2HRZ/4HR 6 WHO 1991 IUATLD 1996 2HRZ/4H R 6 WHO 1991 IUATLD 1986 2S(OR E)HRZ/4H3R3 6 (1982,1991)WHO(1991) 2S(OR E)3H3R3Z3/4H3R3 6 IUHTLD(1986) (1991, ) 2SHRZ/6S2H2Z2 8 IUATLD(1986) 2S(OR E)HRZ/6HT 8 WHO(1991),IUATSD(1986) 2S(OR E)HRZ/6HE 8 WHO(1991) 2SHR/7HR 9 IRATLD(1986) (1982) 9HR 9 IUATLD(1986) (1982) 2SHP/10HP 12 IUATLD(1986) (1982) 2SHT/10HT 12 IUATLD(1986) (1982) 2 3 / / 8 300 15 750 10 600 10 600 15 1000 15 1000 30 2000 50 3500 25* 1200 40 2000 16 1200 20 12000 2 100 / /

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1 I(va) Lpl TG Lpl a( b.) Apoc Apoc CM VLDF 1/500 LDL LDL LDL VLDF - 1/10000 APOE -VLDL 1/100 VLDL-TG VLDL CM a. b. 1/100 APOB APOB LDL / APOAI VLDL 2 TC TG CM VLDL LDL HDL - a. b. -VLDL - -

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1 2

1 mg mg/d h Tolbutamide (D860) 500 250 2000 6 8 1 3 Chlorpropamide 125 125 375 36 60 1 250 Glyburide 2.5 1.25 15 10 24 1 3 Glipidide Glidazide Glibomaride Gilquidone Phenethylbiquanide Metformin 500 3000 5 5 30 6 12 1 3 2 4h,, 80 40 320 24 1 3, 25 25 50 12 1 3, 30 15 180 12 1 3 95%,5%, 25 25 75 6 7 2 3 75mg, 250 250 1500, (+), 5 6 2 3,

2 (h) (h) (h) 1/2 1 2 4 5 7 (regular) 1/2 1 2 4 5 7 (CZI) 1/2 1 2 4 12 16 (semilente) 1 4 6 12 24 28 (Lente) 1 2 6 12 24 28 (NPH) 4 8 14 24 36 (PZI) 4 8 18 24 36 (ultralente)