SARS综述_临床版.doc

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1 SARS ( ) Severe Acute Respiratory Syndrome SARS SARS ( 1) [1] SARS SARS 1 SARS May 14, available at 1 SARS

1 SARS May 14, 2003. available at http://www.who.

2 SARS WHO SARS SARS Virus [2] 2 SARS ( SARS SARS SARS SARS 1. SARS [3] 3 3 SARS from Kenneth W.Tsang,2003 [3]

3 2. SARS Christopher M. Boot 144 SARS [4] 77% SARS Christopher M. Booth SARS ( 4) SARS (from Booth C M. 2003) [4]

4 4 SARS (From Booth C M. 2003) [4] 3. Christl A Donnelly [5] 1425 SARS SARS SARS from Donnelly C A [5] 4. WHO SARS 1 2 ph 4

5 SARS-CoV 5. WHO SARS [6][19] ARDS. [7] 6 SARS ( 7) SARS 6. SARS A HE 100 B HE 200 C D HE 400 (from Lee N.2003) [7]

6 7.SARS SARS CoV A,B A from Thomas G.Ksiazek, SARS [8]

7 9. SARS [8] [9] 10. SARS from Peiris J S M,2003 [9]

8 [10] 11. RT-PCR SRAS-CoV (from Peiris J S M,2003) [9]

9 12. SRAS-CoV from Christin Drosten,2003 [10] [4]

10 13 SARS (from Booth C M. 2003) [4]

11 14. SARS (from Booth C M. 2003) [4] 15. SARS (from Booth C M. 2003) [4] [11] 16 SARS from Hon K L E.2003 [11] 3 SARS WHO

12 1. SARS Lee N [7] % % Changi General Hospital CT SARS A: B: ; C: (from Lee N.2003) [7] 18 Changi General Hospital Day1, Day5, Day7 [18]

19 CT 2 3 5 17. SARS A: B: ; C: (from Lee N.

13 19 CT Day2, Day3, Day5 [18] 2. SARS SARS-CoV WHO PCR PCR PCR PCR SARS SARS RNA DNA PCR SARS CoV PCR ELISA SARS Vero E6 SARS-CoV SARS Cov Fouchier R A. SARS [20] WHO SARS SARS-CoV

14 SARS SARS W H Seto [12] SARS 13 SARS 241 SARS SARS ICU SARS SARS [13] Bag-valve-mask SARS WHO CDC edu.cn SARS 4 SARS ARDS [8], SARS 3.7 WHO [14] SARS

69 13 SARS ICU SARS SARS [13] Bag-valve-mask

15 RNA 1) 95 2) ) SARS SARS Kaletra [4] / ARDS ARDS ARDS

16 ARDS J J Cordingley [15] ARDS CO2 2 3 ph 7.2 6ml/kg, cmh20 PEEP 15 cmh20 I:E 1:1 2:1 PEEPi 40 SARS 20 3 SARS ( ) [16], SARS-CoV SARS-CoV RNA 5 SARS SARS 5 10 [17] SARS (Viral replicative phase) immune hyperactive phase (pulmonary destruction phase) (fully recovery) 6 SARS SARS 1. SARS 2. 3.

[16], SARS-CoV SARS-CoV RNA 5 SARS SARS 5 10 [17] SARS (Viral replicative

17 4. 5. SARS SARS SARS SARS SARS ( ) 1. Cumulative Number of Reported Probable Cases of Severe Acute Respiratory Syndrome (SARS). May 14, 2003, available at 2. Coronavirus never before seen in humans is the cause of SARS. Apri1 16, 2003, available at 3. Donnelly C A, Ghani A C, Leung G M, et al. Epidemiological determinants of spread of causal agent of severe acute respiratory syndrome in Hong Kong. THE LANCET. Published online. 2003, May 7 4. Booth C M, Matukas L M, Tomlinson G A, et al.clinical Features and Short-term Outcomes of 144 Patients With SARS in the Greater Toronto Area. JAMA. 2003; 289: Donnelly C A, Ghani A C, Leung G M, et al. Epidemiological determinants of spread of causal agent of severe acute respiratory syndrome in Hong Kong. THE LANCET. Published online. 2003, May 7 6. Yeung M C, Yu W C.Outbreak of severe acute respiratory syndrome in Hong Kong special adeministrative region: case report.bmj 2003 ;326: Lee N, Hui D, Wu A, et al. A major outbreak of severe acute respiratory syndrome in HongKong. The New England Journal of Medicine.2003;April 7: SUNG SARS April 29, Peiris J S M, Chu C M, Cheng V C C, et al. Clinical progression and viral load in a community outbreak of coronavirus-associated SARS pneumonia: a prospective study. The Lancet. Published online. 2003, May Drosten C, Gunther S, Preiser W, et al. Identification of a novel coronavirus in patients with severe acute respiratory syndrome. The New England Journal of Medicine. Published online.2003;april Hon K L E, Leung C W, Cheng W T F, et al. Clinical presentations and outcome of severe acute respiratory syndrome in children.the Lancet. Published online. 2003; April Seto W H, Tsang D, Yung R W H. et al. Effectiveness of precautions against droplets and contact in prevention of nosocomial transmission of severe acute respiratory syndreome(sars). THE LANCET. 2003; 361: Lapinsky S E, Hawryluck L. ICU mamagement of severe acute respiratory syndrome. Intensice Care Medicine. Published online.2003,may So L K Y, Lau A C W, Yam L Y C, et al. Development of a standard treatment protocol for severe acute respiratory syndrome.lancet. 2003;361: Cordingley J J, Keogh B F. The pulmonary physician in critical care 8: ventilatory

Donnelly C A, Ghani A C, Leung G M, et al. Epidemiological determinants of spread of causal agent of severe acute respiratory syndrome in Hong Kong. THE LANCET. Published online. 2003, May 7 4.

18 management of ALI/ARDS. Thorax 2002;57: Ruan Y J, Wei C L, Ee L A, et al. Comparative full-lenth genome sequence analysis of 14 SARS coronavirus isolates and common mutations associated with putative origins of infection. The Lancet. Published online. 2003, May May Radiological Appearances of Recent Cases of Atypical Pneumonia in Hong Kong. May 15, available at Nicholls J M, Poon L M, Lee K C, et al. Lung pathology of fatal severe acute respiratory syndrome. The Lancet Published online. 2003, May Fouchier RA, Kuiken T, Schutten M, et al. Koch's postulates fulfilled for SARS virus. Nature 2003;423:240

May 10 2003 http://sc.info.gov.hk/gb/www.info.gov.hk/gia/general/200305/10/0510213.htm 18. Radiological Appearances of Recent Cases of Atypical Pneumonia in Hong Kong. May 15, 2003.

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270 2 270 ISSN 0255-6162 GPN 2006900031 270 92 6 20 161-2 0226531318 http://www.nlfd.gov.tw Severe Acute Respiratory Syndrome SARS 1 270 2 270 3 270 4 270 SARS Complete Genome Length (bp) GenBank Notation BCCA