过红玲顾浩王耘 ** 乔延江 100102 目的 : 建立中药功效概念网络, 揭示中药功效间的联系, 明确功效概念网络的应用途径方法 : 通过整理 2010 年版 中华人民共和国药典 ( 一部 ) 记载的中药功效, 对中药功效概念间的关联关系进行系 统分析, 构建功效概念网络, 并从中抽提特定功效的子网络, 利用网络聚类算法发现连锁出现的功效群结 果 : 构建包含 422 个功效概念的中药功效概念网络, 发现经常连锁出现的 21 个功效群, 并以活血功效为例, 构建了活血功效的子网络, 分析子网络在药物配伍中的应用方法结论 : 中药功效概念网络是中医基础理论 和临床用药经验的集中体现, 能够系统揭示中药功效之间的联系, 有利于指导中药的合理应用配伍, 为疾病 的治疗提供新的思路 : 中药功效概念网络配伍 doi: 10.11842/wst.2013.04.004 中图分类号 :R285 文献标识码 :A 1. 数据来源 2010 [1] [2] [3] [4] 2. 中药功效概念的整理方法 459 + + + [5] 422 收稿日期 :2012-11-12 * ** 修回日期 :2013-07-19 国家自然科学基金委面上项目 (30973946): 基于三阴三阳系统的药性组合模式及其作用机理研究, 负责人 : 王耘 ; 国家自然科学基金委面上项目 (81173568): 基于三阴三阳的经方药对语法系统及其作用机制研究, 负责人 : 王耘 ; 科学技术部国家科技支撑计划项目 (2008BAI51B01): 中药有效 成分群辨识技术研究, 负责人 : 张宏桂 通讯作者 : 王耘, 教授, 博士生导师, 主要研究方向 : 中药方剂的系统生物学研究 638
2013 Vol.15 No.4 3. 功效概念网络构建 1 2 Score 1 Cytoscape [6] 健脾 益气 活血 4. 功效网络概念聚类分析 NeMo [7] NeMo Score r ab a b S ab a b λ: N n a a n b b e 1 补中 补脾 1. 功效概念网络的基本特征 2 2 639
2 95.73% 4.27% 3 [9] 48 4 健脾 温中 补脾 1 益气行气 2. 功效子网络的抽提及其在药物配伍中的应用活血破血补中 2 补血 滋阴 3 3 4 [8] 3 3 4 640
2013 Vol.15 No.4 3. 基于功效概念网络的功效群发现 NeMo 1 4 1 1 [10] 2 1 功效群 分数 功效 1 3.815 通窍, 顺气, 通痹, 续伤, 祛寒, 解痉, 制酸, 止痛 2 2.456 除胀, 健胃, 醒脾, 和中, 消食 3 2.066 逐水, 托毒, 行水, 清火, 拔毒, 行血, 定痛 4 1.889 通经, 通络, 调经, 祛瘀, 散瘀 5 1.59 益精, 清肝, 乌发, 聪耳, 退翳, 消翳 6 1.425 消食, 开郁, 消暑, 化湿 7 1.226 逐水, 托毒, 行水, 清火, 拔毒, 行血, 定痛, 利湿, 利尿 8 1.075 活络, 止痉, 止痒, 散寒 9 1.069 镇惊, 解郁, 补气, 益智, 镇心, 养心 10 1.069 豁痰, 解暑, 涤痰, 除烦, 润肺 11 0.988 益肺, 益气, 益胃, 止渴 12 0.941 补肾, 益肾, 止带, 固脱, 止遗, 固肾 13 0.941 通径, 补血, 通经, 通络, 调经, 祛瘀, 散瘀 14 0.912 补中, 摄血, 复脉, 补脾, 健脾 15 0.834 温胃, 温中, 温阳, 发汗 16 0.634 解毒, 止血, 消斑, 止痢 17 0.545 豁痰, 解暑, 涤痰, 除烦, 润肺, 生津, 养阴 18 0.54 活血, 止痛, 逐瘀, 利水, 下乳 19 0.454 敛疮, 透疹, 散血, 泻火, 排脓, 凉血 20 0.378 益精, 清肝, 乌发, 聪耳, 退翳, 消翳, 养肝, 平肝, 定惊 21 0.269 开胃, 和胃, 下气, 理气, 温经, 缓急, 通窍, 顺气, 通痹, 续伤, 祛寒, 解痉, 制酸 641
. 2011, 9(42) 1665~1672. 2,,.., 2008, 4(32) 273~275. 3,,,.. - 2011, 1(13) 93~95. 4,,,.., 2009,5(34) 524~529. 5,, 2008, 10(5) 105-108. 2003, 13(11) 2498~2504. cytoscape. BMC bioinformatics, 2010, 11(1) 1~9.,. 6 Paul S, Andrew M, Owen O, et al. a software environment for integrated models of biomolecular interaction networks. Genome Res, 7 Corban G R, Rachit V, Joel S B N. Network module in identification 8,,. 40., 2012, 18(10) 1~2. 9,,. 48., 2010, 29(6) 407~407. 1, 嵎. 10,. :, 2005. Construction and Application of Traditional Chinese Medicine Efficacy Concept Network Guo Hongling, Gu Hao, Wang Yun, Qiao Yanjiang (Research Center of Traditional Chinese Medicine Information Engineering, Beijing University of Chinese Medicine, Beijing 100102, China) Abstract: This study was aimed to establish Chinese medicine efficacy concept network in order to reveal the inner relation between traditional Chinese medicine (TCM) and efficacy as well as to suggest the application way of efficacy concept network. Through the collation of medicine efficacy recorded in the Pharmacopoeia of the People's Republic of China (2010 Edition, Volume I), the correlation relationship between TCM efficacy concept was systematically analyzed, and the efficacy concept network was constructed in order to extract specific effica - cy sub-network based on efficacy concept network and then to discover the efficacy groups by utilizing the network clustering algorithm. In the Chinese medicine efficacy concept network, 422 efficacy concepts were constructed and 21 tightly efficacy groups were discovered. Using the efficacy of promoting blood circulation as an example, the application of sub-networks was discussed. Chinese medicine efficacy concept network can be used to reflect the basic theory and clinical experiences in Chinese medicine, to systematically reveal the relationship between TCM efficacy concepts, which can be beneficial to guide the reasonable application of Chinese medicine in disease treatment. Keywords: Traditional Chinese medicine efficacy, concept network, compatibility ( 责任编辑 : 李沙沙张志华, 责任译审 : 王晶 ) 642