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麟矮刁
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1 4 5 Vol. 4 No Journal of Food Safety and Quality Oct., 2013 Visfatin A-FABP PPARγ2 张正武 1, 潘红梅 1, 张丽娟 2, 张雪辉 1, 殷建忠 (1., ; 2., ) 1* 摘要 :, (adipocyte fatty acid binding protein, A-FABP) (visfatin), (metabolic syndrome, MS) (peroxisome proliferator activated receptor gamma 2, PPARγ), MS Visfatin A-FABP PPARγ2 (cardio-cerebrovascular disease), (non-communicable disease, NCD) 关键词 : ; ; ; Research progress on cardio-cerebrovascular disease visfatin, a-fabp, pparγ2 gene polymorphism and their relationships with cardio/cerebrovascular disease ZHANG Zheng-Wu 1, PAN Hong-Mei 1, ZHANG Li-Juan 2, ZHANG Xue-Hui 1, YIN Jian-Zhong 1* (1. Research Institute of Nutrition and Food Science, Kunming Medical University, Kunming , China; 2. School of Basic Medicine, Yunnan College of Traditional Chinese Medicine, Kunming , China) ABSTRACT: Scholars at home and abroad have detected lard type fatty acid binding protein (A-FABP) and visfatin level, and evaluated their relevance to the metabolic syndrome (MS). Besides, peroxidase body growth activated receptor (PPARγ) may also play key role in diseases including obesity, high blood pressure, abnormal lipid metabolism, and thus could be one of the important candidate genes of MS. The paper their relationship with cardio-cerebrovascular disease, and provide scientific references for the prevention and control of non-communicable disease (NCD). KEY WORDS: visfatin; adipocyte fatty acid binding protein(a-fabp); peroxisome proliferator activated receptor gamma 2(PPARγ2); non-communicable disease(ncd), (chronic non-communicable disease, NCD) 基金项目 : ( , ) Fund: Supported by the National Natural Science Foundation of China ( , ) * 通讯作者 :,, yinjianzhong2005@sina.com *Corresponding author: YIN Jian-Zhong, Professor, Research Institute of Nutrition and Food, Science, Kunming Medical University, Kunming , China. yinjianzhong2005@sina.com

2 5, : Visfatin A-FABP PPARγ %, [1] [2] (fatty acid, FA) NCD, [3], NCD FA, [4-5] FA NCD FA, FA, (saturated fatty acid, SFA) (monounsaturated fatty acid, MUFA) (polyunsaturated fatty acids, PUFA) PUFA n-6 n-3 3 FA NCD, (visfatin) (adipocyte fatty acid binding protein, A-FABP), (metabolic syndrome, MS),, FA FA visfatin A-FABP PPARγ2 NCD 1 NCD 防治现状 NCD,,, [6], NCD,, NCD [1], %( %), 2.6%, 18.6%, 22.8% 7.1% 2010 NCD [7], 18, 30.6% 12.0%, % 69%, 9.7%, [7] [6,8-15], NCD,, FA NCD 2 脂肪细胞因子 A-FABP 的研究进展 A-FABP FABP,, FA,, A-FABP [16] A-FABP PPARγ FA LDL, A-FABP, A-FABP, (free fatty acid, FFA), A-FABP FFA, FFA, FA β-, FA A-FABP, Cabré [17] 188 (familial combined hyperlipidemia, FCHL) A-FABP,, FCHL A-FABP, A-FABP Xu [18] 229 A-FABP, A-FABP (HOMA-IR), A-FABP MS, Xu [19] 495 5, A-FABP, A-FABP A-FABP MS, A-FABP MS, IR, A-FABP MS, A-FABP MS MS,

3 脂肪细胞因子 visfatin 的研究进展 Visfatin,, Visfatin MS, MS, [20-21] 2005 visfatin, visfatin,, visfatin, [20-21] visfatin, visfatin [22-23],,, 4 PPARγ2 基因多态性的研究进展 (peroxisome proliferator activated receptor gamma 2, PPARγ2) PPARγ [20-24],, PPARγ, PPARγ,, MS [25-26] PPARγ, 6, Pro12Ala Prol115Gln C 161T 1431C/T P3-681C/G P2-689C/T [24], PPARγ PPARγ,, PPARγ MS, MS [27], PPARγ, ( ) PPARγ2 Pro12Ala, PPARγ MS, MS MS 5 展望, FA NCD PPARγ2 NCD, PPARγ2 NCD,, PPARγ2 NCD,,,, FA, NCD, NCD [28-29], 15.4%; 8.0%, 19.1%; 4.0%, 9.3%; 8.3%, 24.4% 23.4%; 21.5%, 39.6%, 13.6%; 15.8%, 14.9%; 8.1%, 25.4% 18, [1] 2010 NCD [7], 4,, 4 FA A-FABP visfatin PPARγ2 Pro12Ala C161 T NCD 4,, FA

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5 cid binding protein levels predict the development of the metabolic syndrome: a 5 year prospective study [J]. Circulation, 2007, 115 (12): [20] Fukuhara A, Matsuda M, Nishizawa M, et al. Visfatin : a protein secreted by visceral fat that mimics the effects of insulin [J]. Science, 2005, 307(5708): [21] Fukuhara A, Matsuda M, Nishizawa M, et al. Retraction[J]. Science, 2007, 318(5850): 565. [22],. - [J]. :, 2012, 10(1): 7 9. Li LJ, Li N. Progress of adipocytokin visfatin [J]. J Yanan Univ: Med Sci, 2012, 10(1): 7 9. [23],. [J]., 2012, 32(11): Yang YH, Wang JS. Progress of diseases related with visfatin [J]. Chin J Gerontol, 2012, 32(11): [24],. PPARγ [J]., 2012, 12(19): Qi CN, Guo SX. Research progress of peroxisome proliferator activated receptors γ gene and metabolic syndrome [J]. Prog Mod Biomed, 2012, 12(19): [25] Valve R, Sivenius K, Miettinen R, et al. Two polymorphisms in the peroxisome proliferator-pctivated receptor-γ gene are associated with severe overweight among obese Women [J]. J Clin Endocrinol Metab, 1999, 84(10): [26] Jussi PK, Mauno V, Pasi V, et al. The Pro12Ala polymorphism of the PPARγ2 gene regulates weight from birth to adulthood [J]. Obes Res, 2004, 12(2): [27],. γ [J]., 2010, 20(2): Dong JM, Wu M. Research progress of peroxisome proliferators activated receptors γ and metabolic syndrome [J]. Chin J Health Lab Technol, 2010, 20(2): [28],,,. [J]., 2013, 34(5): Su MH, Wang RX, Fan JH, et al. Assessing the relationship between dietary fatty acid intake and obesity of Dai nationality by semi-quantitative food frequency questionnaire [J]. J Kunming Med Univ, 2013, 34(5): [29],,,. [J]., 2013, 42(4): Wang RX, Yin JZ, Ran X, et al. Applicating food frequency questionnaire to assess the relationship between dietary polyunsaturated fatty acid intake and hypertension, dyslipidemia of Pumi nationality [J]. J Hyg Res, 2013, 42(4): 作者简介 ( 责任编辑 : 赵静 ) 张正武, 公共卫生硕士, 主要研究方向为营养与代谢性疾病 zhangzhengwuyn@126.com 殷建忠, 教授, 硕士生导师, 主要研究方向为营养与食品安全 yinjianzhong2005@sina.com

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