2002 9 1
2002 9 i-base Publications 2001 12 Introduction to Combination Therapy i-base Publications 2002 9 2
2002 9 HAART CD4 3
2002 9 HAART CD4 CD4 50 copies 500 copies 50 20 copies 4
2002 9 50 copies CD4 5
2002 9 CD4 300 CD4 200 CD4 300 CD4 200 PCP 100 CD4 CD4 200 CD 200 CD4 CD4 2001 2 6
2002 9 thymus 30 20 30 50 7
2002 9 45 http://www.hbroussais.fr 45 CD4 8
2002 9 CD4 CD4 100 CD4 CD4 10 CD4 9
2002 9 10
2002 9 Peripheral Neuropathy ddc ddi d4t ritonavir 3TC Hydroxyurea L-acetyl carnitine amino acid Lipodystrophy Protease Inhibitors NNRTIs X DEXA 11
2002 9 1) 2) 12
2002 9 Structured Treatment Interruptions 13
2002 9 CD4 6 12 14
2002 9 CD4 15
2002 9 16
2002 9 17
2002 9 ---- 2-3 ( ) 18
2002 9 30 14 19
2002 9 20
2002 9 95% 20 1 81% 95% 81% 90-95% 64% 80-90% 50% 70-80% 25% 70% 6% 400 copies 85% 50 copies 21
2002 9 - - - - - 25 22
2002 9 23
2002 9 24
2002 9 ddi (indinavir) (nelfinavir) (ritonavir) (saquinavir) 6 7 8 9 10 11 12 1 2 3 4 5 6 7 8 9 10 11 12 1 2 3 25
2002 9 + + 26
2002 9 6 2 3 2 3 27
2002 9 500 500 50 50 50 50 1 2 500 copies 3 4 50 copies 50 500 50 copies 28
2002 9 PIs NNRTIs 3 4 50 500 500 500 50 50 copies/ml 29
2002 9 30
2002 9 Nukes PI NNRTI 100,000 CD4 300 100,000 efavirenz 100,000 31
2002 9 300,000 nevirapine 100,000 CD4 35 A AZT d4t abacavir AZT 3TC ddi d4t (Neuropathy) mitochindrial ddi d4t 32
2002 9 RTIs PIs (indinavir/ritonavir) (saquinavir/ritonavir) ritonavir (indinavir) (saquinavir) amprenavir lopranavir Combivir Trizivir 33
2002 9 5 6 7 salvage treatment A B 34
2002 9 A B 2 1 1 2 * d4t+ddi** D4T+3TC AZT+ddI AZT+3TC PI NNRTI 2 indinavir nelfinavir ( ) saquinavir (lopinavir/r nevirapine efavirenz indinavir + ritonavir saquinavir + ritonavir amprenavir + ritonavir 2 x PIs * abacavir **d4t ddi lactic acidosis neuropathy 35
2002 9 ritonavir) nevirapine * RTIs Reverse Transcriptase Inhibitors d4t Zerit, stavudine 1 2 2 AZT Retrovir, zidovudine 1 2 2 ddi 100mg Videx, didanosine 2 4 1 4 ddi 200mg ddi ddi / 2 1 2 1 1 1 3TC Epivir, lamivudine 1 2 2 abacavir Ziagen, 1592 1 2 2 (ddc) Hivid, zalcitabine 1 3 3 1 2 Combivir (AZT/3TC ) 1 2 2 (AZT/3TC/abacavir Trizivir 1 2 2 ) Tenofovir* Viread 1 1 1 36
2002 9 NNRTIs non-nucleoside Reverse Transcriptase Inhibitors efavirenz Sustiva 3 1 3 nevirapine Viramune 1 2 2 delavirdine* Rescriptor 6 2 12 PIs Protease Inhibitors indinavir Crixivan 2 3 6 2 1 Viracept (folm 5 2 10 nelfinavir coated) ritonavir Norvir 6 2 12 (saquinavir Fortovase, 8 2 16 SGC [ Invirase ] amprenavir Agenerase 8 2 16 Lopinavir/r Kaletra, ABT-378/r 3 2 6 37
2002 9 400mg/400mg 4 1 10 2 200mg/800mg 2 2 8 (ritonavir/indinavir 2 100mg/800mg 1 2 6 2 400mg/400mg 4 2 12 (ritonavir/saquinavir 2 100mg/1000m 1 10 22 (ritonavir/saquinavir g 2 1250mg/1200 5 6 22 (nelfinavir/saquinavir) mg 2 amprenavir 600mg/100mg 4 amprenavir 1 2 2 200mg ( ) Hydroxyurea Hydrea ddi d4t Interleukin-2 IL-2 CD4 5 I-L2 5 38
2002 9 1 2 503 02-23711406 1:00-6:00 39
2002 9 40