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1 ABSTRACT 3 5 13 14 14 15 15 16 17 18 18 18 18-21 28 33 34 46 47 53 54 2
- A L Aeq CNE 463 3-5 L Aeq L Aeq CNE WHO/ISH 1999 [49] 18.6kPa / 12.0kPa EpiInfo6.04 SPSS10.0 Logistic 10 L Aeq.10min 83.5+3.8 db(a) 76.0 96.4dB(A) 8 L Aeq.8h 89.3+4.0dB(A) (79.0 98.8) db(a) 97 L Aeq.8h 85 db(a) 91 19.7 3
BMI P<0.05 L Aeq - P>0.05 CNE - P<0.01 L Aeq.8h CNE X 2 =21.779 Logistic OR=1.062 BMI OR=1.280 OR=1.945 CNE OR 1.040 P=0.197 85dB(A) L Aeq.8h CNE CNE 1dB(A) 4 - Logistic 4
Dose-Response Relationship for Noise Induced Hypertension in Ground Crew at Airport Graduate Student: Zhu Wenjie Supervisor: Department: Prof Zhao Yiming The Third Hospital of Peking University Abstract Objective: 1). To observe the noise exposure level and characteristics of ground crew at airport, 2). To determine the dose-response relationship for noise induced hypertension in ground crew at airport, 3). To evaluate the application value of equivalent continuous A-weighted sound pressure noise level (L Aeq ) and cumulative noise exposure (CNE) as noise exposure assessment indices. Methods: 463 ground crew at airport were selected as investigating population. Some of them were selected to collect personal noise exposure data by dosimeter during a working day. Collected data were translated from dosimeter to computer by cable. The data were saved in computer and calculated for equivalent continuous A-weighted sound pressure noise level (L Aeq ). According to equal-energy rule, L Aeq and noise exposure duration were combined into cumulative noise exposure (CNE). The definition of hypertension followed by WHO/ISH (1999) [49], systolic blood pressure at least 18.6kPa and/or diastolic blood pressure 12.0kPa. The cases, who were diagnosed as suffering from hypertension and taking anti-hypertension drugs routinely, were defined as hypertension. The data were input into computer with EpiInfo 6.04 software and analyzed by SPSS software for data statistics and logistic regression model. Results: Ground crew at airport were exposed to non-steady noise, L Aeq.10min was 83.5+3.8 db(a)(76.0 96.4dB(A)), L Aeq.8h was 89.3+4.0dB(A) (79.0 98.8dB(A)), 97% of ground crew exposure to noise beyond 85dB(A). There were 91 hypertension patients in the population with prevalence of 19.7%. There were significant correlation between 5
the hypertension prevalence and noise exposure duration, CNE, age, BMI parents hypertension history (P<0.05). There were no significant correlation between L Aeq and the hypertension prevalence (P>0.05). CNE calculated by L Aeq.8h was better than other noise assessment indices with highest trend chi-square value for dose response relationship (X 2 trend=21.779). From logistic regression model we find age, parents hypertension history, BMI are independent risk factors of hypertension, odds ratio of CNE was 1.040 without significant (P=0.197). Conclusions: Ground crew at airport was exposed to non-steady noise with feature of dynamic and irregular. The noise exposure level of most crew was beyond 85 db(a). CNE calculated by L Aeq.8h is the best noise assessment index. After adjusting confounding effect, risk of hypertension increased about 4% by 1dB(A) of more noise exposure, but without significant. It needs to explore more cases in future to confirm the real relationship for noise induced hypertension in ground crew at airport. Key Words: non-steady state noise dose-response relationship cumulative noise exposure hypertension dosimeter logistic regression model 6
, - 80 90 80 1977 Johsson A [1] 70 80 7
90 1 1 40% 10% 50% 1980 5 1 6 90dB(A) 4 [34] 1980 1981 10 93 [35] 1984 [2] 1985 [3] 1989 3 1000 8
[4] 80 90 8.62 r 0.9478 P<0.01 [5] 1991 1101 Logistic > > [6 7] [8] 80 90 1995 126 P<0.05 [9] 6 9
[36] 1996 218 [37] 1996 189 P<0.01 r 1 =0.943 r 2 =0.985 P <0.005 [10] 1996 P<0.05 - [11] 1997 [12] 1997 99 96 [13] [14 15 16 17 18 19 20 21 22 23 24] - [25 26 27 28 29 30 31 32 33] [38 39 40 41] 10
- 80 90 10 [8] 11
1992 105dB A 3 A B 32 B 6 Ising [43] 1980 [44] 65dB(A) 90dB(A) [42] [45] [46] 12
1 2 [47] 3 - - 13
14
, 15
463 439 24 1 1 16