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4 542 J Diagn Concepts Pract 2013, Vol.12, No.5 潘家坪 1,2, 黄文强 1*, 沈利 2, 范宇平 1, 王羽 1, 阮井玲 1, 胡烨 1, 滕晓明 1 (1., ; 2., ) [ ] : (Ureaplasma urealyticum, Uu),, Uu :, Uu 96, Uu ( ) 2, 2 :96 Uu, Uu 86, 10 Uu (P=0.44,P=0.35); (P=0.65,P=0.78),Uu, (P=0.39,P=0.44) : Uu,Uu : ; ; :R446.5 DOI: /j.issn :A : (2013) Effect of urogenital Ureaplasma urealyticum infection on routine semen parameters PAN Jiaping 1,2, HUANG Wenqiang 1, SHEN Li 2, FAN Yuping 1, WANG Yu 1, RUAN Jingling 1, HU Ye 1, TENG Xiaoming Reproductive Medicine Center, Shanghai First Maternity and Infant Hospital, Tongji University School of Medicine, Shanghai , China; 2. Department of Pathogen Biology, Tongji University School of Medicine, Shanghai , China [Abstract] Objective: To study the effect of Ureaplasma urealyticum infection on routine semen parameters by comparing the semen parameters before and after treatment. Methods: Of 258 male partners of pre-pregnancy examination in reproductive medicine center of Shanghai First Maternity and Infant Hospital, after eliminating cases with other influencing factors, 96 cases of Ureaplasma urealyticum infected male partner were enrolled and divided into two groups according to the treatment outcome whether turned to negative or not turned to negative. Computer asisitant analysis of semen parameters before and after treatment were performed for comparing the sperm concentration and motility rate. Results: Ureaplasma urealyticum turned to negative in 86 cases (cured group) and remained positive in 10 cases (noncured group)after treatment. There was no significant difference in sperm concentration and motility before and after treatment in either the cured group (P =0.44,P =0.35)or non-cured group (P =0.65,P =0.78). There was no significant difference in sperm concentration and motility between the cured group and non-cured group after treatment (P=0.39,P= 0.44). Conclusions: Ureaplasma urealyticum infection has no obvious impact on semen parameters. The relationship between Ureaplasma urealyticum infection and male infertility need to be further explored. Key words: Ureaplasma urealyticum; Sperm concentration; Sperm motility,,uu, 1973 (Ureaplasma urealyticum,uu),, Uu DNA : ( ) : [email protected],,

5 %~42%); (PR) 32%(95% 31%~34%) Uu Uu 2012,, ,,48 h Uu ;,, Uu ( /ml) (CASA), SPSS x±s,, 96,P<0.05 Uu, g, 10 d, 7 d Uu Uu Uu, 25~62, 1, 1~3 (34±6),, 86 Uu ( ), 25~62, (34±6) ; 2~7 d, 10 Uu ( ), 28~37, (34±3) ;, (33.10±2.94) 10 6 /ml, ; (30.30±1.64)%; ; (36.27 ±2.85) 10 6 /ml, 37 (32.36±1.45)%, (28.11±4.87) 10 6 /ml, ( 31.66± CASA 2.13)%; (24.99±4.74) 10 6 /ml, 37, (30.30±4.33)% 5, (P=0.44,P=0.35); CASA /ml (P=0.65,P=0.78)( 1 2) (95% ~ ); (PR+NP) 40%(95% (P=0.39,P=0.44)( 3) 1 ( 10 6 /ml) P (%) P ± ± ± ± ( 10 6 /ml) P (%) P ± ± ± ± ( 10 6 /ml) P (%) P ± ± ± ±4.01

45)%, (28.11±4.87) 10 6 /ml, ( 31.66± CASA 2.13)%; (24.99±4.74) 10 6 /ml, 37, (30.30±4.33)% 5, (P=0.44,P=0.35); CASA 2 15 10 6 /ml (P=0.65,P=0.

6 544 J Diagn Concepts Pract 2013, Vol.12, No.5, Uu,,3% [1] 12% Uu [1] Zeighami H, Peerayeh SN, Safarlu M. Detection of [2-4] Uu, Ureaplasma urealyticum in semen of infertile men by PCR[J]. Pak J Biol Sci,2007,10(21): [5] [2] Salmeri M, Valenti D, La Vignera S, et al. Prevalence of,uu Ureaplasma urealyticum and Mycoplasma hominis infection, in unselected infertile men[j]. J Chemother,2012,24(2): [3] Xu C, Lu MG, Feng JS, et al. Germ cell apoptosis induced by ureaplasma urealyticum infection [J]. Asian J ph,, Androl,2001,3(3): [6] [4] Gdoura R, Kchaou W, Ammar-Keskes L, et al. Assess- Uu ment of Chlamydia trachomatis, Ureaplasma urealyticum,, Ureaplasma parvum, Mycoplasma hominis, and Mycoplasma genitalium in semen and first void urine speci- Uu mens of asymptomatic male partners of infertile couples [J]. J Androl,2008,29(2): [5] Lozano-Hernández R, Vivas-Acevedo G, Mu 觡 oz de Vera, Uu MG. Mycoplasmas and antibodies anti-chlamydia in semen of infertile men and their relationship with seminal, Uu /, quality and markers of male accessory sex glands[j]. Invest Clin,2012,53(2): [7], [6] Marconi M, Pilatz A, Wagenlehner F, et al. Impact of infection on the secretory capacity of the male accessory [8],, glands[j]. Int Braz J Urol,2009,35(3): [7] Gdoura R, Kchaou W, Znazen A, et al. Screening for,uu,1 bacterial pathogens in semen samples from infertile men, 1 with and without leukocytospermia[j]. Andrologia,2008,40 [9] (4): ;, [8] Sancler-Silva YFR, Monteiro GA, Ignacio FS, et al. 161, processing of semen with pyospermia allows its use in e-,, quine embryo transfer programs [J]. Reprod Fertil Dev,, 10 d 7 d 2012,25(1):229. Uu, 1, [9] Pajovic B, Radojevic N, Vukovic M, et al. Semen analysis Uu before and after antibiotic treatment of asymptomatic chlamydia-and ureaplasma-related pyospermia [J]. Andrologia,2013,45(4): (P= 0.39,P=0.44), [10],., [J].,2003,25(4): Uu ph [11]. [10-11] [J].,, 30 min 2006,20(2):57-59., ph, [ ] ( : ) Uu ( 本文编辑 : 褚敬申 )

J Chemother,2012,24(2):81-86. [3] Xu C, Lu MG, Feng JS, et al. Germ cell apoptosis induced by ureaplasma urealyticum infection [J]. Asian J ph,, Androl,2001,3(3):199-204.

864 现代药物与临床 Drugs & Clinic 第 31 卷第 6 期 2016 年 6 月 of apoptosis related factors, decrease the incidence of adverse reactions, which is of great

864 现代药物与临床 Drugs & Clinic 第 31 卷第 6 期 2016 年 6 月 of apoptosis related factors, decrease the incidence of adverse reactions, which is of great 现代药物与临床 Drugs & Clinic 第 31 卷第 6 期 2016 年 6 月 863 曲妥珠单抗联合多西紫杉醇治疗 Her-2 阳性乳腺癌的临床研究 * 周永安, 刘训碧黄石市中心医院 ( 普爱院区 ) 乳腺肿瘤外科, 湖北黄石 435000 摘要 : 目的探析注射用曲