MS 快速报告提供临床医师更好的治疗选择 传统鉴定 自动化鉴定 质谱鉴定 数天 数小时 数分钟 Vitek MS 鉴定 16 个菌只需 20 分钟 VITEK MS 质谱仪数据库独有临床病原体 安全有效的操作前处理用于 VITEK MS 鉴定布鲁菌属 Mesureur et al, 法国国家健康与医

精准感染诊疗的突破 快速鉴定/药敏解决方案 Downloaded from www.biomerieux.com.cn. All rights reserved @2016

MS 快速报告提供临床医师更好的治疗选择 传统鉴定 自动化鉴定 质谱鉴定 数天 数小时 数分钟 Vitek MS 鉴定 16 个菌只需 20 分钟 VITEK MS 质谱仪数据库独有临床病原体 安全有效的操作前处理用于 VITEK MS 鉴定布鲁菌属 Mesureur et al, 法国国家健康与医学研究院,Journal of Clinical Microbiology,2015 MALDI-TOF MS 对霍乱弧菌鉴定的评价 Rychert et al, 哈佛大学医学院附属麻省总医院,Journal of Clinical Microbiology,2015 MALDI-TOF 质谱鉴定引起脑脓肿的人型支原体一例报告 Pailhories et al, 法国 d'angers 大学医学院,International Journal of Infectious Disease,2015

快速精确感染诊断 同一种细菌间有很大的个体差异, 就好像人与人之间的不同 所以同种细菌的代表性菌株数必须达到一定量才能支持诊断级的报告 封闭的临床数据库, 平均每个菌种的菌株大于 10 株 - 金黄色葡萄球菌 : 328 株 - 大肠埃希菌 : 475 株 - 白色念珠菌 : 133 株 - 肺炎链球菌 : 306 株专利的图谱分析系统 (ASC), 整合流行病学指南, 支持菌株变异的判断, 不是传统的图谱匹配法符合 IVD 要求, 提供一次性靶板, 避免污染, 保证结果的精准开放的科研菌库, 支持定制化数据库 菌株分型溯源和耐药分析

梅里埃提供从样本采集到 从样本采集到最终鉴定药敏报告完整流程 梅里埃完整的采集样本 前处理 培养等 一系列的产品 VITEK MS 质谱鉴定 + VITEK 2 药敏 一站式鉴定药敏分析 提高效率, 减少人为误差 独特的实时监测, 实现当天报告的药敏结果 快速 手工操作时间少, 附加试剂少, 减少工作量与错误率 封闭性卡片, 保证生物安全性 Etest 与 ATB 等提供非常见菌的药敏检测 MS 20 minutes 6 hours 9 hours

药敏报告的原厂解决方案 原厂开发的流程信息系统支持信息的精准传递 连接所有微生物仪器, 并与 LIS/HIS 无 缝连接, 实现完美工作流程 远程报告功能, 使临床诊疗直接受益 于快速鉴定质谱技术 丰富而强大的流行病学统计功能与标 本流程管理功能, 让微生物实验室进 入数字时代 VITEK 2 鉴定 / 药敏系统 24 hours 全自动 vitek 2 鉴定 / 药敏系统提供了可当日发鉴定 / 药敏报告的引领技术, 搭配 AES 高级专家系统自动识别 3500 种耐药表型及超过 20000 种的菌种 / 抗生素 MIC 分布组合, 确保提供最高质量的快速报告 MYLA 抗感染信息化管理系统创新的 Myla 软件藉由仪器的链接, 工作流程信息化管理提供微生物实验室更简易的工作流程

Abiotrophia defectiva Achromobacter denitrificans Achromobacter xylosoxidans Acinetobacter baumannii complex Acinetobacter haem bacter junii Acinetobacter lwoffii Actinomyces meyeri Actinomyces neuii Actinomyces odontolyticus Aerococcus viridans Aeromonas Aeromonas sobria Aggregatibacter actinomycetemcomitans Aggregatibacter aphrophilus Aggregatibacter segnis Alcaligenes faeca Bacteroides caccae Bacteroides fragilis Bacteroides ovatus Bacteroides thetaiotaomicron Bacteroides uniformis Bacteroides vulga parapertussis Bordetella pertussis Brevundimonas diminuta Burkholderia multivorans Campylobacter coli Campylobacter jejuni C Candida dubliniensis Candida famata Candida glabrata Candida guilliermondii Candida haemulonii Candida inconspicua Candida in kefyr Candida krusei Candida lambica Candida lipolytica Candida lusitaniae Candida norvegensis Candida parapsilosis Candida p rugosa Candida tropicalis Candida utilis Candida zeylanoides Chryseobacterium indologenes Citrobacter amalonaticus Citrobacter freundii Citrobacter koseri Citrobacter youngae Clostridium clostridioforme Clostridium difficile Clostridium perfringens Clostridium ra terium jeikeium Cronobacter sakazakii Cryptococcus neoformans Edwardsiella hoshinae Edwardsiella tarda Eikenella corrodens Eliz goseptica Enterobacter aerogenes Enterobacter asburiae Enterobacter cancerogenus Enterobacter cloacae Enterobacter gergoviae E Enterococcus casseliflavus Enterococcus durans Enterococcus faecalis Enterococcus faecium Enterococcus gallinarum Escherichia fergusonii Escherichia hermannii Ewingella americana Finegoldia magna Fusobacterium necrophorum Fusobacterium nucleatum Ga Gemella haemolysans Gemella morbillorum Geotrichum capitatum Granulicatella adiacens Haemophilus influenzae Haemophilus p Haemophilus parainfluenzae Hafnia alvei Kingella denitrificans Kingella kingae Klebsiella oxytoca Klebsiella pneumoniae Kodamaea cus garvieae Lactococcus lactis ssp lactis Leclercia adecarboxylata Legionella pneumophila Leuconostoc mesenteroides Leuconostoc des Listeria monocytogenes Malassezia furfur Malassezia pachydermatis Micrococcus luteus/lylae Mobiluncus curtisii Moraxella (Bra Morganella morganii Neisseria cinerea Neisseria gonorrhoeae Neisseria meningitidis Neisseria mucosa Ochrobactrum anthropi O Oligella urethralis Pantoea agglomerans Parvimonas micra Pasteurella multocida Pediococcus acidilactici Peptoniphilus asaccharolytic cus anaerobius Prevotella bivia Prevotella buccae Prevotella denticola Prevotella intermedia Prevotella melaninogenica Propionibacte mirabilis Proteus penneri Proteus vulgaris Providencia rettgeri Providencia stuartii Pseudomonas aeruginosa Pseudomonas fluoresc putida Pseudomonas stutzeri Ralstonia pickettii Raoultella ornithinolytica Raoultella planticola Rhizobium radiobacter Rhodotorula m mucilaginosa Saccharomyces cerevisiae Salmonella group Serratia fonticola Serratia liquefaciens Serratia marcescens Serratia odorif um multivorum Sphingobacterium spiritivorum Sphingomonas paucimobilis Staphylococcus aureus Staphylococcus capitis Staphylococ Staphylococcus cohnii ssp urealyticus Staphylococcus epidermidis Staphylococcus haemolyticus Staphylococcus hominis ssp hominis lugdunensis Staphylococcus saprophyticus Staphylococcus schleiferi Staphylococcus sciuri Staphylococcus simulans Staphylococcus phomonas maltophilia Streptococcus agalactiae Streptococcus anginosus Streptococcus constellatus Streptococcus dysgalactiae Strep ssp gallolyticus Streptococcus infantarius ssp coli (Str.lutetiensis) Streptococcus infantarius ssp infantarius Streptococcus intermedius S Streptococcus oralis Streptococcus mutans Streptococcus pneumoniae Streptococcus pyogenes Streptococcus salivarius ssp salivariu sanguinis Trichosporon asahii Trichosporon inkin Trichosporon mucoides Vibrio cholerae Vibrio parahaemolyticus Vibrio vulnificus Y Yersinia frederiksenii Yersinia intermedia Yersinia kristensenii Yersinia pseudotuberculosis Abiotrophia defectiva Achromobacter den bacter xylosoxidans Acinetobacter baumannii complex Acinetobacter haemolyticus Acinetobacter junii Acinetobacter lwoffii Actino Actinomyces neuii Actinomyces odontolyticus Aerococcus viridans Aeromonas hydrophila/caviae Aeromonas sobria Aggregatibacter a tans Aggregatibacter aphrophilus Aggregatibacter segnis Alcaligenes faecalis ssp faecalis Bacteroides caccae Bacteroides fragilis B Bacteroides thetaiotaomicron Bacteroides uniformis Bacteroides vulgatus Bordetella parapertussis Bordetella pertussis Brevundim Burkholderia multivorans Campylobacter coli Campylobacter jejuni Candida albicans Candida dubliniensis Candida famata Candida guilliermondii Candida haemulonii Candida inconspicua Candida intermedia Candida kefyr Candida krusei Candida lambica Ca Candida lusitaniae Candida norvegensis Candida parapsilosis Candida pelliculosa Candida rugosa Candida tropicalis Candida utilis des Chryseobacterium indologenes Citrobacter amalonaticus Citrobacter braakii Citrobacter freundii Citrobacter koseri Citrobacter yo clostridioforme Clostridium difficile Clostridium perfringens Clostridium ramosum Corynebacterium jeikeium Cronobacter sakazak neoformans Edwardsiella hoshinae Edwardsiella tarda Eikenella corrodens Elizabethkingia meningoseptica Enterobacter aerogene asburiae Enterobacter cancerogenus Enterobacter cloacae Enterobacter gergoviae Enterococcus avium Enterococcus casseliflavus E Enterococcus faecalis Enterococcus faecium Enterococcus gallinarum Escherichia coli Escherichia fergusonii Escherichia hermannii Ew Finegoldia magna Fusobacterium necrophorum Fusobacterium nucleatum Gardnerella vaginalis Gemella haemolysans Gemella morb capitatum Granulicatella adiacens Haemophilus influenzae Haemophilus parahaemolyticus Haemophilus parainfluenzae Hafnia alve cans Kingella kingae Klebsiella oxytoca Klebsiella pneumoniae Kodamaea ohmeri Lactococcus garvieae Lactococcus lactis ssp lacti boxylata Legionella pneumophila Leuconostoc mesenteroides Leuconostoc pseudomesenteroides Listeria monocytogenes Malassezia pachydermatis Micrococcus luteus/lylae Mobiluncus curtisii Moraxella (Branhamella) catarrhalis Morganella morganii Neisseria cin gonorrhoeae Neisseria meningitidis Neisseria mucosa Ochrobactrum anthropi Oligella ureolytica Oligella urethralis Pantoea agglom micra Pasteurella multocida Pediococcus acidilactici Peptoniphilus asaccharolyticus Peptostreptococcus anaerobius Prevotella bivia Prevotella denticola Prevotella intermedia Prevotella melaninogenica Propionibacterium acnes Proteus mirabilis Proteus penneri Providencia rettgeri Providencia stuartii Pseudomonas aeruginosa Pseudomonas fluorescens Pseudomonas putida Pseudomonas s pickettii Raoultella ornithinolytica Raoultella planticola Rhizobium radiobacter Rhodotorula mucilaginosa Rothia mucilaginosa Saccha Salmonella group Serratia fonticola Serratia liquefaciens Serratia marcescens Serratia odorifera Sphingobacterium multivorum Sp spiritivorum Sphingomonas paucimobilis Staphylococcus aureus Staphylococcus capitis Staphylococcus cohnii ssp cohnii Staphyloc urealyticus Staphylococcus epidermidis Staphylococcus haemolyticus Staphylococcus hominis ssp hominis Staphylococcus lugdunens saprophyticus Staphylococcus schleiferi Staphylococcus sciuri Staphylococcus simulans Staphylococcus warneri Stenotrophomonas ma cus agalactiae Streptococcus anginosus Streptococcus constellatus Streptococcus dysgalactiae Streptococcus gallolyticus ssp gallolytic infantarius ssp coli (Str.lutetiensis) Streptococcus infantarius ssp infantarius Streptococcus intermedius Streptococcus mitis/streptococcus o mutans Streptococcus pneumoniae Streptococcus pyogenes Streptococcus salivarius ssp salivarius Streptococcus sanguinis Trichosporo ron inkin Trichosporon mucoides Vibrio cholerae Vibrio parahaemolyticus Vibrio vulnificus Yersinia enterocolitica Yersinia frederiksenii Yersinia kristensenii Yersinia pseudotuberculosis Abiotrophia defectiva Achromobacter denitrificans Achromobacter xylosoxidans baumannii complex Acinetobacter haemolyticus Acinetobacter junii Acinetobacter lwoffii Actinomyces meyeri Actinomyces neuii Acti cus Aerococcus viridans Aeromonas hydrophila/caviae Aeromonas sobria Aggregatibacter actinomycetemcomitans Aggregatibac Aggregatibacter segnis Alcaligenes faecalis ssp faecalis Bacteroides caccae Bacteroides fragilis Bacteroides ovatus Bacteroides th Bacteroides uniformis Bacteroides vulgatus Bordetella parapertussis Bordetella pertussis Brevundimonas diminuta Burkholderia mul bacter coli Campylobacter jejuni Candida albicans Candida dubliniensis Candida famata Candida glabrata Candida guilliermondii C Candida inconspicua Candida intermedia Candida kefyr Candida krusei Candida lambica Candida lipolytica Candida lusitaniae Ca Candida parapsilosis Candida pelliculosa Candida rugosa Candida tropicalis Candida utilis Candida zeylanoides Chryseobacteriu Citrobacter amalonaticus Citrobacter braakii Citrobacter freundii Citrobacter koseri Citrobacter youngae Clostridium clostridioforme Clostridium perfringens Clostridium ramosum Corynebacterium jeikeium Cronobacter sakazakii Cryptococcus neoformans Edward Edwardsiella tarda Eikenella corrodens Elizabethkingia meningoseptica Enterobacter aerogenes Enterobacter asburiae Enterobacte Enterobacter cloacae Enterobacter gergoviae Enterococcus avium Enterococcus casseliflavus Enterococcus durans Enterococcus faec faecium Enterococcus gallinarum Escherichia coli Escherichia fergusonii Escherichia hermannii Ewingella americana Finegoldia mag Vitek MS质谱透过临床库与 科研库的整合提供了更好鉴 定能力 高级科研应用包括 定制菌株质谱数据库 细菌耐药性分析 血液和尿液样本直接鉴定 定制菌株质谱数据库 菌株分型溯源 细菌耐药性分析 血液和尿液直接鉴定 Downloaded from www.biomerieux.com.cn. All rights reserved @2016 菌株分型溯源

olyticus Acinetohydrophila/caviae lis ssp faecalis tus Bordetella andida albicans termedia Candida elliculosa Candida braakii Citrobacter mosum Corynebacabethkingia meninnterococcus avium coli Escherichia rdnerella vaginalis arahaemolyticus ohmeri Lactococpseudomesenteroinhamella) catarrhalis ligella ureolytica us Peptostreptococrium acnes Proteus ens Pseudomonas ucilaginosa Rothia era Sphingobactericus cohnii ssp cohnii Staphylococcus warneri Stenotrotococcus gallolyticus treptococcus mitis/ s Streptococcus ersinia enterocolitica itrificans Achromomyces meyeri ctinomycetemcomiacteroides ovatus onas diminuta glabrata Candida ndida lipolytica Candida zeylanoiungae Clostridium ii Cryptococcus s Enterobacter 的图谱 nterococcus durans ingella americana illorum Geotrichum i Kingella denitrifis Leclercia adecarfurfur Malassezia erea Neisseria erans Parvimonas Prevotella buccae Proteus vulgaris tutzeri Ralstonia romyces cerevisiae hingobacterium occus cohnii ssp is Staphylococcus ltophilia Streptococus Streptococcus ralis Streptococcus n asahii Trichospo- Yersinia intermedia Acinetobacter nomyces odontolytiter aphrophilus etaiotaomicron tivorans Campyloandida haemulonii ndida norvegensis m indologenes Clostridium difficile siella hoshinae r cancerogenus alis Enterococcus na Fusobacterium INTEGRATION COVERAGE ACCURACY 持续累积更多的菌株, 建立更多 平均每一菌种 >10 株 MS 权重矩阵分析提供更准确的鉴定 分析软件原理梅里埃获得两项国际专利的分析软件 - 高级图谱鉴别器是使用权重矩阵的方式建立菌株库 临床库包含了 755 菌种 (645 为细菌 ;110 为真菌 ), 大于 13000 菌株, 资料库建立包含不同株间的图谱, 不同培养基生长的图谱, 甚至包含了不同孵育时间的图谱都是梅里埃 Vitek MS 数据库建立时所考虑到的重点 为了建立菌株库的权重矩阵, 每一标准菌株的图谱都被区分为 1300 个区间, 并依照区间内顶峰的有无累积每一菌种于每一区间的权重分数 透过数据库权重矩阵的分析, 能够提高图谱相似的菌属间的正确鉴定率 Candida albicans -0.888-3.246 1.116 0.751-1.01-1.762 Hafnia alvei -0.071 2.076-1.736-2.258-2.699-1.741 Streptococcus pneumonia -1.672-2.259-1.867-2.774-1.867-2.631 Streptococcus mitis -1.568-0.613-1.495-0.943-1.815-2.887 Vibrio cholerae 0.342-3.433-2.283-6.456-3.198-0.304 bin values are for illustration purpose only 资料分析当一未知菌种经由 Vitek MS 质谱分析得到图谱后, 会先进行去除背景干扰的分析 而后该图谱即被区分为 1300 区间, 并利用 1300 区间中顶峰出现的有无, 进行数据库中已建立好的权重矩阵分析而得到该菌种与数据库中各别菌种的相对分数, 并将此相对分数转换为菌种鉴定的相似百分比及信赖分数 透过权重矩阵分析多层的把关为我们提供 >99% 信赖分数的鉴定结果 优势透过每一菌种图谱中 1300 个区间的分析, 比单纯比对图谱方法有更强大的鉴定准确率及区分相似组成蛋白成分或相似图谱的菌种间鉴别能力 权重矩阵的分析方式提供了比市面上其他微生物质谱系统更快速的分析时间及更准确的鉴定能力

全新的服务体验生物梅里埃致力于打造高效专业的服务, 基于传统的现场服务模式, 远程在线服务帮助客户更加有效和及时的解决问题和进行软件升级 免费热线随时联系梅里埃 4006308137 扫一扫 微信服务公众号体验全新的服务平台 文件号 : CM042E2016 梅里埃公司保留该文件的最终解释权 LOGO 及图片均为梅里埃公司版权所有 梅里埃诊断产品 ( 上海 ) 有限公司上海市浦东新区康桥工业区浦三路 4633 号邮编 : 201315 电话 : (021) 6097 8388 传真 : (021) 6097 8399 客户服务热线 : 400 630 8137 北京分公司电话 : (010) 8535 8388 广州分公司电话 : (020) 8762 7010 成都分公司电话 : (028) 8620 2052 www.biomerieux.com.cn 欢迎关注梅里埃微信公众号 服务就在您身边

SCI 和国内核心期刊参考文献 定制菌株质谱数据库实现多重耐药菌分析 用于 VITEK MS Saramis 科研系统快速鉴定耐甲氧西林金黄色葡萄球菌 (MRSA) Shan et al. 浙江大学第二附属医院,Current Microbiology,2015 菌株分型溯源与亚种分析 VITEK MS 具核梭杆菌亚种分离研究 Nie et al, 深圳市第四人民医院,Journal of Clinical Microbiology,2015 细菌与真菌鉴定准确率评估 VITEK MS 质谱仪中国多中心细菌鉴定评估研究 Luo et al, 中国解放军 301 医院,Journal of Medical Microbiology,2015 MALDI-TOF 质谱方法对于病原真菌鉴定准确率的 Meta 分析 Ling et al, 安徽医科大学第一附属医院,Journal of Clinical Microbiology,2015 VITEK MS 质谱技术与测序技术联合的鉴定方法对于中国真菌监测项目的应用 Zhang et al, 北京协和医院,Journal of Clinical Microbiology,2014 血液和尿液样本直接鉴定 快速尿液标本制备用于 MALDI-TOF MS 鉴定细菌 Veron et al, 梅里埃研发部门,European Journal of Clinical Microbiology,2015 利用裂解 - 过滤法和带有 SARAMIS 数据库检测从血培养阳性瓶中分离的细菌和酵母菌 Fothergil et al, 美国埃默里大学附属格雷迪医院,Journal of Clinical Microbiology,2013 VITEK MS 质谱仪数据库独有临床病原体 安全有效的操作前处理用于 VITEK MS 鉴定布鲁菌属 Mesureur et al, 法国国家健康与医学研究院,Journal of Clinical Microbiology,2015 MALDI-TOF MS 对霍乱弧菌鉴定的评价 Rychert et al, 哈佛大学医学院附属麻省总医院,Journal of Clinical Microbiology,2015 MALDI-TOF 质谱鉴定引起脑脓肿的人型支原体一例报告 Pailhories et al, 法国 d'angers 大学医学院,International Journal of Infectious Disease,2015