3 1005-2216 2014 01-0003 - 05 杨 孜 子 痫 前 期 ; 预 测 Keywords: pre-eclampsia; prediction R714. 24 + 4 C tion 10. 12 P = 0. 000 OR 2. 95 95% CI 1. 74 ~ 4. 26 P = 0. 007 4 - pre-eclampsia Pl- GF VEGF -1 sflt-1 Endoglin seng Ⅲ β 2 DNA 1 sflt-1 seng VEGF PlGF sflt-1 PIGF sflt-1 /PIGF 1 2 2006 1 1. 1 predic- 81370723 7132215 100191 Zi_yagn@ email. com sflt 2012 3 PIGF OR 7. 64 95% CI 5. 34 ~
4 2014 1 30 1 5 2008 1g 6-7 16 75 ~ 100 mg /d 10 2010 National Institute for Health and Clinical Excellence NICE 12 75 mg 11 80% 20 80 1 Meta 12-14 1. 2 1 10% 25 ~ 150mg 8 32 20 34 8 2 20 30 C E 2. 1 20 30 9 C E 10-11 15 2012 Cochrane Library 2006 Lancet C E 16 2410 25 5- C 1000 mg E 267 mg
5 BMI > 30 HELLP APS 18 ~ 22 C E APS C E L- 25 ~ 150 mg C 100 ~ 1000 mg E 5 ~ 250 mg C E 17-18 CO H 2 S 1999 22 19 20 21 21 2. 2. 2 2007 2013 ESH 2. 2 ESC 130 ~ 139mmHg 2. 2. 1 1mmHg = 0. 133kPa 85 ~ 89mmHg 2003 120 ~ 130mmHg 80 ~ 90mmHg prehypertension 23 - - APS 11 80 ~ 100mmHg < 150mmHg 37 150 /100mmHg
6 2014 1 30 1-2. 2. 3 16 2005 2 PRECOG 2 3 4 20 3. 2 2009-1 15 24-25 3 24-25 3. 1 - - 26 prediction screening
櫚 櫚 櫚 櫚 櫚 櫚 櫚 櫚 櫚 櫚 櫚 櫚 櫚 櫚 櫚 櫚 櫚 櫚 櫚 櫚 櫚 櫚 櫚 櫚 櫚 櫚 櫚 櫚 櫚 櫚 櫚 櫚 櫚 櫚 櫚 櫚 櫚 櫚 櫚 櫚 櫚 櫚 櫚 櫚 櫚 櫚 櫚 櫚 櫚 櫚 櫚 櫚 櫚 櫚 櫚 櫚 櫚 櫚 櫚 櫚 櫚 櫚 櫚 櫚 櫚 櫚 櫚 櫚 櫚 櫚 櫚 櫚 櫚 櫚 櫚 櫚 櫚 櫚 櫚 櫚 7 preeclampsia in low-risk nulliparous women J. Obstet Gynecol 2012 119 6 1234-1242. 3 Loire P Vicaut E Cruaud P et al. Limited value of angiogenic factors in obese women M. Pregnancy Hypertension An International Journal of Women's Cardiovascular Health 2012 2368-2370. 4 Ghosh SK Raheja S Tuli A et al. Serum placental growth factor as a predictor of early onset preeclampsia in overweight / obese pregnant women J. J Am Soc Hypertens 2013 7 2 137-148. 5. - J. 2003 4 2 83-89. d on incidence of pregnancy toxaemia J. Lancet 1937 2 1397-1399. 10 Magee LA Helewa M Moutquin JM et al. Diagnosis evaluation and management of the hypertensive disorders of pregnancy J. J Obstet Gynaecol Can 2008 30 S1-48. 11 Visintin C Mugglestone MA Almerie MQ et al. Management of hypertensive disorders during pregnancy summary of NICE guidance J. BMJ 2010 340 c2207. 12 Coomarasamy A Honest H Papaioannou S et al. Aspirin for prevention of preeclampsia in women with historical risk factors a systematic review J. Obstet Gynecol 2003 101 1319-1332. 13 Askie LM Duley L Henderson-Smart DJ et al. Antiplatelet a- gents for prevention of pre-eclampsia a meta-analysis of individual patient data J. Lancet 2007 369 1791 1798. 14 Bujold E Roberge S Lacasse Y et al. Prevention of preeclampsia and intrauterine growth restriction with aspirin started in early pregnancy a meta-analysis J. Obstet Gynecol 2010 116 402-414. 1. 15 Lowe S Brown M Dekker G et al. Guidelines for the management of hypertensive disorders of pregnancy australia and new 2 Myatt L Rebecca G Clifton et al. First-trimester prediction of Zealand J. Aust U Z J Obstet Gyneacol 2009 J. 2011 7 385-389. 49 242-246. 16 Poston L Briley AL Seed PT et al. Vitamin C and vitamin E in pregnant women at risk for pre-eclampsia VIP trial randomised placebo-controlled trial J. Lancet 2006 367 1145-1154. 17 Brion LP Bell EF Raghuveer TS. Vitamin E supplementation for prevention of morbidity and mortality in preterm infants J. Cochrane Database of Syst Rev 2003 3 CD003665. 18. E J. 2011 37 61-63. 19 Chappell LC Seed PT Briley AL et al. Effect of antioxidants on the occurrence of pre-eclampsia in women at increased risk a randomised trial J. Lancet 1999 354 810-816. 6. 20 Vadillo-Ortega F Perichart-Perera O Espino S et al. Effect of J. 2006 9 10-14. supplementation during pregnancy with L-arginine and antioxi- 7. dant vitamins in medical food on pre-eclampsia in high risk J. 2005 40 302-305. population randomised controlled tria J. BMJ 2011 342 8 Ma RQ Sun MN Yang Z. Effects of preeclampsia-like symptoms d2901. at early gestational stage on feto-placental outcomes in a mouse 21 Costantine MM Cleary K. Eunice kennedy shriver national institute of child health and human development obstetric--fetal 9 Theobald GW Camb MD. Effect of calcium and vitamins a and pharmacology research units network pravastatin for the model J. Chin Med J Engl 2010 123 6 707-712. prevention of preeclampsia in high-risk pregnant women J. Obstet Gynecol 2013 121 349-353. 22 Cindrova-Davies T Herrera EA Niu Y et al. Reduced cystathionine γ-lyase and increased mir-21 expression are associated with increased vascular resistance in growth-restricted pregnancies hydrogen sulfide as a placental vasodilator J. Am J Pathol 2013 182 1448-1458. 23 Bertoia ML Waring ME Gupta PS et al. Implications of new hypertension guidelines in the United States J. Hypertension 2012 60 639-644. 24. J. 2009 44 337-340. 25. J. 2009 24 2768-2771. 26. 191 J. 2006 22 828-831. 2013-10 - 15 櫚 櫚 櫚 櫚 欢 迎 投 稿 欢 迎 订 阅