聯絡方式 Name: 陳玉昆 E-mail:yukkwa@kmu.edu.tw Tel:7-311101~7007 現職 高雄醫學大學牙醫學系系主任自 018/08 至 高雄醫學大學牙醫學系教授自 015/0 高雄醫學大學附設醫院口腔病理暨顎顏面影像科主任自 004/0 高雄醫學大學附設醫院牙科部主治醫師自 1994/08 至 學歷 高雄醫學大學牙醫學研究所碩士自 1987/09 至 1990/06 高雄醫學大學牙醫學系學士自 1980/09 至 1986/06 經歷 高雄醫學大學牙醫學系系主任自 018/08 至 高雄醫學大學牙醫學系系主任 ( 代理 ) 自 018/0 至 018/07 高雄醫學大學牙醫學系教授自 015/0 至
高雄醫學大學牙醫學系副教授自 009/08 至 015/01 高雄醫學大學牙醫學系助理教授自 003/0 至 009/07 高雄醫學大學牙醫學系講師自 1998/10 至 003/01 高雄醫學大學附設醫院牙科部主治醫師自 1994/08 至 研究專長及領域 口腔病理組織學 口腔腫瘤 口腔影像學 口腔診斷 著作目錄 期刊論文 ( 依年度排序, 最新的排前面 )* 通訊作者 1. Chen CY, Chen YK, Wang WC, Hsu HJ*. Ectopic third molar associated with a cyst in the sigmoid notch. J Dent Sci 018;13(): 17-4 (SCI).. Chiu HL, Wei YW, Wang WC, Chen YK*. Simple and effective methods to protect the photostimulable phosphor storage plate sensor. J Dent Sci 018;13(1): 85-6 (SCI). 3. Chen JH, Tseng CH, Wang CC, Chen YC, Cheong FH, Chen YK*. Clinicopathological analysis of 3 radicular cysts of the jawbone in a population of southern Taiwanese patients. Kaohsiung J Med Sci 018;34: 49-54 (SCI). 4. Huang HY, Wang WC, Lin PY, Huang CP, Chen CY, Chen YK*. The roles of autophagy and hypoxia in human inflammatory periapical lesions. Int Endod J 018;51(S): e15-e145 (SCI). (The first two authors have equal contribution) 5. Liao PH, Wang YY, Wang WC, Chen CH, Kao YH, Hsu JW, Chen CY, Chen PH, Yuan SS*, Chen YK*. Overexpression of sprouty in human oral squamous cell carcinogenesis. Arch Oral Biol 018; 87(3): 131-4 (SCI). 6. Wang YY, Hsieh PW, Chen YK, Hu SC, Hsu YL, Tsai CH, Yuan SF*.CYT-Rx0 inhibits cervical cancer cell growth and migration through oxidative stress induced DNA damage, cell apoptosis and epithelial-to-mesenchymal transition inhibition. Int J Gynecol Cancer 017; 7(7): 1306-17 (SCI). 7. Huang HY, Chen YK, Ko EC, Chuang FH, Chen PH, Chen CY, Wang WC*. Retrospective analysis of
nonendodontic periapical lesions misdiagnosed as endodontic apical periodontitis lesions in a population of Taiwanese patients. Clin Oral Investig 017; 1(6): 077-8 (SCI). (The first two authors have equal contribution) 8. Wang YY, Chen YK, Hu SC, Hsu YL, Tsai CH, Chi TC, Huang WL, Hsieh PW, Yuan SF*. CYT-Rx0 inhibits ovarian cancer cells in vitro and in vivo through oxidative stress-induced DNA damage and cell apoptosis. Cancer Chemother Pharmacol 017; 79(6):119-40 (SCI). 9. Wang YY, Chen YK, Hsu YL, Chiu WC, Tsai CH, Hu SC, Hsieh PW, Yuan SF*. Synthetic β-nitrostyrene derivative CYT-Rx0 as inhibitor of oral cancer cell proliferation and tumor growth through glutathione suppression and reactive oxygen species induction. Head Neck 017; 39(6): 1055-64 (SCI). 10. Lin YM, Ko EC, Chen YK, Chen CY, Chen CH*. Hemangioendothelioma of the oral cavity- mimics cystic lesion- A case report. Taiwan J Oral Maxillofac Surg 016; 7(3): 11-. 11. Chiang MC, Chen PH, Chen YK, Chen CH, Ho ML, Wang YH*. Characterization of a novel dermal fibrosis model induced by areca nut extract that mimics oral submucous fibrosis. PLoS One 016 Nov 16;11(11): e0166454 (SCI). 1. Wang WC, Chen CY, Hsu HK, Lin LM, Chen YK*. Chemopreventive effect of Toona Sinensis leaf extract on 7,1-dimethylbenz[a]anthracene-induced hamster buccal pouch squamous cell carcinogenesis. Arch Oral Biol 016; 70: 130-4 (SCI). 13. Chen YK, Huang AH*, Chan AW, Lin LM*. Human dental pulp stem cells derived from cryopreserved dental pulp tissues of vital extracted teeth with disease demonstrate hepatic-like differentiation. J Tissue Eng Regen Med 016; 10: 475-85 (SCI). 14. Wang WC, Chen CY, Hsu HJ, Kuo JH, Lin LM, Chen YK*. Sialolithiasis of minor salivary glands: A review of 17 cases. J Dent Sci 016; 11: 15-5 (SCI). 15. Cheng YW, Huang LL, Kao YH. Ko EC, Chen YK, Chen YF*. Taiwan J Oral Maxillofac Surg 016; 7(1): 30-7. 16. Lei F, Chen JY, Wang WC, Lin LM, Huang HC, Ho KY, Chen YK*. Retrospective study of oral and maxillofacial lesions in older Taiwanese patients. Gerodontology 015; 3: 81-7 (SCI). 17. Chen CY, Sung CL, Hiseh MY, Wang WC, Chen YK*, Lin LM. Adult juvenile xanthogranuloma in the buccal mucosa - a case report. J Dent Sci 015; 10: 334-7 (SCI). 18. Chen JCH, Chen YK, Wang CK*. Prevalence of ponticuli posticus among patients referred for dental examinations by cone-beam CT. The Spine J 015; 15: 170-6 (SCI). 19. Lei F, Chen JY, Lin LM, Wang WC, Huang HC, Chen CH, Ho KY*, Chen YK. Retrospective study of biopsied oral and maxillofacial lesions in pediatric patients from southern Taiwan. J Dent Sci 014; 9: 351-8 (SCI). (Ho KY and Chen YK have equal contribution) 0. Chen PH, Huang B, Shieh TY, Wang YH, Chen YK, Wu JH, Huang JH, Chen CC*, Lee KW*. The influence of monoamine oxidase variants on the risk of betel quid-associated oral and pharyngeal cancer. Sci World J 014; 014: 183548 (SCI). 1. Wang YY, Tail YH, Wang WC, Chen CY, Kao YH, Chen YK*, Chen CH*. Malignant transformation in 5071 southern Taiwanese patients with potentially malignant oral mucosal disorders. BMC Oral Health 014; 14: 99 (SCI).. Lei F, Chen PH, Chen JY, Wang WC, Lin LM, Huang HC, Ho KY, Chen CH, Chen YK*. Retrospective study of biopsied head and neck lesions in a cohort of referral Taiwanese patients. Head Face Med 014; 10: 8 (SCI). 3. Chen JY, Wang WC, Lin LM, Chen YK*. Incidental detection of a rare inverted and impacted maxillary third molar in a patient of mandibular unicystic ameloblastoma. Dentistry 014; 4: 13. 4. Chen JCH, Wang CK, Lin LM, Huang YD, Geist JR*, Chen YK*. Retrospective comparison of the frequency, distribution and radiographic features of osteosclerosis of the jaws between Taiwanese and American cohorts using cone-beam computed tomography. Oral Radiol 014; 30: 53-63 (SCI). 5. Chen YK, Huang AH, Lin LM*. Sphere-forming-like cells (squamospheres) with cancer stem-like cell traits from VX rabbit buccal squamous-cell carcinomas. Int J Oral Sci 014; 6: 1-8 (SCI). 計劃編號 : NSC 99-314-B-037-048, NSC 100-314-B-037-048 6. Chen JCH, Lin LM, Chen CH, Geist JR*, Chen YK*.Evaluation of cancellous bone density in the alveolar bone by cone-beam computed tomography in Taiwanese adults. Asian Biomed 013; 7: 753-60 (SCI).
7. Chen JCH, Lin LM, Geist JR, Chen JY, Chen CH*, Chen YK*. A retrospective comparison of the location and diameter of the inferior alveolar canal at the mental foramen and length of the anterior loop between American and Taiwanese cohorts using CBCT. Surg Radiol Anat 013; 35: 11-8 (SCI). (First two authors have equal contribution) 8. Tang JY, Hsi E, Huang YC, Hsu NC, Chen YK, Chu PY, Chai CY*. ATG9A overexpression is associated with disease recurrence and poor survival in patients with oral squamous cell carcinoma. Virchows Arch 013; 463: 737-4 (SCI). 9. Chen CY, Wu CW, Wang WC, Lin LM, Chen YK*. Clear-cell variant of calcifying epithelial odontogenic tumor (Pindborg tumor) in the mandible. Int J Oral Sci 013; 5: 115-9 (SCI). 30. Chen YK, Huang AH, Cheng PH, Yang SH*, Lin LM*. Overexpression of Smad proteins, especially Smad7, in oral epithelial dysplasias. Clin Oral Investig 013; 17: 91-3 (SCI). 計劃編號 : NSC 97-314-B-037-05-MY3 研究計劃 序號 計畫名稱 補助或委託機構 執行期限 執行情形 經費總額 計畫內擔任的工作 1 Orai 與 STIM 表現與人類口腔鱗狀細胞癌預後之相關性探討 MOST 107-314-B-037-045 - 科技部 107/08/01-108/07/31 執行中 1,000,000 主持人 Sprouty 1 與 Sprouty 4 表現與人類口腔鱗狀細胞癌化預後之相關性探討 (/)MOST105-314-B-037-033-MY 科技部 106/08/01-107/07/31 執行中 1,105,000 主持人 3 Sprouty 1 與 Sprouty 4 表現與人類口腔鱗狀細胞癌化預後之相關性探討 (1/)MOST105-314-B-037-033-MY 科技部 105/08/01-107/07/31 已結案 1,070,000 主持人 4 Sprouty 表現與人類口腔鱗狀細胞癌預後之相關性研究 MOST104-314-B-0 37-058 科技部 104/08/01-105/07/31 已結案 1,00,000 主持人 5 分析口乾症病人唾液胜肽與功能, 開發口乾症之分子診斷 預防 促進口腔健康與咀嚼吞嚥機能之方法 MOST107-314-B-468-007 科技部 107/08/01-108/07/31 執行中 80,000 共同主持人 6 探討 DNA 修復蛋白 MRE11 在口腔癌轉移過程中扮演的角色 MOST107-314-B-037-007 科技部 107/01/01-1071031 執行中 650,000 共同主持人
序號 計畫名稱 補助或委託機構 執行期限 執行情形 經費總額 計畫內擔任的工作 7 以生物路徑為導向結合蛋白質體學分析來篩選口腔癌癌化 發生與預後相關的基因 MOST105-314-B-037-01 科技部 105/08/01-107/07/31 已結案 1,00,000 共同主持人 8 藉由唾液中之生物標識開發男性口腔癌的早期檢測與預後評估方法 MOST106-314-B-037-01 科技部 105/08/01-107/07/31 已結案 85,000 共同主持人 9 單胺氧化酶 (MAO) 與兒茶酚氧位甲基轉移酶 (COMT) 在檳榔致口腔及咽癌化中所扮演的角色及分子機轉 MOST106-314-B-037-014 科技部 105/08/01-107/07/31 已結案 955,000 共同主持人 10 嚼檳榔者相關口腔惡性病變探討 : 檳榔 - 基因之聯合效應與代謝體學應用 MOST104-314-B-037-040 科技部 104/08/01-105/07/31 已結案 650,000 共同主持人 11 以動物及細胞試驗建立檳榔萃取物誘發之口腔黏膜下纖維化及口腔癌並研究細胞激素 IL-6 在纖維化 / 癌化過程的影響 MOST104-314-B-037-059-MY 科技部 104/08/01-105/07/31 已結案 1,860,000 共同主持人 1 提升口腔癌前病變及口腔癌診斷率之整合性研究 MOHW107-TDU-B-1-114016 衛福部 107/01/01-110/1/31 執行中 60,000,000 分項計畫主持人 13 以改善患者存活及生活品質為中心思考的整合性癌症轉譯研究 MOHW106-TDU-B-1-144007 衛福部 10/01/01-106/1/31 已結案 10,000,000 分項計畫主持人