 J Sims M D Dawson K A Newman K E et al. Effects of dietary mannan oligosaccharide bacitra- 5. cin methylene disalicylate or both on the live performance and intestinal microbiology of turkeys J. 6. Poultry Science J J J D J J J J FEED RESEARCH NO

研發與創新驗顯示, 停止攝食乳酸菌後, 在幾週內乳酸菌便會消失, 並不會持續存在於腸道內, 但是短暫的定殖, 還是有刺激腸道免疫系統的效果, 尤其是對服用抗生素或腹瀉感

研發與創新驗顯示, 停止攝食乳酸菌後, 在幾週內乳酸菌便會消失, 並不會持續存在於腸道內, 但是短暫的定殖, 還是有刺激腸道免疫系統的效果, 尤其是對服用抗生素或腹瀉感乳酸菌之保健功效與產品開發撰文 / 陳慶源黃崇真邱雪惠廖啟成益生菌是指具有改善宿主體內內生性微生物相平衡, 並有益於宿主健康的單一或數種微生物一般而言, 益生菌被認定為活菌本身, 但是, 近年發現某類益生菌所衍生之活性