本月專題聽 DNA 和 RNA 的對話葡萄糖代謝 : mg/dl mg/ dl glucose sensor glucose transporter

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1 / 藍色圓圈的約定 / 藍色圓圈的約定文 / 陳思達 WHO 1991 Frederick Banting 葡萄糖的代謝 ATP 1 32 科學研習 DEC 2016 No.55-12

2 本月專題聽 DNA 和 RNA 的對話葡萄糖代謝 : mg/dl mg/ dl glucose sensor glucose transporter hexokinase glucokinase 33

3 / 藍色圓圈的約定 / β α glycolysis ATP anabolic catabolic 30 ketone 何謂糖尿病 HbA1C 6.5% 200 (1) impaired glucose tolerance oral glucose tolerance test OGTT mg/dl (2) impaired fasting glucose mg/dl Banting Joslin Diabetic Center biguanide sulfonylurea 科學研習 DEC 2016 No.55-12

4 IAA, GADA, ICA本月專題聽 DNA 和 RNA 的對話 UKPDS 7% 糖尿病疾病生理學 idiopathic human leukocyte antigen, HLA T- 2 2 glucolipotoxicity endoplasmic reticulum, ER 第一型糖尿病發病自然史 2. diabetes-pathogenesis-genetics-and-immunotherapy/genetic-markers-serological-autoantibodies-and-prediction-of-type-1-diabetes 35

5 / 藍色圓圈的約定 / 3 3 Ralph DeFronzo 1988 incretin ominous ocet 4 4 Stanley Schwartz egregious 糖尿病的新發展 genome-wide association study noncoding regionmicro RNA mirna 3 Clinical Science (2009) 116, 科學研習 DEC 2016 No.55-12

6 本月專題聽 DNA 和 RNA 的對話糖尿病八部曲高血糖 Diabetes, VOL. 58, 2009: ominous ocet 糖 β Amylin 3. α Schwartz SS, et al. Diabetes Care 2016:39(2) 37

7 / 藍色圓圈的約定 / mirna mirna mir-375 mir-375 microarray mirna mirna mirna mir-1 mir- 133 mir-192 mir mirna 7 DNA 1.5% DNA noncoding RNA retrotransposon intron RNA RNA mrna RNA trna RNA rrna RNA sirna RNA mirna RNA snrna RNA 1993 mirna 20 non-coding mrna mrna 6 6 mirna non-coding RNA 結語 6. RNA DNA RNA 38 科學研習 DEC 2016 No.55-12

8 7. RNA 本月專題聽 DNA 和 RNA 的對話糖尿病糖尿病併發症參考資料 Mark A. Atkinson, The pathogenesis and natural history of type 1 diabetes. Cold Spring Harb Perspect Med 2012; doi: /cshperspect.a Wanzhu JIN and Mary-Elizabeth PATTI, Genetic determinants and molecular pathways in the pathogenesis of type 2 diabetes. Clinical Science (2009) 116, doi: /cs Ralph A. DeFronzo, From the triumvirate to the ominous octet: a new paradigm for the treatment of type 2 diabetes mellitus. Diabetes, 58, 2009: Stanley S. Schwartz, Solomon Epstein, Barbara E. Corkey, Struan F.A. Grant, James R. Gavin III, and Richard B. Aguilar, The time is right for a new classification system for diabetes: rationale and implications of the b-cell-centric classification schema. Diabetes Care 2016; 39: DOI: / dc Amit K. Pandey, Priyanka Agarwal, Kirandeep Kaur and Malabika Datta, MicroR- NAs in diabetes: tiny players in big disease. Cell Physiol Biochem 2009; 23: Claudiane Guay and Romano Regazzi, Circulating micrornas as novel biomarkers for diabetes mellitus. Nat. Rev. Endocrinol. 9, (2013)

第二章 : 中醫對糖尿病的治療中藥內治法... 36... 36... 38 中藥外治法... 41... 41... 45 針灸療法... 47... 48... 49... 50... 51 推拿療法... 52... 54... 54... 5

第二章 : 中醫對糖尿病的治療中藥內治法... 36... 36... 38 中藥外治法... 41... 41... 45 針灸療法... 47... 48... 49... 50... 51 推拿療法... 52... 54... 54... 5 目錄前言... 3 序一...劉良 6 序二... 方宏勳 7 序三... 余寶珠 8 第一章認識糖尿病什麼是糖尿病... 16 糖尿病的由來... 16 世界各國糖尿病的發病情況... 18 本港糖尿病的發病情況... 19 現代醫學對糖尿病的認識... 20 糖尿病的症狀... 20 糖尿病常見的分型及病因... 20 糖尿病的診斷標準... 22 糖尿病的併發症... 22 引起糖尿病的高危因素...

本月專題 聽 DNA 和 RNA 的對話 葡萄糖代謝 : mg/dl mg/ dl glucose sensor glucose transporter

本月專題聽 DNA 和 RNA 的對話葡萄糖代謝 : mg/dl mg/ dl glucose sensor glucose transporter