Vol.26, No.09 本院第 186 次藥委會通過之新藥 Rescula 0.12%, isopropyl ocular docosanoid ( ) R-Tech Ueno 5 ml/btl unoprostone hypotensive agents Co. Ltd Avodart 0.5 mg/cap dutasteride 5-alpha reductase ( )Cardinal Health inhibitors Elidel Cream1%, pimecrolimus ascomycin ( )Novartis 15 g/tube;30 g/tube derivatives Caphos 667 mg/tab calcium acetate nutritional Agents ( ) Carnitene Injection L-carnitine nutritional Agents ( )Sigma-Tau 1 g/5 ml/amp Butaro Nasal Spray butorphanol tartrate narcotic agonist- ( ) 10 mg/ml, 2.5 ml/btl antagonist analgesics Crestor 10 mg/tab rosuvastatin HMG-CoA ()IPR reductase inhibitors (AstraZeneca) Ascotyl Enteric- aspirin nonsteroidal anti- ( ) microencapsulated inflammatory Capsule 100 mg/cap salicylates Photofrin 5 ml/vial; porfimer sodium antineoplastics ()Weyth 75 ml/vial Reyataz 150 mg/cap, atazanavir HIV-1 protease ( )Bristol- 200 mg/cap inhibitors Myers Squibb Zinca 50 mg/cap zinc acetate nutritional agents ( ) 藥劑部藥品異動專欄 一 新進藥品 Frisium 10 mg/tab clobazam 94.8.1 Invanz inj 1g ertapenem 94.8.1 ESBL strain infection Olmetec 20 mg/tab olmesartan medoxomil 94.8.4 Zanidip 10 mg/tab lercanidipine HCl 94.8.4 本院第 186 次藥委會通過之新藥... 1 藥劑部藥品異動專欄... 1 最新美國藥物安全警訊公告... 2 藥品健保給付規定之相關異動... 3 本院新藥介紹 Candesartan Cilexetil Blopress Tablet... 4 Porfimer Sodium Phtofrin for Injection... 5 Atazanavir Sulfate Reyataz Capsule... 7
藥劑部藥品異動專欄 二 藥品開方異動 Emthexate PF inj methotrexate 94.8.15 1 gm/40 ml/vial Thymoglobuline anti-human thymocyte 9 94.8.25 for inj 25 mg/vial globulin rabbit for inj ATG-Fresenius S 100 mg/ 5 ml/vila Heparin (without heparin 9 94.8.25 preservatives) Heparin 25000 IU/ 5000 IU/5 ml 5 ml/amp (without preservatives) 濃度為原品項之五倍, 請醫療科部審慎使用 三 藥品取消或暫停使用 Haldol 0.5 mg/tab haloperidol Serenace 0.5 mg/tab 94.8.1 Mevalotin pravastatin sodium 185 40 MG 94.8.1 20 mg/tab Mevalotin protect 40 mg/tab Fentanyl inj fentanyl Jannssen Pharmaceutics 94.8.4 0.5 mg/10 ml/amp N.V. Mayne Pharma Pty Ltd Micardis 40 mg/tab telmisartan 185 94.8.4 Lipanthyl fenofibrate 185 160 MG Supra tab 94.8.4 200 mg/cap 8 Lipanthyl Supra 160 mg/tab Lipanthyl 200 mg/cap Levitra 10 mg/tab vardenafil 185 20 mg 94.8.4 8 Levitra 20 mg/tab Mifegyne mifepristone Apano 200 mg/tab 94.8.22 200 mg/tab micronised Decaris 50 mg/tab levamisole HCl 94.8.24 2005 年 8 月美國藥物安全警訊公告 1.Lipitor Atorvastatin FDA Lipitor (atorvastatin) 2005 7 8 Lipitor 20 FDA 2 Vol.26 No.09
藥品健保給付規定之相關異動 http://www.fda.gov/medwatch/safety/2005/ safety05.htm#fakelipitor 2005/7/29 2.Perrigo Infants' Oral Drops Containing Enclosed Syringe Perrigo FDA 1.6 ml 1 acetaminophen 2 acetaminophen dextromethorphan HBr pseudoephedrine HCl 3 dextromethorphan HBr pseudoephedrine HCl * Infant Pain Reliever 160 mg Acetaminophen (0.5oz. and 1.0oz) * Infant Pain Reliever 160 mg Acetaminophen (0.5oz. and 1.0oz) * Cough and Cold Infant Drops (0.5oz) * Decongestant and Cough Infant Drops (0.5oz) http://www.fda.gov/medwatch/safety/2005/ safety05.htm#perrigo 2005/7/29 藥品健保給付規定之相關異動 94 9 1 0940069446 1.1. 1.1.1 : (88/09/01 92/2/1 94/09/01) 1. 每月至多以處方 40 gm 為限 94 年 9 月 1 日 0940016237 1.3. Neurologic drugs 1.3.2. Antiepileptic drugs 1.3.2.3. topiramate ( Topamax)(90/09/1 92/11/01 93/06/01 94/03 /01 94/09/01) 1. (add on therapy) 2. 限 Topamax 膜衣錠 2 topiramate 100mg 3 Vol.26 No.09
本院新藥介紹 Candesartan Cilexetil Blopress Tablet 成分及性狀 Blopress candesartan cilexetil 8 作用 Blopress angiotensin II angiotensin II AT1 藥物動力學 Blopress 15% 9 99% 67% 33% 適應症 不良反應 注意事項 1. 2. 3. Clcr 15 ml/min) 4. 5. ( ) 6. renin-angiotensin-aldosterone system 7. 禁忌 1. 2. 交互作用 1. Blopress heparin 2. Blopress 劑量及用法 8 16 儲存 30 參考資料 1. AHFS Drug Information. Bethesda: American Society of Hospital Pharmacists, 2005, available from: STAT!Ref Online Electronic Medical Library. 2. PDR Electronic Library, Thomson MICROMEDEX, Greenwood Village, Colorado (Vol. 124, expires 6/2005). 3. Sweetman S (Ed), Martindale: the Complete Drug Reference. London: Pharmaceutical Press. Electronic version, MICROMEDEX, Greenwood Village, Colorado, Edition expires 2005. 4. Japan Pharmaceutical Reference (JPR), Administration and Products in Japan. 12th ed Tokyo: Japan Pharmaceutical, Medical & Dental Supply Exporters Association, 2005/4. 5. DRUGDEX System. Thomson MICROMEDEX, Greenwood Village, Colorado (Vol. 124, expires 6/2005). 6. Drug Facts and Comparisons 59th ed. Missouri: Facts and Comparisons, 2005. 4 Vol.26 No.09
1. 2. 3. reninangiotensin-aldosterone system 4. 5. 8 8 16 Blopress Porfimer Sodium Phtofrin for Injection 成分及性狀 Photofrin 15 75 porfimer sodium 作用 Porfimer photodynamic therapy PDT photosensitizing agent 40-72 porfimer 40-50 630 nm 藥物動力學 Porfimer 21.5 (11~28 ) 90% 0.49 0.28 L/kg 0.051 0.035 ml/min/kg 適應症 1. Nd:Yag 2. 3. 不良反應 porfimer ( 30 ) / / 注意事項 1. 2. endobronchial 40-50 3. 1 5 Vol.26 No.09
4. 5. porfimer 30 90 porfimer 6. 2-4 4 7. 禁忌 1. 2. porphyrins 3. 4. 交互作用 1. tetracyclines, sulfonamides, phenothiazines, sulfonylurea hypoglycemic agents, thiazide diuretics, griseofulvin, and fluoroquinolones 2. dimethyl sulfoxide carotene ethanol formate mannitol PDT 3. allopurinol PDT 4. thromboxane A2 glucocorticoid hormones PDT 劑量及用法 Photofrin 3-5 2 mg/kg 40-50 630 nm 90-120 30 Photofrin 5% 2.5 mg/ml 30 儲存 15-25 參考資料 1. PDR Electronic Library, Thomson MICROMEDEX, Greenwood Village, Colorado (Vol. 125 expires 9/2005). 2. DRUGDEX System. Thomson MICROMEDEX, Greenwood Village, Colorado (Vol. 125 expires 9/2005). 3. The circular from the manufacturer of Photofrin. 1. Nd:Yag 6 Vol.26 No.09
2. 3. 1. porfimer 30 90 2. 3. 2-4 4 Photofrin 3-5 2 mg/kg 40-50 630 nm 90-120 30 Atazanavir Sulfate Reyataz Capsule 成分及性狀 atazanavir 150 200 作用 Atazanavir sulfate azapeptide HIV HIV-1 protease inhibitors 藥物動力學 2-2.5 86% CSF/plasma=0.002-0.02 CYP 3A 79 13% 7% 7 Atazanavir CYP 3A4 UGT 1A1 CYP 1A2 CYP 2C9 適應症 不良反應 P-R 注意事項 1. 2. P-R 3. 4. 5. 6. B 禁忌 1. 2. CYP 3A cisapride ergot alkaloids midazolam pimozide triazolam 7 Vol.26 No.09
交互作用 1. Atazanavir CYP 3A UGT 1A1 CYP 3A UGT 1A1 2. Atazanavir CYP450 CYP 3A rifamycin atazanavir CYP 3A atazanavir 3. Atazanavir omeprazole azazanavir - 76% 78% 4. atazanavir indinavir Crixivan irinotecan Campto lovastatin Delipic proton pump inhibitors rifampin simvastatin Zocor St. John s wort 劑量及用法 1. 2. didanosine 2 1 atazanavir 3. 400 4. ritonavir 100 mg qd 100 mg ritonavir qd/600 mg efavirenz qd Child-Pugh Class B 300 儲存 25 參考資料 1. AHFS Drug Information. Bethesda: American Society of Hospital Pharmacists, 2005, available from: STAT!Ref Online Electronic Medical Library. 2. Sweetman S (Ed), Martindale: the Complete Drug Reference. London: Pharmaceutical Press. Electronic version, MICROMEDEX, Greenwood Village, Colorado, Edition expires 5/2005. 3. Drug Facts and Comparisons 59th ed. Missouri: Facts and Comparisons, 2005. 4. DRUGDEX System. Thomson MICROMEDEX, Greenwood Village, Colorado (Vol. 124, expires 6/2005). 1. 2. 3. 4. Reyataz 5. P-R 1. 400 2 200 2. (Child- Pugh B ) 300 (Child-Pugh C ) 8 Vol.26 No.09