3236 黄炳昆 伍学焱 SF-36 15 1 1456 3 34% 2030 4. 4% 13. 2% 2000 1. 71 3. 66 3 2010 2 SF-36 9. 7% 0. 92 3-4 2012 Penson 16 ADA 5 exploratory comprehensive evaluation of erectile dysfunction ExCEED 20 90 6 12 2005 ADA 7 Vinik 2003 8 63% 9 67% 20% ~ 71% 17-20 10 HbA1c BMI 21 Massachusetts Male Aging Study 19 28% 9. 6% 3 11-14 De Berardis 9 5477 2 9 58% 22 2 75. 2% HbA1c > 6. 5% DOI 10. 3877 /cma. j. issn. 1674-0785. 2013. 08. 004 100730 24 Email wsheyan@ vip. sina. com 23 25
3237 S2 ~ S4 Saenz de Tejada 28 De Angelis 31 NO E1 PGE1 NO NO NO PGE1 NO NO cgmp PGE1 NO camp cgmp camp ADA 64 Banting Brownlee 32-33 ROS AGEs NO C PKC enos 26 1. Hecht 27 34 35 1. Saenz de Tejada 28 IIEF-5 NO 25 21 NO Cellek 29 2. 2. 30
3238 3. PDE5 - - PDE5 NO PSA NO PDE5 4. PDE5 30 min 5. 60 min 36 37 2 h 75% 38 20 min 28. 5% ~ 55% PDE5 35 90% 1. 5 PDE5 NO PDE5 30 min cgmp 2. PED5 PGE1 cgmp PDE5 PGE1 PDE5 cgmp 70% EMEA FDA 92% PGE1 PDE5 4 h 30 min 60% ~ 85% FDA SURE 39 4262 3. 57. 8% PDE5 -
3239 16 Penson DF Latini DM 17 Klein R Klein BE Lee KE 5% 135-141. 2% ~ 3% 70% ~ 87% 19 Feldman HA Goldstein I Hatzichristou DG Aging Study. J Urol 1994 151 54-61. 20 Giuliano FA Leriche A Jaudinot EO Urology 2004 64 1196-1201. 21 Penson DF 1 Wild S Roglic G Green A et al. Global prevalence of diabetes estimates for the year 2000 and projections for 2030. Diabetes Care 2004 27 1047-1053. 2 Yang W Lu J Weng J et al. Prevalence of Diabetes among Men and Women in China. NEngl J Med 2010 362 1090-1101. 3 Amos AF McCarty DJ Zimmet P. The rising global burden of diabetes and its complications estimates and projections to the year 2010. Diabet Med 1997 14 Suppl 5 S1-85. 4 Crofford OB. Diabetes control and complications. Annu Rev Med 1995 46 267-279. 5 ADA. Standards of Medical Care in Diabetes-2012. Diabetes Care 2012 35 Suppl 1 S11-63. 6 NIH Consensus Development Panel on Impotence. NHI Consensus Conference Impotence. JAMA 1993 270 83-90. 7 Boulton AJ Vinik AI Arezzo JC et al. Diabetic neuropathies a statement by the American Diabetes Association. Diabetes Care 2005 28 956-962. 8 Vinik AI Maser RE Mitchell BD et al. Diabetic autonomic neuropathy. Diabetes Care 2003 26 1553-1579. 9 De Berardis G Franciosi M Belfiglio M et al. Erectile dysfunction and quality of life in type 2 diabetic patients a serious problem too often o- verlooked. Diabetes Care 2002 25 284-291. 10 Ansong KS Lewis C Jenkins P et al. Help-seeking decisions among men with impotence. Urology 1998 52 834-837. 11 Sánchez-Cruz JJ Cabrera-León A Martín-Morales A et al. Male erectile dysfunction and health-related quality of life. Eur Urol 2003 44 245-253. 12 Litwin MS Nied RJ Dhanani N. Health-related quality of life in men with erectile dysfunction. J Gen Intern Med 1998 13 159-166. 13 Penson DF Feng Z Kuniyuki A et al. General quality of life 2 years following treatment for prostate cancer what influences outcomes Results from the prostate cancer outcomes study. 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Impotence and its medical and psychosocial correlates results of the Massachusetts Male et al. Prevalence of erectile dysfunction among 7689 patients with diabetes or hypertension or both. Wessells H. Erectile Dysfunction in Diabetic Patients. Diabetes Spectrum 2004 17 225-230. 22 Yang G Pan C Lu J. Prevalence of erectile dysfunction among Chinese men with type 2 diabetes mellitus. Int J Impot Res 2010 2 310-317. 23 Thompson IM Tangen CM Goodman PJ et al. Erectile dysfunction and subsequent cardiovascular disease. JAMA 2005 294 2996-3002. 24 Lue TF. Erectile Dysfunction. N Engl J Med 2000 342 1802-1813. 25 Kahn CR Weir CC King CL. Joslin.. 2007 1039-1040. 26 Dean RC Lue TF. Physiology of penile erection and pathophysiology of erectile dysfunction. Urol Clin North Am 2005 32 379-V. 27 Hecht MJ Neund rfer B Kiesewetter F et al. Neuropathy is a major contributing factor to diabetic erectile dysfunction. Neurol Res 2001 23 651-654. 28 Saenz de Tejada I Goldstein I Azadzoi K et al. Impaired neurogenic and endothelium-mediated relaxation of penile smooth muscle from diabetic men with impotence. N Engl J Med 1989 320 1025-1030. 29 Cellek S Rodrigo J Lobos E et al. Selectivenitrergicneurodegeneration in diabetes mellitus-a nitric oxide-dependent phenomenon. Br J Pharmacol 1999 128 1804-1812. 30 Malavige LS Levy JC. Erectile dysfunction in diabetes mellitus. J Sex Med 2009 6 1232-1247. 31 De Angelis L Marfella MA Siniscalchi M et al. Erectile and endothelial dysfunction in Type II diabetes a possible link. Diabetologia 2001 44 1155-1160. 32 Brownlee M. Biochemistry and molecular cell biology of diabetic complications. Nature 2001 414 813-820. 33 Brownlee M. The Pathobiology of Diabetic Complications a unifying mechanism. Diabetes 2005 54 1615-1625. 34.. 2004 18 68-72. 35 Hatzimouratidis K Amar E Eardley I et al. Guidelines on male sexual dysfunction erectile dysfunction and premature ejaculation. Eur Urol 2010 57 804-814. 36 Kannel WB McGee DL. Diabetes and glucose tolerance as risk factors for cardiovascular disease the framingham study. Diabetes Care 1979 2 120-126. 37 Ma RC So WY Yang X et al. Erectile dysfunction predicts coronary heart disease in type 2 diabetes. J Am Coll Cardiol 2008 51 2045-2050. 38 Kloner RA Mullin SH Shook T et al. Erectile dysfunction in the cardiac patient how common and should we treat J Urol 2003 170
3240 S46-50. 39 Mirone V Costa P Damber JE et al. An evaluation of an alternative dosing regimen with tadalafil 3 times /week for men with erectile dysfunction SURE study in 14 European countries. Eur Urol 2005 47 846-854. 2013-02-18 黄炳昆, 伍学焱. 糖尿病与勃起功能障碍 [J /CD]. 中华临床医师杂志 : 电子版,2013,7( 8) : 3236-3240.