1. 2. DNA
RNA 3. cell cycle nonspecific agents CCNSA cell cycle specific agents, CCSA
growth fraction GF GF CCNSA CCSA
DNA DNA RNA DNA
natural resistance acquired resistance multidrug resistance MDR
DNA
P-glucoproteinP-p drug efflux pump
S 1. methotrexate methotrexatemtx FH 2 fi FH 4 fi fidna
fi 2. 2. fluorouracil fluorouracil 5-FU FU 5F-dUMP dump fi DNA DNA 3. 3. mercaptopurine mercaptopurine 6-MP MP S
hydroxycarbamide hydroxycarbamide HU HU fi fi DNA DNA S G 1 5. 5. DNA DNA cytarabine cytarabine Ara Ara-C DNA DNA DNA DNA fi
alkylating agents fidna DNA DNA
cyclophosphamide cyclophosphamide CTX CTX thiotepa thiotepa TSPA TSPA busulfan busulfan carmustine carmustine 2. 2. DNA DNA cisplatin cisplatin carboplatin carboplatin
DNA DNA mitomycin mitomycin C DNA DNA DNA DNA bleomycin bleomycin BLM BLM fi fidna DNA fi DNA DNA G 2
camptothecine CPT DNA DNA
dactinomycin dactinomycin DNA DNA RNA RNA RNA RNA mrna mrna doxorubicin doxorubicin adriamycin adriamycin daunorubicin daunorubicin rubidomycin rubidomycin
M RNA G vinblastine vinblastine vincristin vincristin vindesine vindesine
fi M paclitaxel paclitaxel taxotere taxotere 2. harringtonine harringtonine homoharringtonine homoharringtonine
aminoglutethimideag arsenic trioxideast