Microsoft Word gc 焦鹏涛.doc

Size: px

Start display at page:

Download "Microsoft Word gc 焦鹏涛.doc"

娘寿
5 years ago
Views:

1 生物工程学报 Chinese Journal of Biotechnology DOI: /j.cjb 焦鹏涛等 /B 型流感病毒研究进展 Jun. 25, 2018, 34(6): Chin J Biotech, All rights reserved 特邀综述 821 B 焦鹏涛 1,2*, 范文辉 1*, 孙业平 1, 刘文军 1,3, 李晶 1, ,,,. B., 2018, 34(6): Jiao PT, Fan WH, Sun YP, et al. Research advance of influenza B viruses. Chin J Biotech, 2018, 34(6): 摘要 : B 型流感病毒为单股负链分节段 RNA 病毒, 常在全球范围内以与 A 型流感病毒共流行的方式引起流感的局部暴发或季节性流行, 对儿童青少年老人等特定人群易感, 且感染儿童及青少年后引起的死亡率较高, 给人类的公共卫生健康造成了严重威胁 B 型流感病毒与 A 型相比更容易引发患者发生并发症, 且其在流行季节造成的疾病负担甚至超过 A 型近期, 特别是 2017 年入冬后,B 型流感病毒在我国的很多地区成为了引起流感发生的优势毒株, 给人们的健康生活带来极大困扰鉴于此, 文中从 B 型流感病毒的结构流行病学免疫学及防治等方面进行了综述, 旨在增强人们对该病毒的认识, 为 B 型流感的防控提供借鉴和参考 : B 型流感病毒, 病原学, 流行情况, 免疫学, 研究进展 Research advance of influenza B viruses Pengtao Jiao 1,2*, Wenhui Fan 1*, Yeping Sun 1, Wenjun Liu 1, 3, and Jing Li 1, 3 1 Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing , China 2 College of Animal Science and Technology, Guangxi University, Nanning , Guangxi, China 3 University of Chinese Academy of Sciences, Beijing , China Abstract: Influenza B virus (IBV) is a segmented negative-strand RNA virus, which often causes local outbreak or seasonal epidemic along with influenza A virus (IAV) in the world. It is pathogenic to children, teenagers and elderly people and has a higher mortality rate in children and adolescents, so it poses a serious threat to public health and health. IBV is more likely to cause complications than IAV and the disease burden of IBV even exceeds IAV in the epidemic season. Recently, especially after winter of 2017, IBV has become the dominant strain in many areas of our country and seriously affects people s health. In view of this, this article reviews the structure, epidemiology, immunology and prevention of IBV, aiming at enhancing public s perceptions of the virus and providing reference for making strategies for Received: April 12, 2018; Accepted: May 29, 2018 Supported by: National Key Research Program (Nos. 2016YFD , 2016YFC , 2016YFC ), National Natural Science Foundation of China (Nos , ). Corresponding author: Jing Li. Tel/Fax: ; lj418@163.com *These authors contributed equally to this study. (Nos. 2016YFD , 2016YFC , 2016YFC ) (Nos , )

2 822 ISSN CN /Q Chin J Biotech prevention and control of influenza B. Keywords: influenza B virus, etiology, epidemiology, immunology, research advance (Influenza virus) (NP) (M1) A B C D [1-2] A (IAV) [3] B (IBV) [4-5] C D [6] IBV Francis Chang IBV 2000 Osterhaus [4] HA IBV B/Victoria/2/87 B-Victoria B/Yamagata/16/88 B-Yamagata IAV IBV 70 IBV 16 [7-8] IBV IAV H3N2 IAV H1N1 [9] IBV 29% [10] 2017 Yamagata IBV IAV H1N1 H3N2 IBV [11] IBV 1 IBV 的结构特性 IBV RNA PA PB1 PB2 NP NS1 NS2 M1 BM2 3 HA NA NB PB1 1 PB1 RNA [9] PB2 2 CAP mrna RNA mrna 5 mrna [12] PA 3 [13] PA PB1 PB2 RNA RNA [14] HA 4 HA [15] NP 5 NP vrnp [16] NA NB 6 NA NB NB [14,16] 7 M1 BM2 M1 BM2 RNA [17] NS1 NS2 8 NS1

3 焦鹏涛等 /B 型流感病毒研究进展 823 [18-19] NS2 vrnp [20] IBV 1 2 IBV 的流行病学 IBV IBV IBV H1N1 H3N2 2 4 [9] IBV [21] IBV IAV [22] IBV Koutsakos [23] IBV % IBV IBV [24] [25] [26] [27] [28] [29] IBV 38% [30] IBV [31] IBV IAV [32] Walther [33] IBV B Yamagata Victoria Yamagata α-2,6 Victoria α-2,6 α-2,3 Victoria α-2,3 Yamagata α-2,6 Victoria 2017 ( cn/cnic/zyzx/lgzb/) ( 64 ) IBV Victoria H1N H3N IBV Yamagata H1N1 ( 1A) 1 15 H3N2 H1N1 H1N1 H3N ( 1B) IBV Yamagata H1N1 Victoria 3 IBV 的免疫学 3.1 IBV 诱发的天然免疫应答 HA IAV IBV HA [23-34] IBV IAV [35] Trevor [36] cjb@im.ac.cn

4 824 ISSN CN /Q Chin J Biotech IBV vrnp (Early endosome) IAV vrnp (Late endosome) IBV IBV DC IAV (IBV 2 4 h -λ mrna IAV -λ mrna 8 16 h ) [4] IBV RIG-I NS1 N TRIM25 RIG-I/TRIM25/NS1 NS1 C RIG-I RIG-I [37] MDA-5 IBV [38] PKR IBV PKR vrnp vrnp PKR [21] 3.2 IBV 诱发的体液免疫应答 IAV IBV HA HA [39] IBV HA HA [40-41] HA NA IBV IBV Yamagata NA Victoria [41] IBV IBV CR8033 CR8071 CR IBV CR8033 CR8071 HA CR9114 HA IAV ( H1 H3 H5 H7 H9 ) CR8033 CR8071 IBV IBV [42] IBV 46B8 IBV HA HA 46B8 HA (301 ) IBV IBV C12G6 IBV IBV [43] HA NA 1F2 IBV [44] 3.3 IBV 诱发的细胞免疫应答 CD8 + T IAV CD8 + T IBV IBV CD8 + T IBV CD8 + T CD4 + T IBV [45] IAV IBV T IBV IAV

5 焦鹏涛等 /B 型流感病毒研究进展 825 IBV NP T [46-47] IBV T (CTLs) γ [48] IAV PB1 T IBV PB1 T [49] NP PB1 HA CD4 + T IAV 16 IBV CD4 + T [50] 4 IBV 的防治 (NAIs) IAV M2 IBV BM2 IBV BM2 B [51] NA IAV IBV IBV [10] ( NA E119A R152K D198N I222T H274Y R371K ) [10,52-53] IBV IBV CR8033 CR8071 CR9114 IBV CR8033 CR8071 IBV CR8033 CR8071 CR [42] 5A7 IBV HA CR9114 CR IBV B/Victoria/2/87 [54] C12G6 IgG1 Fc IgG V 1940 IBV IBV C12G6 C12G6 HA CR8033 C12G6 IBV C12G6 CR8033 C12G6 (ADCC) IBV [55-56] C12G6 CR8033 CR B8 HA cjb@im.ac.cn

6 826 ISSN CN /Q Chin J Biotech ADCC 72 h IBV [57] HA NA 1F2 IBV [44] NA HCA2 IBV 72 h IBV (E117D D197E) [58-59] IBV HA NA B 表 1 不同类型流感病毒的比较 Table 1 Comparison of different types of influenza viruses Types A B C D References distinction Encoded polypeptide PB2 PB2 PB2 PB2 [1 6, 58] PB1 PB1 PB1 PB1 PA PA P3 P3 HA HA HEF HEF NP NP NP NP NA NA, NB M1, M2 M1, M2 M1, CM2 M1, M2 NS1, NS2 NS1, NS2 NS1, NS2 NS1, NEP Cell surface glycoproteins HA (1 15) NA (1 9) HA NA Hemagglutininesterase-fusion protein (HEF) Hemagglutininesterase-fusion protein (HEF) [1 6, 58] Natural reservoir Types of gene mutation Human, avian, swine, dogs, horses, tigers, seals Antigenic drift and shift Human, seals Human, swine, dogs Swine, cattle [1 6, 58 67] Antigenic drift Antigenic drift Antigenic drift [9, 37, 68] Receptor preference on the surfaces of cells α-2,3-linked sialic acid (avian influenza A virus) α-2,3-linked sialic acid (human influenza A virus) α-2,3-and-α-2,6- linked sialic acid (BV) α-2,6-linked sialic acid (BY) N-acetyl-9-Oacetylneuraminic acid 9-O-acetylated sialic acids [37, 60, 67] The first reported time [1,42, 69] Outbreak time of influenza virus Spanish Flu Pandemic in 1918 (H1N1) Asia Flu in 1957 (H2N2) Hong Kong Flu (China) in 1968 (H3N2) Canada 1986 America 1989 China 1994, 1997, 2000 The first isolation in 1947 The first isolation in 2011 [1 6, 64, 68]

焦鹏涛等 /B 型流感病毒研究进展 827 HA NA IAV H1N1 H3N2 IBV Yamagata Victoria [37] WHO Ambrose [66] 2001 2011 10 50% WHO IAV H1N1 H3N2 IBV

9% [68] ) 2018 2 WHO 2018 2019 ( B-Yamagata B-Victoria ) 图 1 2017 2018 年我国流感病毒流行情况 Fig.

表 2 世界卫生组织优先推荐季节性流感病毒疫苗组分 Table 2 The WHO recommended composition of influenza virus vaccines in influenza season Recommended

7 焦鹏涛等 /B 型流感病毒研究进展 827 HA NA IAV H1N1 H3N2 IBV Yamagata Victoria [37] WHO Ambrose [66] % WHO IAV H1N1 H3N2 IBV Victoria ( 2) Yamagata Victoria Yamagata [67] 2017 Yamagata B ( 1.9% [68] ) WHO ( B-Yamagata B-Victoria ) 图年我国流感病毒流行情况 Fig. 1 The distribution of influenza virus strains in China ( ). (A) The Southern provinces. (B) The Northern provinces. 表 2 世界卫生组织优先推荐季节性流感病毒疫苗组分 Table 2 The WHO recommended composition of influenza virus vaccines in influenza season Recommended composition A (H1N1) A/Michigan/45/2015 (H1N1) A/Michigan/45/2015 (H1N1) A (H3N2) A/Hong Kong (China)/4801/2014 A/Singapore/INFIMH /2016 B/Victoria B/Brisbane/60/2008 B/Colorado/06/2017 B/Yamagata B/Phuket/3073/ cjb@im.ac.cn

8 828 ISSN CN /Q Chin J Biotech IAV H3N2 A/ Singapore/INFIMH /2016 (H3N2) A/Hong Kong/4801/2014 IBV Victoria B/Colorado/06/2017 B/Brisbane/60/2008 [63] 2018 NS1 IAV IBV NS1 IBV [19] 5 小结与展望 IAV IBV IBV IBV IBV IBV IBV IBV IBV IBV B B B B REFERENCES [1] Hause BM, Collin EA, Liu R, et al. Characterization of a novel influenza virus in cattle and swine: proposal for a new genus in the orthomyxoviridae family. mbio, 2014, 5(2): e [2] Smith DB, Gaunt ER, Digard P, et al. Detection of influenza C virus but not influenza D virus in Scottish respiratory samples. J Clin Virol, 2016, 74: [3] El Moussi A, Pozo F, Kacem MABH, et al. Virological surveillance of influenza viruses during the , and seasons in Tunisia. PLoS ONE, 2013, 8(9): e [4] Osterhaus ADME, Rimmelzwaan GF, Martina BEE, et al. Influenza B virus in seals. Science, 2000, 288(5468): [5] Ramis AJ, Van Riel D, van de Bildt MWG, et al. Influenza A and B virus attachment to respiratory tract in marine mammals. Emerg Infect Dis, 2012, 18(5): [6] McCullers JA, Hayden FG. Fatal influenza B infections: time to reexamine influenza research priorities. J Infect Dis, 2012, 205(6): [7] Glezen WP, Schmier JK, Kuehn CM, et al. The burden of influenza B: a structured literature review. Am Public Health, 2013, 103(3): e43 e51. [8] Zhao B, Qin S, Teng Z, et al. Epidemiological study of influenza B in Shanghai during the seasons: implications for influenza vaccination strategy. Clin Microbiol Infec, 2015, 21(7): [9] Thompson WW, Shay DK, Weintraub E, et al. Influenza-associated hospitalizations in the United States. JAMA, 2004, 292(11): [10] Koutsakos M, Nguyen TH, Barclay WS, et al. Knowns and unknowns of influenza B viruses. Future Microbiol, 2016, 11(1): [11] Zhou M, Li LL, Mao CM, et al. Deep analysis of influenza epidemic in China in this year. Chin J

9 焦鹏涛等 /B 型流感病毒研究进展 829 Nosocomiol, 2018, 28(4): (in Chinese).,,,.., 2018, 28(4): [12] Reich S, Guilligay D, Pflug A, et al. Structural insight into cap-snatching and RNA synthesis by influenza polymerase. Nature, 2014, 516(7531): [13] Sanz-Ezquerro JJ, de la Luna S, Ortín J, et al. Individual expression of influenza virus PA protein induces degradation of coexpressed proteins. J Virol, 1995, 69(4): [14] Deng QJ, Wang D, Xiang XX, et al. Nuclear localization of influenza B polymerase proteins and their binary complexes. Virus Res, 2011, 156(1/2): [15] Sherry L, Punovuori K, Wallace LE, et al. Identification of cis-acting packaging signals in the coding regions of the influenza B virus HA gene segment. J Gen Virol, 2015, 97(2): [16] Sherry L, Smith M, Davidson S, et al. The N terminus of the influenza B virus nucleoprotein is essential for virus viability, nuclear localization, and optimal transcription and replication of the viral genome. J Virol, 2014, 88(21): [17] Mould JA, Paterson RG, Takeda M, et al. Influenza B Virus BM2 protein has ion channel activity that conducts protons across membranes. Dev Cell, 2003, 5(1): [18] Dauber B, Heins G, Wolff T. The influenza B virus nonstructural NS1 protein is essential for efficient viral growth and antagonizes beta interferon induction. J Virol, 2004, 78(4): [19] Hai R, Martínez-Sobrido L, Fraser KA, et al. Influenza B virus NS1-truncated mutants: live-attenuated vaccine approach. J Virol, 2008, 82(21): [20] Paragas J, Talon J, O Neill RE, et al. Influenza B and C Virus NEP (NS2) proteins possess nuclear export activities. J Virol, 2001, 75(16): [21] Dauber B, Martínez-Sobrido L, Schneider J, et al. Influenza B virus ribonucleoprotein is a potent activator of the antiviral kinase PKR. PLoS Pathog, 2009, 5(6): e [22] Jackson D, Elderfield RA, Barclay WS. Molecular studies of influenza B virus in the reverse genetics era. J Gen Virol, 2011, 92(1): [23] Wang MY, Veit M. Hemagglutinin-esterase-fusion (HEF) protein of influenza C virus. Prot Cell, 2016, 7(1): [24] Nulens EF, Bourgeois MJ, Reynders MB. Post-influenza aspergillosis, do not underestimate influenza B. Infect Drug Resist, 2017, 21(10): [25] Tewawong N, Suwannakarn K, Prachayangprecha S, et al. Molecular epidemiology and phylogenetic analyses of influenza B virus in Thailand during 2010 to PLoS ONE, 2015, 1(10): e [26] Harvala H, Smith D, Salvatierra K, et al. Burden of influenza B virus infections in Scotland in 2012/13 and epidemiological investigations between 2000 and Euro Surveill, 2014, 19(37): [27] Sam IC, Su YCF, Chan YF, et al. Evolution of influenza B Virus in Kuala Lumpur, Malaysia, between 1995 and J Virol, 2015, 89(18): [28] Ju JB, Chen AP, Chu XD, et al. Clinical epidemiological study on 178 patients with influenza virus type B. Mod Prevent Med, 2008, 35(2): (in Chinese).,,,. 178., 2008, 35(2): [29] Baik JS, Kim JY, Heo JH, et al. Neurological manifestations associated with epstein-barr viral infection. J Korean Neurol Assoc, 1996, 14(1): [30] Pica N, Chou YY, Bouvier NM, et al. Transmission of influenza B viruses in the guinea pig. J Virol, 2012, 86(8): [31] Feng L, Shay DK, Jiang Y, et al. Influenza-associated mortality in temperate and subtropical Chinese cities, Bull World Health Organ, 2012, 90(4): B. [32] Mccullers JA, Wang GC, He SQ, et al. Reassortment and insertion-deletion are strategies for the evolution of influenza B viruses in nature. J Virol, 1999, 73(9): [33] Walther T, Karamanska R, Chan RWY, et al. Glycomic analysis of human respiratory tract tissues and correlation with influenza virus infection. PLoS Pathog, 2013, 9(3): e [34] Matrosovich MN, Gambaryan AS, Tuzikov AB, et al. Probing of the receptor-binding sites of the H1 and H3 influenza A and influenza B Virus hemagglutinins by synthetic and natural sialosides. Virology, 1993, 196(1): cjb@im.ac.cn

10 830 ISSN CN /Q Chin J Biotech [35] Jiang JW, Li J, Fan WH, et al. Robust Lys63-linked ubiquitination of RIG-I promotes cytokine eruption in early influenza B virus infection. J Virol, 2016, 90(14): [36] Bedford T, Suchard MA, Lemey P, et al. Integrating influenza antigenic dynamics with molecular evolution. elife, 2014, 3: e1914. [37] van de Sandt CE, Bodewes R, Rimmelzwaan GF, et al. Influenza B viruses: not to be discounted. Fut Microbiol, 2015, 10(9): [38] Loo YM, Fornek J, Crochet N, et al. Distinct RIG-I and MDA5 signaling by RNA Viruses in innate immunity. J Virol, 2008, 82(1): [39] Huang YW, Gao LD, Li FC, et al. Characterization of influenza B viruses isolated in Hunan Province after pandemic influenza A (H1N1). Chin J Infect Dis, 2012, 30(6): (in Chinese).,,,. H1N1., 2012, 30(6): [40] Skowronski DM, Hottes TS, de Serres G, et al. Influenza Β/Victoria antigen induces strong recall of Β/Yamagata but lower Β/Victoria response in children primed with two doses of Β/Yamagata. Pediatr Infect Dis J, 2011, 30(10): [41] Wohlbold TJ, Nachbagauer R, Xu H, et al. Vaccination with adjuvanted recombinant neuraminidase induces broad heterologous, but not heterosubtypic, cross-protection against influenza virus infection in mice. mbio, 2015, 6(2): e2556. [42] Dreyfus C, Laursen NS, Kwaks T, et al. Highly conserved protective epitopes on influenza B viruses. Science, 2012, 337(6100): [43] Shen CG, Chen JY, Li R, et al. A multimechanistic antibody targeting the receptor binding site potently cross-protects against influenza B viruses. Sci Transl Med, 2017, 9(412): eaam5752. [44] Wohlbold TJ, Podolsky KA, Chromikova V, et al. Broadly protective murine monoclonal antibodies against influenza B virus target highly conserved neuraminidase epitopes. Nat Microbiol, 2017, 2(10): [45] Epstein SL, Lo CY, Misplon JA, et al. Mechanism of protective immunity against influenza virus infection in mice without antibodies. J Immunol, 1998, 160(1): [46] Robbins PA, Lettice LA, Rota P, et al. Comparison between two peptide epitopes presented to cytotoxic T lymphocytes by HLA-A2. Evidence for discrete locations within HLA-A2. J Immunol, 1989, 143(12): [47] Robbins PA, Rota PA, Shapiro SZ. A broad cytotoxic T lymphocyte response to influenza type B virus presented by multiple HLA molecules. Int Immunol, 1997, 9(6): [48] van de Sandt CE, Dou YY, Trierum SEVV, et al. Influenza B virus-specific CD8 + T-lymphocytes strongly cross-react with viruses of the opposing influenza B lineage. J Gen Virol, 2015, 96(8): [49] Terajima M, Babon JAB, Co MDT, et al. Cross-reactive human B cell and T cell epitopes between influenza A and B viruses. Virol J, 2013, 10: 244. [50] Babon JAB, Cruz J, Ennis FA, et al. A human CD4 + T cell epitope in the influenza hemagglutinin is cross-reactive to influenza A virus subtypes and to influenza B virus. J Virol, 2012, 86(17): [51] Ma CL, Soto CS, Ohigashi Y, et al. Identification of the pore-lining residues of the BM2 ion channel protein of influenza B Virus. J Biol Chem, 2008, 283(23): [52] Burnham AJ, Armstrong J, Lowen AC, et al. Competitive fitness of influenza B viruses with neuraminidase inhibitor-resistant substitutions in a coinfection model of the human airway epithelium. J Virol, 2015, 89(8): [53] Orozovic G, Orozovic K, Lennerstrand J, et al. Detection of resistance mutations to antivirals oseltamivir and zanamivir in avian influenza a viruses isolated from wild birds. PLoS ONE, 2011, 6(1): e [54] Yasugi M, Kubota KR, Yamashita A, et al. Human monoclonal antibodies broadly neutralizing against influenza B virus. PLoS Pathog, 2013, 9(2): e [55] Cox F, Kwaks T, Brandenburg B, et al. HA antibody-mediated fcγriiia activity is both dependent on FcR engagement and interactions between HA and sialic acids. Front Immunol, 2016, 29(7):399. [56] Leon PE, He W, Mullarkey CE, et al. Optimal activation of Fc-mediated effector functions by influenza virus

11 焦鹏涛等 /B 型流感病毒研究进展 831 hemagglutinin antibodies requires two points of contact. Proc Natl Acad Sci USA, 2016, 113(40): E5944 E5951. [57] Chai N, Swem LR, Park S, et al. A broadly protective therapeutic antibody against influenza B virus with two mechanisms of action. Nat Commun, 2017, 8: [58] Doyle TM, Li C, Bucher DJ, et al. A monoclonal antibody targeting a highly conserved epitope in influenza B neuraminidase provides protection against drug resistant strains. Biochem Biophys Res Commun, 2013, 441: [59] Elderfield RA, Koutsakos M, Frise R, et al. NB protein does not affect influenza B virus replication in vitro and is not required for replication in or transmission between ferrets. J Gen Virol, 2016, 97(3): [60] Ambrose CS, Levin MJ. The rationale for quadrivalent influenza vaccines. Hum Vaccin Immunother, 2012, 8(1): [61] Belshe RB, Coelingh K, Ambrose CS, et al. Efficacy of live attenuated influenza vaccine in children against influenza B viruses by lineage and antigenic similarity. Vaccine, 2010, 28(9): [62] Yang J, Jit M, Leung KS, et al. The economic burden of influenza-associated outpatient visits and hospitalizations in China: a retrospective survey. Infect Dis Poverty, 2015, 4: 44. [63] Recommended composition of influenza virus vaccines for use in the northern hemisphere influenza season. Wkly Epidemiol Rec, 2018, 93(12): [64] Chiapponi C, Faccini S, de Mattia A, et al. Detection of influenza D Virus among swine and cattle, Italy. Emerg Infect Dis, 2016, 22(2): [65] Muraki Y, Hongo S. The molecular virology and reverse genetics of influenza C virus. Jpn J Infect Dis, 2010, 63(3): [66] Song H, Qi JX, Khedri Z, et al. An open receptor-binding cavity of hemagglutinin-esterasefusion glycoprotein from newly-identified influenza D virus: basis for its broad cell tropism. PLoS Pathog, 2016, 12(1): e [67] Morens DM, Taubenberger JK, Folkers GK, et al. Pandemic influenza s 500th anniversary. Clin Infec Dis, 2010, 51(12): [68] Francis TJ. A new type of virus from epidemic influenza. Science, 1940, 92(2392): [69] Chen JM, Guo YJ, Wu KY, et al. The origin and evolution of two genetic lineages of influenza B virus. Chin J Virol, 2001, 17(4): (in Chinese).,,,.., 2001, 17(4): ( 本文责编郝丽芳 ) cjb@im.ac.cn

Microsoft Word - 邵惠训清样.doc

Microsoft Word - 邵惠训清样.doc 中国医药生物技术 2014 年 4 月第 9 卷第 2 期 Chin Med Biotechnol, April 2014, Vol. 9, No. 2 145 DOI:10.3969/cmba.j.issn.1673-713X.2014.02.012 综述 H7N9 禽流感疫情引发人们的思考邵惠训 2003 2004 年, 在亚洲广袤地区