33 J Chin Med 14(1): 33-45, 2003 1 2,3 4 1 2 3 4 (2002 9 12 2002 12 24 2002 12 25 ) KENLU model.k-300 TOSHIBA SSA-270A 1 2 3 4 50 04-22340047 04-22342508E-mail jcmt22@ms38.hinet.net
34 5 6 7 8 9 10 1 2 3 140/90 mmhg4 5 6
35 Araliaceae Panax ginseng C.A. Meyer. Liliaceae Ophiopogon japonicus Ker-Gawl. Magnoliaceae Schizandra chinensis Baill. 11-15 1 KENLU model.k-300 Supine position Korotkoff sound Korotkoff sound Korotkoff Systolic Blood Pressure Diastolic Blood Pressure DBP +SBP DBP/3 Mean Arterial Pressure 2 TOSHIBA Sonolayer SSA-270A 5 R-R Heart Rate 3 TOSHIBA Sonolayer SSA-270A Left semilateral position 2.5 MHz Left parasternal long axis view M 50 mm/sec M- R- LV End Diastolic Diameter LV End Systolic Diameter LVEDD-LVESD 100 % / LVEDD Fractional shortening Teichholz LV End Diastolic Volume & LV End Systolic Volume LVEDV-LVESV Stroke Volume LVEDV-LVESV 100 % / LVEDV Ejection fraction Cardiac Output MAP 80/ CO Peripheral Resistance
36 A0A1A2.A8 Wilcoxon Signed-Rank Test An-A0/ A0 Mann-Whitney U test 1 () P < 0.01 P < 0.01 P < 0.05 P < 0.01 P < P < 0.05 P < 0.05 P < 0.01P < 0.05 1 () P < 0.05 P < 0.01 3 P < 0.05 2 () P < 0.05 P < 0.01 P < 0.05 P < 0.05P < 0.01 P < 0.05 3
37 1 / n = 15 n = 15 28.7 ± 3.4 28.2 ± 2.7 164.9 ± 8.2 167.6 ± 7.1 58.9 ± 10.2 62.5 ± 8.8 / 11 / 4 11 / 4 mmhg 15.5 ± 10.3 114.0 ± 13.7 mmhg 68.9 ± 8.9 72.3 ± 9.3 / 70.0 ± 10.6 74.27 ± 10.8 mm 48.47 ± 4.64 45.33 ± 3.56 mm 30.47 ± 4.26 28.53 ± 3.25 % 67.10 ± 5.30 66.80 ± 6.40 % 37.26 ± 4.98 37.15 ± 4.05 1.38 ± 0.37 1.53 ± 0.37 mmhg () mmhg () () () n-1 n 1
38 2 HR 70.0 ± 10.6 74.3 ± 10.8 10 66.5 ± 10.8 * 73.5 ± 9.0 # 20' 66.0 ± 9.4 ** 69.7 ± 7.4 ** 30' 66.1 ± 11.1 * 71.1 ± 7.1 * 40' 65.3 ± 10.1 ** 70.9 ± 8.2 60' 62.5 ± 9.2 ** 70.4 ± 7.3 * 90' 61.6 ± 9.2 ** 69.5 ± 7.2 * 120' 62.5 ± 8.1 ** 69.9 ± 8.1 * Wilcoxon Signed-Rank Test*P < 0.05 **P < 0.01 Mann-Whitney U test#p < 0.05 3 Fs 37.3 ± 5.0 37.2 ± 4.1 66.8 ± 6.4 67.1 ± 5.3 10' 37.5 ± 5.1 38.1 ± 4.4 * 67.1 ± 6.5 68.1 ± 5.7 * 20' 37.2 ± 6.1 38.6 ± 4.6 ** # 66.6 ± 7.7 68.7 ± 5.9 ** # 30' 37.2 ± 6.1 38.6 ± 4.6 * 67.6 ± 6.3 68.7 ± 5.3 ** 40' 37.4 ± 5.6 39.1 ± 3.6 ** ## 66.8 ± 7.1 69.4 ± 4.7 ** ## 60' 37.4 ± 5.5 39.3 ± 3.9 ** # 67.0 ± 7.0 69.6 ± 5.0 * # 90' 38.0 ± 5.1 38.7 ± 3.4 * 67.5 ± 6.6 69.0 ± 4.4 * 120' 38.1 ± 5.2 * 38.6 ± 4.0 * 67.5 ± 6.7 * 68.3 ± 4.4 * Wilcoxon Signed-Rank Test*P < 0.05 **P < 0.01 Mann-Whitney U test#p < 0.05 ##P < 0.01 EF () P < 0.05 P < 0.05 4 P < 0.01 P < 0.01 P < 0.05 P < 0.05 P < 0.05 P < 0.001 2 P < 0.01 P < 0.05 P < 0.05 P < 0.05 P < 0.01 3 P < 0.01 P < 0.001 2
39 4 LVEDD 48.5 ± 4.6 45.3 ± 3.6 10' 48.5 ± 4.6 45.57 ± 3.4 20' 48.5 ± 4.5 45.6 ± 3.6 30' 48.5 ± 4.7 45.6 ± 3.6 40' 48.3 ± 4.4 46.0 ± 3.9 * # 60' 48.4 ± 4.3 45.9 ± 4.2 90' 48.5 ± 4.2 46.2 ± 4.3 * # 120' 48.5 ± 4.2 46.3 ± 4.2 * # Wilcoxon Signed-Rank Test*P < 0.05 **P < 0.01 Mann-Whitney U test#p < 0.05 mmhg () mmhg/ml/min () () () n-1 n 2
40 2 16 17 221 18 19 20 21 533 532 22 86.7 % 63.3 % 23 24 25 86.7 % 73.3 % 26 EF CO FS EF MVV RFF IVR 27 28 263
41 Preload Afterload Contractility 29-31 LVEDD Preload 32 Volume Pressure M-mode Fs EF Performance Afterload LV systolic wall stress Systemic vascular resistance Reciprocal action 33 34 Poiseuille 35 R = η γ 36 37
42 38 39 40 41 42 1995 43 1996 44 1997 45 1997 46 5/15
43 1. 203201996 2. pp.6797-67991975 3. p.81985 4. p.171989 5. 8659-6591996 6. 71891987 7. 1524-261984 8. 1650-541997 9. 125-81984 10. pp.1071985 11. 30412-4171992 12. pp.389-3961983 13. pp.11-121990 14. 13pp.273-277 15. pp.120-1231987 16. p.3161982 17. 3p.221 18. p.381974 19. p.3461980 20. p.361984 21. p.1291982 22. 2623-241998 23. 2125-261999 24. 17154-1561998 25. 104871999 26. 5112-1131998 27. 511-121993
44 28. 1989 pp.11-13 29. Joseph G. Murphy: Mayo Clinic cardiology review. Lippincott Williams & Wikins, Philadelphia, pp.30, 2000. 30. Gravanis M. B: Cardiovascular pathophysiology, Maryland Composition company, Inc. pp. 381-385, 1987. 31. David McCall, S. H. Rahimtoola: Heart failure, Chapman & hall, New York, pp.15-18, 1995. 32. Takahiko Miki, Yoshiyuki Yokota, Hisashi Fukuzaki: Afterload mismatch in patients with hypertrophic nonobstructive cardiomyopathy. Japanese Circulation Journal, Vol 54, June: 603-614, 1990. 33. pp.163-1641984 34. 10p.103 35. 10pp.17-19 36. Gravanis M. B: Cardiovascular pathophysiology. Maryland Composition company, Inc. p.3831987 37. p.31983 38. p.1991991 39. 37p.13 40. 38p.238 41. 37p.12 42. 38pp.246-247 43. 232951995 44. 11361996 45. 171881997 46. 19491997
45 J Chin Med 14(1): 33-45, 2003 EFFECT OF SHENG-MAI-SAN ON HUMAN BLOOD PRESSURE, HEART RATE AND LEFT VENTRICULAR PERFORMANCE Yao-Chin Hsu 1, Jung-Chou Chen 2,3, Lin MaoTsun 4 1 Department of Chinese Medicine, Chi-Mei Medical Center Tainan, Taiwan 2 School of Chinese Medicine, China Medical College Changhua, Taiwan 3 Department of Chinese Medicine, Show-Chwan Memorial Hospital Taichung, Taiwan 4 Medical Research Department, Chi-Mei Medical Center Tainan, Taiwan (Received 12 th September 2002, revised Ms received 24 th December 2002, accepted 25 th December 2002) Thirty volunteers matching the criteria of Healthy were recruited from the staff of China Medical College Hospital. Sheng-Mai-San was prescribed for the study group and Placebo to the control group. Effect of Sheng-Mai-San on human blood pressure, heart rate and left ventricular performance was evaluated before and after the administration of these agents. A Kenlu-model K-300 Sphygmomanometer, TOSHIBA SSA-270A echocardiography (M-mode) and electrocardiography were arranged for the detection and record of cardiovascular parameters. After taking Sheng-Mai-San, the study group showed reduction of the blood pressure and the peripheral resistance, in the meanwhile increase of the fractional shortening and the ejection fraction was noted. The result suggest that Sheng-Mai-San may be a potential cardiovascular activator to the the healthy, and it can promote the left ventricular performance by vasodilatation. Key words: Sheng-Mai-San, Healthy, Blood pressure, Heart rate and Left ventricular performance. Correspondce to: Chen Jung-Chou, Tel: 04-22340047, Fax: 04-22342508, E-mail: jcmt22@ms38.hinet.net