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9 years ago
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1 Chikungunya RNAi

2 1 Chikungunya Chikungunya Alphaviruses WHO La Réunion

3 PubMed chikungunya ,000 Aedes albopictus 100 PLoS Pathogens 150 chloroquine USAMRIID 20 80

4 3 Health and Human Services HHS Institute of Medicine IOM

5 4 1

6 5 RNAi RNA RNA interference RNAi mrna RNA double strand RNA dsrna mrna RNAi RNA Science Citation Index Expanded SCI-E RNAi 1. RNAi SCI-E , RNAi ~2007 SCI-E RNAi 2. RNAi 2002 HIV-1 sirna Lee NS et al, 2002 RNAi 2

7 6 1 HIV-1 rev sirna sirna HIV-1 HIV-1 RNA HIV RNA RNAi HIV-1 sirna RNA sirnas HIV TRBP RNA shrnas HIV sirnas HIV-lhNef HIV-1 sirna RNAi sirna HIV-1 RNAi Xia HB et al, 2002 HIV-1 RNA Boden D et al, 2003 Das AT et al, 2004 RNAi HIV-1 RNA RNAi Westerhout EM et al, 2005 sirnas Sabariegos R et al, 2006 sirna HIV shrna (anti-hiv shrna) CCR5 anti-ccr5 ribozyme nucleolar-localizing TAR decoy HIV Li MJ et al, 2005 shrnas HIV RNAi ter Brake O et al, 2006 RNA short hairpin RNAs shrnas) RNA long hairpin RNAs lhrnas) RNAs sirnas HIV-1 sirnas lhrnas Nef 3' HIV-1 HIV-1 Konstantinova P et al, 2007 HIV HIV-1 RNAi HIV-1 sirna HIV-1 Tat

8 7 Dicer RNA (SRS)Bennasser Y et al, 2005 Dicer TRBP HIV-1 TAR RNA Dicer RNA TRBP PKR dsrna RNA PKR Haase AD et al, 2005 sirnas Morris KV and Rossi JJ, 2006 RNAi sirnas RNAi sirna sirna RNAi Mescalchin A et al, HIV-1 RNAi RNAi (1) HIV-1 sirna shrnas sirna TAR (2) sirna RNAi (3) sirna sirna HIV-1 RNAi RNAi

9 8 1 University of Haifa Glucose Tolerance Factor GTF GTF GTF GTF LDL HDL GTF GTF GTF GTF Proceedings of the National Academy of Science Esra Tasali

10 ,500 DNA Reproductive Sciences Genes in Glucose Metabolism and Association with Spina Bifida Hope Northrup DNA 3 Spina Bifida Association 1 7 Northrup the U.S. National Institute of Diabetes and Digestive and Kidney Diseases, NIDDK Robert G Nelson

11 Nelson Journal of the American Medical Association 1, University of Nebraska Medical Center's Department of Pediatrics Pascale H Lane 2 Lane Nelson 2 gastric inhibitory polypeptide GIP American Journal of Physiology - Endocrinology and Metabolism GIP GIP Receptor Antagonism Reverses Obesity, Insulin Resistance, and Associated Metabolic Disturbances Induced in Mice by Prolonged Consumption of High-Fat Dietpro3 GIP GIP pro3 GIP pro3 GIP

12 11 Weill Cornell Medical College Pbx-1 Prep-1-10 IL Immunity IL-10 IL-10 IL-10 T CD36 CD36 IL-10 CD36 IL-10 CD36 IL-10 Pbx-1 Prep-1 Pbx-1 Prep-1 IL-10 Wafik S. El-Deiry TRAIL TRAIL Deiry TRAIL TRAIL Journal of Clinical Investigation TRAIL TRAIL B

13 12 1 TRAIL TRAIL 5 TRAIL TRAIL TRAIL National Institute of Environmental Health Sciences The American Thoracic Society ATS American Journal of Respiratory and Critical Care Medicine parathion 3 Malathion 60 permethrin

14 Current Biology Polytechnic University of Marche Roberto Danovaro 65 Danovaro

2012_A4.indd

2012_A4.indd 查尔斯沃思中国在线医学期刊简介 www.charlesworth.com.cn 新英格兰医学杂志 The New England Journal of Medicine 马萨诸塞州医学会 (Massachusetts Medical Society) 成立于 1781 年, 是美国一个州属专业医学会, 拥有 2 万