Microsoft Word - molecules supple.docx

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嗣崇季
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1 Supporting Information Secondary Metabolites from the Marine-Derived Fungus Dichotomomyces sp. L-8 and Their Cytotoxic Activity Li-Hong Huang 1,2, Yan-Xiu Chen 1,2, Jian-Chen Yu 3, Jie Yuan 3, Hou-Jin Li 4, Wen-Zhe Ma 5, Ramida Watanapokasin 6, Kun-Chao Hu 1,2, Shah Iram Niaz 7, De-Po Yang 1,2 and Wen-Jian Lan 1,2, * 1 School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou , China; huanglh23@mail2.sysu.edu.cn (L.H.H.); chenyx239@mail2.sysu.edu.cn (Y.X C.); Hukch@mail2.sysu.edu.cn (K.C.H.); lssydp@mail.sysu.edu.cn (D.P.Y.) 2 Guangdong Technology Research Center for Advanced Chinese Medicine, Guangzhou , China 3 Zhongshan School of Medicine, Sun Yat-sen University, 74 Zhongshan Road II, Guangzhou , China; lisana121406@163.com (J.-C.Y.); yuanjie@mail.sysu.edu.cn (J.Y.) 4 School of Chemistry, Sun Yat-sen University, Guangzhou , China; ceslhj@mail.sysu.edu.cn 5 State Key Laboratory of Quality Research in Chinese Medicine, Macau Institute for Applied Research in Medicine and Health, Macau University of Science and Technology, Avenida Wai Long, Taipa , Macau (SAR), China; wzma@must.edu.mo 6 Department of Biochemistry, Faculty of Medicine, Srinakharinwirot University, Bangkok 10110, Thailand; ramidawa@yahoo.com 7 Institute of Chemical Sciences, Gomal University, D.I.Khan 29050, Pakistan; shah_iram2000@yahoo.com * Correspondence: lanwj@mail.sysu.edu.cn; Tel.:

2 List of Content Supporting Information... 1 Figure S1. HR-ESI-MS spectrum of dichotone A (1)... s1 Figure S2. 1 H NMR spectrum of dichotone A (1) in CDCl 3 (400MHz)... s2 Figure S3. 13 C NMR spectrum of dichotone A (1) in CDCl 3 (100MHz)... s3 Figure S4. DEPT 135 spectrum of dichotone A (1) in CDCl 3 (100MHz)... s4 Figure S5. HMQC spectrum of dichotone A (1) in CDCl 3... s5 Figure S6. 1 H- 1 H COSY spectrum of dichotone A (1) in CDCl 3... s6 Figure S7. HMBC spectrum of dichotone A (1) in CDCl 3... s7 Figure S8. HR-ESI-MS spectrum of dichotone B (2)... s8 Figure S9. 1 H NMR spectrum of dichotone B (2) in CDCl 3 (400MHz)... s9 Figure S C NMR spectrum of dichotone B (2) in CDCl 3 (100MHz)... s10 Figure S11. DEPT 135 spectrum of dichotone B (2) in CDCl 3 (100MHz)... s11 Figure S12. HMQC spectrum of dichotone B (2) in CDCl 3... s12 Figure S13. 1 H- 1 H COSY spectrum of dichotone B (2) in CDCl 3... s13 Figure S14. HMBC spectrum of dichotone B (2) in CDCl 3... s14 Figure S15. 1 H NMR spectrum of dichotocejpin C (3) in acetone-d 6 (400MHz)... s15 Figure S C NMR spectrum of dichotocejpin C (3) in acetone-d 6 (100MHz)... s16 Figure S17. 1 H NMR spectrum of bis-n-norgliovictin (4) in DMSO-d 6 (400MHz)... s17 Figure S C NMR spectrum of bis-n-norgliovictin (4) in DMSO-d 6 (100MHz)... s18 Figure S19. 1 H NMR spectrum of bassiatin (5) in CDCl 3 (400MHz)... s19 Figure S C NMR spectrum of bassiatin (5) in CDCl 3 (100MHz)... s20 Figure S21. 1 H NMR spectrum of 3R, 6R-bassiatin (6) in CDCl 3 (400MHz)... s21 Figure S C NMR spectrum of 3R, 6R-bassiatin (6) in CDCl 3 (100MHz)... s22

3 Figure S1. HR-ESI-MS spectrum of dichotone A (1) s1

4 Figure S2. 1 H NMR spectrum of dichotone A (1) in CDCl3 (400MHz) s2

5 Figure S3. 13 C NMR spectrum of dichotone A (1) in CDCl3 (100MHz) s3

6 Figure S4. DEPT 135 spectrum of dichotone A (1) in CDCl3 (100MHz) s4

7 Figure S5. HMQC spectrum of dichotone A (1) in CDCl3 s5

8 Figure S6. 1 H- 1 H COSY spectrum of dichotone A (1) in CDCl3 s6

9 Figure S7. HMBC spectrum of dichotone A (1) in CDCl3 s7

10 Figure S8. HR-ESI-MS spectrum of dichotone B (2) s8

11 Figure S9. 1 H NMR spectrum of dichotone B (2) in CDCl3 (400MHz) s9

12 Figure S C NMR spectrum of dichotone B (2) in CDCl3 (100MHz) s10

13 Figure S11. DEPT 135 spectrum of dichotone B (2) in CDCl3 (100MHz) s11

14 Figure S12. HMQC spectrum of dichotone B (2) in CDCl3 s12

15 Figure S13. 1 H- 1 H COSY spectrum of dichotone B (2) in CDCl3 s13

16 Figure S14. HMBC spectrum of dichotone B (2) in CDCl3 s14

17 Figure S15. 1 H NMR spectrum of dichotocejpin C (3) in acetone-d6 (400MHz) s15

18 Figure S C NMR spectrum of dichotocejpin C (3) in acetone-d6 (100MHz) s16

19 Figure S17. 1 H NMR spectrum of bis-n-norgliovictin (4) in DMSO-d6 (400MHz) s17

20 Figure S C NMR spectrum of bis-n-norgliovictin (4) in DMSO-d6 (100MHz) s18

21 Figure S19. 1 H NMR spectrum of bassiatin (5) in CDCl3 (400MHz) s19

22 Figure S C NMR spectrum of bassiatin (5) in CDCl3 (100MHz) e s20

23 Figure S21. 1 H NMR spectrum of 3R, 6R-bassiatin (6) in CDCl3 (400MHz) N O O O s21

24 Figure S C NMR spectrum of 3R, 6R-bassiatin (6) in CDCl3 (100MHz) N O O O s22

Microsoft Word - Electronic Supplementary Information.doc

Microsoft Word - Electronic Supplementary Information.doc Electronic Supplementary Material (ESI) for RSC Advances. This journal is The Royal Society of Chemistry 2015 Electronic Supplementary Information Natural Thioredoxin Reductase Inhibitors from Jatropha