/ 藍色圓圈的約定 / 藍色圓圈的約定 文 / 陳思達 WHO 1991 Frederick Banting 11 14 葡萄糖的代謝 ATP 1 32 科學研習 DEC 2016 No.55-12
本月專題 聽 DNA 和 RNA 的對話 葡萄糖代謝 : 1. http://www.wikiwand.com/zhtw/%e8%91%a1%e8%90%84%e7%b3%96 60 100 mg/dl 70 140 mg/ dl glucose sensor glucose transporter hexokinase glucokinase 33
/ 藍色圓圈的約定 / β α glycolysis ATP anabolic catabolic 30 ketone 何謂糖尿病 1999 126 200 HbA1C 6.5% 200 (1) impaired glucose tolerance oral glucose tolerance test OGTT 140 200 mg/dl (2) impaired fasting glucose 100 125 mg/dl 1 1921 Banting Joslin Diabetic Center biguanide sulfonylurea 1920 1950 20 1977 1997 34 科學研習 DEC 2016 No.55-12
IAA, GADA, ICA本月專題 聽 DNA 和 RNA 的對話 UKPDS 7% 糖尿病疾病生理學 idiopathic human leukocyte antigen, HLA T- 2 2 glucolipotoxicity endoplasmic reticulum, ER 第一型糖尿病發病自然史 2. http://www.intechopen.com/books/type-1- diabetes-pathogenesis-genetics-and-immunotherapy/genetic-markers-serological-autoantibodies-and-prediction-of-type-1-diabetes 35
/ 藍色圓圈的約定 / 3 3 Ralph DeFronzo 1988 incretin ominous ocet 4 4 Stanley Schwartz 2016 2 11 egregious 11 5 5 糖尿病的新發展 genome-wide association study noncoding regionmicro RNA mirna 3 Clinical Science (2009) 116, 99 111 3. 36 科學研習 DEC 2016 No.55-12
本月專題 聽 DNA 和 RNA 的對話 糖尿病八部曲 高血糖 Diabetes, VOL. 58, 2009:773-795 4. ominous ocet 糖 11 10. 1. β 7. 8. -1 9. 2. Amylin 3. α 4. 5. 6. 11. 5. 11 Schwartz SS, et al. Diabetes Care 2016:39(2) 37
/ 藍色圓圈的約定 / mirna mirna mir-375 mir-375 microarray mirna mirna mirna mir-1 mir- 133 mir-192 mir-377 6 7 mirna 7 DNA 1.5% DNA noncoding RNA retrotransposon intron RNA RNA mrna RNA trna RNA rrna RNA sirna RNA mirna RNA snrna RNA 1993 mirna 20 non-coding mrna mrna 6 6 mirna non-coding RNA 結語 6. RNA DNA RNA 38 科學研習 DEC 2016 No.55-12
7. RNA 本月專題 聽 DNA 和 RNA 的對話 糖尿病 糖尿病併發症 參考資料 1. 2015 2015 3 2. Mark A. Atkinson, The pathogenesis and natural history of type 1 diabetes. Cold Spring Harb Perspect Med 2012; doi: 10.1101/cshperspect.a007641 3. Wanzhu JIN and Mary-Elizabeth PATTI, Genetic determinants and molecular pathways in the pathogenesis of type 2 diabetes. Clinical Science (2009) 116, 99-111 doi:10.1042/cs20080090 4. Ralph A. DeFronzo, From the triumvirate to the ominous octet: a new paradigm for the treatment of type 2 diabetes mellitus. Diabetes, 58, 2009: 773-795. 5. Stanley S. Schwartz, Solomon Epstein, Barbara E. Corkey, Struan F.A. Grant, James R. Gavin III, and Richard B. Aguilar, The time is right for a new classification system for diabetes: rationale and implications of the b-cell-centric classification schema. Diabetes Care 2016; 39:179-186. DOI: 10.2337/ dc15-1585 6. Amit K. Pandey, Priyanka Agarwal, Kirandeep Kaur and Malabika Datta, MicroR- NAs in diabetes: tiny players in big disease. Cell Physiol Biochem 2009; 23: 221-232 7. Claudiane Guay and Romano Regazzi, Circulating micrornas as novel biomarkers for diabetes mellitus. Nat. Rev. Endocrinol. 9, (2013) 513-521. 39