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1 5 4 Vol. 5 No Journal of Food Safety and Quality Apr., 2014 湛剑龙 1, 胡萍 1*, 陈韵 1, 李立郎 1, 朱秋劲 1, 王晓宇 2, 谢和 (1.,, ; 2.,, ) 2 摘要 :,,,,,, ;,,,,, 关键词 : ; ; Research on application of functional lactic acid bacteria ZHAN Jian-Long 1, HU Ping 1*, CHEN Yun 1, LI Li-Lang 1,, ZHU Qiu-Jin 1, WANG Xiao-Yu 2, XIE He 2 (1. College of Liquor Making and Food Engineering, Guizhou University, Guiyang , China; 2. College of Life Science, Guizhou University, Guiyang , China) ABSTRACT: Lactic acid bacteria are gram-positive, non-spore, anaerobic, a class of bacteria using carbohydrates to produce lactic acid, which are valuable resource of microorganisms, and are closely related to our health. This paper described the function of lactic acid bacteria on improving immune, antioxidant, decreasing cholesterol, antihypertensive, antibacterial, and improving the flavor functions, which were currently being used in food and medicines. Some applications were also described such as lactic acid bacteria, genetic engineering lactic acid, lactic acid producing enzyme, lactobacillus, lactobacillus starch entrapped and Se lactic acid, so as to provide a reference for the further development and utilization. KEY WORDS: lactic acid bacteria; function; applied technology 1 引言,,, [1], 18, 200, [2,3] :,,,,,,,,, [4-6], [7], 2 免疫功能, 基金项目 : ( ) Fund: Supported by National Natural Science Foundation of China ( ) * 通讯作者 :,,, ls.phu@gzu.edu.cn *Corresponding author: HU Ping, Professor, College of Liquor Making and Food Engineering, Guizhou University, Guiyang , China. ls.phu@gzu.edu.cn

(1. College of Liquor Making and Food Engineering, Guizhou University, Guiyang 550025, China; 2.

2 4, : 1003,,,, [8] [9], 42, Chuang [10], DCST, IL-10, IL-12 P70, IFN-γ, T TH,,, Beatriz [11],,, OspA IL-8, Th1/Th2 Sudo [12] (GF) IgE, 3 抗氧化 (free radical),,,,,,,, DNA [13,14] Kim [15] (Lactobacillus acidophilus)kctc3111, (jonsonii) KCTC3141, (Lactobacillus acidophilus)kctc3151, KCTC3498, KCTC ,, GPX, Srikanjana [16] Miang FTL2311 FTL10BR,,, Dawei [17] FC225,, FC225 Nrf2,, FC225 Nrf2 Cheng-Chih [18], :,, [19], CGMCC No.5093, SOD, GSH-Px, MDA,,,,, 4 降胆固醇,, : ; [20-22] Tahri [23],,,,, Guijie [24] :,,,,

acidophilus)kctc3151, KCTC3498, KCTC3111 49.7 65.

3 1004 5, /, 12 h, (63.45 ~81.62 ) (18.38 ~36.55 ), Huang Y [25] ATCC4356 Niemann-Pick C1-like 1 NPC1L1,, ATCC4356 NPC1L1, Caco-2 Yoon [26] [27] 5 抗高血压 Yu [28], (ACE),, LG 42 Osuntoki [29],,, ACE (ACE),, [30,31] Flambard [32] 6 产乳酸链球菌素 (Nisin),,, Nisin,, [33,34],,, ATP K +, [35,36] [37] Nisin,, Nisin, Nisin,, Nisin,, Nisin Nisin, [38],, enterocin LM-2, 100 d, Nisin,,, [39], [40] 7 改善风味,,, [41,42],,, [43] Smit [44],,,,,,, Jiang [45] : Saccharomyces cerevisiae 3 /, 30, ph (v:v), 49.5 g/l, 4.14 g/l 4.14 g/ L,, 1.16 g/ L 3.56 [46],,

Osuntoki [29],,, ACE (ACE),, [30,31] Flambard [32] 6 产乳酸链球菌素 (Nisin),,, Nisin,, [33,34],,, ATP K +, [35,36] [37] Nisin,, Nisin,

4 4, : 1005,,,, [47] 8 乳酸菌的应用技术,, 8.1 基因工程乳酸菌 Field [48] 29 S29G, S29A, S29D S29E,,, Li [49], Lactobacillus casei CICC6028, N-2, g/l, g/l Mundi [50] La -5 NCC2705,, CFSM CIAB flaa, Christina [51] MLE, Lactobacillal, psip409,, MLE, [52], 8.2 乳酸菌产酶, Justyna [53] / GTFA / reuteransucrase Ogbonnaya [54] NRRL B-763,, Balakrishnan [55],,,,,, 8.3 乳酸菌制剂, Marion-Eliëtte [56], ,,,, Mary [57], , L 100 g 97mL, 1,, L Wang [58], 140 mg 3 ml, ph 4.3, 6 μl 0.1 mol/lhcl 8.4 淀粉包埋制备微囊乳酸菌 MA [59],,, : 5 g, ph 6.0, 20, 200r/min 50min,, 67.12%, [60],,,

CFSM CIAB flaa, Christina [51] MLE, Lactobacillal, psip409,, MLE, [52], 8.

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DARU J Pharma Sci, 2013, 21(1):33. [63],,. [J]., 2008, 36(20): 8621 8622, 8625. Zhu SL, Gao W, Chen L. Effects of lactobacillus rich in selenium on tissue lipid per oxidation response [J].

研發與創新驗顯示, 停止攝食乳酸菌後, 在幾週內乳酸菌便會消失, 並不會持續存在於腸道內, 但是短暫的定殖, 還是有刺激腸道免疫系統的效果, 尤其是對服用抗生素或腹瀉感

研發與創新驗顯示, 停止攝食乳酸菌後, 在幾週內乳酸菌便會消失, 並不會持續存在於腸道內, 但是短暫的定殖, 還是有刺激腸道免疫系統的效果, 尤其是對服用抗生素或腹瀉感乳酸菌之保健功效與產品開發撰文 / 陳慶源黃崇真邱雪惠廖啟成益生菌是指具有改善宿主體內內生性微生物相平衡, 並有益於宿主健康的單一或數種微生物一般而言, 益生菌被認定為活菌本身, 但是, 近年發現某類益生菌所衍生之活性