3237 S2 ~ S4 Saenz de Tejada 28 De Angelis 31 NO E1 PGE1 NO NO NO PGE1 NO NO cgmp PGE1 NO camp cgmp camp ADA 64 Banting Brownlee ROS AGEs NO C P

Transcription

1 3236 黄炳昆 伍学焱 SF % % 13. 2% SF % Penson 16 ADA 5 exploratory comprehensive evaluation of erectile dysfunction ExCEED ADA 7 Vinik % 9 67% 20% ~ 71% HbA1c BMI 21 Massachusetts Male Aging Study 19 28% 9. 6% De Berardis % % HbA1c > 6. 5% DOI /cma. j. issn wsheyan@ vip. sina. com 23 25

2 3237 S2 ~ S4 Saenz de Tejada 28 De Angelis 31 NO E1 PGE1 NO NO NO PGE1 NO NO cgmp PGE1 NO camp cgmp camp ADA 64 Banting Brownlee ROS AGEs NO C PKC enos Hecht Saenz de Tejada 28 IIEF-5 NO NO Cellek

3 PDE5 - - PDE5 NO PSA NO PDE5 4. PDE5 30 min min h 75% min 28. 5% ~ 55% PDE % 1. 5 PDE5 NO PDE5 30 min cgmp 2. PED5 PGE1 cgmp PDE5 PGE1 PDE5 cgmp 70% EMEA FDA 92% PGE1 PDE5 4 h 30 min 60% ~ 85% FDA SURE % PDE5 -

4 Penson DF Latini DM 17 Klein R Klein BE Lee KE 5% % ~ 3% 70% ~ 87% 19 Feldman HA Goldstein I Hatzichristou DG Aging Study. J Urol Giuliano FA Leriche A Jaudinot EO Urology Penson DF 1 Wild S Roglic G Green A et al. Global prevalence of diabetes estimates for the year 2000 and projections for Diabetes Care Yang W Lu J Weng J et al. Prevalence of Diabetes among Men and Women in China. NEngl J Med Amos AF McCarty DJ Zimmet P. The rising global burden of diabetes and its complications estimates and projections to the year Diabet Med Suppl 5 S Crofford OB. Diabetes control and complications. Annu Rev Med ADA. Standards of Medical Care in Diabetes Diabetes Care Suppl 1 S NIH Consensus Development Panel on Impotence. NHI Consensus Conference Impotence. JAMA Boulton AJ Vinik AI Arezzo JC et al. Diabetic neuropathies a statement by the American Diabetes Association. Diabetes Care Vinik AI Maser RE Mitchell BD et al. Diabetic autonomic neuropathy. Diabetes Care De Berardis G Franciosi M Belfiglio M et al. Erectile dysfunction and quality of life in type 2 diabetic patients a serious problem too often o- verlooked. Diabetes Care Ansong KS Lewis C Jenkins P et al. Help-seeking decisions among men with impotence. Urology Sánchez-Cruz JJ Cabrera-León A Martín-Morales A et al. Male erectile dysfunction and health-related quality of life. Eur Urol Litwin MS Nied RJ Dhanani N. Health-related quality of life in men with erectile dysfunction. J Gen Intern Med Penson DF Feng Z Kuniyuki A et al. General quality of life 2 years following treatment for prostate cancer what influences outcomes Results from the prostate cancer outcomes study. J Clin Oncol J nler M Moon T Brannan W et al. The effect of age ethnicity and geographical location on impotence and quality of life. Br J Urol De Berardis G Pellegrini F Franciosi M et al. Longitudinal assessment of quality of life in patients with type 2 diabetes and self-reported erectile dysfunction. Diabetes Care Lubeck DP et al. Do impotent men with diabetes have more severe erectile dysfunction and worse quality of life than the general population of impotent patients Results from the Exploratory Comprehensive Evaluation of Erectile Dysfunction ExCEED database. Diabetes Care et al. Prevalence of self-reported erectile dysfunction in people with long-term IDDM. Diabetes Care Fedele D Coscelli C Santeusanio F et al. Erectile dysfunction in diabetic subjects in Italy. GruppoItaliano Studio Deficit Erettilenei Diabetici. Diabetes Care et al. Impotence and its medical and psychosocial correlates results of the Massachusetts Male et al. Prevalence of erectile dysfunction among 7689 patients with diabetes or hypertension or both. Wessells H. Erectile Dysfunction in Diabetic Patients. Diabetes Spectrum Yang G Pan C Lu J. Prevalence of erectile dysfunction among Chinese men with type 2 diabetes mellitus. Int J Impot Res Thompson IM Tangen CM Goodman PJ et al. Erectile dysfunction and subsequent cardiovascular disease. JAMA Lue TF. Erectile Dysfunction. N Engl J Med Kahn CR Weir CC King CL. Joslin Dean RC Lue TF. Physiology of penile erection and pathophysiology of erectile dysfunction. Urol Clin North Am V. 27 Hecht MJ Neund rfer B Kiesewetter F et al. Neuropathy is a major contributing factor to diabetic erectile dysfunction. Neurol Res Saenz de Tejada I Goldstein I Azadzoi K et al. Impaired neurogenic and endothelium-mediated relaxation of penile smooth muscle from diabetic men with impotence. N Engl J Med Cellek S Rodrigo J Lobos E et al. Selectivenitrergicneurodegeneration in diabetes mellitus-a nitric oxide-dependent phenomenon. Br J Pharmacol Malavige LS Levy JC. Erectile dysfunction in diabetes mellitus. J Sex Med De Angelis L Marfella MA Siniscalchi M et al. Erectile and endothelial dysfunction in Type II diabetes a possible link. Diabetologia Brownlee M. Biochemistry and molecular cell biology of diabetic complications. Nature Brownlee M. The Pathobiology of Diabetic Complications a unifying mechanism. Diabetes Hatzimouratidis K Amar E Eardley I et al. Guidelines on male sexual dysfunction erectile dysfunction and premature ejaculation. Eur Urol Kannel WB McGee DL. Diabetes and glucose tolerance as risk factors for cardiovascular disease the framingham study. Diabetes Care Ma RC So WY Yang X et al. Erectile dysfunction predicts coronary heart disease in type 2 diabetes. J Am Coll Cardiol Kloner RA Mullin SH Shook T et al. Erectile dysfunction in the cardiac patient how common and should we treat J Urol

5 3240 S Mirone V Costa P Damber JE et al. An evaluation of an alternative dosing regimen with tadalafil 3 times /week for men with erectile dysfunction SURE study in 14 European countries. Eur Urol 黄炳昆, 伍学焱. 糖尿病与勃起功能障碍 [J /CD]. 中华临床医师杂志 : 电子版,2013,7( 8) :