http / /www. psychjm. net. cn 2014 27 4 1 1. 2. 1 A 20100501 2mg /d 100422 2 5 ~ 10mg 1 ~ 2 /d 10 ~ 20mg /d 15. 69 ± 4. 21 mg /d B 1 20100501 3-4 3 ~

2014 27 4 http / /www. psychjm. net. cn 刘 云 蒋 光 明 孙 建 中 孙 亚 军 焦 小 雷 陈 金 山 3 CCMD - 3 165 3 A B C 2 PANSS PANSS - F = 896. 936 ~ 1484. 087 P < 0. 01 F = 6. 962 ~ 41. 495 P < 0. 01 F = 3. 455 P = 0. 034 3 F = 227. 991 ~ 615. 334 P < 0. 01 3 F = 0. 073 ~ 1. 473 P > 0. 05 24h F = 5. 386 ~ 8. 075 P < 0. 01 1 F = 7. 357 ~ 8. 546 P < 0. 01 2 F = 0. 616 ~ 1. 205 P > 0. 05 R749 A doi 10. 3969 /j. issn. 1007-3256. 2014. 04. 005 Effectiveness of risperidone combining short - term intramuscular haloperidol in the treatment of the agitated behavior of psychotic patients a randomized controlled study LIU Yun JIANG Guang - ming SUN Jian - zhong SUN Ya - jun JIAO Xiao - lei CHEN Jin - shan Department of Psychiatry the 3rd People's Hospital of Fuyang Fuyang 236015 China Abstract Objective To compare the efficacy of risperidone combining short - term intramuscular haloperidol or clonazepam and intramuscular haloperidol in the treatment of the agitated behavior of patients in the acute phase of schizophrenia. Methods 165 patients associated with impulsive behavior who met the diagnostic criteria of CCMD - 3 for schizophrenia were randomly divided into three groups. Group A was treated with risperidone combining short - term intramuscular haloperidol B with risperidone combining short - term intramuscular donazepam and C with only haolperidol. During a two - week observation period the efficacy was evaluated by PANSS. Results The effect of interaction between time and groups was statistically significant by repetitive measure ANOVA. The differences between time F = 896. 936 ~ 1484. 087 P < 0. 01 on all items of excitement of PANSS and groups F = 3. 455 P < 0. 01 on only hostility item indicated statistical significance. Intra - group comparison All items of excitement of PANSS had significant differences F = 227. 991 ~ 615. 334 P < 0. 01 between time - points of evaluation by repetitive measure ANOVA and LSD. At each time - point by multivariate analysis of variance and LSD the comparisons on each item of excitement of PANSS between three groups show that no significant difference before treatment F = 0. 073 ~ 1. 473 P > 0. 05 significant difference after 24 hours of treatment F = 5. 386 ~ 8. 075 P < 0. 01 and after one - week of treatment F = 7. 357 ~ 8. 546 P < 0. 01 except anger and delayed gratification difficulties At the end of observation period there were no significant difference among three groups F = 0. 616 ~ 1. 205 P > 0. 05 except excitement. Conclusion Risperidone combined short - term haloperidol intramuscular could be a good means of controlling agitated behavior of patients in the acute phase of schizophrenia. Key words Schizophrenia Risperidone Clonazepam Haloperidol Short - term intramuscular Agitated behavior 09C178 236015 E - mail psyah@ 126. com 303

http / /www. psychjm. net. cn 2014 27 4 1 1. 2. 1 A 20100501 2mg /d 100422 2 5 ~ 10mg 1 ~ 2 /d 10 ~ 20mg /d 15. 69 ± 4. 21 mg /d B 1 20100501 3-4 3 ~ 6mg /d 5 1004232 1mg 2 /d 3 ~ 6mg /d 4. 11 ± 0. 84 mg /d C 6 100422 5 ~ 10mg 1 ~ 2 /d 10 ~ 20mg /d 16. 21 ± 4. 59 mg /d 10 A B 4 ~ 6mg /d 20100315 2mg /d 3mg /d4 1 1. 1 2009 6-2011 6 100203 10 ~ 25 mg /d 3 Chi- nese Classification and Diagnostic Criteria of Mental Disease third edition CCMD - 3 2 1 1. 2. 2 PANSS - Positive and Nega- P4 + P7 + G8 + G14 + S1 + S2 + S3 tive Syndrome Scale PANSS 60 24 3 5 7 14 2 15 5 3 Kappa 18 ~ 59 1. 3 Excel2013 stata12. 0 165 LSD 3 A 8 31 24 18 ~ 58 30. 22 ± 10. 98 0 ~ 30 B 18 37 18 ~ 59 33. 75 ± 12. 05 1 ~ 30 C 30 25 18 ~ 54 33. 06 ± 10. 32 1 ~ 25 896. 936 F 2 340 = 1397. 668 F 2 321 = P > 0. 05 1484. 087 F 2 327 = 1360. 189 F 2 338 = 1274. 371 F 2 343 = 1155. 106 P = 0. 000 1. 2 304 4 ~ 6mg /d 4. 56 ± 0. 68 mg /d 7 C C 5 1 = 0. 87 2 2. 1 PANSS - F 2 340 = 1237. 932 F 3 370 = F 5 340 = 6. 962 F 5 370 = 41. 495 F 5 340 =

2014 27 4 http / /www. psychjm. net. cn 8. 252 F 4 321 = 9. 165 F 4 327 = 8. 554 F 5 338 = 7. 189 F 5 343 = 7. 386 P = 0. 000 3 PANSS - 6 1 F = 227. 991 ~ 615. 334 P < F 2 162 = 3. 455 0. 01 LSD 3 P = 0. 034 1 2. 2 3 PANSS - 3 P < 0. 01 1 2. 3 3 PANSS - 3 PANSS F = 0. 073 ~ 1. 473 P > 0. 05 24 h PANSS F = 5. 386 ~ 8. 075 P < 0. 01 1 PANSS F = 7. 357 ~ 8. 546 P < 0. 01 2 3 PANSS - F = 0. 616 ~ 1. 205 P > 0. 05 2 1 3 PANSS - x ± s 24h 1w 2w A 5. 06 ± 0. 978 a 4. 04 ± 0. 925 bc 2. 16 ± 0. 710 c 1. 94 ± 0. 620 465. 240 0. 000 B 5. 12 ± 0. 940 a 4. 22 ± 0. 789 bc 2. 70 ± 0. 707 c 2. 24 ± 0. 605 358. 929 0. 000 C 5. 14 ± 1. 010 a 4. 62 ± 0. 908 bc 2. 31 ± 0. 467 1. 91 ± 0. 566 431. 580 0. 000 F P A 4. 81 ± 1. 010 a 3. 80 ± 0. 728 bc 2. 11 ± 0. 689 c 1. 91 ± 0. 695 227. 991 0. 000 B 4. 83 ± 0. 792 a 3. 99 ± 0. 769 bc 2. 55 ± 0. 675 c 1. 93 ± 0. 634 361. 273 0. 000 C 4. 82 ± 0. 873 a 4. 35 ± 0. 749 bc 2. 17 ± 0. 560 c 1. 81 ± 0. 495 403. 755 0. 000 A 4. 72 ± 0. 882 a 3. 75 ± 0. 744 bc 2. 09 ± 0. 473 c 1. 87 ± 0. 558 447. 453 0. 000 B 4. 75 ± 0. 657 a 3. 92 ± 0. 665 bc 2. 51 ± 0. 583 c 1. 89 ± 0. 505 465. 974 0. 000 C 4. 78 ± 0. 840 a 4. 29 ± 0. 909 bc 2. 14 ± 0. 572 c 1. 78 ± 0. 465 497. 303 0. 000 A 4. 65 ± 0. 848 a 3. 71 ± 0. 788 bc 2. 06 ± 0. 512 c 1. 85 ± 0. 495 615. 334 0. 000 B 4. 70 ± 0. 614 a 3. 85 ± 0. 639 bc 2. 46 ± 0. 503 c 1. 85 ± 0. 405 395. 525 0. 000 C 4. 72 ± 0. 809 a 4. 25 ± 0. 728 bc 2. 11 ± 0. 580 c 1. 74 ± 0. 527 526. 734 0. 000 A 4. 57 ± 0. 785 a 3. 64 ± 0. 722 bc 2. 03 ± 0. 377 c 1. 81 ± 0. 523 410. 839 0. 000 B 4. 60 ± 0. 606 a 3. 79 ± 0. 582 bc 2. 16 ± 0. 609 c 1. 82 ± 0. 482 486. 162 0. 000 C 4. 65 ± 0. 745 a 4. 18 ± 0. 774 bc 2. 08 ± 0. 488 c 1. 72 ± 0. 454 485. 127 0. 000 A 4. 58 ± 0. 731 a 3. 64 ± 0. 749 bc 2. 02 ± 0. 473 c 1. 80 ± 0. 495 397. 554 0. 000 B 4. 66 ± 0. 626 a 3. 84 ± 0. 681 bc 2. 19 ± 0. 543 c 1. 85 ± 0. 351 450. 972 0. 000 C 4. 62 ± 0. 780 a 4. 16 ± 0. 681 bc 2. 07 ± 0. 528 c 1. 73 ± 0. 497 443. 216 0. 000 A 4. 55 ± 0. 788 a 3. 61 ± 0. 808 bc 2. 01 ± 0. 495 c 1. 79 ± 0. 452 426. 324 0. 000 B 4. 58 ± 0. 702 a 3. 77 ± 0. 687 bc 2. 41 ± 0. 730 c 1. 82 ± 0. 482 332. 064 0. 000 C 4. 62 ± 0. 855 a 4. 15 ± 0. 783 bc 2. 06 ± 0. 390 c 1. 71 ± 0. 463 414. 566 0. 000 a P < 0. 01 1w b P < 0. 01 2w c P < 0. 01 305

http / /www. psychjm. net. cn 2014 27 4 2 3 PANSS - x ± s A n = 55 B n = 55 C n = 54 F P 5. 06 ± 0. 978 5. 12 ± 0. 940 5. 14 ± 1. 010 0. 091 0. 913 4. 81 ± 1. 010 4. 83 ± 0. 792 4. 82 ± 0. 873 1. 473 0. 233 4. 72 ± 0. 882 4. 75 ± 0. 657 4. 78 ± 0. 840 0. 073 0. 929 4. 65 ± 0. 848 4. 70 ± 0. 614 4. 72 ± 0. 809 0. 080 0. 923 4. 57 ± 0. 785 4. 60 ± 0. 606 4. 65 ± 0. 745 0. 169 0. 845 4. 58 ± 0. 731 4. 66 ± 0. 626 4. 62 ± 0. 780 0. 156 0. 855 4. 55 ± 0. 788 4. 58 ± 0. 702 4. 62 ± 0. 855 0. 130 0. 878 4. 04 ± 0. 925 4. 22 ± 0. 789 4. 62 ± 0. 908 ef 5. 386 0. 006 3. 80 ± 0. 728 3. 99 ± 0. 769 4. 35 ± 0. 749 ef 7. 282 0. 001 3. 75 ± 0. 744 3. 92 ± 0. 665 4. 29 ± 0. 909 ef 6. 332 0. 002 24h 3. 71 ± 0. 788 3. 85 ± 0. 639 4. 25 ± 0. 728 e 6. 180 0. 003 3. 64 ± 0. 722 3. 79 ± 0. 582 4. 18 ± 0. 774 ef 8. 075 0. 000 3. 64 ± 0. 749 3. 84 ± 0. 681 4. 16 ± 0. 681 e 6. 931 0. 001 3. 61 ± 0. 808 3. 77 ± 0. 687 4. 15 ± 0. 783 ef 6. 642 0. 002 2. 16 ± 0. 710 2. 70 ± 0. 707 e 2. 31 ± 0. 467 f 8. 279 0. 000 2. 11 ± 0. 689 2. 55 ± 0. 675 e 2. 17 ± 0. 560 g 7. 3575 0. 000 2. 09 ± 0. 473 2. 51 ± 0. 583 e 2. 14 ± 0. 572 g 8. 292 0. 000 1w 2. 06 ± 0. 512 2. 46 ± 0. 503 e 2. 11 ± 0. 580 g 8. 546 0. 000 2. 03 ± 0. 377 2. 16 ± 0. 609 2. 08 ± 0. 488 0. 630 0. 529 2. 02 ± 0. 473 2. 19 ± 0. 543 2. 07 ± 0. 528 0. 710 0. 478 2. 01 ± 0. 495 2. 41 ± 0. 730 e 2. 06 ± 0. 390 g 8. 428 0. 000 1. 94 ± 0. 620 2. 24 ± 0. 605d 1. 91 ± 0. 566f 4. 580 0. 009 1. 91 ± 0. 695 1. 93 ± 0. 634 1. 81 ± 0. 495 0. 616 0. 541 1. 87 ± 0. 558 1. 89 ± 0. 505 1. 78 ± 0. 465 0. 792 0. 455 2w 1. 85 ± 0. 495 1. 85 ± 0. 405 1. 74 ± 0. 527 1. 048 0. 353 1. 81 ± 0. 523 1. 82 ± 0. 482 1. 72 ± 0. 454 0. 703 0. 497 1. 80 ± 0. 495 1. 85 ± 0. 351 1. 73 ± 0. 497 1. 205 0. 303 1. 79 ± 0. 452 1. 82 ± 0. 482 1. 71 ± 0. 463 0. 953 0. 388 A d P < 0. 05 e P < 0. 01 B f P < 0. 05 g P < 0. 01 3 P < 0. 01 PANSS - PANSS - LSD 9 PANSS 24h ~ 1w 2w P < 0. 01 3 7 10 306

2014 27 4 http / /www. psychjm. net. cn 边 云 卞 清 涛 韩 笑 乐 2010 1-2014 2 91 10 ICD - 10 ALT AST GGT TBA T - BIL D - BIL I - BIL / A /G 14. 28% ALT GGT TBA ALT TBA P < 0. 05 T - BIL D - BIL I - BIL I - BIL P < 0. 05 ALT F = 3. 664 P = 0. 03 ALT P < 0. 05 R749 A doi 10. 3969 /j. issn. 1007-3256. 2014. 04. 006 The effect of atypical antipsychotic on liver function of schizophrenia patients and paliperidone' superiority BIAN Yun BIAN Qing - tao HAN Xiao - le Beijing Huilongguan Hospital Beijing 100096 China Abstract Objective other atypical antipsychotics. Methods To explore the effect of atypical antipsychotics on liver function and paliperidone'superiority compared to With retrospective study method data related to liver function of newly admitted schizophrenic 檪 檪 檪 檪 檪 檪 檪 檪 檪 檪 檪 檪 檪 檪 檪 檪 檪 檪 檪 檪 檪 檪 檪 檪 檪 檪 檪 檪 檪 檪 檪 檪 檪 檪 檪 檪 檪 檪 檪 檪 檪 檪 檪 檪 檪 檪 MECT 89-91. Simpson GM. Risperidone liquid concentrate and oral lorazepam versus intramuscular haloperidol and intramuscular. J Clin Psychia- Care Pharm 2012 18 5 Suppl B S1-20. 4 J 2012 22 2 89-91. 5. J. 2010 24 2 / 6 Currier GW lorazepam for treatment of psychotic agitation J try 2001 62 3 153-157. 7 3 Maher AR Theodore G. Summary of the comparative effectiveness review on off - label use of atypical antipsychotics J. J Manag... J. 2001 11 2 83-85. 8. J. 2011 28 3 338-341 343. 1 Hughes DH Kleespies PM. Treating aggression in the Psychiatric 9. emergency service J. J Chin Psychiatry 2003 64 Suppl4 10-15. J. 2010 23 2 122-123. 2. M. 2014-03 - 13 2003. 307