* 100850 2003 3 SARS-CoV 2002 Severe Acute Respiratory Syndrome SARS SARS-CoV SARS-CoV 5 S E M N SARS-CoV SARS-CoV IBV TGV IBV E M SARS Severe Acute Respiratory Syndrome 2002 * 30080017,30270315 1
2003 3 SARS-CoV 1-3 RNA 1 2 3 HCoV-229E 1 HCoV-OC43 2 1 SARS-CoV 5 [rep] [S] [E] [M] [N] 3 rep 2/3 rep 4 S E M N 1 SARS GenBank 16 2 IBV IBV BCK 4 BCoV BCoV Q BCoV ENT BCoV LUN 1 HCoV 229E 4 MHV MHV2 MHV Penn 97 1 MHV ML10 1 PEDV 1 TGV SARS 3 SARS Urbani SARS CUHK W1 SARS canada 1 ClustalX(V1.8) 4 2
Bootstrap Neighbor Joining method Tree-Explore 5 S E M N SARS 3
1 SARS GenBank ACCESSION bp 01 AJ311317 IBV BCK 27635 Avian infectious bronchitis virus (strain Beaudette CK) complete genomic RNA. 02 NC_001451 IBV 27608 Avian infectious bronchitis virus, complete genome. 03 AF220295 BCoV Q 31100 Bovine coronavirus strain Quebec, complete genome. 04 AF391541 BCoV ENT 31028 Bovine coronavirus isolate BCoV-ENT, complete genome. 05 AF391542 BCoV LUN 31028 Bovine coronavirus isolate BCoV-LUN, complete genome. 06 NC_003045 BCoV 31028 Bovine coronavirus, complete genome. 07 NC_002645 HCoV 229E 27317 Human coronavirus 229E, complete genome. 08 AF201929 MHV 2 31276 Murine hepatitis virus strain 2, complete genome. 09 AF208066 MHV Penn 97 1 31112 Murine hepatitis virus strain Penn 97-1, complete genome. 10 AF208067 MHV ML 10 31233 Murine hepatitis virus strain ML-10, complete genome. 11 NC_001846 MHV 31357 Murine hepatitis virus, complete genome. 12 NC_003436 PEDV 28033 Porcine epidemic diarrhea virus, complete genome. 13 NC_002306 TGV 28586 Transmissible gastroenteritis virus, complete genome. 14 AY278554 SARS CUHK W1 29736 SARS coronavirus CUHK-W1, complete genome. 15 AY278741 SARS Urbani 29727 SARS coronavirus Urbani, complete genome. 16 NC_004718 SARS canada 29736 SARS coronavirus, complete genome. 4
1. SARS-CoV (a) (b) 1 (a) SARS-CoV (b) SARS-CoV 5
SARS-CoV 13 1-a 2 BCoV MHV 1 HCoV-229E PEDV TGV 3 IBV SARS-CoV 1-b SARS-CoV IBV 2. SARS-CoV SARS-CoV 5 SARS-CoV 2 (a1) 6
(a2) (b1) 7
(b2) (c1) 8
(c2) (d1) 9
(d2) (e1) 10
(e2) 2 5 a b c d e rep S E M N 1 SARS-CoV 2 SARS-CoV 11
rep S E M N N 1 SARS-CoV rep S E M N S M SARS-CoV IBV E SARS-CoV TGV N TGV SARS-CoV SARS-CoV TGV SARS-CoV N rep 5 SARS-CoV 3. SARS-CoV SARS-CoV 5 SARS-CoV 3 (a1) 12
(a2) (b1) 13
(b2) (c1) 14
(c2) (d1) 15
(d2) (e1) 16
(e2) 3 5 a b c d e rep S E 17
M N 1 SARS-CoV 2 SARS-CoV rep S M N E 1 3 3 IBV 1 TGV SARS-CoV rep S E M N E IBV TGV SARS-CoV E M SARS-CoV M IBV rep S N 5 SARS-CoV SARS-CoV IBV TGV E M SARS-CoV SARS-CoV IBV TGV IBV E M 1 P. A. Rota et al. (2003) Characterization of a Novel Coronavirus Associated with Severe Acute Respiratory Syndrome. Published online May 1, 2003; 10.1126/science.1085952 18
(Science Express Research Articles) 2 S. M. Poutanen et al. (2003) Identification of Severe Acute Respiratory Syndrome in Canada. N. Engl. J. Med. Available April 17 at http://nejm.org/earlyrelease/sars.asp#4-2. 3 T. G. Ksiazek, et al. (2003) A Novel Coronavirus Associated with Severe Acute Respiratory Syndrome N. Engl. J. Med. 348(20):1947-1958 4 Thompson,J.D., Gibson,T.J., Plewniak,F., Jeanmougin,F. and Higgins,D.G. (1997) The ClustalX windows interface: flexible strategies for multiple sequence alignment aided by quality analysis tools. Nucleic Acids Research, 24:4876-4882. 5 Tree-Explore program was downloaded from http://evolgen.biol.metro -u.ac.jp/te/te_man.html. 19