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1 7 4 Vol. 7 No Journal of Food Safety and Quality Apr., 2016 熊 1, 琳 2* 1,, 李维红 2 1,, 杨晓玲 2, 高雅琴 1, 2 (1., ; 2. ( ), ) 摘要 :,,, 4, 关键词 : ; ; Review of risk factors of drug residues in meat products XIONG Lin 1, 2, LI Wei-Hong 1, 2, YANG Xiao-Lin 1, 2,GAO Ya-Qin 1, 2 (1. Lanzhou Institute of Husbandry and Pharmaceutical Sciences, Chinese Academy of Agricultural Sciences, Lanzhou , China; 2. Laboratory of Quality & Safety Risk Assessment for Livestock Product (Lanzhou), Ministry of Agriculture, Lanzhou , China) ABSTRACT: The problem of drug residues in meat seriously affects human health. The food safety problems brought by the veterinary drug residue in meat emerge endlessly in recent years. Along with the monitoring for various kinds of veterinary drug residues in meat more and more strict and standard, and more and more drug residues risk factors were found and evaluated. In this paper, we summarized the specific material categories of 4 kinds of risk factors in meat including antibiotics, parasitic resistance, hormone and antibiotic chemicals, and the hazard to health, as well as the comparison of limit standard at home and abroad. This article clearly reviewed the meat safety and quality monitoring of specific projects as starting point and monitoring indicators, and determined the monitoring risk factors according to the harm of risk factors and the necessity. By effective monitoring and risk assessment, it can provide a reference for safety inspection and research of meat quality. KEY WORDS: food safety; meat products; safety risk factor 基金项目 : ( ) (145RJZA150) Fund: Supported by Basic Scientific Research Funds of National Research Institute( ) and Scientific Plan Funds of Gansu Province(145RJZA150) * 通讯作者 :,,, xionglin807@sina.com *Corresponding author: XIONG Lin, Master, Research Assistant, Lanzhou Institute of Husbandry and Pharmaceutical Sciences, Chinese Academy of Agricultural Sciences, No.355, Xiaoxihu Road, Lanzhou , China. xionglin807@sina.com

Lanzhou Institute of Husbandry and Pharmaceutical Sciences, Chinese Academy of Agricultural Sciences, Lanzhou 730050, China; 2.

2 4, : 引言,,,, [1], [2], 噁,, [3],, [4-7], [8-10],, [11],,,,, 2 肉制品中兽药残留风险因子 ( ) 抗生素类药物风险因子,,, 10,, β- 内酰胺类药物风险因子 β-, β- β-,,, [12,13] : 氨基糖苷类药物风险因子,,, [14] : B 14, [15], FDA [16] 四环素类药物风险因子,,,,, [17-19] :, [20] [16] [21] 100 μg/kg 氯霉素类药物风险因子,,,,,,,,,, [22,23] : 3 [21] , [24] , (FDA) 11,

1.3 四环素类药物风险因子,,,,, [17-19] :, [20] [16] [21] 100 μg/kg 2.1.4 氯霉素类药物风险因子,,,,,,,,,, [22,23] : 3 [21] 2002 3 15, [24] 2002 1, (FDA) 11,

3 大环内脂类药物风险因子, [25] : (MRL) 40~200 μg/kg, MRL 200 μg/kg, MRL 50~1500 μg/kg, MRL 50~1500 μg/kg, MRL 50~200 μg/kg [21] 作用于 G+ 细菌的其他抗生素类药物风险因子 2.2 抗寄生类药物风险因子,, [17] [26-28] : ( ) [29],,, [30],,, [20] [21] 100 μg/kg 2.3 激素类药物风险因子,,, β-, 1996 [20], [24],, 2,, 性激素类药物风险因子,,,, [31] : 20 70, 1980, 皮质激素类药物风险因子,,,, [32,33] : [20], 0.75 μg/kg [21] 孕激素类药物风险因子,,, [34] : 21α- 17α-

2 抗寄生类药物风险因子,, [17] [26-28] : ( ) [29],,, [30],,, [20] [21] 100 μg/kg 2.

4 4, : β- 受体激动剂类药物风险因子 β-,,, [35],, β- 30, 20 [36-38],, ; , [39], 2.4 抗菌类 ( 化学药物 ) [40] 磺胺类药物风险因子,,, [41,42] : -5- 噁噁噁噁 [20] 100 μg/kg, [16] 100 μg/kg 呋喃类药物风险因子,, 4 [43,44] : [20] A, 1995, 2002 [16] [39], 硝基咪唑类药物风险因子, [45-47] : 11, 喹诺酮类药物风险因子 20,, [45],,,, [48,49] : 噁 [50] (FDA) ~500 μg/kg [21] 3 结论,,,,,,, 参考文献 [1] Fink-Gremmels J. Residues in meat and meat products of feed and drug

4.3 硝基咪唑类药物风险因子, [45-47] : 11, 2.4.4 喹诺酮类药物风险因子 20,, [45],,,, [48,49] : 噁 [50] (FDA) 2005 7 10~500 μg/kg

5 residues [J]. Encyclopediaof Meat Sciences (Second Edition), 2014: [2] Chayada C, Urairat K, Soparat Y, et al. Efficient hydrophilic interaction liquid chromatography tandem mass spectrometry for the multiclass analysis of veterinary drugs in chicken muscle [J]. Anal Chim Acta, 2010, 682: [3] Anton K, Patrick B, Kathryn M, et al. Quantitative multiresidue method for about 100 veterinary drugs in different meat matrices by sub 2-μm particulate high-performance liquid chromatography coupled to time of flight mass spectrometry [J]. J Chromatogr.A, 2008, 1194; [4] Baptistaa F M, Albanb L, Olsenb A M, et al. Evaluation of the antibacterial residue surveillance programme in Danish pigs using Bayesian methods [J]. Prev Vet Med, 2012, 106: [5] Kaufmann A. Validation of multiresidue methods for veterinary drug residues; related problems and possible solutions [J]. Anal Chim Acta, 2009, 637: [6] Toldrá F, Reig M. Chemical Analysis for specific components veterinary drug residue analysis [J]. Encyclopedia of Meat Sci (Second Edition), 2014: [7] Menz J. Schneider M, Kümmerer K. Usage pattern-based exposure screening as a simple tool for the regional priority-setting in environmental risk assessment of veterinary antibiotics: A case study of north-western Germany [J]. Chemosphere, 2015, 127: [8] Andrée S, Jira W, Schwind K-H, et al. Chemical safety of meat and meat products [J]. Meat Sci, 2010, 86: [9] Du W, Fu Q, Zhao G, et al. Dummy-template molecularly imprinted solid phase extraction for selective analysis of ractopamine in pork [J]. Food Chem, 2013, 139: [10] Hao B, Jia X F, Zhang J, et al. Multi-residual analysis of 16 b-agonists in pig liver, kidney and muscle by ultra performance liquid chromatography tandem mass spectrometry [J]. Food Chem, 2009, 114: [11],,,. [J]., 2008, 42(8): Li YH, Li WP, Li H, et al. Over view of international risk assessment of veterinary drug residue in food of animal origin [J]. China J Vet Med, 2008, 42(8): [12] GB [S]. GB Method for determination of nine penicillins residues in livestock and poultry muscles-lc-ms-ms method [S]. [13] GB / [S]. GB Determination of cephapirin and ceftiofur residues in foodstuff of anminal origin-lc-ms-ms method [S]. [14] GB / [S]. GB Determination of aminoglycosides residues in animal tissues-hplc-ms/ms method [S]. [15] Commission Regulation.(EC)No 378/2005on detailed rules for the implementation of Regulation (EC) No 1831/2003 of the European Parliament and of the Council as regards the duties and tasks of the Community Reference Laboratory concerning applications for authorisations of feed additives [S]. [16] Federal government of the United States. Livestock and poultry veterinary drug residue limits standards in the United States: CFR-TITLE21: Food and Drugs, Part 556 [S]. [17] GB / [S]. GB Determination of tetracycline residues in food of anminal origin-lc-ms-ms method and HPLC method [S]. [18] DB [S]. DB Zhejiang province Standard-Determination of Oxytetracycline, Tetracycline, Chlortetracycline and Doxycycline residues in aquatic product-hplc with fluorescence detector [S]. [19] Natalija V, Davorin B, Bela N. Risk assessment of streptomycin and tetracycline residues in meat and milk on Croatian market [J]. Food Chem Toxicol, 2011, 49(2): [20] Council Directive 96/23/EC of 29 April 1996 on measures to monitor certain substances and residues thereof in live animals and animal products and repealing Directives 85/358/EEC and 86/469/EEC and Decisions 89/187/EEC and 91/664/EEC [Z]. [21] [Z]. No Bulletin of ministry of agriculture-the maximum residue limit of veterinary drug in animal derived food [Z]. [22] [Z]. No Bulletin of ministry of agriculture -Determination of chloramphenicol, thiamphenicol and florfenionl in fishery products by GC-MS [Z]. [23] [Z]. No Bulletin of ministry of agriculture-determination of chloramphenicol in tissues by GC-MS method [Z]. [24] [Z]. No Bulletin of ministry of agriculture-the detailed list of forbidden veterinary drug and compound in food-producing animal [Z]. [25] SN/T : [S]. SN/T Chinese national standard-determination of macrolide antibiotic residues in animal derived food part2: LC-MS/MS method [S]. [26] Waal TD, Danaher M. Veterinary drugs residues: ectoparasiticides [J]. Encyclopedia Food Saf, 2014, 3: [27] GB [S]. GB Method for the determination of benzimidazole residues in edible animal muscle and liver [S]. [28] GB [S]. GB Determination of benzimidazoles residues in fugu, eel and baked eel by-lc-ms/ms method [S]. [29] [Z].. No Bulletin of ministry of agriculture-determination of abamectin residues in animal derived foodby HPLC [Z]. [30] GB [S].

[3] Anton K, Patrick B, Kathryn M, et al.

6 4, : 1577 GB Determination of organophosphorus pesticide multiresidues in animal food [S]. [31] GB / [S]. GB Determination of hormone multiresidues in foodstuffs of animal origin-lc-ms/ms [S]. [32] [Z].. No Bulletin of ministry of agriculture-determination of glucocorticosteroid residues in animal products LC-MS/MS method [Z].. [33] SN / [S]. SN Determination of glucocorticosteroid residues in foodstuffs of animal origin for import and export-lc-ms/ms method [S]. [34] GB [S]. GB Method for the determination of testosterone, epitestosterone and progesterone residues in bovine liver and muscle tissues-lc-ms/ms [S]. [35],,,. [J]., 2015, 48(3): Hao HH, Cheng GY, Dai MH, et al. Rethinking the withdrawal of antimicrobial growth promotants in animal feed [J]. Sci Agric Sinica, 2015, 48(3): [36] 1025 β- - [Z]. No Bulletin of ministry of agriculture-determination of β-agonist residues in animal origin food by LC-MS/MS [Z]. [37] GB β- - [S]. GB Chinese national standard-analysis of β-agonist residues in food of animal origin by LC-MS/MS [S]. [38] β- -. [Z]. No Bulletin of ministry of agriculture-determination of 16 β-agonist residues in feed LC-MS/MS [Z]. [39] [Z]. No Bulletin of ministry of agriculture-the detailed list of forbidden veterinary drug used in feed and drink water [Z]. [42] GB [S]. GB Determination of 18 sulfanilamides residues in fugu and ell LC-MS/MS method [S]. [43] [Z]. No bulletin of ministry of agriculture-determination of nitrofuran metabolites in animal derived food by LC-MS/MS method [Z]. [44] GB [S]. GB Method for the determination residues of the Metabolites of nitrofuran in pork, beef, chicken,porcine liver and aquatic products-lc-ms/ms [S]. [45] GB [S]. GB Determination of nitroimidazole metabolites in foodstuffs of animal origin [S]. [46] [Z]. No Bulletin of ministry of agriculture Determination of four nitroimidazole residues in edible tissues of animal LC-MS/MS [Z]. [47] GB [S]. GB Determination of nitroimidazole residues in feed LC-MS/MS [S]. [48],,, [J]., 2007, 25(4): Yue ZF, Lin XY, Tang S B, et al. Determination of 16 quinolone residues in animal tissues using high performance liquid chromatography coupled with electrospray ionization tandem mass spectrometry [J]. Chin J Chromatogr, 2007, 25(4): [49] 1025 [Z]. No 1025 Bulletin of ministry of agriculture-determination of fluoroquinolones Residues in animal derived food by HPLC [Z]. [50] Federal government of the United States. Commission Regulation(EC) No 726/2004. Laying down Community procedures for the establishment of residue limits of pharmacologically active substances in foodstuffs of animal [Z]. ( 责任编辑 : 姚菲 ) [40] Shani S, Charles G, Renate Re, et al. Simultaneous screening and confirmation of multiple classes of drug residues in fish by liquid chromatography-ion trap mass spectrometry [J]. J Chromatogr A, 2009, 作者简介 1216: [41] [Z]. No Bulletin of ministry of agriculture-determination of 熊琳, 硕士, 助理研究员, 主要研究方向为农产品质量安全 xionglin807@sina.com sulfanilamide residues in edible tissues of animal LC-MS/MS [Z]..

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82 - (5) ㈢102961021950329 () (6) ㈣102961021950329 - (7) ㈤1001171001903947 呋 (8) ㈥102961021950329 (9) ㈦10047 1001900952 (10) ㈧102961021950329 (11) ㈨102 . 5 : 81-91 2014 Ann. Rept. Food Drug Res. 5 : 81-91 2014 81 102 1 1 1 1 1 1 1 7 2 3 4 8 5 6 9 1 1 2 3 4 5 6 7 8 9 102211 861 呋 Quinolone beta- 呋 Chloramphenicol 861 35 6425 Azaperone(Lincomycin) (Trimethoprim)Tilmicosin(Nicarbazin)

Microsoft Word _熊 琳 二校

Microsoft Word _熊琳二校