EGFR-TK Giotrif (Afatinib) 2013 2 2010 2010 8,194 19.96% Giotrif EGFR-TK (NSCLC) EGFR- TKI NSCLC Afatinib (Giotrif) 20304050 mg/tab( ) Giotrif EGFR-TK (NSCLC)
EGFR-TKI Giotrif 40mg ( : / ) Giotrif 1. CTCAE a Giotrif 1 2 b 2 c e 3 0/1 b 10 mg d a. NCI Common Terminology Criteria for Adverse Events b loperamide c >48 >7 d 20 mg afatinib e CTCAE2 ( ) 50% 2. afatinib afatinib 3. > 3 x ULN / 或 轉 胺 酶 > 5 x ULN afatinib / 或 轉 胺 酶 變 成 三 倍 afatinib / 4. EGFR-TKI 3 40 mg >CTCAE 1 50 mg
5. 50 mg 1. Giotrif Giotrif 3 1 2. 3. Giotrif 4. Giotrif 100ml (15 ) 100ml 5. Giotrif 8 Afatinib ErbB Afatinib ErbB EGFRErbB1 HER2ErbB2 HER4(ErbB4) homodimers heterodimers afatinib 1. Afatinib P-gp afatinib 2. P-gp ritonavircyclosporine Aketoconazole itraconazoleerythromycinverapamilquinidinetacrolimusnelfinavir
1. saquinavir amiodarone afatinib afatinib 2. P-gp rifampicin carbamazepine phenytoin phenobarbital St. John s Wort afatinib 1. GIOTRIF 2. D 3. afatinib 4. 65 (65 ) 5. GIOTRIF CrCl<30 ml/min GIOTRIF 6. Child Pugh C GIOTRIF GIOTRIF ChildPugh A B GIOTRIF 96%grade 315% 90%grade 316% 71%grade 39% 31% 21% 29%grade 34% 17%grade 31% 17% 11% 30 C
026033 EGFR-TK gefitinibiressa erlotinibtarcevaafatinib Afatinib IressaTarceva EGFRErbB1 HER2 ErbB2 HER4ErbB4( ) 1. GIOTRIF 2. Micromedex 3. UpToDate
FDA (FDA)2011 5 31 Drospirenone (Venous thromboembolism, VTE) Drospirenone Levonorgestrel 2 3 FDA Drospirenone 35 (Estrogen) (Progestin) (Estrogen) (Progestin) ( ) 1989 FDA (1) 35 (2) 40 1989 1930 (Estrogen) (Progestin) 1. 0.05mg (Venous thrombosis) 2. 0.025~0.035 mg Norethindrone ( LevonorgestrelNorgestimate )
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24 4 Yaz drospirenone 3mg ethinyl estradiol 0.02mg 1. Micromedex 2. 3. UpToDate 4. Bayer HealthCare Online. http://www.yaz-hk.com/scripts/pages/cn/homepage/index.php 5. US. Food and Drug Administration. FDA Drug Safety Communication 4 Oct 2012: Updated information about the risk of blood clots in women taking birth control pills containing drospirenone. http://www.fda.gov/drugs/drugsafety/ucm299305.htm.
Behcet's Disease (Behcet s disease, BD) (Behcet s syndrome, S-S) (ocular-oral-genital syndrome)behçet's disease 1937 Hulusi Behcet Behcet`s Disease Behcet s disease 30 40 (Silk Road Disease) Behcet s disease 1. HLA- B51 2. EB 病 毒 和 單 純 疱 疹 病 毒 感 染 有 關 3. Behcet s disease
: UpToDate-Treatment of Behçet s disease : UpToDate- Treatment of Behçet s disease 714 3070% Behcet s disease
Behcet s disease 1990 (the International Study Group for Behcet's Disease 1990) 1. 瘡 或 疱 疹 性 口 腔 潰 瘍 2. 3. (anterior uveitis) (posterior uveitis) 4. 丘 疹 膿 疱 型 皮 疹 5. ( positivepathergy test ) 0.1ml 24~48h (ESR)C (CRP) (Anticardiolipin antibody) (Antineutrophil cytoplasmic antibody) Behcet s disease
1. 3-4 Sucralfate 2. (1) Colchicine (2) Colchicine (1.0-2.0 mg/day) Behcet s disease (3) Thalidomide(100-300 mg/day) Thalidomide Behcet s disease thalidomide (4) Azathioprine (2.5 mg/kg/day) azathioprine2.5 / azathioprine (5) Cyclophosphamide cyclophosphamide cyclophosphamide 0.75~1g/m 2 Behcet s disease (6) Cyclosporine (5mg/kg/day) Behcet s disease Cyclosporine (7) Infliximab (anti-tnf) (
ESR C- CRP )Infliximab Behcet s disease 3-5 mg/kg 2-6 8 Azathioprine (8) Interferon- alpha (INF- alpha) 3 10 6 ~19 10 6 IU Behcet s disease Behcet s disease 20~40 Behcet s disease 1. Sakane T, Takeno M, Inaba G. Carrent ConceptsBehcet s Disease. NEJM1999;17:1284-91. 2. International Study Group for Behcet s Disease (ISGBD). Criteria for diagnosis of Behcet s disease. Lancet 1990; 335: 1078-80. 3. Advance Access publication 20 December 2005.Rheumatology 2006;45:245 247 4. Sakane T, Takeno M, Inaba G.Carrent ConceptsBehcet s Disease.NEJM 1999;17:1284-91. 5. Sfikakis PP (2002). "Behçet's disease: a new target for anti-tumour necrosis factor treatment". Ann Rheum Dis. 61 Suppl 2. 6. Clinicalmanifestations and diagnosis of Behçet s disease, 2013 Uptodate 7. Treatment of Behçet s disease, 2013 Uptodate 8. The American Behçet s Disease A sociation
103 1-103 3 ( ) ( ) Tinten 500mg (Acetaminophen) (OTINT) Paramol 500mg (Acetaminophen) (OPAR01) 1. Bambec 10mg (Bambuterol) (OBAM) Lamvita (Bcomplex)20ml (ILAM) ENT Ointment 3.5g/tube (TENT) Zinc oxide 28.4g/tube (Zinc oxide) (TZINC) B.B. Lotion 100ml (Benzyl benzoate ) (TBBL) Glucal Black inj. 5ml/Amp (IGLUC) Baburol 10mg (Bambuterol) (OBAB) Anvita (Bcomplex)20ml (IANV) ENT Ointment g/tube (TENT01) ZINC oxide()28.4g/tub e (Zinc oxide) (TZINC-1) Jalin Lotion 60mL (Benzyl benzoate ) (TJAL) Calglon10% 10ml/Amp (ICAL01) 2. 1. 2. 1. 2. 3. Thiamine 100mg,Pyridoxine 200mg, B12 2mg/20ml 2 1. 2. 1. 2. 3. 1. 2. 3. Benzyl benzoate 250mg/mL60mL/Bot 1. 2. Calglon 10% 10ml Glucal Black inj 5ml
Panacal 30mg/ml/Amp (Diphenhydramine) (IPANA) Quimadine F.C. 20mg (Famotidine) (OQUI) ABIPLATIN 50mg/100ml (Cisplatin) (IABI50) Diphenhydramine 30mg/ml/Amp (Diphenhydramin e) (IDIPH) Famotidine F.C. 20mg (Famotidine) (OFAMO) Cisplatin 50mg/50ml (Cisplatin) (ICIS) 1. 2. 1. ( stress ) Zollinger-Ellison 2. 1. 2. ( ) ( ) Glucobay 50mg (Acarbose) (OGLUC) Glucobay 100mg (Acarbose) (OGLU100) 1. 2. Ferrum Hausmann tab 100mg (Fe(OH)3 polymaltose complex) (OFER) La Ferrum 100mg(Fe(OH)3 polymaltose complex) (OLAF01) 3. Acarbose 100mg/tab 1. 2. ( ) Neulasta 6mg (Pegfilgrastim) 1. (INEU) 2. Pegfilgrastim6mg/syri. Levemir300 Units/3ml 1.
(ILEV02) Brilinta F.C 90mg (Ticagrelor) (OBRIL) Neupro transdermal patch 6mg/24H (Rotigotine) (TNEU) 2. Insulin Detemir300 Units/3ml/vial 1. BrilintaAspirin ( ST ST ) Clopidogrel Brilinta Brilinta BrilintaAspirin Aspirin 100 mg 2. Ticagrelor90mg/tab 1. 2. Rotigotine6mg/24H/patch ( ) REVLimid mg (Lenalidomide) 1. Revlimiddexamethasone (OREV15) (multiple myeloma, MM) 2. Lenalidomide15mg/cap Giotrif 40mg (Afatinib dimaleate) 1. GIOTRIF EGFRTK (OGIO30) (NSCLC) 2. Afatinib dimaleate40mg/tab Duratocin100mcg/mL (Carbetocin) 1. (IDUR) 2. Carbetocin100mcg/mL1mL/amp Feburic 80mg (Febuxostat) 1. (OFEB) 2. Febuxostat80mg/tab Bicillin 2.4 Miu/4mL/Syringe 1. (IBIC01) 2. Penicillin G benzathine2.4 Miu/4mL/Syringe 3.