chemotherapy chemotherapy
机体 抗菌药物 及病原微生物的相互作用关系
antibiotics antibiotics antibacterial spectrum antibacterial spectrum antibacterialactivity antibacterialactivity
minimal inhibitory concentration MIC bacteriostatic bacteriostatic minimal bactericidal concentration MBC bactericide bactericide
chemotherapeutic index LD 50 / ED 50 LD 5 / ED 95 post antibiotic effect PAE
resistance resistance intrinsic resistance 2. acquired resistance
b
PBPs PBPs penicillin penicillin binding binding proteins proteins PBPs PBPs fi fi autolysins autolysins
G+
Lipoteichoic acid GRAM POSITIVE Peptidoglycan-teichoic acid Cytoplasmic membrane Cytoplasm GRAM NEGATIVE Porin Lipopolysaccharide Periplasmic space Outer Membrane Inner (cytoplasmic) membrane Cytoplasm Braun lipoprotein
b b b PBPs PBPs trapping mechanism trapping mechanism 3. 3. PBPs PBPs PBPs PBPs
porin porin 5. 6.
b XFGK Gpenicillin G U
im im c.s.f c.s.f
ampicillin ampicillin amoxicillin amoxicillin 4. 4. carbenicillin carbenicillin piperacillin piperacillin
cephalosporins C 7-ACA b b cephalosporins C 7-ACA b b
imipenem imipenem DHP DHP-1 tienam tienam cilastatin cilastatin meropenem meropenem CNS CNS
cepharmycins cepharmycins G+ G+ G- b cefoxitin cefoxitin cefmetazole cefmetazole
oxacephalosporins b latamoxef flomoxef oxacephalosporins oxacephalosporins b latamoxef latamoxef flomoxef flomoxef
b monobactams monobactams G+ G+ G- aztreonam aztreonam carumonam carumonam
b b b b clavulanic clavulanic acid acid