沙眼衣原体与前列腺炎的关系

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兰屐洪
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2 1. Mårdh Colleen Nilsson

3 Mårdh PA Colleen S 1 nonacute prostatitis 79 healthy volunteers 20 (Complement-fixing antibodies to Chlamydia) 33% 5%

4 Mårdh PA Colleen S 2 Mårdh Mårdh Mardh PA, Colleen S. Search for uro-genital tract infections in patients with symptoms of prostatitis. Studies on aerobic and strictly anaerobic bacteria, mycoplasmas, fungi, trichomonads and viruses. Scand J Urol Nephrol. 1975;9:8-16.

5 Mårdh PA Colleen S 33% STD

6 Mårdh PA, Ripa KT, Colleen S EPS IgG IgA IgG IgM 7 6

7 Mårdh PA, Ripa KT, Colleen S 13 nongonococcal urethritis NGU) Mårdh PA

8 Nilsson S, Johannisson G, Lycke E. 1 Nilsson Meares-Stamey % 26 EPS EPS 20 /HP

9 Nilsson S, Johannisson G, Lycke E. 2 Ct % Age No. (Positive (Negative) ~ ~ ~ ~

10 Nilsson S, Johannisson G, Lycke E. 3 Ct EPS * Ct 19 27% 1 4% 96 * 26 EPS WBC 20WBC/HPF

11 Nilsson S, Johannisson G, Lycke E. 4 1 lymecycline 92% Nilsson Mardh sub-acute silent prostatitis Nilsson S, Johannisson G, Lycke E. Isolation of Chlamydia trachomatis from the urethra and from prostatic fluid in men with signs and symptoms of acute urethritis. Acta Derm Venereol. 1981;61:

12 Poletti F, Medici MC, Alinovi A Poletti % Poletti Poletti F, Medici MC, Alinovi A et al. Isolation of Chlamydia trachomatis from the prostatic cells in patients affected by nonacute abacterial prostatitis. J Urol. 1985;134:

13 Bruce AW, Chadwick P, Willett WS Bruce 56 (39/70)

14 Bruce AW, Reid G Bruce Bruce 6 Bruce AW, Chadwick P, Willett WS et al. The role of chlamydiae in genitourinary disease. J Urol. 1981;126: Bruce AW, Reid G. Prostatitis associated with Chlamydia trachomatis in 6 patients. J Urol. 1989;142:

15 Kuroda K, Sawamura Y, Tajima M Kuroda 21.1% Kuroda K, Sawamura Y, Tajima M et al. Detection of Chlamydia trachomatis in urethra of patients with urogenital infection. Hinyokika Kiyo. 1989;35:

16 Shurbaji (31%) H-E 1 Shurbaji

17 Shurbaji MS, Dumler JS, Gage WR Shurbaji 36 12(33%) Shurbaji MS, Gupta PK, Myers J. Immunohistochemical demonstration of Chlamydial antigens in association with prostatitis. Mod Pathol. 1988;1: Shurbaji MS, Dumler JS, Gage WR et al. Immunohistochemical detection of chlamydial antigens in association with cystitis. Am J Clin Pathol. 1990;93:

18 Intraprostatic urinary reflux, IPUR Intraprostatic urinary reflux, IPUR

19 Abdelatif OM Kadar A Abdelatif 23 7(30.4%) Kadar 34 NIH 11 3 Abdelatif OM, Chandler FW, McGuire BS Jr. Chlamydia trachomatis in chronic abacterial prostatitis: demonstration by colorimetric in situ hybridization. Hum Pathol. 1991;22: Kadar A, Bucsek M, Kardos M et al. Detection of Chlamydia trachomatis in chronic prostatitis by in situ hybridization (preliminary methodical report) Orv Hetil. 1995;136:

21 Badalyan RR, Fanarjyan SV, Aghajanyan IG. Meares-Stamey Badalyan Meares-Stamey PCR Uu

22 Badalyan RR, Fanarjyan SV, Aghajanyan IG. Meares-Stamey Meares-Stamey 4 A B Meares-Stamey 4 PCR Ct PCR Uu % % Ct+Uu % 1 Ct Uu 14 36% %

23 Badalyan RR ( %) 4 Badalyan Badalyan RR, Fanarjyan SV, Aghajanyan IG. Chlamydial and ureaplasmal infections in patients with nonbacterial chronic prostatitis. Andrologia. 2003;35:

24 Badalyan RR, Fanarjyan SV, Aghajanyan IG. Badalyan Meares-Stamey

25 Krieger JN, Riley DE Krieger PCR (chronic prostatitis/chronic pelvic pain syndrome CP/CPPS) %

26 Krieger JN, Riley DE 2 DNA 25% 77% 16S rdnas 16S rdnas (p <0.01) Krieger CP/CPPS Krieger JN, Riley DE. Chronic prostatitis: Charlottesville to Seattle. J Urol. 2004;172(6 Pt 2):

27 1 CAP/CPPS NIH

28 2 NIH Meares-Stamey 4

29 Meares-Stamey 4 1 PCR

30 Meares-Stamey 4 2 Meares-Stamey 4 VB2 EPS / VB3 VB1 10

31 PCR

32 mrna NIH A B

33 1 (chlamydial urethro-prostatitis) Peeters MF, Polak-Vogelzang AA, Debruyne FM, et al. Role of mycoplasmas in chronic prostatitis. Yale J Biol Med. 1983;56: Krieger JN. Prostatitis Syndromes. In: Holmes KK, Mardh P-A, Sparling PE, et al. eds. Sexually Transmitted Diseases. 3rd ed. New York: McGraw-Hill, 1999,

34 2 CAP/CPPS

泌尿生殖道不同部位沙眼衣原体感染的诊断和治疗评估

泌尿生殖道不同部位沙眼衣原体感染的诊断和治疗评估 1 2 3 1 2 3 1 : Reiter 9-1-1 Annal of internal medicine 5PMN/1000 (+) (+) NGU DFA 10PMN/1000 DFA(+) + GS=Gram Stain PMN=polymorphonuclear leukocytes DFA=direct fulorescent antibody (Annal internal medicine)