Dengue Fever 5294 242 21 1
1.1 1944 1 1950 2 1953 Philipines hemorrhagic fever 1956 15 Thai hemorrhagic fever Dengue hemorrhagic fever DHF 3 1 2 3 4 1956 Graham1903 Bancroft1906 1.2 1942 40 1981 80 21987 1387 500 5 2 1 1988 4389 1988 1234 2
1870 1889 1902 1915 25-50 1922 20-30 1927 1931 1942 80 1981 80 2 1987 1123 527 5 2 1 2.9 1988 10,420 4389 3534 1 3 1989 594 35 16 19 5 2 1 1990 136 10 1 1 1991 804 175 26 16 4 1992 23 4 19 2 2 1993 13 1994 244 222 22 158 20 38 3 1 1 1 3
26 7 1995 369 329 40 179 1 3 3 69 8 6 51 6 1996 42 16 14 2 26 1997 76 19 57 1998 348 238 135 64 24 6 4 3 1 1 110 1999 49 20 29 2000 140 113 2 109 27 2001 218 2002 17 5294 2819 1958 377 66 18 1 2 2003 2/28 49 26 9 12 2 4
1.3 2002 2001 2002 0-9 31.4 1062.0 10-19 167.3 3396.4 20-29 2210.1 60911.5 30-39 2511.5 59911.3 40-49 5022.9 97518.4 50-59 4420.2 114421.6 60-69 4018.3 108020.4 70 188.3 4428.3 218 5294 2001 /2002 1 1.4 5
1.5 25 25 1 1 6
2.1 Dengue Fever Aedes aegypti Aedes albopictus " " ( ) 8 15 15-50 2.2 1907 Craig Family Togavirdae Flavivirus enveloped, single-stranded RNA viruses IIIIIIIV 29 7
typespecific immunity primary infection homotypic immunity secondary infection anamnestic antibody response secondary-type immune response dengue hemorrhagic fever,dhf dengue shock syndrome, DSS arbovirus 2.3 1 2 3 2 8
polynesiensis modirittatus polynesiensis 2 2.4 3-14 viremia 8-12 3 9
3 15) 8-12 -1 5 7 17-1 0 5 10 20 30 10 31 4 10
2.5 1 1 3~8 2 12 3 39 40 3-6 3 1-2 2-3 4 breakbone fever 5 4 7 5 6 7 1 8 1987 1988 250 98 36 98 95 97 11
22.4 78 62.6 1.3 7 14 9-10 -- 5 2 1 3~8 1~10 2 3~6 3 6 4 Confluent convalescent rash 7 5 plasma leakage 12
hypovolemic shock 20mmHg Dengue shock syndromedss 1-2 DIC 10~50 6 7 13
3 1 2 3 4 1 2 3 14
3.1 1 N E W S 1500 8 2 9 10 5-6 15
3-4 5-6 1-2 1 3-4 6-8 2-3 1 9 3 16
12 25-30 35 51 12 6 1 2 10 4 34.3 17.1 2.9 5.7 28.6 11.4 2 0 0 0 1 2 40 0 0 0 20 40 2 1993 24 43 42 22 0 131 400 18.3 32.8 32.1 16.8 0 100 19 3 27 0 0 49 400 38.8 6.1 55.1 0 0 100 3 1993 2 23 18 2 4 0.5-2 96 76 43 81 0.5 8 6 8 15 4 1993 17
10 125 125 0.0 0.0 12 130 12 2 1.5 15 55 53 2 3.6 20 131 82 49 37.4 25 53 12 41 77.4 30 30 4 26 86.6 35 292 143 149 51 5 4 85.2 50 367 488 50 90 161 165 265 287 347 395 488 179 15 5 3 1 2 1 1 1 209 22 0 4 0 0 1 1 0 0 28 201 15 9 3 1 3 2 1 1 237 85.2 6.4 3.8 1.3 0.4 1.3 0.8 0.4 0.4 100 1.3 2-3 20560 6 3.2. 1960 18
3.3 1 1 2 3 2 1 19
2 7 1 2 3 4 5 6 7 8 9 1-3 4-7 8-17 18-28 29-37 37-49 50-59 60-76 41 1-2 3-5 6-9 10-14 15-20 21-27 28-31 32-40 78 1-4 5-9 10-19 20-34 35-49 50-74 79-99 100-199 200 1-3 4-10 11-30 31-100 101-300 301-1000 1001-30003001-10000 10001 7 2-1 100 100 50 10 20 4 2-2 100 100 50 5 20
10 4 2-3 100 100 50 10 20 4 2-4 100 100 50 60 1205 3 50 10 0.2 3.4 50 21
35 20 5 4 3 22
4.1 4.2 1 ( ) ULV ULV 23
--- --- --- --- --- 2 1 2 1 2 3 3 24
1 2 3 4 5 6 25
4 1 1 1 2 3 4 5 2 1 2 3 4 5 6 26
7 8 9 3 1 2 3 4 1 2 3 4 5 5 1 2 3 4 5 6 7 6 1 27
2 3 4 5 6 7 1 2 3 5? 1 28
1 2 2 1 ( ) 2 3 3 29
1 2 4 / / 30
5 6 1 2 31
6 1 2 3 4 30 30 5 7 32
91 5294 1 2 3 4 5 33
34